Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/27917 https://doi.org/10.3922/j.psns.2010.1.008 |
Resumo: | Electrical or chemical stimulation of the dorsal periaqueductal gray (DPAG) has been accepted as an animal model of panic attacks. This study investigates the influence of anticipatory anxiety in the occurrence of panic-like behavior induced by N-methyl-D-aspartate (NMDA) microinjection into the DPAG of rats. Behavioral (i.e., contextual fear conditioning) and pharmacological (i.e., pentylenetetrazol) manipulations were employed as animal models of anticipatory anxiety. In the first experiment, animals exposed to contextual cues that had been previously associated with electric footshocks through contextual fear conditioning were less likely than non-conditioned control animals to display defensive reactions such as running and jumping in response to microinjection of NMDA (0.3 µl of 15.0 µg/µl) into the DPAG. In the second experiment, rats were injected intraperitoneally with the anxiogenic drug pentylenetetrazol (PTZ, 15 mg/kg) 5 minutes before receiving intra-DPAG microinfusion with the same dose of NMDA as in Experiment 1. Panic-related behaviors were registered in an experimental arena immediately after NMDA microinfusion. As compared with saline pre-treated animals, PTZ significantly attenuated NMDA-induced panic-like reactions. These results further demonstrate the usefulness of DPAG chemical stimulation as an animal model of panic attacks and suggest that behavioral and pharmacological activation of the brain mechanisms underlying anticipatory anxiety might exert an antipanic-like effect. |
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Galvão, Bruno de OliveiraLarrubia, Bruno CostaHommes, Wouter JanCardenas, Luis FernandoCruz, Antonio Pedro de MelloLandeira-Fernandez, J.2017-12-07T04:55:25Z2017-12-07T04:55:25Z2010GALVÃO, Bruno de Oliveira et al. Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate. Psychology & Neuroscience, v. 3, n. 1, p. 67-72, 2010. DOI: https://doi.org/10.3922/j.psns.2010.1.008. Disponível em: https://www.scielo.br/j/pn/a/MXwVCrBJpMjcK3Y99h53NKH/abstract/?lang=en#. Acesso em: 10 set. 2021.http://repositorio.unb.br/handle/10482/27917https://doi.org/10.3922/j.psns.2010.1.008Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São PauloPsychology & Neuroscience - This work is licensed under a Creative Commons Attribution 4.0 International License (CC BY). Fonte: https://www.scielo.br/j/pn/a/MXwVCrBJpMjcK3Y99h53NKH/?lang=en. Acesso em: 10 set. 2021.info:eu-repo/semantics/openAccessEffects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartateinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleAnsiedadeMedoDistúrbios do pânicoElectrical or chemical stimulation of the dorsal periaqueductal gray (DPAG) has been accepted as an animal model of panic attacks. This study investigates the influence of anticipatory anxiety in the occurrence of panic-like behavior induced by N-methyl-D-aspartate (NMDA) microinjection into the DPAG of rats. Behavioral (i.e., contextual fear conditioning) and pharmacological (i.e., pentylenetetrazol) manipulations were employed as animal models of anticipatory anxiety. In the first experiment, animals exposed to contextual cues that had been previously associated with electric footshocks through contextual fear conditioning were less likely than non-conditioned control animals to display defensive reactions such as running and jumping in response to microinjection of NMDA (0.3 µl of 15.0 µg/µl) into the DPAG. In the second experiment, rats were injected intraperitoneally with the anxiogenic drug pentylenetetrazol (PTZ, 15 mg/kg) 5 minutes before receiving intra-DPAG microinfusion with the same dose of NMDA as in Experiment 1. Panic-related behaviors were registered in an experimental arena immediately after NMDA microinfusion. As compared with saline pre-treated animals, PTZ significantly attenuated NMDA-induced panic-like reactions. These results further demonstrate the usefulness of DPAG chemical stimulation as an animal model of panic attacks and suggest that behavioral and pharmacological activation of the brain mechanisms underlying anticipatory anxiety might exert an antipanic-like effect.engreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINALARTIGO_EffectsContextualFear.pdfARTIGO_EffectsContextualFear.pdfapplication/pdf406489http://repositorio2.unb.br/jspui/bitstream/10482/27917/1/ARTIGO_EffectsContextualFear.pdfae4f3d1d1d1c44f6ccf0355d45a905e0MD51open access10482/279172023-06-04 19:07:14.008open accessoai:repositorio2.unb.br:10482/27917Biblioteca Digital de Teses e DissertaçõesPUBhttps://repositorio.unb.br/oai/requestopendoar:2023-06-04T22:07:14Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.pt_BR.fl_str_mv |
Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate |
title |
Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate |
spellingShingle |
Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate Galvão, Bruno de Oliveira Ansiedade Medo Distúrbios do pânico |
title_short |
Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate |
title_full |
Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate |
title_fullStr |
Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate |
title_full_unstemmed |
Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate |
title_sort |
Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate |
author |
Galvão, Bruno de Oliveira |
author_facet |
Galvão, Bruno de Oliveira Larrubia, Bruno Costa Hommes, Wouter Jan Cardenas, Luis Fernando Cruz, Antonio Pedro de Mello Landeira-Fernandez, J. |
author_role |
author |
author2 |
Larrubia, Bruno Costa Hommes, Wouter Jan Cardenas, Luis Fernando Cruz, Antonio Pedro de Mello Landeira-Fernandez, J. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Galvão, Bruno de Oliveira Larrubia, Bruno Costa Hommes, Wouter Jan Cardenas, Luis Fernando Cruz, Antonio Pedro de Mello Landeira-Fernandez, J. |
dc.subject.keyword.pt_BR.fl_str_mv |
Ansiedade Medo Distúrbios do pânico |
topic |
Ansiedade Medo Distúrbios do pânico |
description |
Electrical or chemical stimulation of the dorsal periaqueductal gray (DPAG) has been accepted as an animal model of panic attacks. This study investigates the influence of anticipatory anxiety in the occurrence of panic-like behavior induced by N-methyl-D-aspartate (NMDA) microinjection into the DPAG of rats. Behavioral (i.e., contextual fear conditioning) and pharmacological (i.e., pentylenetetrazol) manipulations were employed as animal models of anticipatory anxiety. In the first experiment, animals exposed to contextual cues that had been previously associated with electric footshocks through contextual fear conditioning were less likely than non-conditioned control animals to display defensive reactions such as running and jumping in response to microinjection of NMDA (0.3 µl of 15.0 µg/µl) into the DPAG. In the second experiment, rats were injected intraperitoneally with the anxiogenic drug pentylenetetrazol (PTZ, 15 mg/kg) 5 minutes before receiving intra-DPAG microinfusion with the same dose of NMDA as in Experiment 1. Panic-related behaviors were registered in an experimental arena immediately after NMDA microinfusion. As compared with saline pre-treated animals, PTZ significantly attenuated NMDA-induced panic-like reactions. These results further demonstrate the usefulness of DPAG chemical stimulation as an animal model of panic attacks and suggest that behavioral and pharmacological activation of the brain mechanisms underlying anticipatory anxiety might exert an antipanic-like effect. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010 |
dc.date.accessioned.fl_str_mv |
2017-12-07T04:55:25Z |
dc.date.available.fl_str_mv |
2017-12-07T04:55:25Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GALVÃO, Bruno de Oliveira et al. Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate. Psychology & Neuroscience, v. 3, n. 1, p. 67-72, 2010. DOI: https://doi.org/10.3922/j.psns.2010.1.008. Disponível em: https://www.scielo.br/j/pn/a/MXwVCrBJpMjcK3Y99h53NKH/abstract/?lang=en#. Acesso em: 10 set. 2021. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unb.br/handle/10482/27917 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://doi.org/10.3922/j.psns.2010.1.008 |
identifier_str_mv |
GALVÃO, Bruno de Oliveira et al. Effects of contextual fear conditioning and pentylenetetrazol on panic-like reactions induced by dorsal periaqueductal gray stimulation with N-methyl-D-aspartate. Psychology & Neuroscience, v. 3, n. 1, p. 67-72, 2010. DOI: https://doi.org/10.3922/j.psns.2010.1.008. Disponível em: https://www.scielo.br/j/pn/a/MXwVCrBJpMjcK3Y99h53NKH/abstract/?lang=en#. Acesso em: 10 set. 2021. |
url |
http://repositorio.unb.br/handle/10482/27917 https://doi.org/10.3922/j.psns.2010.1.008 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo |
publisher.none.fl_str_mv |
Pontificia Universidade Católica do Rio de JaneiroUniversidade de BrasíliaUniversidade de São Paulo |
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Universidade de Brasília (UnB) |
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UNB |
institution |
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Repositório Institucional da UnB |
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