A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen

Bibliographic Details
Main Author: Vilela, Marcelo José
Publication Date: 1995
Other Authors: Hashimoto, Takashi, Nishikawa, Takeji, North, Alison J., Garrod, David
Format: Article
Language: eng
Source: LOCUS Repositório Institucional da UFV
Download full: http://jcs.biologists.org/content/108/4/1743.long
http://www.locus.ufv.br/handle/123456789/18876
Summary: não consta número
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network_acronym_str UFV
network_name_str LOCUS Repositório Institucional da UFV
repository_id_str 2145
spelling Vilela, Marcelo JoséHashimoto, TakashiNishikawa, TakejiNorth, Alison J.Garrod, David2018-04-19T16:58:22Z2018-04-19T16:58:22Z1995-01-131477-9137http://jcs.biologists.org/content/108/4/1743.longhttp://www.locus.ufv.br/handle/123456789/18876não consta númeroThe epidermal blistering desease, pemphigus vulgaris (PV), with a cytoplasmic domain of human Dsg3. Antibodies in is caused by circulating autoantibodies that react with a PV sera bind to the surface of MDCK cells but do not cause desmosomal glycoprotein desmoglein (Dsg3). This antigen loss of intercellular adhesion. This is the first demonstrais expressed only in stratified epithelial tissues. Here we tion of the expression of a polypeptide related to human PV show that the simple epithelial canine kidney cell line, antigen by a simple epithelial cell type. MDCK, expresses at least two desmoglein isoforms recognised by different monoclonal antibodies. One of these isoforms is a 130×103 Mr polypeptide that is recognised by both PV autoantisera and a monoclonal antibody reactive.engJournal Of Cell Sciencev. 108, p. 1743-1750, janeiro 1995The Company of Biologists Limitedinfo:eu-repo/semantics/openAccessDesmosomeCell adhesionDesmogleinPemphigus vulgarisMDCK cellA simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigeninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALartigo.pdfartigo.pdfartigoapplication/pdf455131https://locus.ufv.br//bitstream/123456789/18876/1/artigo.pdf0d76caecfc10c94b7ad8e3645158a495MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/18876/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILartigo.pdf.jpgartigo.pdf.jpgIM Thumbnailimage/jpeg5532https://locus.ufv.br//bitstream/123456789/18876/3/artigo.pdf.jpgbee8f8621a17c96178a823c7880d22e8MD53123456789/188762018-04-19 23:00:46.105oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452018-04-20T02:00:46LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.en.fl_str_mv A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen
title A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen
spellingShingle A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen
Vilela, Marcelo José
Desmosome
Cell adhesion
Desmoglein
Pemphigus vulgaris
MDCK cell
title_short A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen
title_full A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen
title_fullStr A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen
title_full_unstemmed A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen
title_sort A simple epithelial cell line (MDCK) shows heterogeneity of desmoglein isoforms, one resembling pemphigus vulgaris antigen
author Vilela, Marcelo José
author_facet Vilela, Marcelo José
Hashimoto, Takashi
Nishikawa, Takeji
North, Alison J.
Garrod, David
author_role author
author2 Hashimoto, Takashi
Nishikawa, Takeji
North, Alison J.
Garrod, David
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Vilela, Marcelo José
Hashimoto, Takashi
Nishikawa, Takeji
North, Alison J.
Garrod, David
dc.subject.pt-BR.fl_str_mv Desmosome
Cell adhesion
Desmoglein
Pemphigus vulgaris
MDCK cell
topic Desmosome
Cell adhesion
Desmoglein
Pemphigus vulgaris
MDCK cell
description não consta número
publishDate 1995
dc.date.issued.fl_str_mv 1995-01-13
dc.date.accessioned.fl_str_mv 2018-04-19T16:58:22Z
dc.date.available.fl_str_mv 2018-04-19T16:58:22Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://jcs.biologists.org/content/108/4/1743.long
http://www.locus.ufv.br/handle/123456789/18876
dc.identifier.issn.none.fl_str_mv 1477-9137
identifier_str_mv 1477-9137
url http://jcs.biologists.org/content/108/4/1743.long
http://www.locus.ufv.br/handle/123456789/18876
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartofseries.pt-BR.fl_str_mv v. 108, p. 1743-1750, janeiro 1995
dc.rights.driver.fl_str_mv The Company of Biologists Limited
info:eu-repo/semantics/openAccess
rights_invalid_str_mv The Company of Biologists Limited
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Journal Of Cell Science
publisher.none.fl_str_mv Journal Of Cell Science
dc.source.none.fl_str_mv reponame:LOCUS Repositório Institucional da UFV
instname:Universidade Federal de Viçosa (UFV)
instacron:UFV
instname_str Universidade Federal de Viçosa (UFV)
instacron_str UFV
institution UFV
reponame_str LOCUS Repositório Institucional da UFV
collection LOCUS Repositório Institucional da UFV
bitstream.url.fl_str_mv https://locus.ufv.br//bitstream/123456789/18876/1/artigo.pdf
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repository.mail.fl_str_mv fabiojreis@ufv.br
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