The role of metronidazole on the establishment and persistence of oral candidosis
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Publication Date: | 2015 |
Other Authors: | , , , |
Format: | Article |
Language: | eng |
Source: | Brazilian journal of oral sciences (Online) |
Download full: | https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641894 |
Summary: | The aim of this study was to study the effects of metronidazole on the establishment of oral candidosis and Candida albicans colonization in the oral cavity of rats. Forty-eight male rats, negative for yeasts in the oral cavity, were used in the study. The rats were inoculated with a suspension of Candida albicans and treated with metronidazole or plain water (control group). The rats of the candidosis experimental group were sacrificed 7, 15, or 30 days after inoculation and their tongues were analyzed by light microscopy. Colonization by Candida albicans was evaluated 1, 2, 5 and 7 days after inoculation and progressively at 15-day intervals, with a total of 18 collections. The results demonstrated the development of candidosis on the tongue dorsum was similar between the Control and Metronidazole groups for each sacrifice period. However, the colonization results showed that yeasts were recovered in the Metronidazole group in greater numbers than in the Control group after the 37th day of the experiment (6th collection). According this, the long term metronidazole therapy favored the colonization of C. albicans in the oral cavity of rats. |
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The role of metronidazole on the establishment and persistence of oral candidosisCandida albicans. Candidosis. Metronidazole. RatsOdontologiaThe aim of this study was to study the effects of metronidazole on the establishment of oral candidosis and Candida albicans colonization in the oral cavity of rats. Forty-eight male rats, negative for yeasts in the oral cavity, were used in the study. The rats were inoculated with a suspension of Candida albicans and treated with metronidazole or plain water (control group). The rats of the candidosis experimental group were sacrificed 7, 15, or 30 days after inoculation and their tongues were analyzed by light microscopy. Colonization by Candida albicans was evaluated 1, 2, 5 and 7 days after inoculation and progressively at 15-day intervals, with a total of 18 collections. The results demonstrated the development of candidosis on the tongue dorsum was similar between the Control and Metronidazole groups for each sacrifice period. However, the colonization results showed that yeasts were recovered in the Metronidazole group in greater numbers than in the Control group after the 37th day of the experiment (6th collection). According this, the long term metronidazole therapy favored the colonization of C. albicans in the oral cavity of rats.Universidade Estadual de Campinas2015-11-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/864189410.20396/bjos.v5i17.8641894Brazilian Journal of Oral Sciences; v. 5 n. 17 (2006): Apr./Jun.; 1041-1047Brazilian Journal of Oral Sciences; Vol. 5 No. 17 (2006): Apr./Jun.; 1041-10471677-3225reponame:Brazilian journal of oral sciences (Online)instname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPenghttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641894/9392Yujra, Veronica QuispeScherma, Alexandre PradoJunqueira, Juliana CamposJorge, Antônio Olavo CardosoRocha, Rosilene Fernandesinfo:eu-repo/semantics/openAccess2016-02-25T09:26:31Zoai:ojs.periodicos.sbu.unicamp.br:article/8641894Revistahttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/PUBhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/oaibrjorals@fop.unicamp.br||brjorals@fop.unicamp.br1677-32251677-3217opendoar:2016-02-25T09:26:31Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP)false |
dc.title.none.fl_str_mv |
The role of metronidazole on the establishment and persistence of oral candidosis |
title |
The role of metronidazole on the establishment and persistence of oral candidosis |
spellingShingle |
The role of metronidazole on the establishment and persistence of oral candidosis Yujra, Veronica Quispe Candida albicans. Candidosis. Metronidazole. Rats Odontologia |
title_short |
The role of metronidazole on the establishment and persistence of oral candidosis |
title_full |
The role of metronidazole on the establishment and persistence of oral candidosis |
title_fullStr |
The role of metronidazole on the establishment and persistence of oral candidosis |
title_full_unstemmed |
The role of metronidazole on the establishment and persistence of oral candidosis |
title_sort |
The role of metronidazole on the establishment and persistence of oral candidosis |
author |
Yujra, Veronica Quispe |
author_facet |
Yujra, Veronica Quispe Scherma, Alexandre Prado Junqueira, Juliana Campos Jorge, Antônio Olavo Cardoso Rocha, Rosilene Fernandes |
author_role |
author |
author2 |
Scherma, Alexandre Prado Junqueira, Juliana Campos Jorge, Antônio Olavo Cardoso Rocha, Rosilene Fernandes |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Yujra, Veronica Quispe Scherma, Alexandre Prado Junqueira, Juliana Campos Jorge, Antônio Olavo Cardoso Rocha, Rosilene Fernandes |
dc.subject.por.fl_str_mv |
Candida albicans. Candidosis. Metronidazole. Rats Odontologia |
topic |
Candida albicans. Candidosis. Metronidazole. Rats Odontologia |
description |
The aim of this study was to study the effects of metronidazole on the establishment of oral candidosis and Candida albicans colonization in the oral cavity of rats. Forty-eight male rats, negative for yeasts in the oral cavity, were used in the study. The rats were inoculated with a suspension of Candida albicans and treated with metronidazole or plain water (control group). The rats of the candidosis experimental group were sacrificed 7, 15, or 30 days after inoculation and their tongues were analyzed by light microscopy. Colonization by Candida albicans was evaluated 1, 2, 5 and 7 days after inoculation and progressively at 15-day intervals, with a total of 18 collections. The results demonstrated the development of candidosis on the tongue dorsum was similar between the Control and Metronidazole groups for each sacrifice period. However, the colonization results showed that yeasts were recovered in the Metronidazole group in greater numbers than in the Control group after the 37th day of the experiment (6th collection). According this, the long term metronidazole therapy favored the colonization of C. albicans in the oral cavity of rats. |
publishDate |
2015 |
dc.date.none.fl_str_mv |
2015-11-25 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641894 10.20396/bjos.v5i17.8641894 |
url |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641894 |
identifier_str_mv |
10.20396/bjos.v5i17.8641894 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8641894/9392 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Universidade Estadual de Campinas |
publisher.none.fl_str_mv |
Universidade Estadual de Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Oral Sciences; v. 5 n. 17 (2006): Apr./Jun.; 1041-1047 Brazilian Journal of Oral Sciences; Vol. 5 No. 17 (2006): Apr./Jun.; 1041-1047 1677-3225 reponame:Brazilian journal of oral sciences (Online) instname:Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP |
instname_str |
Universidade Estadual de Campinas (UNICAMP) |
instacron_str |
UNICAMP |
institution |
UNICAMP |
reponame_str |
Brazilian journal of oral sciences (Online) |
collection |
Brazilian journal of oral sciences (Online) |
repository.name.fl_str_mv |
Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP) |
repository.mail.fl_str_mv |
brjorals@fop.unicamp.br||brjorals@fop.unicamp.br |
_version_ |
1788167622016106496 |