Factors influencing phagocytosis of Salmonella Typhimurium by macrophages in murine schitosomiasis

Detalhes bibliográficos
Autor(a) principal: Muniz-Junqueira, Maria Imaculada
Data de Publicação: 1997
Outros Autores: Prata, Aluízio, Tosta, Carlos Eduardo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UnB
Texto Completo: http://repositorio.unb.br/handle/10482/2798
Resumo: 6 f.
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spelling Muniz-Junqueira, Maria ImaculadaPrata, AluízioTosta, Carlos Eduardo2009-12-21T16:32:51Z2009-12-21T16:32:51Z1997MUNIZ-JUNQUEIRA, Maria Imaculada; PRATA, Aluízio; TOSTA, Carlos Eduardo. Factors influencing phagocytosis of Salmonella Typhimurium by macrophages in murine schitosomiasis. Revista da Sociedade Brasileira de Medicina Tropical, v. 30, n. 2, p. 101-106, mar./abr.1997. Disponível em: <http://www.scielo.br/pdf/rsbmt/v30n2/0746.pdf>. Acesso em: 21 dez. 2009.http://repositorio.unb.br/handle/10482/27986 f.Investigamos a influência da carga bacteriana e de anticorpos específicos sobre a fagocitose na esquistossomose. Macrófagos de camundongos esquistossomóticos mostraram uma menor capacidade para aumentar a fagocitose mesmo na presença de alta carga bacteriana, devido a um reduzido envolvimento destas células na fagocitose e a uma incapacidade para aumentar o número de bactérias fagocitadas por macrófago. Camundongos normais e infectados por Salmonella typhimurium aumentaram sua capacidade fagocitária quando expostos a uma alta carga bacteriana. Anticorpos para Salmonella typhimurium significantemente aumentaram a capacidade fagocitária de macrófagos de camundongos esquistossomóticos devido ao aumento do número de bactérias ingeridas mas não causaram nenhuma modificação no número de macrófagos envolvidos na fagocitose. Nossos dados indicam que macrófagos de camundongos esquistossomóticos trabalham próximo ao seu limite funcional, desde que nenhum aumento significante na fagocitose foi observado após aumentar a carga bacteriana. Anticorpos específicos podem melhorar sua capacidade fagocitária e, portanto, poderiam auxiliar na eliminação da infecção concomitante por Salmonella.We investigated the influence of Salmonella typhimurium load and specific antibodies on phagocytosis in schistosomiasis. Macrophages from Schistosoma mansoniinfected mice showed depressed capacity to increase the phagocytosis in the presence of a high bacterial load, due to a reduced involvement of these cells in phagocytosis and to a deficient ability to increase the number of phagocytosed bacteria. Normal and Salmonella-infected mice increased their phagocytic capacity when exposed to a high bacterial load. Antibody to Salmonella increased the phagocytic capacity of macrophages from Schistosoma-infected mice due to an increase in the number of bacteria phagocytosed but caused no modification in the number of macrophages engaged in phagocytosis. Our data indicate that macrophages from Schistosomainfected mice work close to their functional limit, since no increase in phagocytosis was observed after increasing the bacterial load. Specific antibodies can improve their phagocytic capacity and, therefore, could help clearing concurrent infection.Faculdade de Medicina (FMD)Factors influencing phagocytosis of Salmonella Typhimurium by macrophages in murine schitosomiasisinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSchistosomiasisSalmonella typhimuriumMacrophagesPhagocytosisChronic salmonellosisBRAinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_FactorsInfluencingPhagocytosis.pdfARTIGO_FactorsInfluencingPhagocytosis.pdfapplication/pdf374342http://repositorio2.unb.br/jspui/bitstream/10482/2798/1/ARTIGO_FactorsInfluencingPhagocytosis.pdfd63156f415810d558a9e2b9fae7df4b5MD51open