Leishmania (Viannia) naiffi : rare enough to be neglected?
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/29539 http://dx.doi.org/10.1590/0074-02760150128 |
Resumo: | In the Brazilian Amazon, American tegumentary leishmaniasis (ATL) is endemic and presents a wide spectrum of clinical manifestations due, in part, to the circulation of at least seven Leishmaniaspecies. Few reports of Leishmania (Viannia) naiffiinfection suggest that its occurrence is uncommon and the reported cases present a benign clinical course and a good response to treatment. This study aimed to strengthen the clinical and epidemiological importance of L. (V.) naiffiin the Amazon Region (Manaus, state of Amazonas) and to report therapeutic failure in patients infected with this species. Thirty Leishmania spp samples isolated from cutaneous lesions were characterised by multilocus enzyme electrophoresis. As expected, the most common species was Leishmania (V.) guyanensis (20 cases). However, a relevant number ofL. (V.) naiffi patients (8 cases) was observed, thus demonstrating that this species is not uncommon in the region. No patient infected withL. (V.) naiffievolved to spontaneous cure until the start of treatment, which indicated that this species may not have a self-limiting nature. In addition, two of the patients experienced a poor response to antimonial or pentamidine therapy. Thus, either ATL cases due to L. (V.) naifficannot be as uncommon as previously thought or this species is currently expanding in this region. |
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Silva, Giselle Aparecida FagundesRomero, Gustavo Adolfo SierraCupolillo, ElisaYamashita, Ellen Priscila GadelhaSilva, Adriano GomesGuerra, Jorge Augusto de OliveiraCruz, Alda Maria da2017-12-07T05:11:37Z2017-12-07T05:11:37Z2015-09FAGUNDES-SILVA, Giselle Aparecida et al. Leishmania (Viannia) naiffi: rare enough to be neglected? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 6, p. 797-800, set. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000600797&lng=en&nrm=iso>. Acesso em: 9 maio 2018. doi: http://dx.doi.org/10.1590/0074-02760150128.http://repositorio.unb.br/handle/10482/29539http://dx.doi.org/10.1590/0074-02760150128Instituto Oswaldo Cruz, Ministério da SaúdeMemórias do Instituto Oswaldo Cruz - This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000600797&lng=en&nrm=iso. Acesso em: 9 maio 2018.info:eu-repo/semantics/openAccessLeishmania (Viannia) naiffi : rare enough to be neglected?info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEnzimasAmazôniaLeishmanioseIn the Brazilian Amazon, American tegumentary leishmaniasis (ATL) is endemic and presents a wide spectrum of clinical manifestations due, in part, to the circulation of at least seven Leishmaniaspecies. Few reports of Leishmania (Viannia) naiffiinfection suggest that its occurrence is uncommon and the reported cases present a benign clinical course and a good response to treatment. This study aimed to strengthen the clinical and epidemiological importance of L. (V.) naiffiin the Amazon Region (Manaus, state of Amazonas) and to report therapeutic failure in patients infected with this species. Thirty Leishmania spp samples isolated from cutaneous lesions were characterised by multilocus enzyme electrophoresis. As expected, the most common species was Leishmania (V.) guyanensis (20 cases). However, a relevant number ofL. (V.) naiffi patients (8 cases) was observed, thus demonstrating that this species is not uncommon in the region. No patient infected withL. (V.) naiffievolved to spontaneous cure until the start of treatment, which indicated that this species may not have a self-limiting nature. In addition, two of the patients experienced a poor response to antimonial or pentamidine therapy. Thus, either ATL cases due to L. (V.) naifficannot be as uncommon as previously thought or this species is currently expanding in this region.Faculdade de Medicina (FMD)engreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_LeishmaniaVianniaNaiffi.pdfARTIGO_LeishmaniaVianniaNaiffi.pdfapplication/pdf238003http://repositorio2.unb.br/jspui/bitstream/10482/29539/1/ARTIGO_LeishmaniaVianniaNaiffi.pdf98ab2b1fca86ec47e7c85d677fbb06fcMD51open access10482/295392023-08-25 00:28:16.243open accessoai:repositorio2.unb.br:10482/29539Biblioteca Digital de Teses e DissertaçõesPUBhttps://repositorio.unb.br/oai/requestopendoar:2023-08-25T03:28:16Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.pt_BR.fl_str_mv |
Leishmania (Viannia) naiffi : rare enough to be neglected? |
title |
Leishmania (Viannia) naiffi : rare enough to be neglected? |
