Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Motriz (Online) |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-65742022000100607 |
Resumo: | Abstract Aim: We investigated the effects of continuous or interval aerobic exercise training on vascular reactivity of female rats fed with fructose. Methods: Female Wistar rats (8-wk old) were divided into: sedentary (SD), continuous training (CTR), and interval training (ITR). Moderate intensity training protocols consisted of running 3 days/week for 7 weeks. CTR ran 40 min at 30%–40% of the maximal speed (MS) and TRI consisted of 7 sets of 1 min at 70% of MS followed by 3 min at 35% of MS. Animals were fed with standard chow and fructose (10%) in drinking water. Concentration-response curves to acetylcholine and phenylephrine, and oxidative stress biomarkers, were determined in the aorta. Body weight gain, visceral fat, and plasma triglycerides and glucose were also evaluated. Results: Endothelium-dependent relaxation was significantly increased by both exercise regimens (CTR: Emax = 85 ± 6% and ITR: Emax = 84 ± 1%) compared to sedentary rats (SD: Emax = 62 ± 5%). The contractile maximal response was not different but phenylephrine potency was increased in CTR (pEC50: 8.41 ± 0.19) and reduced in ITR (pEC50: 7.06 ± 0.11) compared to SD (pEC50: 7.77 ± 0.08). In addition, the generation of superoxide was lower in trained groups as compared with sedentary (about −28% in CTR and −22% in ITR). TBARS and nitrate/nitrite levels were not modified. Compared to the SD group, ITR gained 39% less body weight and CTR has 29% less visceral fat. Glucose and triglycerides were not modified. Conclusion: CTR and ITR, carried out 3 days/week, were efficient to improve endothelium-dependent relaxation and reduce superoxide generation in the aorta from female rats fed with fructose. |
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Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructoseinterval exercisefructosevascular reactivityendotheliumoxidative stressAbstract Aim: We investigated the effects of continuous or interval aerobic exercise training on vascular reactivity of female rats fed with fructose. Methods: Female Wistar rats (8-wk old) were divided into: sedentary (SD), continuous training (CTR), and interval training (ITR). Moderate intensity training protocols consisted of running 3 days/week for 7 weeks. CTR ran 40 min at 30%–40% of the maximal speed (MS) and TRI consisted of 7 sets of 1 min at 70% of MS followed by 3 min at 35% of MS. Animals were fed with standard chow and fructose (10%) in drinking water. Concentration-response curves to acetylcholine and phenylephrine, and oxidative stress biomarkers, were determined in the aorta. Body weight gain, visceral fat, and plasma triglycerides and glucose were also evaluated. Results: Endothelium-dependent relaxation was significantly increased by both exercise regimens (CTR: Emax = 85 ± 6% and ITR: Emax = 84 ± 1%) compared to sedentary rats (SD: Emax = 62 ± 5%). The contractile maximal response was not different but phenylephrine potency was increased in CTR (pEC50: 8.41 ± 0.19) and reduced in ITR (pEC50: 7.06 ± 0.11) compared to SD (pEC50: 7.77 ± 0.08). In addition, the generation of superoxide was lower in trained groups as compared with sedentary (about −28% in CTR and −22% in ITR). TBARS and nitrate/nitrite levels were not modified. Compared to the SD group, ITR gained 39% less body weight and CTR has 29% less visceral fat. Glucose and triglycerides were not modified. Conclusion: CTR and ITR, carried out 3 days/week, were efficient to improve endothelium-dependent relaxation and reduce superoxide generation in the aorta from female rats fed with fructose.Universidade Estadual Paulista2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-65742022000100607Motriz: Revista de Educação Física v.28 2022reponame:Motriz (Online)instname:Universidade Estadual Paulista (UNESP)instacron:UNESP10.1590/s1980-657420220005522info:eu-repo/semantics/openAccessJoaquim,Anderson GregorioOharomari,Leandro KansukeVale,Gabriel Tavares doTirapelli,Carlos RenatoMoraes,Camila deeng2022-09-05T00:00:00Zoai:scielo:S1980-65742022000100607Revistahttp://www.periodicos.rc.biblioteca.unesp.br/index.php/motrizPUBhttps://old.scielo.br/oai/scielo-oai.phpmotriz@rc.unesp.br||mauerber@rc.unesp.br||azanesco@rc.unesp.br1980-65741415-9805opendoar:2022-11-08T16:30:55.083148Motriz (Online) - Universidade Estadual Paulista (UNESP)true |