accessCC-LICENSElicense_urllicense_urltext/plain49http://repositorio2.unb.br/jspui/bitstream/10482/2798/2/license_urlfd26723f8d7edacdb29e3f03465c3b03MD52open accesslicense_textlicense_textapplication/octet-stream19796http://repositorio2.unb.br/jspui/bitstream/10482/2798/3/license_textfdfcda7eda6bbee2685363ca76182053MD53open accesslicense_rdflicense_rdfapplication/octet-stream12170http://repositorio2.unb.br/jspui/bitstream/10482/2798/4/license_rdf28c18d8d50ea5f68c8c3d89546d38e8dMD54open accessLICENSElicense.txtlicense.txttext/plain1857http://repositorio2.unb.br/jspui/bitstream/10482/2798/5/license.txtda9fedf14ea98d2a0fbcde05959eae45MD55open accessTEXTARTIGO_FactorsInfluencingPhagocytosis.pdf.txtARTIGO_FactorsInfluencingPhagocytosis.pdf.txtExtracted texttext/plain24064http://repositorio2.unb.br/jspui/bitstream/10482/2798/6/ARTIGO_FactorsInfluencingPhagocytosis.pdf.txt1b8e3d18e5602f832930d5d5b85fd368MD56open access10482/27982023-08-24 23:43:31.727open accessoai:repositorio2.unb.br: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 Digital de Teses e DissertaçõesPUBhttps://repositorio.unb.br/oai/requestopendoar:2023-08-25T02:43:31Repositório Institucional da UnB - Universidade de Brasília (UnB)false
dc.title.en.fl_str_mv Factors influencing phagocytosis of Salmonella Typhimurium by macrophages in murine schitosomiasis
title Factors influencing phagocytosis of Salmonella Typhimurium by macrophages in murine schitosomiasis
spellingShingle Factors influencing phagocytosis of Salmonella Typhimurium by macrophages in murine schitosomiasis
Muniz-Junqueira, Maria Imaculada
Schistosomiasis
Salmonella typhimurium
Macrophages
Phagocytosis
Chronic salmonellosis
title_short Factors influencing phagocytosis of Salmonella Typhimurium by macrophages in murine schitosomiasis
title_full Factors influencing phagocytosis of Salmonella Typhimurium by macrophages in murine schitosomiasis
title_fullStr Factors influencing phagocytosis of Salmonella Typhimurium by macrophages in murine schitosomiasis
title_full_unstemmed Factors influencing phagocytosis of Salmonella Typhimurium by macrophages in murine schitosomiasis
title_sort Factors influencing phagocytosis of Salmonella Typhimurium by macrophages in murine schitosomiasis
author Muniz-Junqueira, Maria Imaculada
author_facet Muniz-Junqueira, Maria Imaculada
Prata, Aluízio
Tosta, Carlos Eduardo
author_role author
author2 Prata, Aluízio
Tosta, Carlos Eduardo
author2_role author
author
dc.contributor.author.fl_str_mv Muniz-Junqueira, Maria Imaculada
Prata, Aluízio
Tosta, Carlos Eduardo
dc.subject.keyword.en.fl_str_mv Schistosomiasis
Salmonella typhimurium
Macrophages
Phagocytosis
Chronic salmonellosis
topic Schistosomiasis
Salmonella typhimurium
Macrophages
Phagocytosis
Chronic salmonellosis
description 6 f.
publishDate 1997
dc.date.issued.fl_str_mv 1997
dc.date.accessioned.fl_str_mv 2009-12-21T16:32:51Z
dc.date.available.fl_str_mv 2009-12-21T16:32:51Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MUNIZ-JUNQUEIRA, Maria Imaculada; PRATA, Aluízio; TOSTA, Carlos Eduardo. Factors influencing phagocytosis of Salmonella Typhimurium by macrophages in murine schitosomiasis. Revista da Sociedade Brasileira de Medicina Tropical, v. 30, n. 2, p. 101-106, mar./abr.1997. Disponível em: <http://www.scielo.br/pdf/rsbmt/v30n2/0746.pdf>. Acesso em: 21 dez. 2009.
dc.identifier.uri.fl_str_mv http://repositorio.unb.br/handle/10482/2798
identifier_str_mv MUNIZ-JUNQUEIRA, Maria Imaculada; PRATA, Aluízio; TOSTA, Carlos Eduardo. Factors influencing phagocytosis of Salmonella Typhimurium by macrophages in murine schitosomiasis. Revista da Sociedade Brasileira de Medicina Tropical, v. 30, n. 2, p. 101-106, mar./abr.1997. Disponível em: <http://www.scielo.br/pdf/rsbmt/v30n2/0746.pdf>. Acesso em: 21 dez. 2009.
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