In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio2.unb.br/jspui/handle/10482/47633 https://doi.org/10.1016/j.ejps.2023.106517 |
Resumo: | The in-situ formation of nanoparticles from polymer-based solid medicines, although previously described, has been overlooked despite its potential to interfere with oral drug bioavailability. Such polymeric pharmaceuticals are becoming increasingly common on the market and can become even more popular due to the dizzying advance of 3D printing medicines. Hence, this work aimed to study this phenomenon during the dissolution of 3D printed tablets produced with three different polymers, hydroxypropylmethylcellulose acetate succinate (HPMCAS), polyvinyl alcohol (PVA), and Eudragit RL PO® (EUD RL) combined with plasticizers and the model drug naringenin (NAR). The components’ interaction, dissolution behavior, and characteristics of the formed particles were investigated employing thermal, spectroscopic, mechanical, and chromatographic assays. All the systems generated stable spherical-shaped particles throughout 24 h, encapsulating over 25% of NAR. Results suggest encapsulation efficiencies variations may depend on interactions between polymer-drug, drug-plasti cizer, and polymer-plasticizer, which formed stable nanoparticles even in the drug absence, as observed with the HPMCAS and EUD RL formulations. Additionally, components solubility in the medium and previous formulation treatments are also a decisive factor for nanoparticle formation. In particular, the treatment provided by hot-melt extrusion and FDM 3D printing affected the dissolution efficiency enhancing the interaction between the com ponents, reverberating on particle size and particle formation kinetics mainly for HPMCAS and EUD RL. In conclusion, the 3D printing process influences the in-situ formation of nanoparticles, which can directly affect oral drug bioavailability and needs to be monitored. |
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Pires, Felipe QueirozGross, Idejan PadilhaBarreto, Livia Cristina Lira de SáGratieri, TaísGelfuso, Guilherme MartinsBáo, Sônia NairCunha Filho, Marcílio Sérgio Soares daUniversity of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and CosmeticsUniversity of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and CosmeticsUniversity of Brasilia, Faculty of CeilandiaUniversity of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and CosmeticsUniversity of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and CosmeticsUniversity of Brasilia, Institute of Biological Sciences, Laboratório de Microscopia e MicroanáliseUniversity of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics2024-02-01T15:21:57Z2024-02-01T15:21:57Z2023-07-03PIRES, Felipe Q. et al. In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices. European Journal of Pharmaceutical Sciences, v. 188,106517, 1 set. 2023. DOI: https://doi.org/10.1016/j.ejps.2023.106517. Disponível em: https://www.sciencedirect.com/science/article/pii/S0928098723001471?via%3Dihub. Acesso em: 02 fev. 2024.http://repositorio2.unb.br/jspui/handle/10482/47633https://doi.org/10.1016/j.ejps.2023.106517engElsevier B.V.This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).info:eu-repo/semantics/openAccessIn-situ formation of nanoparticles from drug-loaded 3D polymeric matricesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNaringeninaNanopartículasMedicamentosThe in-situ formation of nanoparticles from polymer-based solid medicines, although previously described, has been overlooked despite its potential to interfere with oral drug bioavailability. Such polymeric pharmaceuticals are becoming increasingly common on the market and can become even more popular due to the dizzying advance of 3D printing medicines. Hence, this work aimed to study this phenomenon during the dissolution of 3D printed tablets produced with three different polymers, hydroxypropylmethylcellulose acetate succinate (HPMCAS), polyvinyl alcohol (PVA), and Eudragit RL PO® (EUD RL) combined with plasticizers and the model drug naringenin (NAR). The components’ interaction, dissolution behavior, and characteristics of the formed particles were investigated employing thermal, spectroscopic, mechanical, and chromatographic assays. All the systems generated stable spherical-shaped particles throughout 24 h, encapsulating over 25% of NAR. Results suggest encapsulation efficiencies variations may depend on interactions between polymer-drug, drug-plasti cizer, and polymer-plasticizer, which formed stable nanoparticles even in the drug absence, as observed with the HPMCAS and EUD RL formulations. Additionally, components solubility in the medium and previous formulation treatments are also a decisive factor for nanoparticle formation. In particular, the treatment provided by hot-melt extrusion and FDM 3D printing affected the dissolution efficiency enhancing the interaction between the com ponents, reverberating on particle size and particle formation kinetics mainly for HPMCAS and EUD RL. In conclusion, the 3D printing process influences the in-situ formation of nanoparticles, which can directly affect oral drug bioavailability and needs to be monitored.Faculdade UnB Ceilândia (FCE)Curso de Farmácia (FCE-FAR)Faculdade de Ciências da Saúde (FS)Departamento de Farmácia (FS FAR)Instituto de Ciências Biológicas (IB)Departamento de Biologia Celular (IB CEL)reponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_In-situFormationNanoparticles.pdfARTIGO_In-situFormationNanoparticles.pdfapplication/pdf4784779http://repositorio2.unb.br/jspui/bitstream/10482/47633/1/ARTIGO_In-situFormationNanoparticles.pdfa93c18376c1cf6e098353ddb1300e2c6MD51open accessLICENSElicense.txtlicense.txttext/plain102http://repositorio2.unb.br/jspui/bitstream/10482/47633/2/license.txtaed4704d04bb260d4decd80db311aaa5MD52open access10482/476332024-02-01 12:21:57.978open accessoai:repositorio2.unb.br:10482/47633U3VibWlzc8OjbyBlZmV0aXZhZGEgZGUgYWNvcmRvIGNvbSBsaWNlbsOnYSBjb25jZWRpZGEgcGVsbyBhdXRvciBlL291IGRldGVudG9yIGRvcyBkaXJlaXRvcyBhdXRvcmFpcy4KBiblioteca Digital de Teses e DissertaçõesPUBhttps://repositorio.unb.br/oai/requestopendoar:2024-02-01T15:21:57Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.pt_BR.fl_str_mv |
