Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction
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Publication Date: | 2015 |
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Format: | Article |
Language: | eng |
Source: | Repositório Institucional da UnB |
Download full: | http://repositorio.unb.br/handle/10482/29648 http://dx.doi.org/10.1590/S0102-86502015001000010 |
Summary: | Purpose: to evaluate the influence of glutamine and obstructive jaundice on left colon healing in rats. Methods: sixteen male rats were allocated across four groups: LG - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct ligation until euthanasia. L - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. M - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. MG - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct manipulation until euthanasia. On the day of euthanasia, bursting pressure of the sutured bowel segment was measured and samples were collected for histopathological analysis. Results: there were no differences in bursting pressure among groups : LG vs. M (110 ± 28 vs. 173 ± 12; p = 0.08). Groups L and MG were not different from group M (156 ± 12 and 118 ± 22. Glutamine supplementation was associated with less edema, polymorphonuclear lymphocyte infiltration, bacterial colonies, and abscess formation, as well as with increased collagen formation. Conclusion: obstructive jaundice had no negative effect and glutamine supplementation had no positive effect on colonic scar strength in rats. |
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Alecrim, Hugo MuscelliDuarte, Sérgio Andurte CarvalhoAmaral, Maria Eduarda BonavidesDiógenis, FilipeCarneiro, Fabiana PiraniSousa, João Batista de2017-12-07T05:12:00Z2017-12-07T05:12:00Z2015-01ALECRIM, Hugo Muscelli et al. Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction. Acta Cirurgica Brasileira, São Paulo, v. 30, n. 1, p. 73-79, jan. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000100073&lng=en&nrm=iso>. Acesso em: 17 abr. 2018. doi: http://dx.doi.org/10.1590/S0102-86502015001000010.http://repositorio.unb.br/handle/10482/29648http://dx.doi.org/10.1590/S0102-86502015001000010Sociedade Brasileira para o Desenvolvimento da Pesquisa em CirurgiaActa Cirurgica Brasileira - This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY NC 4.0). Fonte: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000100073&lng=en&nrm=iso. Acesso em: 17 abr. 2018.info:eu-repo/semantics/openAccessEffect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstructioninfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleCólon (Anatomia)Cicatrização de feridasCirurgiaRatosPurpose: to evaluate the influence of glutamine and obstructive jaundice on left colon healing in rats. Methods: sixteen male rats were allocated across four groups: LG - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct ligation until euthanasia. L - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. M - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. MG - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct manipulation until euthanasia. On the day of euthanasia, bursting pressure of the sutured bowel segment was measured and samples were collected for histopathological analysis. Results: there were no differences in bursting pressure among groups : LG vs. M (110 ± 28 vs. 173 ± 12; p = 0.08). Groups L and MG were not different from group M (156 ± 12 and 118 ± 22. Glutamine supplementation was associated with less edema, polymorphonuclear lymphocyte infiltration, bacterial colonies, and abscess formation, as well as with increased collagen formation. Conclusion: obstructive jaundice had no negative effect and glutamine supplementation had no positive effect on colonic scar strength in rats.Faculdade de Medicina (FMD)engreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_EffectGlutamineSupplementation.pdfARTIGO_EffectGlutamineSupplementation.pdfapplication/pdf1026736http://repositorio2.unb.br/jspui/bitstream/10482/29648/1/ARTIGO_EffectGlutamineSupplementation.pdf6b9fde07a6f2bae16f8644ea73f6dcf6MD51open access10482/296482023-08-24 23:15:05.041open accessoai:repositorio2.unb.br:10482/29648Biblioteca Digital de Teses e DissertaçõesPUBhttps://repositorio.unb.br/oai/requestopendoar:2023-08-25T02:15:05Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.pt_BR.fl_str_mv |
Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction |
title |
Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction |
spellingShingle |
Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction Alecrim, Hugo Muscelli Cólon (Anatomia) Cicatrização de feridas Cirurgia Ratos |
title_short |
Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction |
title_full |
Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction |
title_fullStr |
Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction |
title_full_unstemmed |
Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction |
title_sort |
Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction |
author |
Alecrim, Hugo Muscelli |
author_facet |
Alecrim, Hugo Muscelli Duarte, Sérgio Andurte Carvalho Amaral, Maria Eduarda Bonavides Diógenis, Filipe Carneiro, Fabiana Pirani Sousa, João Batista de |
author_role |
author |
author2 |
Duarte, Sérgio Andurte Carvalho Amaral, Maria Eduarda Bonavides Diógenis, Filipe Carneiro, Fabiana Pirani Sousa, João Batista de |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Alecrim, Hugo Muscelli Duarte, Sérgio Andurte Carvalho Amaral, Maria Eduarda Bonavides Diógenis, Filipe Carneiro, Fabiana Pirani Sousa, João Batista de |
dc.subject.keyword.pt_BR.fl_str_mv |
Cólon (Anatomia) Cicatrização de feridas Cirurgia Ratos |
topic |
Cólon (Anatomia) Cicatrização de feridas Cirurgia Ratos |
description |
Purpose: to evaluate the influence of glutamine and obstructive jaundice on left colon healing in rats. Methods: sixteen male rats were allocated across four groups: LG - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct ligation until euthanasia. L - Common bile duct ligation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. M - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. No glutamine supplementation. MG - Common bile duct manipulation followed by colotomy and bowel suture on postoperative day 7. Supplementation with glutamine 2% from day 4 after duct manipulation until euthanasia. On the day of euthanasia, bursting pressure of the sutured bowel segment was measured and samples were collected for histopathological analysis. Results: there were no differences in bursting pressure among groups : LG vs. M (110 ± 28 vs. 173 ± 12; p = 0.08). Groups L and MG were not different from group M (156 ± 12 and 118 ± 22. Glutamine supplementation was associated with less edema, polymorphonuclear lymphocyte infiltration, bacterial colonies, and abscess formation, as well as with increased collagen formation. Conclusion: obstructive jaundice had no negative effect and glutamine supplementation had no positive effect on colonic scar strength in rats. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015-01 |
dc.date.accessioned.fl_str_mv |
2017-12-07T05:12:00Z |
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2017-12-07T05:12:00Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
ALECRIM, Hugo Muscelli et al. Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction. Acta Cirurgica Brasileira, São Paulo, v. 30, n. 1, p. 73-79, jan. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000100073&lng=en&nrm=iso>. Acesso em: 17 abr. 2018. doi: http://dx.doi.org/10.1590/S0102-86502015001000010. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unb.br/handle/10482/29648 |
dc.identifier.doi.pt_BR.fl_str_mv |
http://dx.doi.org/10.1590/S0102-86502015001000010 |
identifier_str_mv |
ALECRIM, Hugo Muscelli et al. Effect of glutamine supplementation on left colon healing in rats with extrahepatic biliary obstruction. Acta Cirurgica Brasileira, São Paulo, v. 30, n. 1, p. 73-79, jan. 2015. Disponível em: <http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502015000100073&lng=en&nrm=iso>. Acesso em: 17 abr. 2018. doi: http://dx.doi.org/10.1590/S0102-86502015001000010. |
url |
http://repositorio.unb.br/handle/10482/29648 http://dx.doi.org/10.1590/S0102-86502015001000010 |
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eng |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
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Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia |
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