Neural complications and physical disabilities in leprosy in a capital of northeastern Brazil with high endemicity
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | LOCUS Repositório Institucional da UFV |
Texto Completo: | http://dx.doi.org/10.1590/1809-4503201400040009 http://www.locus.ufv.br/handle/123456789/13113 |
Resumo: | Leprosy is an infectious disease whose etiologic agent is Mycobacterium leprae, manifested by dermatological and neurological signs and symptoms. To investigate neural changes and the degree of physical disability in the eyes, hands and feet before and after treatment, as well as sociodemographic and clinical profile of patients affected by leprosy. A longitudinal epidemiological study comprising 155 patients with leprosy, from a spontaneous demand, diagnosed between March 2010 and February 2011, and treated with multidrug therapy (MDT) between March 2010 and July 2012 in a program for leprosy eradication in São Luis (MA), Brazil. Before treatment, 46.5% of patients were considered as borderline, 51.6% had some alteration in the eyes and 52.3% in the feet, and the radial nerve (18.7%) was the most affected. There was a statistically significant difference between the changes in the radial nerve at the beginning of and after treatment. The analysis points to late diagnosis, as some patients have had abnormal neural and physical disabilities before treatment. |
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Araújo, Ana Eugênia Ribeiro de Araújo eAquino, Dorlene Maria Cardoso deGoulart, Isabela Maria BernardesPereira, Silma Regina FerreiraFigueiredo, Ivan AbreuSerra, Humberto OliveiraFonseca, Poliana Cristina de AlmeidaCaldas, Arlene de Jesus Mendes2017-11-16T11:10:36Z2017-11-16T11:10:36Z2014-03-091980-5497http://dx.doi.org/10.1590/1809-4503201400040009http://www.locus.ufv.br/handle/123456789/13113Leprosy is an infectious disease whose etiologic agent is Mycobacterium leprae, manifested by dermatological and neurological signs and symptoms. To investigate neural changes and the degree of physical disability in the eyes, hands and feet before and after treatment, as well as sociodemographic and clinical profile of patients affected by leprosy. A longitudinal epidemiological study comprising 155 patients with leprosy, from a spontaneous demand, diagnosed between March 2010 and February 2011, and treated with multidrug therapy (MDT) between March 2010 and July 2012 in a program for leprosy eradication in São Luis (MA), Brazil. Before treatment, 46.5% of patients were considered as borderline, 51.6% had some alteration in the eyes and 52.3% in the feet, and the radial nerve (18.7%) was the most affected. There was a statistically significant difference between the changes in the radial nerve at the beginning of and after treatment. The analysis points to late diagnosis, as some patients have had abnormal neural and physical disabilities before treatment.engRevista Brasileira de Epidemiologiavol.17, n.4, p. 899-910, Oct./Dec. 2014LeprosyTherapeuticsDisabled personsMycobacterium lepraeNerve degenerationEpidemiologyNeural complications and physical disabilities in leprosy in a capital of northeastern Brazil with high endemicityinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINAL1415-790X-rbepid-17-04-00899.pdf1415-790X-rbepid-17-04-00899.pdftexto completoapplication/pdf284958https://locus.ufv.br//bitstream/123456789/13113/1/1415-790X-rbepid-17-04-00899.pdf070e283267b4a09ee8bb5c324674a359MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/13113/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAIL1415-790X-rbepid-17-04-00899.pdf.jpg1415-790X-rbepid-17-04-00899.pdf.jpgIM Thumbnailimage/jpeg4231https://locus.ufv.br//bitstream/123456789/13113/3/1415-790X-rbepid-17-04-00899.pdf.jpg6bbe311001d514ee83314e8ef7bebc16MD53123456789/131132017-11-16 22:00:27.933oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452017-11-17T01:00:27LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false |
dc.title.en.fl_str_mv |
Neural complications and physical disabilities in leprosy in a capital of northeastern Brazil with high endemicity |
title |
