Exposure to the herbicide atrazine induces oxidative imbalance, morphological damage and decreased survival in juvenile fish
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Bioscience journal (Online) |
Texto Completo: | https://seer.ufu.br/index.php/biosciencejournal/article/view/65784 |
Resumo: | Synthetic herbicides have been intensively used in weed control, although often involved in environmental contamination, critically affecting non-target species. However, never was investigated the effect of commercial formulation using atrazine on developing juvenile fish exposed for 35 days. Juveniles (Astyanax altiparanae) (n = 600) were assigned to the following ATZ-exposed groups: 0 (CTR-control), 0.56 (ATZ0.56), 1.00 (ATZ1.00), 1.66 (ATZ1.66) and 11.66 (ATZ11.66) μg/L. We found a 36.6% decrease in juvenile survival rate in the ATZ11.66 group compared to control and other groups. Juveniles from ATZ11.66 also showed hyperglycemia and increased cortisol levels. Increased the imbalance oxidative with an increase in malondialdehyde (MDA) and Carbonylated proteins levels markers in muscle, gills, and liver. We also found increased activity of the antioxidant enzymes superoxide dismutase (SOD) in gills and SOD and catalase (CAT) in muscles from ATZ11.66 fish, and increased glutathione S-transferase (GST) activities in the liver from all exposed groups compared to control. The morphological consequences of this were loss of secondary lamella integrity, increased mucus-secreting cells, hyperplasia, and lamellar fusion, as well as increased aneurysms percentage. The liver showed vascular congestion associated with endothelial hyperplasia, steatosis, and a decrease in the nuclei percentage. Our results showed that exposure to a commercial formulation of ATZ at 11.66 μg/L can be causing an imbalance in the oxidative markers and morphological damages and decreased survival in a juvenile Neotropical species of great ecological relevance and commercial interest. |
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Exposure to the herbicide atrazine induces oxidative imbalance, morphological damage and decreased survival in juvenile fishEcotoxicologyOxidative stressSurvival rateWater pollutants. Biological SciencesSynthetic herbicides have been intensively used in weed control, although often involved in environmental contamination, critically affecting non-target species. However, never was investigated the effect of commercial formulation using atrazine on developing juvenile fish exposed for 35 days. Juveniles (Astyanax altiparanae) (n = 600) were assigned to the following ATZ-exposed groups: 0 (CTR-control), 0.56 (ATZ0.56), 1.00 (ATZ1.00), 1.66 (ATZ1.66) and 11.66 (ATZ11.66) μg/L. We found a 36.6% decrease in juvenile survival rate in the ATZ11.66 group compared to control and other groups. Juveniles from ATZ11.66 also showed hyperglycemia and increased cortisol levels. Increased the imbalance oxidative with an increase in malondialdehyde (MDA) and Carbonylated proteins levels markers in muscle, gills, and liver. We also found increased activity of the antioxidant enzymes superoxide dismutase (SOD) in gills and SOD and catalase (CAT) in muscles from ATZ11.66 fish, and increased glutathione S-transferase (GST) activities in the liver from all exposed groups compared to control. The morphological consequences of this were loss of secondary lamella integrity, increased mucus-secreting cells, hyperplasia, and lamellar fusion, as well as increased aneurysms percentage. The liver showed vascular congestion associated with endothelial hyperplasia, steatosis, and a decrease in the nuclei percentage. Our results showed that exposure to a commercial formulation of ATZ at 11.66 μg/L can be causing an imbalance in the oxidative markers and morphological damages and decreased survival in a juvenile Neotropical species of great ecological relevance and commercial interest.Universidade Federal de Uberlândia2023-03-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufu.br/index.php/biosciencejournal/article/view/6578410.14393/BJ-v39n0a2023-65784Bioscience Journal ; Vol. 39 (2023): Continuous Publication; e39034Bioscience Journal ; v. 39 (2023): Continuous Publication; e390341981-3163reponame:Bioscience journal (Online)instname:Universidade Federal de Uberlândia (UFU)instacron:UFUenghttps://seer.ufu.br/index.php/biosciencejournal/article/view/65784/35677Brazil; Contemporary Copyright (c) 2023 Stella Bicalho Silva, Kemilli Pio Gregório, Renata Maria Pereira de Freitas, Ana Luiza Fonseca Destro, Ana Lúcia Salaro, Jener Alexandre Sampaio Zuanon, Reggiani Vilela Gonçalves, Mariella Bontempo Freitashttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess Silva, Stella BicalhoGregório, Kemilli PioFreitas, Renata Maria Pereira deDestro, Ana Luiza FonsecaSalaro, Ana Lúcia Zuanon, Jener Alexandre Sampaio Gonçalves, Reggiani VilelaFreitas, Mariella Bontempo2024-01-31T19:16:18Zoai:ojs.www.seer.ufu.br:article/65784Revistahttps://seer.ufu.br/index.php/biosciencejournalPUBhttps://seer.ufu.br/index.php/biosciencejournal/oaibiosciencej@ufu.br||1981-31631516-3725opendoar:2024-01-31T19:16:18Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)false |
