Protein-species quantitative venomics: looking through a crystal ball
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | The Journal of venomous animals and toxins including tropical diseases (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100205 |
Resumo: | Abstract In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level of the protein species present in the venom, and the absolute quantification of the venom proteins (the term “protein species” is used here to refer to all the different molecular forms in which a protein can be found. Please consult the special issue of Jornal of Proteomics “Towards deciphering proteomes via the proteoform, protein speciation, moonlighting and protein code concepts” published in 2016, vol. 134, pages 1-202). Challenges remain to be solved in order to achieve a compact and automated platform with which to routinely carry out comprehensive quantitative analysis of all toxins present in a venom. This short essay reflects the authors’ view of the immediate future in this direction for the proteomic analysis of venoms, particularly of snakes. |
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The Journal of venomous animals and toxins including tropical diseases (Online) |
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Protein-species quantitative venomics: looking through a crystal ballSnake venomicsTop-down proteomicsTop-down venomicsProtein species-resolved venomicsAbsolute quantificationInductively coupled plasma mass spectrometryAbstract In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level of the protein species present in the venom, and the absolute quantification of the venom proteins (the term “protein species” is used here to refer to all the different molecular forms in which a protein can be found. Please consult the special issue of Jornal of Proteomics “Towards deciphering proteomes via the proteoform, protein speciation, moonlighting and protein code concepts” published in 2016, vol. 134, pages 1-202). Challenges remain to be solved in order to achieve a compact and automated platform with which to routinely carry out comprehensive quantitative analysis of all toxins present in a venom. This short essay reflects the authors’ view of the immediate future in this direction for the proteomic analysis of venoms, particularly of snakes.Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)2017-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100205Journal of Venomous Animals and Toxins including Tropical Diseases v.23 2017reponame:The Journal of venomous animals and toxins including tropical diseases (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1186/s40409-017-0116-9info:eu-repo/semantics/openAccessCalvete,Juan J.Petras,DanielCalderón-Celis,FranciscoLomonte,BrunoEncinar,Jorge RuizSanz-Medel,Alfredoeng2017-07-03T00:00:00Zoai:scielo:S1678-91992017000100205Revistahttp://www.scielo.br/jvatitdPUBhttps://old.scielo.br/oai/scielo-oai.php||editorial@jvat.org.br1678-91991678-9180opendoar:2017-07-03T00:00The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Protein-species quantitative venomics: looking through a crystal ball |
title |
Protein-species quantitative venomics: looking through a crystal ball |
spellingShingle |
Protein-species quantitative venomics: looking through a crystal ball Calvete,Juan J. Snake venomics Top-down proteomics Top-down venomics Protein species-resolved venomics Absolute quantification Inductively coupled plasma mass spectrometry |
title_short |
Protein-species quantitative venomics: looking through a crystal ball |
title_full |
Protein-species quantitative venomics: looking through a crystal ball |
title_fullStr |
Protein-species quantitative venomics: looking through a crystal ball |
title_full_unstemmed |
Protein-species quantitative venomics: looking through a crystal ball |
title_sort |
Protein-species quantitative venomics: looking through a crystal ball |
author |
Calvete,Juan J. |
author_facet |
Calvete,Juan J. Petras,Daniel Calderón-Celis,Francisco Lomonte,Bruno Encinar,Jorge Ruiz Sanz-Medel,Alfredo |
author_role |
author |
author2 |
Petras,Daniel Calderón-Celis,Francisco Lomonte,Bruno Encinar,Jorge Ruiz Sanz-Medel,Alfredo |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Calvete,Juan J. Petras,Daniel Calderón-Celis,Francisco Lomonte,Bruno Encinar,Jorge Ruiz Sanz-Medel,Alfredo |
dc.subject.por.fl_str_mv |
Snake venomics Top-down proteomics Top-down venomics Protein species-resolved venomics Absolute quantification Inductively coupled plasma mass spectrometry |
topic |
Snake venomics Top-down proteomics Top-down venomics Protein species-resolved venomics Absolute quantification Inductively coupled plasma mass spectrometry |
description |
Abstract In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level of the protein species present in the venom, and the absolute quantification of the venom proteins (the term “protein species” is used here to refer to all the different molecular forms in which a protein can be found. Please consult the special issue of Jornal of Proteomics “Towards deciphering proteomes via the proteoform, protein speciation, moonlighting and protein code concepts” published in 2016, vol. 134, pages 1-202). Challenges remain to be solved in order to achieve a compact and automated platform with which to routinely carry out comprehensive quantitative analysis of all toxins present in a venom. This short essay reflects the authors’ view of the immediate future in this direction for the proteomic analysis of venoms, particularly of snakes. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100205 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992017000100205 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1186/s40409-017-0116-9 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
publisher.none.fl_str_mv |
Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) |
dc.source.none.fl_str_mv |
Journal of Venomous Animals and Toxins including Tropical Diseases v.23 2017 reponame:The Journal of venomous animals and toxins including tropical diseases (Online) instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
The Journal of venomous animals and toxins including tropical diseases (Online) |
collection |
The Journal of venomous animals and toxins including tropical diseases (Online) |
repository.name.fl_str_mv |
The Journal of venomous animals and toxins including tropical diseases (Online) - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
||editorial@jvat.org.br |
_version_ |
1748958540101320704 |