dc.title.none.fl_str_mv |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose |
title |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose |
spellingShingle |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose Joaquim,Anderson Gregorio interval exercise fructose vascular reactivity endothelium oxidative stress |
title_short |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose |
title_full |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose |
title_fullStr |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose |
title_full_unstemmed |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose |
title_sort |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose |
author |
Joaquim,Anderson Gregorio |
author_facet |
Joaquim,Anderson Gregorio Oharomari,Leandro Kansuke Vale,Gabriel Tavares do Tirapelli,Carlos Renato Moraes,Camila de |
author_role |
author |
author2 |
Oharomari,Leandro Kansuke Vale,Gabriel Tavares do Tirapelli,Carlos Renato Moraes,Camila de |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Joaquim,Anderson Gregorio Oharomari,Leandro Kansuke Vale,Gabriel Tavares do Tirapelli,Carlos Renato Moraes,Camila de |
dc.subject.por.fl_str_mv |
interval exercise fructose vascular reactivity endothelium oxidative stress |
topic |
interval exercise fructose vascular reactivity endothelium oxidative stress |
description |
Abstract Aim: We investigated the effects of continuous or interval aerobic exercise training on vascular reactivity of female rats fed with fructose. Methods: Female Wistar rats (8-wk old) were divided into: sedentary (SD), continuous training (CTR), and interval training (ITR). Moderate intensity training protocols consisted of running 3 days/week for 7 weeks. CTR ran 40 min at 30%–40% of the maximal speed (MS) and TRI consisted of 7 sets of 1 min at 70% of MS followed by 3 min at 35% of MS. Animals were fed with standard chow and fructose (10%) in drinking water. Concentration-response curves to acetylcholine and phenylephrine, and oxidative stress biomarkers, were determined in the aorta. Body weight gain, visceral fat, and plasma triglycerides and glucose were also evaluated. Results: Endothelium-dependent relaxation was significantly increased by both exercise regimens (CTR: Emax = 85 ± 6% and ITR: Emax = 84 ± 1%) compared to sedentary rats (SD: Emax = 62 ± 5%). The contractile maximal response was not different but phenylephrine potency was increased in CTR (pEC50: 8.41 ± 0.19) and reduced in ITR (pEC50: 7.06 ± 0.11) compared to SD (pEC50: 7.77 ± 0.08). In addition, the generation of superoxide was lower in trained groups as compared with sedentary (about −28% in CTR and −22% in ITR). TBARS and nitrate/nitrite levels were not modified. Compared to the SD group, ITR gained 39% less body weight and CTR has 29% less visceral fat. Glucose and triglycerides were not modified. Conclusion: CTR and ITR, carried out 3 days/week, were efficient to improve endothelium-dependent relaxation and reduce superoxide generation in the aorta from female rats fed with fructose. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-65742022000100607 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-65742022000100607 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/s1980-657420220005522 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Universidade Estadual Paulista |
publisher.none.fl_str_mv |
Universidade Estadual Paulista |
dc.source.none.fl_str_mv |
Motriz: Revista de Educação Física v.28 2022 reponame:Motriz (Online) instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Motriz (Online) |
collection |
Motriz (Online) |
repository.name.fl_str_mv |
Motriz (Online) - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
motriz@rc.unesp.br||mauerber@rc.unesp.br||azanesco@rc.unesp.br |
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1788170937271582720 |