Effects of co-administration of lithium and celecoxib on inflammatory parameters in an animal model of mania induced by amphetamine
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2018 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Dissertação |
| Idioma: | por |
| Título da fonte: | Repositório Institucional da UNESC |
| Texto Completo: | http://repositorio.unesc.net/handle/1/6753 |
Resumo: | Artigo apresentado como requisito parcial para obtenção do grau de Bacharel, no Curso de Medicina, da Universidade do Extremo Sul Catarinense- UNESC. |
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Dal Pont, Gustavo ColomboTonin, Paula TeresinhaVarela, Roger BitencourtFerreira, Camila L.Gava, Fernanda FredericoAndersen, Mônica L.Soares, Jair C.Quevedo, João Luciano deValvassori, Samira da SilvaUniversidade do Extremo Sul Catarinense2019-04-10T13:23:48Z2019-04-10T13:23:48Z2018-12http://repositorio.unesc.net/handle/1/6753Artigo apresentado como requisito parcial para obtenção do grau de Bacharel, no Curso de Medicina, da Universidade do Extremo Sul Catarinense- UNESC.It is observed alterations in levels of inflammatory mediatorsin Bipolar Disorder (BD) patients.Celecoxib (Cel) is an anti-inflammatory drug and can reduce levels of pro-inflammatory cytokines. The present study aimed to evaluate the effects of co-administration of lithium(Li) and Cel on inflammatory parameters in an animal model of mania induced by amphetamine. Were used Wistar rats, 60 days old (250–350g). The animals (n=10 per group) received D-amph (2mg/kg) or Sal intraperitoneally once a day, during 14 days. From the day 8–14, the animals from D-amph and Sal groups received via gavage Li (24 mg/kg), Cel (20 mg/kg), Li + Cel or water. The behavioral analyses were evaluated through Open Field test. Furthermore, were evaluated the levels of IL-1β, IL-4, IL-10, and TNF-α. The administration of D-amph induced hyperactivity in the rats and treatment with Li plus Cel reversed these alterations. The administration of D-amph increased the IL-4, IL-10, and TNF-α levels in the serum, frontal cortex, and striatum of rats, and treatment with Li plus Cel reversed these alterations in all tissue evaluated. The treatment with Li plus Celshowed very effective against inflammation induced by D-amph. However, more studies are necessaries to elucidate these mechanisms.Lítio – Uso terapêuticoCelecoxib – Uso terapêuticoTranstono bipolarPsicose maníaco-depressivaManiaEffects of co-administration of lithium and celecoxib on inflammatory parameters in an animal model of mania induced by amphetamineinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisporreponame:Repositório Institucional da UNESCinstname:Universidade do Extremo Sul Catarinense (Unesc)instacron:UNESCinfo:eu-repo/semantics/openAccessORIGINALInformação do texto competo - Medicina.pdfInformação do texto competo - Medicina.pdfTCCapplication/pdf4584http://repositorio.unesc.net/bitstream/1/6753/1/Informa%c3%a7%c3%a3o%20do%20texto%20competo%20-%20Medicina.pdf1c6e9dc40d415f218ecfb092b602798eMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81748http://repositorio.unesc.net/bitstream/1/6753/2/license.txt8a4605be74aa9ea9d79846c1fba20a33MD521/67532019-11-14 17:57:55.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Repositório de Publicaçõeshttp://repositorio.unesc.net/ |
| dc.title.pt_BR.fl_str_mv |
Effects of co-administration of lithium and celecoxib on inflammatory parameters in an animal model of mania induced by amphetamine |
| title |
Effects of co-administration of lithium and celecoxib on inflammatory parameters in an animal model of mania induced by amphetamine |
| spellingShingle |
Effects of co-administration of lithium and celecoxib on inflammatory parameters in an animal model of mania induced by amphetamine Dal Pont, Gustavo Colombo Lítio – Uso terapêutico Celecoxib – Uso terapêutico Transtono bipolar Psicose maníaco-depressiva Mania |
| title_short |
Effects of co-administration of lithium and celecoxib on inflammatory parameters in an animal model of mania induced by amphetamine |
| title_full |
