L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UnB |
Texto Completo: | http://repositorio.unb.br/handle/10482/26374 https://dx.doi.org/10.1590/S0100-879X2005000100001 |
Resumo: | The present study on molecular characterization of a human papillomavirus (HPV) isolated in Central Brazil describes the L1 gene sequence from a new variant of HPV-58, the isolate Bsb-02. The sample was from a smear obtained from a woman with cervical intraepithelial neoplasia grade II. The whole L1 gene from isolate Bsb-02 was sequenced automatically, showing 99.1% nucleotide identity with the gene from the HPV-58 reference. The clustering between Bsb-02 and HPV-58 reference sequence was also supported by phylogenetic analysis. Fourteen nucleotide substitutions were observed: eight were synonymous and six were associated with amino acid substitutions. A10V and V144I have not been previously described. At GenBank, the only complete L1 sequence from HPV-58 in addition to the HPV-58 reference one is that of Bsb-02. These data provide information that may be relevant to HPV diagnosis and to rational vaccine strategies. HPV variants may also be associated with host immune responses and with the risk of cervical neoplasia. |
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Veras, V.S.Cerqueira, D.M.Martins, C.R.F.2017-12-07T04:42:13Z2017-12-07T04:42:13Z2005Braz J Med Biol Res,v.38,n.1,p.1-4,2005http://repositorio.unb.br/handle/10482/26374https://dx.doi.org/10.1590/S0100-879X2005000100001The present study on molecular characterization of a human papillomavirus (HPV) isolated in Central Brazil describes the L1 gene sequence from a new variant of HPV-58, the isolate Bsb-02. The sample was from a smear obtained from a woman with cervical intraepithelial neoplasia grade II. The whole L1 gene from isolate Bsb-02 was sequenced automatically, showing 99.1% nucleotide identity with the gene from the HPV-58 reference. The clustering between Bsb-02 and HPV-58 reference sequence was also supported by phylogenetic analysis. Fourteen nucleotide substitutions were observed: eight were synonymous and six were associated with amino acid substitutions. A10V and V144I have not been previously described. At GenBank, the only complete L1 sequence from HPV-58 in addition to the HPV-58 reference one is that of Bsb-02. These data provide information that may be relevant to HPV diagnosis and to rational vaccine strategies. HPV variants may also be associated with host immune responses and with the risk of cervical neoplasia.Em processamentoAssociação Brasileira de Divulgação CientíficaL1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHuman papillomavirusHPV-58L1 geneVariantsinfo:eu-repo/semantics/openAccessengreponame:Repositório Institucional da UnBinstname:Universidade de Brasília (UnB)instacron:UNBORIGINAL5605.pdfapplication/pdf627880http://repositorio2.unb.br/jspui/bitstream/10482/26374/1/5605.pdf3383046a149535b16f10bf0e4354bebbMD51open access10482/263742023-10-11 14:27:48.818open accessoai:repositorio2.unb.br:10482/26374Biblioteca Digital de Teses e DissertaçõesPUBhttps://repositorio.unb.br/oai/requestopendoar:2023-10-11T17:27:48Repositório Institucional da UnB - Universidade de Brasília (UnB)false |
dc.title.pt_BR.fl_str_mv |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia |
title |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia |
spellingShingle |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia Veras, V.S. Human papillomavirus HPV-58 L1 gene Variants |
title_short |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia |
title_full |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia |
title_fullStr |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia |
title_full_unstemmed |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia |
title_sort |
L1 sequence of a new human papillomavirus type-58 variant associated with cervical intraepithelial neoplasia |
author |
Veras, V.S. |
author_facet |
Veras, V.S. Cerqueira, D.M. Martins, C.R.F. |
author_role |
author |
author2 |
Cerqueira, D.M. Martins, C.R.F. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Veras, V.S. Cerqueira, D.M. Martins, C.R.F. |
dc.subject.keyword.pt_BR.fl_str_mv |
Human papillomavirus HPV-58 L1 gene Variants |
topic |
Human papillomavirus HPV-58 L1 gene Variants |
description |
The present study on molecular characterization of a human papillomavirus (HPV) isolated in Central Brazil describes the L1 gene sequence from a new variant of HPV-58, the isolate Bsb-02. The sample was from a smear obtained from a woman with cervical intraepithelial neoplasia grade II. The whole L1 gene from isolate Bsb-02 was sequenced automatically, showing 99.1% nucleotide identity with the gene from the HPV-58 reference. The clustering between Bsb-02 and HPV-58 reference sequence was also supported by phylogenetic analysis. Fourteen nucleotide substitutions were observed: eight were synonymous and six were associated with amino acid substitutions. A10V and V144I have not been previously described. At GenBank, the only complete L1 sequence from HPV-58 in addition to the HPV-58 reference one is that of Bsb-02. These data provide information that may be relevant to HPV diagnosis and to rational vaccine strategies. HPV variants may also be associated with host immune responses and with the risk of cervical neoplasia. |
publishDate |
2005 |
dc.date.issued.fl_str_mv |
2005 |
dc.date.accessioned.fl_str_mv |
2017-12-07T04:42:13Z |
dc.date.available.fl_str_mv |
2017-12-07T04:42:13Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Braz J Med Biol Res,v.38,n.1,p.1-4,2005 |
dc.identifier.uri.fl_str_mv |
http://repositorio.unb.br/handle/10482/26374 |
dc.identifier.doi.pt_BR.fl_str_mv |
https://dx.doi.org/10.1590/S0100-879X2005000100001 |
identifier_str_mv |
Braz J Med Biol Res,v.38,n.1,p.1-4,2005 |
url |
http://repositorio.unb.br/handle/10482/26374 https://dx.doi.org/10.1590/S0100-879X2005000100001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UnB instname:Universidade de Brasília (UnB) instacron:UNB |
instname_str |
Universidade de Brasília (UnB) |
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UNB |
institution |
UNB |
reponame_str |
Repositório Institucional da UnB |
collection |
Repositório Institucional da UnB |
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http://repositorio2.unb.br/jspui/bitstream/10482/26374/1/5605.pdf |
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3383046a149535b16f10bf0e4354bebb |
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Repositório Institucional da UnB - Universidade de Brasília (UnB) |
repository.mail.fl_str_mv |
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1797405284632625152 |