Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | LOCUS Repositório Institucional da UFV |
Texto Completo: | https://doi.org/10.1006/phrs.1999.0556 http://www.locus.ufv.br/handle/123456789/19658 |
Resumo: | Atherosclerosis can be defined as being a disease of coronary circulation. The present work evaluates the action of the naringenin, rutin, nicotinic acid, isolated and in association, on the metabolism of lipids. Cholesterol, cholesterol HDL, and triacylglycerols have been dosed after retreat of blood, following the administration of the compounds dissolved in propylene glycol by intraperitoneal route in doses of 5 mg kg^−1body wt. Results evidence that naringenin and nicotinic acid, isolated as well as their association with naringenin and nicotinic acid–rutin, present the largest percentual reduction of cholesterol. On the other hand, the best results for cholesterol-HDL have been obtained with naringenin, while rutin has shown the best triacylglycerols levels. |
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Santos, K.F.R.Oliveira, T.T.Nagem, T.J.Pinto, A.S.Oliveira, M.G.A.2018-05-17T17:31:56Z2018-05-17T17:31:56Z1999-05-2610436618https://doi.org/10.1006/phrs.1999.0556http://www.locus.ufv.br/handle/123456789/19658Atherosclerosis can be defined as being a disease of coronary circulation. The present work evaluates the action of the naringenin, rutin, nicotinic acid, isolated and in association, on the metabolism of lipids. Cholesterol, cholesterol HDL, and triacylglycerols have been dosed after retreat of blood, following the administration of the compounds dissolved in propylene glycol by intraperitoneal route in doses of 5 mg kg^−1body wt. Results evidence that naringenin and nicotinic acid, isolated as well as their association with naringenin and nicotinic acid–rutin, present the largest percentual reduction of cholesterol. On the other hand, the best results for cholesterol-HDL have been obtained with naringenin, while rutin has shown the best triacylglycerols levels.engPharmacological Researchv. 40, n. 6, p. 493-496, Dezembro 1999Academic Pressinfo:eu-repo/semantics/openAccessNaringeninRutinNicotinic acidHypolipidemic actionRatsHypolipidaemic effects of naringenin, rutin, nicotinic acid and their associationsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALartigo.pdfartigo.pdftexto completoapplication/pdf75127https://locus.ufv.br//bitstream/123456789/19658/1/artigo.pdf7205d20be360ee6443949314a79a4b72MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/19658/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILartigo.pdf.jpgartigo.pdf.jpgIM Thumbnailimage/jpeg4819https://locus.ufv.br//bitstream/123456789/19658/3/artigo.pdf.jpg86f24e6f1c822575008e546aff422a6eMD53123456789/196582018-05-17 23:00:35.856oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452018-05-18T02:00:35LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false |
dc.title.en.fl_str_mv |
Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations |
title |
Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations |
spellingShingle |
Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations Santos, K.F.R. Naringenin Rutin Nicotinic acid Hypolipidemic action Rats |
title_short |
Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations |
title_full |
Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations |
title_fullStr |
Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations |
title_full_unstemmed |
Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations |
title_sort |
Hypolipidaemic effects of naringenin, rutin, nicotinic acid and their associations |
author |
Santos, K.F.R. |
author_facet |
Santos, K.F.R. Oliveira, T.T. Nagem, T.J. Pinto, A.S. Oliveira, M.G.A. |
author_role |
author |
author2 |
Oliveira, T.T. Nagem, T.J. Pinto, A.S. Oliveira, M.G.A. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Santos, K.F.R. Oliveira, T.T. Nagem, T.J. Pinto, A.S. Oliveira, M.G.A. |
dc.subject.pt-BR.fl_str_mv |
Naringenin Rutin Nicotinic acid Hypolipidemic action Rats |
topic |
Naringenin Rutin Nicotinic acid Hypolipidemic action Rats |
description |
Atherosclerosis can be defined as being a disease of coronary circulation. The present work evaluates the action of the naringenin, rutin, nicotinic acid, isolated and in association, on the metabolism of lipids. Cholesterol, cholesterol HDL, and triacylglycerols have been dosed after retreat of blood, following the administration of the compounds dissolved in propylene glycol by intraperitoneal route in doses of 5 mg kg^−1body wt. Results evidence that naringenin and nicotinic acid, isolated as well as their association with naringenin and nicotinic acid–rutin, present the largest percentual reduction of cholesterol. On the other hand, the best results for cholesterol-HDL have been obtained with naringenin, while rutin has shown the best triacylglycerols levels. |
publishDate |
1999 |
dc.date.issued.fl_str_mv |
1999-05-26 |
dc.date.accessioned.fl_str_mv |
2018-05-17T17:31:56Z |
dc.date.available.fl_str_mv |
2018-05-17T17:31:56Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://doi.org/10.1006/phrs.1999.0556 http://www.locus.ufv.br/handle/123456789/19658 |
dc.identifier.issn.none.fl_str_mv |
10436618 |
identifier_str_mv |
10436618 |
url |
https://doi.org/10.1006/phrs.1999.0556 http://www.locus.ufv.br/handle/123456789/19658 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartofseries.pt-BR.fl_str_mv |
v. 40, n. 6, p. 493-496, Dezembro 1999 |
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Academic Press info:eu-repo/semantics/openAccess |
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Academic Press |
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openAccess |
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application/pdf |
dc.publisher.none.fl_str_mv |
Pharmacological Research |
publisher.none.fl_str_mv |
Pharmacological Research |
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