Associação da atividade física e de componentes da dieta habitual com estresse oxidativo e outros fatores de risco cardiometabólico em homens de meia-idade

Detalhes bibliográficos
Autor(a) principal: Cocate, Paula Guedes
Data de Publicação: 2013
Tipo de documento: Tese
Idioma: por
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: http://locus.ufv.br/handle/123456789/386
Resumo: The metabolic syndrome (MetS) and oxidative stress have been recognized as important cardiometabolic risk factors. Among the major behavioral risk factors associated with MetS and oxidative stress the sedentary lifestyle and unhealthy dietary pattern are noteworthy. Thus, this cross-sectional study was designed to evaluate the association of habitual physical activity as well as some components of the usual dietary intake with cardiometabolic risk factors in middle-aged men. Among 300 male employees of the Federal University of Viçosa-MG who volunteered to take part in this study 296 (age 50.5 ± 3.5 years and body mass index 25.8 ± 3.5 kg/m 2) completed all phases of the study. The habitual physical activity was assessed by the number of steps walked per day (mean of seven consecutive days). Anthropometric (weight, height and waist circumference) and clinical parameters (blood pressure), the usual dietary intake (food frequency questionnaire) and lifestyle were assessed by validated procedures. Blood biochemical parameters (lipid and glycemic profile), diagnosis of MetS, homeostasis of insulin resistance (HOMA-IR), triacylglycerol and HDL-cholesterol ratio and oxidative stress biomarkers were also determined appropriately. It was found that MetS, adiposity indicators and insulin resistance were significantly (p<0.05) lower in the group of physically active (&#8805; 10,000 steps/day) compared to the group not physically active (< 10,000 steps/day). In addition, the number of steps was negatively associated with adiposity (gynoid, android and total) and insulin resistance, regardless the confounding factors. In contrast, the habitual dietary glycemic load was positively associated with cardiovascular risk factors such as free fatty acids, triacylglycerol/ HDL-c ratio and a biomarker of DNA oxidative stress (8-hydroxy- 2'-deoxyguanosine) in physically active individuals. The analysis of meat consumption showed that participants included in the highest tertile of red meat intake (&#8805; 81.5 g/d) had a higher occurrence of MetS, higher insulin resistance, oxidized LDL (lipid peroxidation biomarker) and triglyceride/HDL-c ratio, as compared to individuals included in the second (56.0 to 81.5 g/d) and first (< 56.0 g/d) tertiles of red meat consumption, independent of confounding factors. However, higher consumption of fruits and vegetables (&#8805; 341.1 g/d) was negatively associated with lipid (8-iso-prostaglandin F2&#945; and oxidized LDL) and DNA (8-hydroxy-2'-deoxyguanosine) oxidation biomarkers after adjustment for confounding factors. These results support the conclusion that the habitual physical activity and some components of the usual dietary intake are associated with cardiometabolic risk factors in middle-aged men. In fact, these data indicate that a higher number of steps per day and fruits and vegetables intake as well as a lower consumption of red meat and diets with high glycemic load may be important strategies to recommend for a healthy lifestyle in order to prevent cardiometabolic risk factors and the related oxidative stress.
