Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate

Detalhes bibliográficos
Autor(a) principal: Caramelli, Bruno
Data de Publicação: 2001
Outros Autores: Bernoche, Claudia Y.S.M. de, Sartori, Ana M.C, Spósito, Andrei Carvalho, Santos, Raul D., Monachini, Maristela C., Strabelli, Tania, Uip, Davi
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/4026
Resumo: 7 f.
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spelling Caramelli, BrunoBernoche, Claudia Y.S.M. deSartori, Ana M.CSpósito, Andrei CarvalhoSantos, Raul D.Monachini, Maristela C.Strabelli, TaniaUip, Davi2010-03-26T13:39:30Z2010-03-26T13:39:30Z2001-12CARAMELLI, Bruno. Hyperlipidemia related to the use of HIV-protease inhibitors: natural history and results of treatment with fenofibrate. Brazilian Journal of Infectious Diseases, Salvador, v. 5, n. 6, p. 332-338, dec. 2001. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600007&Ing=en&nrm=iso>. Acesso em 15 mar. 2010.http://repositorio.unb.br/handle/10482/40267 f.Hyperlipidemia has been frequently recorded as a side effect of treating HIV patients with protease inhibitors (PI). This study was initiated to analyze the modifications on blood lipids in HIV-patients receiving PI and the safety and efficacy of the treatment with fenofibrate. Total (TC) and HDL-cholesterol, triglycerides (TG), and CD4+ T-cell counts were measured in 30 HAART-naive patients (Group I) before and after PI introduction. In a second phase of the study, the effects of fenofibrate on lipids, CPK, CD4+, and viral load were determined in 13 patients (Group II) with elevated TC or TG. In Group I, 60% of the patients showed TC or TG elevations. Average increments of 31% and 146% in TC and TG respectively (p<0.0006 and p<0.0001) were observed. In Group II, fenofibrate treatment was associated with decrements of 6.6% (TC) and 45.7% (TG) (p=0.07 and 0.0002) and no modifications on CPK, CD4+, and viral load. In conclusion, hyperlipidemia is common during the treatment of HIV with protease inhibitors, and fenofibrate appears to be an effective and safe choice for its treatment.Faculdade de Medicina (FMD)Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrateinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleColesterolLipídiosHIV - infecçãoTriglicerídiosBRAinfo:eu-repo/semantics/openAccessporreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_HyperlipidemiaRelatedUseHIV.pdfARTIGO_HyperlipidemiaRelatedUseHIV.pdfapplication/pdf372114http://repositorio2.unb.br/jspui/bitstream/10482/4026/1/ARTIGO_HyperlipidemiaRelatedUseHIV.pdff1ef61b102cc66c7974334dcd6668c81MD51open accessCC-LICENSElicense_urllicense_urltext/plain49http://repositorio2.unb.br/jspui/bitstream/10482/4026/2/license_urlfd26723f8d7edacdb29e3f03465c3b03MD52open accesslicense_textlicense_textapplication/octet-stream19804http://repositorio2.unb.br/jspui/bitstream/10482/4026/3/license_text71892dada5d59e83859450f8db8a6410MD53open accesslicense_rdflicense_rdfapplication/octet-stream12170http://repositorio2.unb.br/jspui/bitstream/10482/4026/4/license_rdf28c18d8d50ea5f68c8c3d89546d38e8dMD54open accessLICENSElicense.txtlicense.txttext/plain1857http://repositorio2.unb.br/jspui/bitstream/10482/4026/5/license.txt4875ce38d6f13b4aa1d81c537b9b0051MD55open accessTEXTARTIGO_HyperlipidemiaRelatedUseHIV.pdf.txtARTIGO_HyperlipidemiaRelatedUseHIV.pdf.txtExtracted texttext/plain86472http://repositorio2.unb.br/jspui/bitstream/10482/4026/6/ARTIGO_HyperlipidemiaRelatedUseHIV.pdf.txt50398b084d66dffaf6c5922f0b5e4123MD56open access10482/40262023-08-25 00:08:41.685open accessoai:repositorio2.unb.br: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 Digital de Teses e DissertaçõesPUBhttps://repositorio.unb.br/oai/requestopendoar:2023-08-25T03:08:41Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.en.fl_str_mv Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
title Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
spellingShingle Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
Caramelli, Bruno
Colesterol
Lipídios
HIV - infecção
Triglicerídios
title_short Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
title_full Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
title_fullStr Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
title_full_unstemmed Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
title_sort Hyperlipidemia related to the use of HIV-protease inhibitors : natural history and results of treatment with fenofibrate
author Caramelli, Bruno
author_facet Caramelli, Bruno
Bernoche, Claudia Y.S.M. de
Sartori, Ana M.C
Spósito, Andrei Carvalho
Santos, Raul D.
Monachini, Maristela C.
Strabelli, Tania
Uip, Davi
author_role author
author2 Bernoche, Claudia Y.S.M. de
Sartori, Ana M.C
Spósito, Andrei Carvalho
Santos, Raul D.
Monachini, Maristela C.
Strabelli, Tania
Uip, Davi
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Caramelli, Bruno
Bernoche, Claudia Y.S.M. de
Sartori, Ana M.C
Spósito, Andrei Carvalho
Santos, Raul D.
Monachini, Maristela C.
Strabelli, Tania
Uip, Davi
dc.subject.keyword.en.fl_str_mv Colesterol
Lipídios
HIV - infecção
Triglicerídios
topic Colesterol
Lipídios
HIV - infecção
Triglicerídios
description 7 f.
publishDate 2001
dc.date.issued.fl_str_mv 2001-12
dc.date.accessioned.fl_str_mv 2010-03-26T13:39:30Z
dc.date.available.fl_str_mv 2010-03-26T13:39:30Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv CARAMELLI, Bruno. Hyperlipidemia related to the use of HIV-protease inhibitors: natural history and results of treatment with fenofibrate. Brazilian Journal of Infectious Diseases, Salvador, v. 5, n. 6, p. 332-338, dec. 2001. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600007&Ing=en&nrm=iso>. Acesso em 15 mar. 2010.
dc.identifier.uri.fl_str_mv http://repositorio.unb.br/handle/10482/4026
identifier_str_mv CARAMELLI, Bruno. Hyperlipidemia related to the use of HIV-protease inhibitors: natural history and results of treatment with fenofibrate. Brazilian Journal of Infectious Diseases, Salvador, v. 5, n. 6, p. 332-338, dec. 2001. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702001000600007&Ing=en&nrm=iso>. Acesso em 15 mar. 2010.
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