dc.title.none.fl_str_mv |
Exposure to the herbicide atrazine induces oxidative imbalance, morphological damage and decreased survival in juvenile fish |
title |
Exposure to the herbicide atrazine induces oxidative imbalance, morphological damage and decreased survival in juvenile fish |
spellingShingle |
Exposure to the herbicide atrazine induces oxidative imbalance, morphological damage and decreased survival in juvenile fish Silva, Stella Bicalho Ecotoxicology Oxidative stress Survival rate Water pollutants. Biological Sciences |
title_short |
Exposure to the herbicide atrazine induces oxidative imbalance, morphological damage and decreased survival in juvenile fish |
title_full |
Exposure to the herbicide atrazine induces oxidative imbalance, morphological damage and decreased survival in juvenile fish |
title_fullStr |
Exposure to the herbicide atrazine induces oxidative imbalance, morphological damage and decreased survival in juvenile fish |
title_full_unstemmed |
Exposure to the herbicide atrazine induces oxidative imbalance, morphological damage and decreased survival in juvenile fish |
title_sort |
Exposure to the herbicide atrazine induces oxidative imbalance, morphological damage and decreased survival in juvenile fish |
author |
Silva, Stella Bicalho |
author_facet |
Silva, Stella Bicalho Gregório, Kemilli Pio Freitas, Renata Maria Pereira de Destro, Ana Luiza Fonseca Salaro, Ana Lúcia Zuanon, Jener Alexandre Sampaio Gonçalves, Reggiani Vilela Freitas, Mariella Bontempo |
author_role |
author |
author2 |
Gregório, Kemilli Pio Freitas, Renata Maria Pereira de Destro, Ana Luiza Fonseca Salaro, Ana Lúcia Zuanon, Jener Alexandre Sampaio Gonçalves, Reggiani Vilela Freitas, Mariella Bontempo |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Stella Bicalho Gregório, Kemilli Pio Freitas, Renata Maria Pereira de Destro, Ana Luiza Fonseca Salaro, Ana Lúcia Zuanon, Jener Alexandre Sampaio Gonçalves, Reggiani Vilela Freitas, Mariella Bontempo |
dc.subject.por.fl_str_mv |
Ecotoxicology Oxidative stress Survival rate Water pollutants. Biological Sciences |
topic |
Ecotoxicology Oxidative stress Survival rate Water pollutants. Biological Sciences |
description |
Synthetic herbicides have been intensively used in weed control, although often involved in environmental contamination, critically affecting non-target species. However, never was investigated the effect of commercial formulation using atrazine on developing juvenile fish exposed for 35 days. Juveniles (Astyanax altiparanae) (n = 600) were assigned to the following ATZ-exposed groups: 0 (CTR-control), 0.56 (ATZ0.56), 1.00 (ATZ1.00), 1.66 (ATZ1.66) and 11.66 (ATZ11.66) μg/L. We found a 36.6% decrease in juvenile survival rate in the ATZ11.66 group compared to control and other groups. Juveniles from ATZ11.66 also showed hyperglycemia and increased cortisol levels. Increased the imbalance oxidative with an increase in malondialdehyde (MDA) and Carbonylated proteins levels markers in muscle, gills, and liver. We also found increased activity of the antioxidant enzymes superoxide dismutase (SOD) in gills and SOD and catalase (CAT) in muscles from ATZ11.66 fish, and increased glutathione S-transferase (GST) activities in the liver from all exposed groups compared to control. The morphological consequences of this were loss of secondary lamella integrity, increased mucus-secreting cells, hyperplasia, and lamellar fusion, as well as increased aneurysms percentage. The liver showed vascular congestion associated with endothelial hyperplasia, steatosis, and a decrease in the nuclei percentage. Our results showed that exposure to a commercial formulation of ATZ at 11.66 μg/L can be causing an imbalance in the oxidative markers and morphological damages and decreased survival in a juvenile Neotropical species of great ecological relevance and commercial interest. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-03-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/65784 10.14393/BJ-v39n0a2023-65784 |
url |
https://seer.ufu.br/index.php/biosciencejournal/article/view/65784 |
identifier_str_mv |
10.14393/BJ-v39n0a2023-65784 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/65784/35677 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
Brazil; Contemporary |
dc.publisher.none.fl_str_mv |
Universidade Federal de Uberlândia |
publisher.none.fl_str_mv |
Universidade Federal de Uberlândia |
dc.source.none.fl_str_mv |
Bioscience Journal ; Vol. 39 (2023): Continuous Publication; e39034 Bioscience Journal ; v. 39 (2023): Continuous Publication; e39034 1981-3163 reponame:Bioscience journal (Online) instname:Universidade Federal de Uberlândia (UFU) instacron:UFU |
instname_str |
Universidade Federal de Uberlândia (UFU) |
instacron_str |
UFU |
institution |
UFU |
reponame_str |
Bioscience journal (Online) |
collection |
Bioscience journal (Online) |
repository.name.fl_str_mv |
Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU) |
repository.mail.fl_str_mv |
biosciencej@ufu.br|| |
_version_ |
1797069065269805056 |