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spelling Cocate, Paula Guedeshttp://lattes.cnpq.br/8323142742874274Longo, Giana Zarbatohttp://lattes.cnpq.br/9611294672834930Hermsdorff, Helen Hermana Mirandahttp://lattes.cnpq.br/8193454290644430Natali, Antônio Joséhttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4795725H4Rosado, Eliane Lopeshttp://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4703173J2Oliveira, Leandro Licursi dehttp://lattes.cnpq.br/05782313922181622015-03-26T12:21:08Z2014-09-032015-03-26T12:21:08Z2013-12-16COCATE, Paula Guedes. Association of physical activity and components of habitual diet with oxidative stress and other cardiometabolic risk factors in middle- aged men. 2013. 117 f. Tese (Doutorado em Dietética e Qualidade de Alimentos; Saúde e Nutrição de Indivíduos e Populações) - Universidade Federal de Viçosa, Viçosa, 2013.http://locus.ufv.br/handle/123456789/386The metabolic syndrome (MetS) and oxidative stress have been recognized as important cardiometabolic risk factors. Among the major behavioral risk factors associated with MetS and oxidative stress the sedentary lifestyle and unhealthy dietary pattern are noteworthy. Thus, this cross-sectional study was designed to evaluate the association of habitual physical activity as well as some components of the usual dietary intake with cardiometabolic risk factors in middle-aged men. Among 300 male employees of the Federal University of Viçosa-MG who volunteered to take part in this study 296 (age 50.5 ± 3.5 years and body mass index 25.8 ± 3.5 kg/m 2) completed all phases of the study. The habitual physical activity was assessed by the number of steps walked per day (mean of seven consecutive days). Anthropometric (weight, height and waist circumference) and clinical parameters (blood pressure), the usual dietary intake (food frequency questionnaire) and lifestyle were assessed by validated procedures. Blood biochemical parameters (lipid and glycemic profile), diagnosis of MetS, homeostasis of insulin resistance (HOMA-IR), triacylglycerol and HDL-cholesterol ratio and oxidative stress biomarkers were also determined appropriately. It was found that MetS, adiposity indicators and insulin resistance were significantly (p<0.05) lower in the group of physically active (&#8805; 10,000 steps/day) compared to the group not physically active (< 10,000 steps/day). In addition, the number of steps was negatively associated with adiposity (gynoid, android and total) and insulin resistance, regardless the confounding factors. In contrast, the habitual dietary glycemic load was positively associated with cardiovascular risk factors such as free fatty acids, triacylglycerol/ HDL-c ratio and a biomarker of DNA oxidative stress (8-hydroxy- 2'-deoxyguanosine) in physically active individuals. The analysis of meat consumption showed that participants included in the highest tertile of red meat intake (&#8805; 81.5 g/d) had a higher occurrence of MetS, higher insulin resistance, oxidized LDL (lipid peroxidation biomarker) and triglyceride/HDL-c ratio, as compared to individuals included in the second (56.0 to 81.5 g/d) and first (< 56.0 g/d) tertiles of red meat consumption, independent of confounding factors. However, higher consumption of fruits and vegetables (&#8805; 341.1 g/d) was negatively associated with lipid (8-iso-prostaglandin F2&#945; and oxidized LDL) and DNA (8-hydroxy-2'-deoxyguanosine) oxidation biomarkers after adjustment for confounding factors. These results support the conclusion that the habitual physical activity and some components of the usual dietary intake are associated with cardiometabolic risk factors in middle-aged men. In fact, these data indicate that a higher number of steps per day and fruits and vegetables intake as well as a lower consumption of red meat and diets with high glycemic load may be important strategies to recommend for a healthy lifestyle in order to prevent cardiometabolic risk factors and the related oxidative stress.A síndrome metabólica (SM) e o estresse oxidativo têm sido reconhecidos como importantes fatores de risco