Effects of co-administration of lithium and celecoxib on inflammatory parameters in an animal model of mania induced by amphetamine |
| title_fullStr |
Effects of co-administration of lithium and celecoxib on inflammatory parameters in an animal model of mania induced by amphetamine |
| title_full_unstemmed |
Effects of co-administration of lithium and celecoxib on inflammatory parameters in an animal model of mania induced by amphetamine |
| title_sort |
Effects of co-administration of lithium and celecoxib on inflammatory parameters in an animal model of mania induced by amphetamine |
| author |
Dal Pont, Gustavo Colombo |
| author_facet |
Dal Pont, Gustavo Colombo Tonin, Paula Teresinha Varela, Roger Bitencourt Ferreira, Camila L. Gava, Fernanda Frederico Andersen, Mônica L. Soares, Jair C. |
| author_role |
author |
| author2 |
Tonin, Paula Teresinha Varela, Roger Bitencourt Ferreira, Camila L. Gava, Fernanda Frederico Andersen, Mônica L. Soares, Jair C. |
| author2_role |
author author author author author author |
| dc.contributor.other.none.fl_str_mv |
Quevedo, João Luciano de |
| dc.contributor.author.fl_str_mv |
Dal Pont, Gustavo Colombo Tonin, Paula Teresinha Varela, Roger Bitencourt Ferreira, Camila L. Gava, Fernanda Frederico Andersen, Mônica L. Soares, Jair C. |
| dc.contributor.advisor1.fl_str_mv |
Valvassori, Samira da Silva |
| contributor_str_mv |
Valvassori, Samira da Silva |
| dc.subject.por.fl_str_mv |
Lítio – Uso terapêutico Celecoxib – Uso terapêutico Transtono bipolar Psicose maníaco-depressiva Mania |
| topic |
Lítio – Uso terapêutico Celecoxib – Uso terapêutico Transtono bipolar Psicose maníaco-depressiva Mania |
| dc.description.pt_BR.fl_txt_mv |
Artigo apresentado como requisito parcial para obtenção do grau de Bacharel, no Curso de Medicina, da Universidade do Extremo Sul Catarinense- UNESC. |
| dc.description.abstract.por.fl_txt_mv |
It is observed alterations in levels of inflammatory mediatorsin Bipolar Disorder (BD) patients.Celecoxib (Cel) is an anti-inflammatory drug and can reduce levels of pro-inflammatory cytokines. The present study aimed to evaluate the effects of co-administration of lithium(Li) and Cel on inflammatory parameters in an animal model of mania induced by amphetamine. Were used Wistar rats, 60 days old (250–350g). The animals (n=10 per group) received D-amph (2mg/kg) or Sal intraperitoneally once a day, during 14 days. From the day 8–14, the animals from D-amph and Sal groups received via gavage Li (24 mg/kg), Cel (20 mg/kg), Li + Cel or water. The behavioral analyses were evaluated through Open Field test. Furthermore, were evaluated the levels of IL-1β, IL-4, IL-10, and TNF-α. The administration of D-amph induced hyperactivity in the rats and treatment with Li plus Cel reversed these alterations. The administration of D-amph increased the IL-4, IL-10, and TNF-α levels in the serum, frontal cortex, and striatum of rats, and treatment with Li plus Cel reversed these alterations in all tissue evaluated. The treatment with Li plus Celshowed very effective against inflammation induced by D-amph. However, more studies are necessaries to elucidate these mechanisms. |
| description |
Artigo apresentado como requisito parcial para obtenção do grau de Bacharel, no Curso de Medicina, da Universidade do Extremo Sul Catarinense- UNESC. |
| publishDate |
2018 |
| dc.date.created.fl_str_mv |
2018-12 |
| dc.date.accessioned.fl_str_mv |
2019-04-10T13:23:48Z |
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2019-04-10T13:23:48Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/masterThesis |
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publishedVersion |
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masterThesis |
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http://repositorio.unesc.net/handle/1/6753 |
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http://repositorio.unesc.net/handle/1/6753 |
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por |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Universidade do Extremo Sul Catarinense |
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