spellingShingle |
Leishmania (Viannia) naiffi : rare enough to be neglected? Silva, Giselle Aparecida Fagundes Enzimas Amazônia Leishmaniose |
title_short |
Leishmania (Viannia) naiffi : rare enough to be neglected? |
title_full |
Leishmania (Viannia) naiffi : rare enough to be neglected? |
title_fullStr |
Leishmania (Viannia) naiffi : rare enough to be neglected? |
title_full_unstemmed |
Leishmania (Viannia) naiffi : rare enough to be neglected? |
title_sort |
Leishmania (Viannia) naiffi : rare enough to be neglected? |
author |
Silva, Giselle Aparecida Fagundes |
author_facet |
Silva, Giselle Aparecida Fagundes Romero, Gustavo Adolfo Sierra Cupolillo, Elisa Yamashita, Ellen Priscila Gadelha Silva, Adriano Gomes Guerra, Jorge Augusto de Oliveira Cruz, Alda Maria da |
author_role |
author |
author2 |
Romero, Gustavo Adolfo Sierra Cupolillo, Elisa Yamashita, Ellen Priscila Gadelha Silva, Adriano Gomes Guerra, Jorge Augusto de Oliveira Cruz, Alda Maria da |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Silva, Giselle Aparecida Fagundes Romero, Gustavo Adolfo Sierra Cupolillo, Elisa Yamashita, Ellen Priscila Gadelha Silva, Adriano Gomes Guerra, Jorge Augusto de Oliveira Cruz, Alda Maria da |
dc.subject.keyword.pt_BR.fl_str_mv |
Enzimas Amazônia |
topic |
Enzimas Amazônia Leishmaniose |
dc.subject.keyword.none.fl_str_mv |
Leishmaniose |
description |
In the Brazilian Amazon, American tegumentary leishmaniasis (ATL) is endemic and presents a wide spectrum of clinical manifestations due, in part, to the circulation of at least seven Leishmaniaspecies. Few reports of Leishmania (Viannia) naiffiinfection suggest that its occurrence is uncommon and the reported cases present a benign clinical course and a good response to treatment. This study aimed to strengthen the clinical and epidemiological importance of L. (V.) naiffiin the Amazon Region (Manaus, state of Amazonas) and to report therapeutic failure in patients infected with this species. Thirty Leishmania spp samples isolated from cutaneous lesions were characterised by multilocus enzyme electrophoresis. As expected, the most common species was Leishmania (V.) guyanensis (20 cases). However, a relevant number ofL. (V.) naiffi patients (8 cases) was observed, thus demonstrating that this species is not uncommon in the region. No patient infected withL. (V.) naiffievolved to spontaneous cure until the start of treatment, which indicated that this species may not have a self-limiting nature. In addition, two of the patients experienced a poor response to antimonial or pentamidine therapy. Thus, either ATL cases due to L. (V.) naifficannot be as uncommon as previously thought or this species is currently expanding in this region. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-09 |
dc.date.accessioned.fl_str_mv |
2017-12-07T05:11:37Z |
dc.date.available.fl_str_mv |
2017-12-07T05:11:37Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FAGUNDES-SILVA, Giselle Aparecida et al. Leishmania (Viannia) naiffi: rare enough to be neglected? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 6, p. 797-800, set. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000600797&lng=en&nrm=iso>. Acesso em: 9 maio 2018. doi: http://dx.doi.org/10.1590/0074-02760150128. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unb.br/handle/10482/29539 |
dc.identifier.doi.pt_BR.fl_str_mv |
http://dx.doi.org/10.1590/0074-02760150128 |
identifier_str_mv |
FAGUNDES-SILVA, Giselle Aparecida et al. Leishmania (Viannia) naiffi: rare enough to be neglected? Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v. 110, n. 6, p. 797-800, set. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762015000600797&lng=en&nrm=iso>. Acesso em: 9 maio 2018. doi: http://dx.doi.org/10.1590/0074-02760150128. |
url |
http://repositorio.unb.br/handle/10482/29539 http://dx.doi.org/10.1590/0074-02760150128 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
publisher.none.fl_str_mv |
Instituto Oswaldo Cruz, Ministério da Saúde |
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Universidade de Brasília (UnB) |
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UNB |
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UNB |
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Repositório Institucional da UnB |
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Repositório Institucional da UnB |
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http://repositorio2.unb.br/jspui/bitstream/10482/29539/1/ARTIGO_LeishmaniaVianniaNaiffi.pdf |
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