A systematic review assessing occurrence of medication-related osteonecrosis of the jaw following dental procedures
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian journal of oral sciences (Online) |
Texto Completo: | https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8666585 |
Resumo: | Aim: This study aimed to systematically review existing literature regarding the association between dental procedures—such as tooth extractions and periodontal therapy—and occurrence of medication-related osteonecrosis of the jaw (MRONJ) in individuals using bone-modifying drugs. Methods: Search strategies were performed in PubMed, Scopus, Web of Science and Cochrane Library for a timeframe ending in December 2021. Study selection, data extraction and risk of bias were analyzed independently by two researchers. Three meta-analyses were performed, estimating the crude risk ratio (RR), the adjusted odds ratio (OR) and the adjusted hazard ratio (HR) for the association between tooth extraction and MRONJ. Results: Of the 1,654 studies initially retrieved, 17 were ultimately included. The majority of patients with MRONJ in these studies were female, with a mean age of 64 years. Zoledronic acid was the most commonly used drug among patients with MRONJ, and cancer was the most frequent underlying health condition. Regarding the performed meta-analyses, crude and adjusted analyses demonstrated that tooth extraction increased the risk for MRONJ by 4.28 (95% confidence interval [95%CI]: 1.73–10.58), the OR for MRONJ by 26.94 (95%CI: 4.17–174.17), and the HR for MRONJ by 9.96 (95%CI: 4.04–24.55). Conclusion: It was concluded that performing dental procedures, especially tooth extraction, in patients using bone-modifying drugs increased the risk of MRONJ occurrence and, therefore, should be avoided. Further studies, using adjusted data, are warranted. |
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UNICAMP-8 |
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Brazilian journal of oral sciences (Online) |
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|
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A systematic review assessing occurrence of medication-related osteonecrosis of the jaw following dental proceduresBisphosphonate-associated osteonecrosis of the jawBone density conservation agentsDiphosphonatesOsteonecrosisSurgery, oralAim: This study aimed to systematically review existing literature regarding the association between dental procedures—such as tooth extractions and periodontal therapy—and occurrence of medication-related osteonecrosis of the jaw (MRONJ) in individuals using bone-modifying drugs. Methods: Search strategies were performed in PubMed, Scopus, Web of Science and Cochrane Library for a timeframe ending in December 2021. Study selection, data extraction and risk of bias were analyzed independently by two researchers. Three meta-analyses were performed, estimating the crude risk ratio (RR), the adjusted odds ratio (OR) and the adjusted hazard ratio (HR) for the association between tooth extraction and MRONJ. Results: Of the 1,654 studies initially retrieved, 17 were ultimately included. The majority of patients with MRONJ in these studies were female, with a mean age of 64 years. Zoledronic acid was the most commonly used drug among patients with MRONJ, and cancer was the most frequent underlying health condition. Regarding the performed meta-analyses, crude and adjusted analyses demonstrated that tooth extraction increased the risk for MRONJ by 4.28 (95% confidence interval [95%CI]: 1.73–10.58), the OR for MRONJ by 26.94 (95%CI: 4.17–174.17), and the HR for MRONJ by 9.96 (95%CI: 4.04–24.55). Conclusion: It was concluded that performing dental procedures, especially tooth extraction, in patients using bone-modifying drugs increased the risk of MRONJ occurrence and, therefore, should be avoided. Further studies, using adjusted data, are warranted.Universidade Estadual de Campinas2022-08-22info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/866658510.20396/bjos.v21i00.8666585Brazilian Journal of Oral Sciences; v. 21 (2022): Continuous Publication; e226585Brazilian Journal of Oral Sciences; Vol. 21 (2022): Continuous Publication; e2265851677-3225reponame:Brazilian journal of oral sciences (Online)instname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPenghttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8666585/29874Brazil; ContemporaryCopyright (c) 2021 Shimelly Monteiro de Castro Lara, Francisco Wilker Mustafa Gomes Muniz, Ana Beatriz Caetano Gerônimo, Cinthia Studzinski dos Santos, Thayanne Brasil Barbosa Calciahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessLara, Shimelly Monteiro de Castro Muniz, Francisco Wilker Mustafa GomesGerônimo, Ana Beatriz Caetano Santos, Cinthia Studzinski dos Barbosa Calcia, Thayanne Brasil2022-08-22T18:51:57Zoai:ojs.periodicos.sbu.unicamp.br:article/8666585Revistahttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/PUBhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/oaibrjorals@fop.unicamp.br||brjorals@fop.unicamp.br1677-32251677-3217opendoar:2022-08-22T18:51:57Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP)false |