In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices |
title |
In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices |
spellingShingle |
In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices Pires, Felipe Queiroz Naringenina Nanopartículas Medicamentos |
title_short |
In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices |
title_full |
In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices |
title_fullStr |
In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices |
title_full_unstemmed |
In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices |
title_sort |
In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices |
author |
Pires, Felipe Queiroz |
author_facet |
Pires, Felipe Queiroz Gross, Idejan Padilha Barreto, Livia Cristina Lira de Sá Gratieri, Taís Gelfuso, Guilherme Martins Báo, Sônia Nair Cunha Filho, Marcílio Sérgio Soares da |
author_role |
author |
author2 |
Gross, Idejan Padilha Barreto, Livia Cristina Lira de Sá Gratieri, Taís Gelfuso, Guilherme Martins Báo, Sônia Nair Cunha Filho, Marcílio Sérgio Soares da |
author2_role |
author author author author author author |
dc.contributor.affiliation.pt_BR.fl_str_mv |
University of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics University of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics University of Brasilia, Faculty of Ceilandia University of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics University of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics University of Brasilia, Institute of Biological Sciences, Laboratório de Microscopia e Microanálise University of Brasilia, School of Health Sciences, Laboratory of Food, Drugs and Cosmetics |
dc.contributor.author.fl_str_mv |
Pires, Felipe Queiroz Gross, Idejan Padilha Barreto, Livia Cristina Lira de Sá Gratieri, Taís Gelfuso, Guilherme Martins Báo, Sônia Nair Cunha Filho, Marcílio Sérgio Soares da |
dc.subject.keyword.pt_BR.fl_str_mv |
Naringenina Nanopartículas Medicamentos |
topic |
Naringenina Nanopartículas Medicamentos |
description |
The in-situ formation of nanoparticles from polymer-based solid medicines, although previously described, has been overlooked despite its potential to interfere with oral drug bioavailability. Such polymeric pharmaceuticals are becoming increasingly common on the market and can become even more popular due to the dizzying advance of 3D printing medicines. Hence, this work aimed to study this phenomenon during the dissolution of 3D printed tablets produced with three different polymers, hydroxypropylmethylcellulose acetate succinate (HPMCAS), polyvinyl alcohol (PVA), and Eudragit RL PO® (EUD RL) combined with plasticizers and the model drug naringenin (NAR). The components’ interaction, dissolution behavior, and characteristics of the formed particles were investigated employing thermal, spectroscopic, mechanical, and chromatographic assays. All the systems generated stable spherical-shaped particles throughout 24 h, encapsulating over 25% of NAR. Results suggest encapsulation efficiencies variations may depend on interactions between polymer-drug, drug-plasti cizer, and polymer-plasticizer, which formed stable nanoparticles even in the drug absence, as observed with the HPMCAS and EUD RL formulations. Additionally, components solubility in the medium and previous formulation treatments are also a decisive factor for nanoparticle formation. In particular, the treatment provided by hot-melt extrusion and FDM 3D printing affected the dissolution efficiency enhancing the interaction between the com ponents, reverberating on particle size and particle formation kinetics mainly for HPMCAS and EUD RL. In conclusion, the 3D printing process influences the in-situ formation of nanoparticles, which can directly affect oral drug bioavailability and needs to be monitored. |
publishDate |
2023 |
dc.date.issued.fl_str_mv |
2023-07-03 |
dc.date.accessioned.fl_str_mv |
2024-02-01T15:21:57Z |
dc.date.available.fl_str_mv |
2024-02-01T15:21:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
PIRES, Felipe Q. et al. In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices. European Journal of Pharmaceutical Sciences, v. 188,106517, 1 set. 2023. DOI: https://doi.org/10.1016/j.ejps.2023.106517. Disponível em: https://www.sciencedirect.com/science/article/pii/S0928098723001471?via%3Dihub. Acesso em: 02 fev. 2024. |
dc.identifier.uri.fl_str_mv |
http://repositorio2.unb.br/jspui/handle/10482/47633 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.1016/j.ejps.2023.106517 |
identifier_str_mv |
PIRES, Felipe Q. et al. In-situ formation of nanoparticles from drug-loaded 3D polymeric matrices. European Journal of Pharmaceutical Sciences, v. 188,106517, 1 set. 2023. DOI: https://doi.org/10.1016/j.ejps.2023.106517. Disponível em: https://www.sciencedirect.com/science/article/pii/S0928098723001471?via%3Dihub. Acesso em: 02 fev. 2024. |
url |
http://repositorio2.unb.br/jspui/handle/10482/47633 https://doi.org/10.1016/j.ejps.2023.106517 |
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Elsevier B.V. |
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Elsevier B.V. |
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