Oxidative stress, cytokine/chemokine and disruption of blood–Brain barrier in neonate rats after meningitis by Streptococcus agalactiae

Detalhes bibliográficos
Autor(a) principal: Teixeira, Antonio Lucio
Data de Publicação: 2011
Outros Autores: Barichello, Tatiana, Lemos, Joelson C., Generoso, Jaqueline S., Cipriano, Andreza L., Milioli, Graziele L., Marcelino, Danielle M., Vuolo, Francieli, Petronilho, Fabricia, Dal-Pizzol, Felipe, Vilela, Márcia Carvalho
Tipo de documento: Artigo
Idioma: eng
Título da fonte: LOCUS Repositório Institucional da UFV
Texto Completo: http://dx.doi.org/10.1007/s11064-011-0514-2
http://www.locus.ufv.br/handle/123456789/22042
Resumo: We verify the levels of cytokine/chemokine, myeloperoxidase activity, oxidative stress and disruption of BBB in hippocampus and cortex of the neonate Wistar rats after meningitis by S. agalactiae. In the hippocampus the levels were increased of CINC-1 at 6 h and 12 h, IL-1β at 6, 12 and 24 h, IL-6 at 6, 24 and 96 h, IL-10 at 24, 48 and 96 h and TNF-α at 24 h and 96 h. In the cortex the CINC-1 and IL-1β levels were found increased at 6 h. The MPO activity was significantly elevated at 24, 48 and 98 h in hippocampus and at 6, 12, 24, 48 and 96 h in the cortex. The breakdown of BBB started at 12 h.TBARS levels were elevated in the hippocampus at 6, 12, 24, 48, 72 and 96 h and cortex at 72 and 96 h. Protein carbonyls were elevated in the hippocampus and cortex at 6, 24, 48, 72 and 96 h. There was a decrease of SOD activity in hippocampus and in cortex. Catalase activity was elevated in hippocampus at 6 h and in the cortex at 12 and 96 h. Neonatal bacterial infections of the CNS are severe, the interference with the complex network of cytokines/chemokine, other inflammatory mediators and oxidants tend to aggravate the illness and can be involved in the breakdown of the BBB.
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spelling Teixeira, Antonio LucioBarichello, TatianaLemos, Joelson C.Generoso, Jaqueline S.Cipriano, Andreza L.Milioli, Graziele L.Marcelino, Danielle M.Vuolo, FrancieliPetronilho, FabriciaDal-Pizzol, FelipeVilela, Márcia Carvalho2018-09-27T01:03:54Z2018-09-27T01:03:54Z2011-06-0315736903http://dx.doi.org/10.1007/s11064-011-0514-2http://www.locus.ufv.br/handle/123456789/22042We verify the levels of cytokine/chemokine, myeloperoxidase activity, oxidative stress and disruption of BBB in hippocampus and cortex of the neonate Wistar rats after meningitis by S. agalactiae. In the hippocampus the levels were increased of CINC-1 at 6 h and 12 h, IL-1β at 6, 12 and 24 h, IL-6 at 6, 24 and 96 h, IL-10 at 24, 48 and 96 h and TNF-α at 24 h and 96 h. In the cortex the CINC-1 and IL-1β levels were found increased at 6 h. The MPO activity was significantly elevated at 24, 48 and 98 h in hippocampus and at 6, 12, 24, 48 and 96 h in the cortex. The breakdown of BBB started at 12 h.TBARS levels were elevated in the hippocampus at 6, 12, 24, 48, 72 and 96 h and cortex at 72 and 96 h. Protein carbonyls were elevated in the hippocampus and cortex at 6, 24, 48, 72 and 96 h. There was a decrease of SOD activity in hippocampus and in cortex. Catalase activity was elevated in hippocampus at 6 h and in the cortex at 12 and 96 h. Neonatal bacterial infections of the CNS are severe, the interference with the complex network of cytokines/chemokine, other inflammatory mediators and oxidants tend to aggravate the illness and can be involved in the breakdown of the BBB.engNeurochemical Researchv. 36, n. 10, p. 1922– 1930, out. 2011Springer Science+Business Mediainfo:eu-repo/semantics/openAccessMeningitisStreptococcus agalactiaeCytokine/chemokineMyeloperoxidase activityOxidative stressOxidative stress, cytokine/chemokine and disruption of blood–Brain barrier in neonate rats after meningitis by Streptococcus agalactiaeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfreponame:LOCUS Repositório Institucional da UFVinstname:Universidade Federal de Viçosa (UFV)instacron:UFVORIGINALartigo.pdfartigo.pdftexto completoapplication/pdf457953https://locus.ufv.br//bitstream/123456789/22042/1/artigo.pdf4f3aa57ed6c704f0adf16d0af7a89123MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748https://locus.ufv.br//bitstream/123456789/22042/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD52THUMBNAILartigo.pdf.jpgartigo.pdf.jpgIM Thumbnailimage/jpeg5074https://locus.ufv.br//bitstream/123456789/22042/3/artigo.pdf.jpg7a0473e637532eb7fee33e233f2f6ff3MD53123456789/220422018-09-26 23:00:53.101oai:locus.ufv.br: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Repositório InstitucionalPUBhttps://www.locus.ufv.br/oai/requestfabiojreis@ufv.bropendoar:21452018-09-27T02:00:53LOCUS Repositório Institucional da UFV - Universidade Federal de Viçosa (UFV)false
