C-Reactive Protein, Endothelial Function and Genetic Influence: Association with Obesity
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Revista Brasileira Multidisciplinar |
Texto Completo: | http://revistarebram.com/index.php/revistauniara/article/view/44 |
Resumo: | Obesity is a multifactor chronic disease and its incidence has been increasing over the years and is being considered a public health problem. It is characterized by a chronic state of low grade inflammation, in which the C-reactive protein levels are usually increased. This inflammatory process can change the endothelial function in these individuals, since elevated levels of C-reactive protein are related to a low production of nitric oxide, which is responsible for the endothelium vasodilation. Several studies have demonstrated the influence of polymorphisms in the genes of C-reactive protein and of the endothelial nitric oxide synthesis enzyme in obese and healthy individuals. Thus this literature review aims at discussing the relationship between obesity and C-reactive protein levels and endothelial function, as well as to elucidate the association of genetic factors. Scientific articles from the databases PubMed, Science Direct and Scielo were consulted, using the following keywords and combinations of them: C-reactive protein, function/endothelial dysfunction, polymorphism and obesity. Thus, we concluded that obese individuals have elevated levels of C-reactive protein as a result of excess of body fat and this implies a reduction in nitric oxide synthesis. All these factors can be influenced by polymorphisms in regulatory genes of the production of these proteins. |
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C-Reactive Protein, Endothelial Function and Genetic Influence: Association with ObesityProteína C Reativa, Função Endotelial e Influência Genética: Associação com a ObesidadeInflammationendothelial dysfunctionpolymorphismsInflamaçãodisfunção endotelialpolimorfismos.Obesity is a multifactor chronic disease and its incidence has been increasing over the years and is being considered a public health problem. It is characterized by a chronic state of low grade inflammation, in which the C-reactive protein levels are usually increased. This inflammatory process can change the endothelial function in these individuals, since elevated levels of C-reactive protein are related to a low production of nitric oxide, which is responsible for the endothelium vasodilation. Several studies have demonstrated the influence of polymorphisms in the genes of C-reactive protein and of the endothelial nitric oxide synthesis enzyme in obese and healthy individuals. Thus this literature review aims at discussing the relationship between obesity and C-reactive protein levels and endothelial function, as well as to elucidate the association of genetic factors. Scientific articles from the databases PubMed, Science Direct and Scielo were consulted, using the following keywords and combinations of them: C-reactive protein, function/endothelial dysfunction, polymorphism and obesity. Thus, we concluded that obese individuals have elevated levels of C-reactive protein as a result of excess of body fat and this implies a reduction in nitric oxide synthesis. All these factors can be influenced by polymorphisms in regulatory genes of the production of these proteins.A obesidade é uma doença crônica e multifatorial, que vem aumentando sua incidência ao longo dos anos e está sendo considerada um problema de saúde pública. É caracterizada por um estado crônico de baixo grau de inflamação, no qual os níveis de proteína C reativa geralmente estão aumentados. Esse processo inflamatório pode alterar a função endotelial nesses indivíduos, uma vez que os níveis elevados de proteína C reativa estão relacionados a uma baixa produção de óxido nítrico, o qual é responsável pela vasodilatação do endotélio. Vários estudos têm demonstrado a influência de polimorfismos nos genes da proteína C reativa e da enzima óxido nítrico sintase endotelial em indivíduos obesos e saudáveis. Dessa forma, esta revisão de literatura tem como objetivo discutir a relação da obesidade com níveis de PCR e função endotelial, bem como elucidar a associação de fatores genéticos. Foram consultados artigos científicos dos bancos de dados PubMed, Science Direct e Scielo, utilizando os seguintes descritores e combinações entre eles: proteína C reativa, função/ disfunção endotelial, polimorfismo e obesidade e seus respectivos em inglês. Com isso, concluímos que indivíduos obesos apresentam elevados níveis de proteína C reativa, em decorrência do excesso de gordura corporal, e isso implica uma redução na síntese de óxido nítrico. Todos esses fatores podem ser influenciados por polimorfismos nos genes reguladores da produção dessas proteínas.Revista Brasileira Multidisciplinar - ReBraM2013-01-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://revistarebram.com/index.php/revistauniara/article/view/4410.25061/2527-2675/ReBraM/2013.v16i1.44Revista Brasileira Multidisciplinar - ReBraM; v. 16 n. 1 (2013): janeiro/junho; 79-902527-26751415-3580reponame:Revista Brasileira Multidisciplinarinstname:Universidade de Araraquara (UNIARA)instacron:UNIARAporhttp://revistarebram.com/index.php/revistauniara/article/view/44/29Abreu, Fabiana Guichard deLemos, Leandro Silva deColato, Alana SchraiberMedeiros, Niara da SilvaFiegenbaum, MariluDani, CarolinePeres, AlessandraRibeiro, Jerri Luizinfo:eu-repo/semantics/openAccess2018-03-08T14:18:36Zoai:ojs.revistarebram.com:article/44Revistahttp://revistarebram.com/index.php/revistauniaraPRIhttps://revistarebram.com/index.php/revistauniara/oairevistauniara@uniara.com||2527-26752527-2675opendoar:2018-03-08T14:18:36Revista Brasileira Multidisciplinar - Universidade de Araraquara (UNIARA)false |
