Infestação prévia com Myocoptes musculinus altera a resposta imune induzida por Toxoplasma gondii

• Autor(a) principal: Welter, Aurea
• Data de Publicação: 2005
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Repositório Institucional da UFU
• Texto Completo: https://repositorio.ufu.br/handle/123456789/16626
• topic: Toxoplasma gondii; Myocoptes musculinus; Coinfecção; Células Th1/Th2; Toxoplasmose; Infestações por ácaros; Coinfection; Th1/Th2 cells; CNPQ::CIENCIAS BIOLOGICAS::IMUNOLOGIA

Toxoplasma gondii is na obligate intracellular parasite that induces a Th1 immune response, in both resistant, BALB/c and susceptible, C57BLL/6, lineages of mice to this parasite. Myocoptes musculinus is a mite that induces a Th2 immune response. In this research wokr was investigated wheter chronic infestation with the M. musculinus influences in the immunopathology and development of T. gondii-induced Th1 responses, in BALB/6 and C57BL/6 lineages of mice. The animals were infested with M. musculinus and one month later were infected via the oral (10 cysts) or intraperitoneal route (100 cysts) with the ME-49 strain of T. gondii being survival and immune response monitored. We observed that the mite infestation accelerated mortality by infection with 10 T. gondii cysts administrated by intraperitoneal route in both BALB/c and C57BL/6 lineage of mice. The splenocytes supernatant IFN-g decreased and IL-4 and IL-5 elevated in coinfected mice from both lineages. These changes were associated with severe pneumonia and wasting condition. In contrast. When inoculated orally with 100 cysts of the parasite, the mite infestation ameliorates mortality. The results suggest that the immune resposnse induced by the M. musculinus interferes in the type-1 immune response induced by T. gondii and it is detrimental to the host but on the other hand this infection can control the severe intestinal lesions indced by na excessive Th1 immne reponse.