dc.title.en.fl_str_mv Oxidative stress, cytokine/chemokine and disruption of blood–Brain barrier in neonate rats after meningitis by Streptococcus agalactiae
title Oxidative stress, cytokine/chemokine and disruption of blood–Brain barrier in neonate rats after meningitis by Streptococcus agalactiae
spellingShingle Oxidative stress, cytokine/chemokine and disruption of blood–Brain barrier in neonate rats after meningitis by Streptococcus agalactiae
Teixeira, Antonio Lucio
Meningitis
Streptococcus agalactiae
Cytokine/chemokine
Myeloperoxidase activity
Oxidative stress
title_short Oxidative stress, cytokine/chemokine and disruption of blood–Brain barrier in neonate rats after meningitis by Streptococcus agalactiae
title_full Oxidative stress, cytokine/chemokine and disruption of blood–Brain barrier in neonate rats after meningitis by Streptococcus agalactiae
title_fullStr Oxidative stress, cytokine/chemokine and disruption of blood–Brain barrier in neonate rats after meningitis by Streptococcus agalactiae
title_full_unstemmed Oxidative stress, cytokine/chemokine and disruption of blood–Brain barrier in neonate rats after meningitis by Streptococcus agalactiae
title_sort Oxidative stress, cytokine/chemokine and disruption of blood–Brain barrier in neonate rats after meningitis by Streptococcus agalactiae
author Teixeira, Antonio Lucio
author_facet Teixeira, Antonio Lucio
Barichello, Tatiana
Lemos, Joelson C.
Generoso, Jaqueline S.
Cipriano, Andreza L.
Milioli, Graziele L.
Marcelino, Danielle M.
Vuolo, Francieli
Petronilho, Fabricia
Dal-Pizzol, Felipe
Vilela, Márcia Carvalho
author_role author
author2 Barichello, Tatiana
Lemos, Joelson C.
Generoso, Jaqueline S.
Cipriano, Andreza L.
Milioli, Graziele L.
Marcelino, Danielle M.
Vuolo, Francieli
Petronilho, Fabricia
Dal-Pizzol, Felipe
Vilela, Márcia Carvalho
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Teixeira, Antonio Lucio
Barichello, Tatiana
Lemos, Joelson C.
Generoso, Jaqueline S.
Cipriano, Andreza L.
Milioli, Graziele L.
Marcelino, Danielle M.
Vuolo, Francieli
Petronilho, Fabricia
Dal-Pizzol, Felipe
Vilela, Márcia Carvalho
dc.subject.pt-BR.fl_str_mv Meningitis
Streptococcus agalactiae
Cytokine/chemokine
Myeloperoxidase activity
Oxidative stress
topic Meningitis
Streptococcus agalactiae
Cytokine/chemokine
Myeloperoxidase activity
Oxidative stress
description We verify the levels of cytokine/chemokine, myeloperoxidase activity, oxidative stress and disruption of BBB in hippocampus and cortex of the neonate Wistar rats after meningitis by S. agalactiae. In the hippocampus the levels were increased of CINC-1 at 6 h and 12 h, IL-1β at 6, 12 and 24 h, IL-6 at 6, 24 and 96 h, IL-10 at 24, 48 and 96 h and TNF-α at 24 h and 96 h. In the cortex the CINC-1 and IL-1β levels were found increased at 6 h. The MPO activity was significantly elevated at 24, 48 and 98 h in hippocampus and at 6, 12, 24, 48 and 96 h in the cortex. The breakdown of BBB started at 12 h.TBARS levels were elevated in the hippocampus at 6, 12, 24, 48, 72 and 96 h and cortex at 72 and 96 h. Protein carbonyls were elevated in the hippocampus and cortex at 6, 24, 48, 72 and 96 h. There was a decrease of SOD activity in hippocampus and in cortex. Catalase activity was elevated in hippocampus at 6 h and in the cortex at 12 and 96 h. Neonatal bacterial infections of the CNS are severe, the interference with the complex network of cytokines/chemokine, other inflammatory mediators and oxidants tend to aggravate the illness and can be involved in the breakdown of the BBB.
publishDate 2011
dc.date.issued.fl_str_mv 2011-06-03
dc.date.accessioned.fl_str_mv 2018-09-27T01:03:54Z
dc.date.available.fl_str_mv 2018-09-27T01:03:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s11064-011-0514-2
http://www.locus.ufv.br/handle/123456789/22042
dc.identifier.issn.none.fl_str_mv 15736903
identifier_str_mv 15736903
url http://dx.doi.org/10.1007/s11064-011-0514-2
http://www.locus.ufv.br/handle/123456789/22042
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartofseries.pt-BR.fl_str_mv v. 36, n. 10, p. 1922– 1930, out. 2011
dc.rights.driver.fl_str_mv Springer Science+Business Media
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