Methods of macrophages activation and their modulation for the prospection of new antileishmania drugs: a review
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Bioscience journal (Online) |
Texto Completo: | https://seer.ufu.br/index.php/biosciencejournal/article/view/53770 |
Resumo: | Leishmaniasis are a group of parasitic zoonoses provoked by protozoa from Leishmania genus and belonging to the group of neglected tropical diseases. The search and development for new drugs is necessary not only to investigate the activity against only the parasite, but also to investigate the possible synergistic effect of new drugs with the immune response of the host. In the present review, macrophages are pointed out as potential targets of the investigation of new antileishmanial drugs, and some methodologies in order to assess their activation as response to Leishmania-infected cells are presented. Macrophages are an important role in the cellular immune response, since they are cells from mononuclear phagocytic system, the first line of defense of the host, against parasites from Leishmania genus. Phagocytic capacity, lysosomal activity, increase of nitric oxide and intracellular calcium levels are parameters regarding assessment of macrophages activation which allow them to be more hostile in order to solve the infection and lead the patient to cure. In this context, we bring 19 substances already investigated and that activate macrophages, what makes them promising in the antileishmanial treatment. Therefore, assessment of macrophages activation, are important tools for discovery of immunomodulatory compounds which have potential to act in synergism with host immune response. Such compounds might be promising as monotherapy in the treatment of leishmaniasis, as well as being used as adjuvants in vaccines and/or in combination with conventional drugs. |
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Methods of macrophages activation and their modulation for the prospection of new antileishmania drugs: a reviewImmunomodulationIntracellular CalciumLeishmaniasisNatural ProductsNitric OxidePhagocytosis.Agricultural SciencesLeishmaniasis are a group of parasitic zoonoses provoked by protozoa from Leishmania genus and belonging to the group of neglected tropical diseases. The search and development for new drugs is necessary not only to investigate the activity against only the parasite, but also to investigate the possible synergistic effect of new drugs with the immune response of the host. In the present review, macrophages are pointed out as potential targets of the investigation of new antileishmanial drugs, and some methodologies in order to assess their activation as response to Leishmania-infected cells are presented. Macrophages are an important role in the cellular immune response, since they are cells from mononuclear phagocytic system, the first line of defense of the host, against parasites from Leishmania genus. Phagocytic capacity, lysosomal activity, increase of nitric oxide and intracellular calcium levels are parameters regarding assessment of macrophages activation which allow them to be more hostile in order to solve the infection and lead the patient to cure. In this context, we bring 19 substances already investigated and that activate macrophages, what makes them promising in the antileishmanial treatment. Therefore, assessment of macrophages activation, are important tools for discovery of immunomodulatory compounds which have potential to act in synergism with host immune response. Such compounds might be promising as monotherapy in the treatment of leishmaniasis, as well as being used as adjuvants in vaccines and/or in combination with conventional drugs.EDUFU2021-12-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://seer.ufu.br/index.php/biosciencejournal/article/view/5377010.14393/BJ-v37n0a2021-53770Bioscience Journal ; Vol. 37 (2021): Continuous Publication; e37077Bioscience Journal ; v. 37 (2021): Continuous Publication; e370771981-3163reponame:Bioscience journal (Online)instname:Universidade Federal de Uberlândia (UFU)instacron:UFUenghttps://seer.ufu.br/index.php/biosciencejournal/article/view/53770/32939Brazil; Contemporary Copyright (c) 2021 Michel Muálem de Moraes Alves; Daniel Dias Rufino Arcanjo, Rita Cássia Viana de Carvalho; Layane Valéria Amorim, Ingredy Lopes dos Santos, Rodolfo Ritchelle Lopes Santos, Kayo Alves Figueiredo, Jessica Freire Silva Figueiredo, Enoque Pereira Costa Sobrinho-Júnior, Lucas Pereira Lima da Cruz, Valeria Carlos Sousa, Laiz Pinheiro dos Santos, Juan Carlos Ramos Gonçalves, Sabrina Maria Portela Carneiro, Ivete Lopes de Mendonça, Fernando Aécio de Amorim Carvalhohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMuálem de Moraes Alves, MichelArcanjo, Daniel Dias Rufino Carvalho, Rita Cássia Viana de Amorim, Layane Valéria Santos, Ingredy Lopes dos Santos, Rodolfo Ritchelle Lopes Figueiredo, Kayo Alves Figueiredo, Jessica Freire Silva Sobrinho-Júnior, Enoque Pereira Costa Cruz, Lucas Pereira Lima da Sousa, Valeria Carlos dos Santos, Laiz Pinheiro Gonçalves, Juan Carlos Ramos Carneiro, Sabrina Maria Portela Ivete Lopes de MendonçaFernando Aécio de Amorim Carvalho2022-02-12T14:34:56Zoai:ojs.www.seer.ufu.br:article/53770Revistahttps://seer.ufu.br/index.php/biosciencejournalPUBhttps://seer.ufu.br/index.php/biosciencejournal/oaibiosciencej@ufu.br||1981-31631516-3725opendoar:2022-02-12T14:34:56Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU)false |
dc.title.none.fl_str_mv |
Methods of macrophages activation and their modulation for the prospection of new antileishmania drugs: a review |