cardiometabólico. Entre os principais fatores de risco comportamentais associados à SM e ao estresse oxidativo destacam- se o estilo de vida sedentário e o padrão alimentar não saudável. Dessa forma, este estudo transversal foi desenvolvido para avaliar a associação da atividade física habitual e de componentes da dieta habitual com fatores de risco cardiometabólico em homens de meia-idade. Dentre os 300 homens servidores da Universidade Federal de Viçosa-MG recrutados, 296 (idade 50,5 ± 3,5 anos e índice de massa corporal 25,8 ± 3,5 kg/m2) completaram todas as etapas do estudo voluntariamente. A atividade física habitual foi avaliada pelo número de passos diários (média de sete dias consecutivos). Variáveis antropométricas (peso, estatura e perímetro da cintura) e clínicas (pressão arterial sistólica e diastólica), a ingestão alimentar habitual (questionário de frequência do consumo alimentar) e o estilo de vida foram avaliados por procedimentos validados. Marcadores metabólicos sanguíneos (perfil glicídico e lipídico), diagnóstico da SM, homeostase da resistência à insulina (HOMA-IR), razão triacilgliceróis e HDL-c e biomarcadores de estresse oxidativo também foram determinados apropriadamente. Verificou-se que a SM, indicadores de adiposidade corporal e resistência à insulina foram significativamente (p< 0,05) inferiores no grupo de indivíduos fisicamente ativos (&#8805; 10.000 passos/ dia) comparado ao grupo não fisicamente ativo (< 10.000 passos/ dia). Além disso, constatou-se que o número de passos foi negativamente associado com adiposidade corporal (ginóide, androide e total) e HOMA-IR, independentemente de fatores de confusão. Em contrapartida, a carga glicêmica da dieta habitual foi positivamente associada com fatores de risco cardiometabólico, como ácidos graxos livres, razão triacilgliceróis/HDL-c e o biomarcador de estresse oxidativo no DNA (8-hidróxi-2 &#769;-deoxiguanosina) entre os participantes fisicamente ativos. Os participantes incluídos no maior tercil de ingestão de carne vermelha (&#8805; 81,5 g/d) apresentaram maior ocorrência de SM, maiores valores de resistência à insulina, de LDL oxidada e da razão triacilgliceróis/HDL-c, em comparação aos indivíduos incluídos no segundo tercil (56,0 a 81,5 g/d) e no primeiro tercil (< 56,0 g/d) de consumo de carne vermelha, independente de variáveis de confusão. Todavia, o maior consumo de frutas, hortaliças e legumes (&#8805; 341,1 g/d) associou-se negativamente com biomarcadores de oxidação em lipídeos (8-iso-prostaglandina F2&#945; e LDL oxidada) e no DNA (8-hidróxi-2 &#769;-deoxiguanosina), após ajuste por variáveis de confusão. Estes resultados apoiam a conclusão de que atividade física habitual e componentes da dieta habitual estão associados com fatores de risco cardiometabólico em homens de meia-idade. De fato, nossos achados indicam que o maior número de passos diários, a maior ingestão de frutas, hortaliças e legumes, bem como, o menor consumo de carnes vermelhas e de dietas de alta carga glicêmica possam ser estratégias importantes na recomendação de hábitos de vida saudáveis para prevenção de fatores de risco cardiometabólico e o estresse oxidativo relacionado.Fundação de Amparo a Pesquisa do Estado de Minas Geraisapplication/pdfporUniversidade Federal de ViçosaDoutorado em Ciência da NutriçãoUFVBRDietética e Qualidade de Alimentos; Saúde e Nutrição de Indivíduos e PopulaçõesAtividade físicaDieta habitualEstresse oxidativoFatores de risco cardiometabólicoPhysical activityUsual dietOxidative stressCardiometabolic risk factorsCNPQ::CIENCIAS DA SAUDE::NUTRICAOAssociação da atividade física e de componentes da dieta habitual com estresse oxidativo e outros fatores de risco cardiometabólico em homens de meia-idadeAssociation of physical activity and components of habitual diet with oxidative stress and other cardiometabolic risk factors in middle- aged meninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/doctoralThesisinfo:eu-repo/semantics/openAccessreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALtexto completo.pdfapplication/pdf1661249https://locus.ufv.br//bitstream/123456789/386/1/texto%20completo.pdf85ec4e84c93db1380a42d93177cf3550MD51TEXTtexto completo.pdf.txttexto completo.pdf.txtExtracted texttext/plain215209https://locus.ufv.br//bitstream/123456789/386/2/texto%20completo.pdf.txtf4dc72baa5dc0c8380aaebd4faa0a642MD52THUMBNAILtexto completo.pdf.jpgtexto completo.pdf.jpgIM Thumbnailimage/jpeg3595https://locus.ufv.br//bitstream/123456789/386/3/texto%20completo.pdf.jpgc011e438b55e8cea8438b343e921fe3aMD53123456789/3862016-04-06 23:07:17.947oai:locus.ufv.br:123456789/386Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452016-04-07T02:07:17LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.por.fl_str_mv Associação da atividade física e de componentes da dieta habitual com estresse oxidativo e outros fatores de risco cardiometabólico em homens de meia-idade
dc.title.alternative.eng.fl_str_mv Association of physical activity and components of habitual diet with oxidative stress and other cardiometabolic risk factors in middle- aged men
title Associação da atividade física e de componentes da dieta habitual com estresse oxidativo e outros fatores de risco cardiometabólico em homens de meia-idade
spellingShingle Associação da atividade física e de componentes da dieta habitual com estresse oxidativo e outros fatores de risco cardiometabólico em homens de meia-idade
Cocate, Paula Guedes
Atividade física
Dieta habitual
Estresse oxidativo
Fatores de risco cardiometabólico
Physical activity
Usual diet
Oxidative stress
Cardiometabolic risk factors
CNPQ::CIENCIAS DA SAUDE::NUTRICAO
title_short Associação da atividade física e de componentes da dieta habitual com estresse oxidativo e outros fatores de risco cardiometabólico em homens de meia-idade
title_full Associação da atividade física e de componentes da dieta habitual com estresse oxidativo e outros fatores de risco cardiometabólico em homens de meia-idade
title_fullStr Associação da atividade física e de componentes da dieta habitual com estresse oxidativo e outros fatores de risco cardiometabólico em homens de meia-idade
title_full_unstemmed Associação da atividade física e de componentes da dieta habitual com estresse oxidativo e outros fatores de risco cardiometabólico em homens de meia-idade
title_sort Associação da atividade física e de componentes da dieta habitual com estresse oxidativo e outros fatores de risco cardiometabólico em homens de meia-idade
author Cocate, Paula Guedes
author_facet Cocate, Paula Guedes
author_role author
dc.contributor.authorLattes.por.fl_str_mv http://lattes.cnpq.br/8323142742874274
dc.contributor.author.fl_str_mv Cocate, Paula Guedes
dc.contributor.advisor-co1.fl_str_mv Longo, Giana Zarbato
dc.contributor.advisor-co1Lattes.fl_str_mv http://lattes.cnpq.br/9611294672834930
dc.contributor.advisor-co2.fl_str_mv Hermsdorff, Helen Hermana Miranda
dc.contributor.advisor-co2Lattes.fl_str_mv http://lattes.cnpq.br/8193454290644430
dc.contributor.advisor1.fl_str_mv Natali, Antônio José
dc.contributor.advisor1Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4795725H4
dc.contributor.referee1.fl_str_mv Rosado, Eliane Lopes
dc.contributor.referee1Lattes.fl_str_mv http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4703173J2
dc.contributor.referee2.fl_str_mv Oliveira, Leandro Licursi de
dc.contributor.referee2Lattes.fl_str_mv http://lattes.cnpq.br/0578231392218162
contributor_str_mv Longo, Giana Zarbato
Hermsdorff, Helen Hermana Miranda
Natali, Antônio José
Rosado, Eliane Lopes
Oliveira, Leandro Licursi de
dc.subject.por.fl_str_mv Atividade física
Dieta habitual
Estresse oxidativo
Fatores de risco cardiometabólico
topic Atividade física
Dieta habitual
Estresse oxidativo
Fatores de risco cardiometabólico
Physical activity
Usual diet
Oxidative stress
Cardiometabolic risk factors
CNPQ::CIENCIAS DA SAUDE::NUTRICAO
dc.subject.eng.fl_str_mv Physical activity
Usual diet
Oxidative stress
Cardiometabolic risk factors
dc.subject.cnpq.fl_str_mv CNPQ::CIENCIAS DA SAUDE::NUTRICAO