dc.title.none.fl_str_mv |
A systematic review assessing occurrence of medication-related osteonecrosis of the jaw following dental procedures |
title |
A systematic review assessing occurrence of medication-related osteonecrosis of the jaw following dental procedures |
spellingShingle |
A systematic review assessing occurrence of medication-related osteonecrosis of the jaw following dental procedures Lara, Shimelly Monteiro de Castro Bisphosphonate-associated osteonecrosis of the jaw Bone density conservation agents Diphosphonates Osteonecrosis Surgery, oral |
title_short |
A systematic review assessing occurrence of medication-related osteonecrosis of the jaw following dental procedures |
title_full |
A systematic review assessing occurrence of medication-related osteonecrosis of the jaw following dental procedures |
title_fullStr |
A systematic review assessing occurrence of medication-related osteonecrosis of the jaw following dental procedures |
title_full_unstemmed |
A systematic review assessing occurrence of medication-related osteonecrosis of the jaw following dental procedures |
title_sort |
A systematic review assessing occurrence of medication-related osteonecrosis of the jaw following dental procedures |
author |
Lara, Shimelly Monteiro de Castro |
author_facet |
Lara, Shimelly Monteiro de Castro Muniz, Francisco Wilker Mustafa Gomes Gerônimo, Ana Beatriz Caetano Santos, Cinthia Studzinski dos Barbosa Calcia, Thayanne Brasil |
author_role |
author |
author2 |
Muniz, Francisco Wilker Mustafa Gomes Gerônimo, Ana Beatriz Caetano Santos, Cinthia Studzinski dos Barbosa Calcia, Thayanne Brasil |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Lara, Shimelly Monteiro de Castro Muniz, Francisco Wilker Mustafa Gomes Gerônimo, Ana Beatriz Caetano Santos, Cinthia Studzinski dos Barbosa Calcia, Thayanne Brasil |
dc.subject.por.fl_str_mv |
Bisphosphonate-associated osteonecrosis of the jaw Bone density conservation agents Diphosphonates Osteonecrosis Surgery, oral |
topic |
Bisphosphonate-associated osteonecrosis of the jaw Bone density conservation agents Diphosphonates Osteonecrosis Surgery, oral |
description |
Aim: This study aimed to systematically review existing literature regarding the association between dental procedures—such as tooth extractions and periodontal therapy—and occurrence of medication-related osteonecrosis of the jaw (MRONJ) in individuals using bone-modifying drugs. Methods: Search strategies were performed in PubMed, Scopus, Web of Science and Cochrane Library for a timeframe ending in December 2021. Study selection, data extraction and risk of bias were analyzed independently by two researchers. Three meta-analyses were performed, estimating the crude risk ratio (RR), the adjusted odds ratio (OR) and the adjusted hazard ratio (HR) for the association between tooth extraction and MRONJ. Results: Of the 1,654 studies initially retrieved, 17 were ultimately included. The majority of patients with MRONJ in these studies were female, with a mean age of 64 years. Zoledronic acid was the most commonly used drug among patients with MRONJ, and cancer was the most frequent underlying health condition. Regarding the performed meta-analyses, crude and adjusted analyses demonstrated that tooth extraction increased the risk for MRONJ by 4.28 (95% confidence interval [95%CI]: 1.73–10.58), the OR for MRONJ by 26.94 (95%CI: 4.17–174.17), and the HR for MRONJ by 9.96 (95%CI: 4.04–24.55). Conclusion: It was concluded that performing dental procedures, especially tooth extraction, in patients using bone-modifying drugs increased the risk of MRONJ occurrence and, therefore, should be avoided. Further studies, using adjusted data, are warranted. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-08-22 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/other |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8666585 10.20396/bjos.v21i00.8666585 |
url |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8666585 |
identifier_str_mv |
10.20396/bjos.v21i00.8666585 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8666585/29874 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
Brazil; Contemporary |
dc.publisher.none.fl_str_mv |
Universidade Estadual de Campinas |
publisher.none.fl_str_mv |
Universidade Estadual de Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Oral Sciences; v. 21 (2022): Continuous Publication; e226585 Brazilian Journal of Oral Sciences; Vol. 21 (2022): Continuous Publication; e226585 1677-3225 reponame:Brazilian journal of oral sciences (Online) instname:Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP |
instname_str |
Universidade Estadual de Campinas (UNICAMP) |
instacron_str |
UNICAMP |
institution |
UNICAMP |
reponame_str |
Brazilian journal of oral sciences (Online) |
collection |
Brazilian journal of oral sciences (Online) |
repository.name.fl_str_mv |
Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP) |
repository.mail.fl_str_mv |
brjorals@fop.unicamp.br||brjorals@fop.unicamp.br |
_version_ |
1800216403685408768 |