Neural complications and physical disabilities in leprosy in a capital of northeastern Brazil with high endemicity |
spellingShingle |
Neural complications and physical disabilities in leprosy in a capital of northeastern Brazil with high endemicity Araújo, Ana Eugênia Ribeiro de Araújo e Leprosy Therapeutics Disabled persons Mycobacterium leprae Nerve degeneration Epidemiology |
title_short |
Neural complications and physical disabilities in leprosy in a capital of northeastern Brazil with high endemicity |
title_full |
Neural complications and physical disabilities in leprosy in a capital of northeastern Brazil with high endemicity |
title_fullStr |
Neural complications and physical disabilities in leprosy in a capital of northeastern Brazil with high endemicity |
title_full_unstemmed |
Neural complications and physical disabilities in leprosy in a capital of northeastern Brazil with high endemicity |
title_sort |
Neural complications and physical disabilities in leprosy in a capital of northeastern Brazil with high endemicity |
author |
Araújo, Ana Eugênia Ribeiro de Araújo e |
author_facet |
Araújo, Ana Eugênia Ribeiro de Araújo e Aquino, Dorlene Maria Cardoso de Goulart, Isabela Maria Bernardes Pereira, Silma Regina Ferreira Figueiredo, Ivan Abreu Serra, Humberto Oliveira Fonseca, Poliana Cristina de Almeida Caldas, Arlene de Jesus Mendes |
author_role |
author |
author2 |
Aquino, Dorlene Maria Cardoso de Goulart, Isabela Maria Bernardes Pereira, Silma Regina Ferreira Figueiredo, Ivan Abreu Serra, Humberto Oliveira Fonseca, Poliana Cristina de Almeida Caldas, Arlene de Jesus Mendes |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Araújo, Ana Eugênia Ribeiro de Araújo e Aquino, Dorlene Maria Cardoso de Goulart, Isabela Maria Bernardes Pereira, Silma Regina Ferreira Figueiredo, Ivan Abreu Serra, Humberto Oliveira Fonseca, Poliana Cristina de Almeida Caldas, Arlene de Jesus Mendes |
dc.subject.pt-BR.fl_str_mv |
Leprosy Therapeutics Disabled persons Mycobacterium leprae Nerve degeneration Epidemiology |
topic |
Leprosy Therapeutics Disabled persons Mycobacterium leprae Nerve degeneration Epidemiology |
description |
Leprosy is an infectious disease whose etiologic agent is Mycobacterium leprae, manifested by dermatological and neurological signs and symptoms. To investigate neural changes and the degree of physical disability in the eyes, hands and feet before and after treatment, as well as sociodemographic and clinical profile of patients affected by leprosy. A longitudinal epidemiological study comprising 155 patients with leprosy, from a spontaneous demand, diagnosed between March 2010 and February 2011, and treated with multidrug therapy (MDT) between March 2010 and July 2012 in a program for leprosy eradication in São Luis (MA), Brazil. Before treatment, 46.5% of patients were considered as borderline, 51.6% had some alteration in the eyes and 52.3% in the feet, and the radial nerve (18.7%) was the most affected. There was a statistically significant difference between the changes in the radial nerve at the beginning of and after treatment. The analysis points to late diagnosis, as some patients have had abnormal neural and physical disabilities before treatment. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-03-09 |
dc.date.accessioned.fl_str_mv |
2017-11-16T11:10:36Z |
dc.date.available.fl_str_mv |
2017-11-16T11:10:36Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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http://dx.doi.org/10.1590/1809-4503201400040009 http://www.locus.ufv.br/handle/123456789/13113 |
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1980-5497 |
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1980-5497 |
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http://dx.doi.org/10.1590/1809-4503201400040009 http://www.locus.ufv.br/handle/123456789/13113 |
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eng |
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eng |
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vol.17, n.4, p. 899-910, Oct./Dec. 2014 |
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