Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1590/s1980-65742022000552 http://hdl.handle.net/11449/247906 |
Resumo: | Aim: We investigated the effects of continuous or interval aerobic exercise training on vascular reactivity of female rats fed with fructose. Methods: Female Wistar rats (8-wk old) were divided into: sedentary (SD), continuous training (CTR), and interval training (ITR). Moderate intensity training protocols consisted of running 3 days/week for 7 weeks. CTR ran 40 min at 30%-40% of the maximal speed (MS) and TRI consisted of 7 sets of 1 min at 70% of MS followed by 3 min at 35% of MS. Animals were fed with standard chow and fructose (10%) in drinking water. Concentration-response curves to acetylcholine and phenylephrine, and oxidative stress biomarkers, were determined in the aorta. Body weight gain, visceral fat, and plasma triglycerides and glucose were also evaluated. Results: Endothelium-dependent relaxation was significantly increased by both exercise regimens (CTR: Emax = 85 ± 6% and ITR: Emax = 84 ± 1%) compared to sedentary rats (SD: Emax = 62 ± 5%). The contractile maximal response was not different but phenylephrine potency was increased in CTR (pEC50: 8.41 ± 0.19) and reduced in ITR (pEC50: 7.06 ± 0.11) compared to SD (pEC50: 7.77 ± 0.08). In addition, the generation of superoxide was lower in trained groups as compared with sedentary (about -28% in CTR and -22% in ITR). TBARS and nitrate/nitrite levels were not modified. Compared to the SD group, ITR gained 39% less body weight and CTR has 29% less visceral fat. Glucose and triglycerides were not modified. Conclusion: CTR and ITR, carried out 3 days/week, were efficient to improve endothelium-dependent relaxation and reduce superoxide generation in the aorta from female rats fed with fructose. |
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Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructoseendotheliumfructoseinterval exerciseoxidative stressvascular reactivityAim: We investigated the effects of continuous or interval aerobic exercise training on vascular reactivity of female rats fed with fructose. Methods: Female Wistar rats (8-wk old) were divided into: sedentary (SD), continuous training (CTR), and interval training (ITR). Moderate intensity training protocols consisted of running 3 days/week for 7 weeks. CTR ran 40 min at 30%-40% of the maximal speed (MS) and TRI consisted of 7 sets of 1 min at 70% of MS followed by 3 min at 35% of MS. Animals were fed with standard chow and fructose (10%) in drinking water. Concentration-response curves to acetylcholine and phenylephrine, and oxidative stress biomarkers, were determined in the aorta. Body weight gain, visceral fat, and plasma triglycerides and glucose were also evaluated. Results: Endothelium-dependent relaxation was significantly increased by both exercise regimens (CTR: Emax = 85 ± 6% and ITR: Emax = 84 ± 1%) compared to sedentary rats (SD: Emax = 62 ± 5%). The contractile maximal response was not different but phenylephrine potency was increased in CTR (pEC50: 8.41 ± 0.19) and reduced in ITR (pEC50: 7.06 ± 0.11) compared to SD (pEC50: 7.77 ± 0.08). In addition, the generation of superoxide was lower in trained groups as compared with sedentary (about -28% in CTR and -22% in ITR). TBARS and nitrate/nitrite levels were not modified. Compared to the SD group, ITR gained 39% less body weight and CTR has 29% less visceral fat. Glucose and triglycerides were not modified. Conclusion: CTR and ITR, carried out 3 days/week, were efficient to improve endothelium-dependent relaxation and reduce superoxide generation in the aorta from female rats fed with fructose.Universidade de São Paulo Escola de Educação Física e Esporte de Ribeirão Preto, SPUniversidade Estadual Paulista Júlio de Mesquita Filho Escola de Ciências Farmacêuticas de Araraquara Departamento de Alimentos e Nutrição, SPEscola de Enfermagem de Ribeirão Preto Departamento de Enfermagem Psiquiátrica e Ciências Humanas Laboratório de Farmacologia, SPUniversidade Estadual Paulista Júlio de Mesquita Filho Escola de Ciências Farmacêuticas de Araraquara Departamento de Alimentos e Nutrição, SPUniversidade de São Paulo (USP)Universidade Estadual Paulista (UNESP)Laboratório de FarmacologiaJoaquim, Anderson GregorioOharomari, Leandro Kansuke [UNESP]do Vale, Gabriel TavaresTirapelli, Carlos Renatode Moraes, Camila2023-07-29T13:29:10Z2023-07-29T13:29:10Z2022-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.1590/s1980-65742022000552Motriz. Revista de Educacao Fisica, v. 28.1980-65741415-9805http://hdl.handle.net/11449/24790610.1590/s1980-657420220005522-s2.0-85142185092Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengMotriz. Revista de Educacao Fisicainfo:eu-repo/semantics/openAccess2023-07-29T13:29:10Zoai:repositorio.unesp.br:11449/247906Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-07-29T13:29:10Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose |
title |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose |
spellingShingle |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose Joaquim, Anderson Gregorio endothelium fructose interval exercise oxidative stress vascular reactivity |
title_short |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose |
title_full |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose |
title_fullStr |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose |
title_full_unstemmed |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose |
title_sort |
Interval or continuous aerobic exercise performed 3 days a week increases endothelium-dependent relaxation in female rats fed with fructose |
author |
Joaquim, Anderson Gregorio |
author_facet |
Joaquim, Anderson Gregorio Oharomari, Leandro Kansuke [UNESP] do Vale, Gabriel Tavares Tirapelli, Carlos Renato de Moraes, Camila |
author_role |
author |
author2 |
Oharomari, Leandro Kansuke [UNESP] do Vale, Gabriel Tavares Tirapelli, Carlos Renato de Moraes, Camila |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (UNESP) Laboratório de Farmacologia |
dc.contributor.author.fl_str_mv |
Joaquim, Anderson Gregorio Oharomari, Leandro Kansuke [UNESP] do Vale, Gabriel Tavares Tirapelli, Carlos Renato de Moraes, Camila |
dc.subject.por.fl_str_mv |
endothelium fructose interval exercise oxidative stress vascular reactivity |
topic |
endothelium fructose interval exercise oxidative stress vascular reactivity |
description |
Aim: We investigated the effects of continuous or interval aerobic exercise training on vascular reactivity of female rats fed with fructose. Methods: Female Wistar rats (8-wk old) were divided into: sedentary (SD), continuous training (CTR), and interval training (ITR). Moderate intensity training protocols consisted of running 3 days/week for 7 weeks. CTR ran 40 min at 30%-40% of the maximal speed (MS) and TRI consisted of 7 sets of 1 min at 70% of MS followed by 3 min at 35% of MS. Animals were fed with standard chow and fructose (10%) in drinking water. Concentration-response curves to acetylcholine and phenylephrine, and oxidative stress biomarkers, were determined in the aorta. Body weight gain, visceral fat, and plasma triglycerides and glucose were also evaluated. Results: Endothelium-dependent relaxation was significantly increased by both exercise regimens (CTR: Emax = 85 ± 6% and ITR: Emax = 84 ± 1%) compared to sedentary rats (SD: Emax = 62 ± 5%). The contractile maximal response was not different but phenylephrine potency was increased in CTR (pEC50: 8.41 ± 0.19) and reduced in ITR (pEC50: 7.06 ± 0.11) compared to SD (pEC50: 7.77 ± 0.08). In addition, the generation of superoxide was lower in trained groups as compared with sedentary (about -28% in CTR and -22% in ITR). TBARS and nitrate/nitrite levels were not modified. Compared to the SD group, ITR gained 39% less body weight and CTR has 29% less visceral fat. Glucose and triglycerides were not modified. Conclusion: CTR and ITR, carried out 3 days/week, were efficient to improve endothelium-dependent relaxation and reduce superoxide generation in the aorta from female rats fed with fructose. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-01 2023-07-29T13:29:10Z 2023-07-29T13:29:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/s1980-65742022000552 Motriz. Revista de Educacao Fisica, v. 28. 1980-6574 1415-9805 http://hdl.handle.net/11449/247906 10.1590/s1980-65742022000552 2-s2.0-85142185092 |
url |
http://dx.doi.org/10.1590/s1980-65742022000552 http://hdl.handle.net/11449/247906 |
identifier_str_mv |
Motriz. Revista de Educacao Fisica, v. 28. 1980-6574 1415-9805 10.1590/s1980-65742022000552 2-s2.0-85142185092 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Motriz. Revista de Educacao Fisica |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965702277300224 |