title |
Methods of macrophages activation and their modulation for the prospection of new antileishmania drugs: a review |
spellingShingle |
Methods of macrophages activation and their modulation for the prospection of new antileishmania drugs: a review Muálem de Moraes Alves, Michel Immunomodulation Intracellular Calcium Leishmaniasis Natural Products Nitric Oxide Phagocytosis. Agricultural Sciences |
title_short |
Methods of macrophages activation and their modulation for the prospection of new antileishmania drugs: a review |
title_full |
Methods of macrophages activation and their modulation for the prospection of new antileishmania drugs: a review |
title_fullStr |
Methods of macrophages activation and their modulation for the prospection of new antileishmania drugs: a review |
title_full_unstemmed |
Methods of macrophages activation and their modulation for the prospection of new antileishmania drugs: a review |
title_sort |
Methods of macrophages activation and their modulation for the prospection of new antileishmania drugs: a review |
author |
Muálem de Moraes Alves, Michel |
author_facet |
Muálem de Moraes Alves, Michel Arcanjo, Daniel Dias Rufino Carvalho, Rita Cássia Viana de Amorim, Layane Valéria Santos, Ingredy Lopes dos Santos, Rodolfo Ritchelle Lopes Figueiredo, Kayo Alves Figueiredo, Jessica Freire Silva Sobrinho-Júnior, Enoque Pereira Costa Cruz, Lucas Pereira Lima da Sousa, Valeria Carlos dos Santos, Laiz Pinheiro Gonçalves, Juan Carlos Ramos Carneiro, Sabrina Maria Portela Ivete Lopes de Mendonça Fernando Aécio de Amorim Carvalho |
author_role |
author |
author2 |
Arcanjo, Daniel Dias Rufino Carvalho, Rita Cássia Viana de Amorim, Layane Valéria Santos, Ingredy Lopes dos Santos, Rodolfo Ritchelle Lopes Figueiredo, Kayo Alves Figueiredo, Jessica Freire Silva Sobrinho-Júnior, Enoque Pereira Costa Cruz, Lucas Pereira Lima da Sousa, Valeria Carlos dos Santos, Laiz Pinheiro Gonçalves, Juan Carlos Ramos Carneiro, Sabrina Maria Portela Ivete Lopes de Mendonça Fernando Aécio de Amorim Carvalho |
author2_role |
author author author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Muálem de Moraes Alves, Michel Arcanjo, Daniel Dias Rufino Carvalho, Rita Cássia Viana de Amorim, Layane Valéria Santos, Ingredy Lopes dos Santos, Rodolfo Ritchelle Lopes Figueiredo, Kayo Alves Figueiredo, Jessica Freire Silva Sobrinho-Júnior, Enoque Pereira Costa Cruz, Lucas Pereira Lima da Sousa, Valeria Carlos dos Santos, Laiz Pinheiro Gonçalves, Juan Carlos Ramos Carneiro, Sabrina Maria Portela Ivete Lopes de Mendonça Fernando Aécio de Amorim Carvalho |
dc.subject.por.fl_str_mv |
Immunomodulation Intracellular Calcium Leishmaniasis Natural Products Nitric Oxide Phagocytosis. Agricultural Sciences |
topic |
Immunomodulation Intracellular Calcium Leishmaniasis Natural Products Nitric Oxide Phagocytosis. Agricultural Sciences |
description |
Leishmaniasis are a group of parasitic zoonoses provoked by protozoa from Leishmania genus and belonging to the group of neglected tropical diseases. The search and development for new drugs is necessary not only to investigate the activity against only the parasite, but also to investigate the possible synergistic effect of new drugs with the immune response of the host. In the present review, macrophages are pointed out as potential targets of the investigation of new antileishmanial drugs, and some methodologies in order to assess their activation as response to Leishmania-infected cells are presented. Macrophages are an important role in the cellular immune response, since they are cells from mononuclear phagocytic system, the first line of defense of the host, against parasites from Leishmania genus. Phagocytic capacity, lysosomal activity, increase of nitric oxide and intracellular calcium levels are parameters regarding assessment of macrophages activation which allow them to be more hostile in order to solve the infection and lead the patient to cure. In this context, we bring 19 substances already investigated and that activate macrophages, what makes them promising in the antileishmanial treatment. Therefore, assessment of macrophages activation, are important tools for discovery of immunomodulatory compounds which have potential to act in synergism with host immune response. Such compounds might be promising as monotherapy in the treatment of leishmaniasis, as well as being used as adjuvants in vaccines and/or in combination with conventional drugs. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-12-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/53770 10.14393/BJ-v37n0a2021-53770 |
url |
https://seer.ufu.br/index.php/biosciencejournal/article/view/53770 |
identifier_str_mv |
10.14393/BJ-v37n0a2021-53770 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://seer.ufu.br/index.php/biosciencejournal/article/view/53770/32939 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
Brazil; Contemporary |
dc.publisher.none.fl_str_mv |
EDUFU |
publisher.none.fl_str_mv |
EDUFU |
dc.source.none.fl_str_mv |
Bioscience Journal ; Vol. 37 (2021): Continuous Publication; e37077 Bioscience Journal ; v. 37 (2021): Continuous Publication; e37077 1981-3163 reponame:Bioscience journal (Online) instname:Universidade Federal de Uberlândia (UFU) instacron:UFU |
instname_str |
Universidade Federal de Uberlândia (UFU) |
instacron_str |
UFU |
institution |
UFU |
reponame_str |
Bioscience journal (Online) |
collection |
Bioscience journal (Online) |
repository.name.fl_str_mv |
Bioscience journal (Online) - Universidade Federal de Uberlândia (UFU) |
repository.mail.fl_str_mv |
biosciencej@ufu.br|| |
_version_ |
1797069082474840064 |