description The metabolic syndrome (MetS) and oxidative stress have been recognized as important cardiometabolic risk factors. Among the major behavioral risk factors associated with MetS and oxidative stress the sedentary lifestyle and unhealthy dietary pattern are noteworthy. Thus, this cross-sectional study was designed to evaluate the association of habitual physical activity as well as some components of the usual dietary intake with cardiometabolic risk factors in middle-aged men. Among 300 male employees of the Federal University of Viçosa-MG who volunteered to take part in this study 296 (age 50.5 ± 3.5 years and body mass index 25.8 ± 3.5 kg/m 2) completed all phases of the study. The habitual physical activity was assessed by the number of steps walked per day (mean of seven consecutive days). Anthropometric (weight, height and waist circumference) and clinical parameters (blood pressure), the usual dietary intake (food frequency questionnaire) and lifestyle were assessed by validated procedures. Blood biochemical parameters (lipid and glycemic profile), diagnosis of MetS, homeostasis of insulin resistance (HOMA-IR), triacylglycerol and HDL-cholesterol ratio and oxidative stress biomarkers were also determined appropriately. It was found that MetS, adiposity indicators and insulin resistance were significantly (p<0.05) lower in the group of physically active (&#8805; 10,000 steps/day) compared to the group not physically active (< 10,000 steps/day). In addition, the number of steps was negatively associated with adiposity (gynoid, android and total) and insulin resistance, regardless the confounding factors. In contrast, the habitual dietary glycemic load was positively associated with cardiovascular risk factors such as free fatty acids, triacylglycerol/ HDL-c ratio and a biomarker of DNA oxidative stress (8-hydroxy- 2'-deoxyguanosine) in physically active individuals. The analysis of meat consumption showed that participants included in the highest tertile of red meat intake (&#8805; 81.5 g/d) had a higher occurrence of MetS, higher insulin resistance, oxidized LDL (lipid peroxidation biomarker) and triglyceride/HDL-c ratio, as compared to individuals included in the second (56.0 to 81.5 g/d) and first (< 56.0 g/d) tertiles of red meat consumption, independent of confounding factors. However, higher consumption of fruits and vegetables (&#8805; 341.1 g/d) was negatively associated with lipid (8-iso-prostaglandin F2&#945; and oxidized LDL) and DNA (8-hydroxy-2'-deoxyguanosine) oxidation biomarkers after adjustment for confounding factors. These results support the conclusion that the habitual physical activity and some components of the usual dietary intake are associated with cardiometabolic risk factors in middle-aged men. In fact, these data indicate that a higher number of steps per day and fruits and vegetables intake as well as a lower consumption of red meat and diets with high glycemic load may be important strategies to recommend for a healthy lifestyle in order to prevent cardiometabolic risk factors and the related oxidative stress.
publishDate 2013
dc.date.issued.fl_str_mv 2013-12-16
dc.date.available.fl_str_mv 2014-09-03
2015-03-26T12:21:08Z
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dc.identifier.citation.fl_str_mv COCATE, Paula Guedes. Association of physical activity and components of habitual diet with oxidative stress and other cardiometabolic risk factors in middle- aged men. 2013. 117 f. Tese (Doutorado em Dietética e Qualidade de Alimentos; Saúde e Nutrição de Indivíduos e Populações) - Universidade Federal de Viçosa, Viçosa, 2013.
dc.identifier.uri.fl_str_mv http://locus.ufv.br/handle/123456789/386
identifier_str_mv COCATE, Paula Guedes. Association of physical activity and components of habitual diet with oxidative stress and other cardiometabolic risk factors in middle- aged men. 2013. 117 f. Tese (Doutorado em Dietética e Qualidade de Alimentos; Saúde e Nutrição de Indivíduos e Populações) - Universidade Federal de Viçosa, Viçosa, 2013.
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dc.publisher.department.fl_str_mv Dietética e Qualidade de Alimentos; Saúde e Nutrição de Indivíduos e Populações
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