Persistent SARS-CoV-2 antigen presence in multiple organs of a naturally infected cat from Brazil

• Autor(a) principal: Jarrah,Samar Afif
• Data de Publicação: 2022
• Outros Autores: Kmetiuk,Louise Bach, Carvalho,Otávio Valério de, Sousa,Alessandra Tammy Hayakawa Ito de, Souza,Valeria Regia Franco, Nakazato,Luciano, Colodel,Edson Moleta, Santos,Andrea Pires dos, Pettan-Brewer,Christina, Hahn,Rosane Christine, Slhessarenko,Renata Dezengrini, Ubiali,Daniel Guimarães, Pereira,Asheley Henrique Barbosa, Morais,Helio Autran de, Biondo,Alexander Welker, Dutra,Valéria
• Tipo de documento: Relatório
• Idioma: eng
• Título da fonte: The Journal of venomous animals and toxins including tropical diseases (Online)
• Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992022000100401
• topic: Coronavirus; SARS-CoV-2; Pets; Cats; Disease transmission

Abstract Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the etiological agent of the disease coronavirus 2019 (COVID-19) in humans. SARS-CoV-2 has been identified in cats with or without clinical signs. Case presentation: We describe the pathological and molecular findings in a six-month-old asymptomatic cat with SARS-CoV-2 infection from Brazil, belonging to a human family with COVID-19 cases. The pool of nasopharynx and oropharynx swabs at day zero tested positive by RT-qPCR for SARS-CoV-2. No amplification resulted from molecular testing performed on days 7 and 14. The cat was hit by a car and died 43 days after the molecular diagnosis. Immunohistochemistry at post-mortem examination demonstrated nucleocapsid protein in samples from the lungs, kidneys, nasal conchae, trachea, intestine, brain and spleen. Conclusion: The present study has highlighted the possibility that viral antigens can be detected by immunohistochemistry in multiple organs six weeks after infection, although the same tissues tested negative by RT-PCR.