dc.title.none.fl_str_mv |
C-Reactive Protein, Endothelial Function and Genetic Influence: Association with Obesity Proteína C Reativa, Função Endotelial e Influência Genética: Associação com a Obesidade |
title |
C-Reactive Protein, Endothelial Function and Genetic Influence: Association with Obesity |
spellingShingle |
C-Reactive Protein, Endothelial Function and Genetic Influence: Association with Obesity Abreu, Fabiana Guichard de Inflammation endothelial dysfunction polymorphisms Inflamação disfunção endotelial polimorfismos. |
title_short |
C-Reactive Protein, Endothelial Function and Genetic Influence: Association with Obesity |
title_full |
C-Reactive Protein, Endothelial Function and Genetic Influence: Association with Obesity |
title_fullStr |
C-Reactive Protein, Endothelial Function and Genetic Influence: Association with Obesity |
title_full_unstemmed |
C-Reactive Protein, Endothelial Function and Genetic Influence: Association with Obesity |
title_sort |
C-Reactive Protein, Endothelial Function and Genetic Influence: Association with Obesity |
author |
Abreu, Fabiana Guichard de |
author_facet |
Abreu, Fabiana Guichard de Lemos, Leandro Silva de Colato, Alana Schraiber Medeiros, Niara da Silva Fiegenbaum, Marilu Dani, Caroline Peres, Alessandra Ribeiro, Jerri Luiz |
author_role |
author |
author2 |
Lemos, Leandro Silva de Colato, Alana Schraiber Medeiros, Niara da Silva Fiegenbaum, Marilu Dani, Caroline Peres, Alessandra Ribeiro, Jerri Luiz |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Abreu, Fabiana Guichard de Lemos, Leandro Silva de Colato, Alana Schraiber Medeiros, Niara da Silva Fiegenbaum, Marilu Dani, Caroline Peres, Alessandra Ribeiro, Jerri Luiz |
dc.subject.por.fl_str_mv |
Inflammation endothelial dysfunction polymorphisms Inflamação disfunção endotelial polimorfismos. |
topic |
Inflammation endothelial dysfunction polymorphisms Inflamação disfunção endotelial polimorfismos. |
description |
Obesity is a multifactor chronic disease and its incidence has been increasing over the years and is being considered a public health problem. It is characterized by a chronic state of low grade inflammation, in which the C-reactive protein levels are usually increased. This inflammatory process can change the endothelial function in these individuals, since elevated levels of C-reactive protein are related to a low production of nitric oxide, which is responsible for the endothelium vasodilation. Several studies have demonstrated the influence of polymorphisms in the genes of C-reactive protein and of the endothelial nitric oxide synthesis enzyme in obese and healthy individuals. Thus this literature review aims at discussing the relationship between obesity and C-reactive protein levels and endothelial function, as well as to elucidate the association of genetic factors. Scientific articles from the databases PubMed, Science Direct and Scielo were consulted, using the following keywords and combinations of them: C-reactive protein, function/endothelial dysfunction, polymorphism and obesity. Thus, we concluded that obese individuals have elevated levels of C-reactive protein as a result of excess of body fat and this implies a reduction in nitric oxide synthesis. All these factors can be influenced by polymorphisms in regulatory genes of the production of these proteins. |
publishDate |
2013 |
dc.date.none.fl_str_mv |
2013-01-10 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://revistarebram.com/index.php/revistauniara/article/view/44 10.25061/2527-2675/ReBraM/2013.v16i1.44 |
url |
http://revistarebram.com/index.php/revistauniara/article/view/44 |
identifier_str_mv |
10.25061/2527-2675/ReBraM/2013.v16i1.44 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
http://revistarebram.com/index.php/revistauniara/article/view/44/29 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Revista Brasileira Multidisciplinar - ReBraM |
publisher.none.fl_str_mv |
Revista Brasileira Multidisciplinar - ReBraM |
dc.source.none.fl_str_mv |
Revista Brasileira Multidisciplinar - ReBraM; v. 16 n. 1 (2013): janeiro/junho; 79-90 2527-2675 1415-3580 reponame:Revista Brasileira Multidisciplinar instname:Universidade de Araraquara (UNIARA) instacron:UNIARA |
instname_str |
Universidade de Araraquara (UNIARA) |
instacron_str |
UNIARA |
institution |
UNIARA |
reponame_str |
Revista Brasileira Multidisciplinar |
collection |
Revista Brasileira Multidisciplinar |
repository.name.fl_str_mv |
Revista Brasileira Multidisciplinar - Universidade de Araraquara (UNIARA) |
repository.mail.fl_str_mv |
revistauniara@uniara.com|| |
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1797174604517605376 |