Síntese, caracterização e atividade biológica de sais com ânions e cátions complexos de Zn, Fe e Ni com 1,10-fenantrolina e ditiocarbimatos

• Autor(a) principal: Bottega, Fernanda Christina
• Data de Publicação: 2012
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: LOCUS Repositório Institucional da UFV
• Texto Completo: http://locus.ufv.br/handle/123456789/2116
• topic: Ditiocarbimatos; Colletotrichum gloeosporioides; Complexos metálicos; Dithiocarbimates; Colletotrichum gloeosporioides; Metal complexes; CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA::QUIMICA INORGANICA

This work consisted of the synthesis, characterization and biological activity of fifteen salts consisting of complex cations of nickel-phenanthroline and iron-phenanthroline and complex anions of zinc-dithiocarbimate and nickeldithiocarbimate. The potassium dithiocarbimate salts used as ligands were synthesized from the appropriate sulfonamides in reaction with carbon disulfide and potassium hydroxide in dimethylformamide. To obtain the final compounds, to the appropriate metal salt solution in DMF were added two equivalents of the potassium ditiocarbimate followed by one equivalent of an aqueous solution of tris(1,10-phenanthroline)(iron or nickel)(II) previously prepared. The new compounds of the general formula [Fe(phen)3][Zn(RSO2N=CS2)2], [Fe(phen)3] Ni(RSO2N=CS2)2] and [Ni(phen)3][Zn(RSO2N=CS2)2] (R= 4-C6H5, 4-FC6H4, 4-ClC6H4, 4-BrC6H4, 4-IC6H4) thus obtained were characterized by their melting points, elemental analyses, electrolytic conductance measurements, and by electronic, infrared vibrational, 1H and 13C NMR spectroscopies. The data are consistent with the proposed formulae. The results obtained for electrolytic conductance in the range of 65-90 M (ohm-1 cm2 mol-1) confirm the 1:1 ratio between the anionic and cationic complexes. The new compounds were tested against the fungi Colletotrichum gloeosporioides Candida albicans and Candida tropicalis, and the bacteria Escherichia coli and Staphylococcus aureus. All compounds tested were active against C. gloeosporioides, E. coli and S. aureus and inactive against C. albicans and C. tropicalis.