Thermodynamic quantities of solvation and dilution for some acetanilide derivatives in octanol and water mutually saturateds
Main Author: | |
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Publication Date: | 2008 |
Other Authors: | , |
Format: | Article |
Language: | eng |
Source: | Eclética Química |
Download full: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702008000400004 |
Summary: | Based on published thermodynamic quantities for solution, partitioning and sublimation of acetanilide (ACN), acetaminophen (ACP) and Phenacetin (PNC), the thermodynamic quantities for drugs solvation in octanol-saturated water (W(ROH)) and water-saturated octanol (ROH(W)) as well as the drugs dilution in ROH(W) were calculated. The Gibbs energies of solvation were favourable in all cases. The respective enthalpies and entropies were negative indicating an enthalpy-driving for the solvation process in all cases. On the other hand, the Gibbs energies of dilution were favourable for ACP and PNC but unfavourable for ACN, whereas the respective enthalpies and entropies were negative for ACP and PNC but positive for ACN indicating enthalpy-driving for the dilution process in the case of the former drugs and entropy-driving for the latter. From the obtained values for the transfer processes, an interpretation based on solute-solvent interactions was developed. |
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Thermodynamic quantities of solvation and dilution for some acetanilide derivatives in octanol and water mutually saturatedsAcetanilide derivativessolvationpartition coefficientoctanolsolution thermodynamicsBased on published thermodynamic quantities for solution, partitioning and sublimation of acetanilide (ACN), acetaminophen (ACP) and Phenacetin (PNC), the thermodynamic quantities for drugs solvation in octanol-saturated water (W(ROH)) and water-saturated octanol (ROH(W)) as well as the drugs dilution in ROH(W) were calculated. The Gibbs energies of solvation were favourable in all cases. The respective enthalpies and entropies were negative indicating an enthalpy-driving for the solvation process in all cases. On the other hand, the Gibbs energies of dilution were favourable for ACP and PNC but unfavourable for ACN, whereas the respective enthalpies and entropies were negative for ACP and PNC but positive for ACN indicating enthalpy-driving for the dilution process in the case of the former drugs and entropy-driving for the latter. From the obtained values for the transfer processes, an interpretation based on solute-solvent interactions was developed.Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP2008-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702008000400004Eclética Química v.33 n.4 2008reponame:Eclética Químicainstname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)instacron:UNESP10.1590/S0100-46702008000400004info:eu-repo/semantics/openAccessBaena,Y.Barbosa,H.Martínez,F.eng2009-01-12T00:00:00Zoai:scielo:S0100-46702008000400004Revistahttp://revista.iq.unesp.br/ojs/index.php/ecletica/PUBhttps://revista.iq.unesp.br/ojs/index.php/ecletica/oaiecletica@ctrlk.com.br||ecletica@iq.unesp.br1678-46181678-4618opendoar:2009-01-12T00:00Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP)false |
dc.title.none.fl_str_mv |
Thermodynamic quantities of solvation and dilution for some acetanilide derivatives in octanol and water mutually saturateds |
title |
Thermodynamic quantities of solvation and dilution for some acetanilide derivatives in octanol and water mutually saturateds |
spellingShingle |
Thermodynamic quantities of solvation and dilution for some acetanilide derivatives in octanol and water mutually saturateds Baena,Y. Acetanilide derivatives solvation partition coefficient octanol solution thermodynamics |
title_short |
Thermodynamic quantities of solvation and dilution for some acetanilide derivatives in octanol and water mutually saturateds |
title_full |
Thermodynamic quantities of solvation and dilution for some acetanilide derivatives in octanol and water mutually saturateds |
title_fullStr |
Thermodynamic quantities of solvation and dilution for some acetanilide derivatives in octanol and water mutually saturateds |
title_full_unstemmed |
Thermodynamic quantities of solvation and dilution for some acetanilide derivatives in octanol and water mutually saturateds |
title_sort |
Thermodynamic quantities of solvation and dilution for some acetanilide derivatives in octanol and water mutually saturateds |
author |
Baena,Y. |
author_facet |
Baena,Y. Barbosa,H. Martínez,F. |
author_role |
author |
author2 |
Barbosa,H. Martínez,F. |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Baena,Y. Barbosa,H. Martínez,F. |
dc.subject.por.fl_str_mv |
Acetanilide derivatives solvation partition coefficient octanol solution thermodynamics |
topic |
Acetanilide derivatives solvation partition coefficient octanol solution thermodynamics |
description |
Based on published thermodynamic quantities for solution, partitioning and sublimation of acetanilide (ACN), acetaminophen (ACP) and Phenacetin (PNC), the thermodynamic quantities for drugs solvation in octanol-saturated water (W(ROH)) and water-saturated octanol (ROH(W)) as well as the drugs dilution in ROH(W) were calculated. The Gibbs energies of solvation were favourable in all cases. The respective enthalpies and entropies were negative indicating an enthalpy-driving for the solvation process in all cases. On the other hand, the Gibbs energies of dilution were favourable for ACP and PNC but unfavourable for ACN, whereas the respective enthalpies and entropies were negative for ACP and PNC but positive for ACN indicating enthalpy-driving for the dilution process in the case of the former drugs and entropy-driving for the latter. From the obtained values for the transfer processes, an interpretation based on solute-solvent interactions was developed. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-12-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702008000400004 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0100-46702008000400004 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0100-46702008000400004 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP |
publisher.none.fl_str_mv |
Fundação Editora da Universidade Estadual Paulista Júlio de Mesquita Filho - UNESP |
dc.source.none.fl_str_mv |
Eclética Química v.33 n.4 2008 reponame:Eclética Química instname:Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Eclética Química |
collection |
Eclética Química |
repository.name.fl_str_mv |
Eclética Química - Universidade Estadual Paulista Júlio de Mesquita Filho (UNESP) |
repository.mail.fl_str_mv |
ecletica@ctrlk.com.br||ecletica@iq.unesp.br |
_version_ |
1754734618503806976 |