Can NLR be a biomarker for mucositis and gvhd in patients undergoing allogeneic HSCT?
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian journal of oral sciences (Online) |
Texto Completo: | https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8668998 |
Resumo: | Allogeneic hematopoietic stem cell transplantation (HSCT) is a treatment for many diseases; however, it can induce complications such as Oral Mucositis (OM) and Graft-versus- Host Disease (GVHD). The neutrophil-lymphocyte ratio (NLR) is a peripheral biomarker of systemic inflammation and an independent prognostic factor for several inflammatory diseases. Aim: This study aimed to evaluate the association of NLR with OM and GVHD in patients undergoing allogeneic HSCT. Methods: Patients who underwent allogeneic HSCT at the Bone Marrow Transplant Service of the Hospital de Clínicas Complex of the Federal University of Paraná were included in the study. Socio-demographic data and blood counts were collected from patients’ medical records. The NLR was calculated and associated with OM and GVHD. Results: 45 patients were included in the study. Although NLR was higher in patients with OM and oral GVHD, no statistical difference was observed, and no relationship between OM and GVHD with NLR could be stated. Conclusion: Although both OM and GVHD are associated with an inflammatory response as well as the immune system, it was not associated with NLR. Further investigation considering other variables related to HSCT might find possible associations, as it could favor patient management and prevention. |
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oai:ojs.periodicos.sbu.unicamp.br:article/8668998 |
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UNICAMP-8 |
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Brazilian journal of oral sciences (Online) |
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|
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Can NLR be a biomarker for mucositis and gvhd in patients undergoing allogeneic HSCT?NeutrophilsLymphocytesHematopoietic stem cell transplantationMucositisGraft vs host diseaseAllogeneic hematopoietic stem cell transplantation (HSCT) is a treatment for many diseases; however, it can induce complications such as Oral Mucositis (OM) and Graft-versus- Host Disease (GVHD). The neutrophil-lymphocyte ratio (NLR) is a peripheral biomarker of systemic inflammation and an independent prognostic factor for several inflammatory diseases. Aim: This study aimed to evaluate the association of NLR with OM and GVHD in patients undergoing allogeneic HSCT. Methods: Patients who underwent allogeneic HSCT at the Bone Marrow Transplant Service of the Hospital de Clínicas Complex of the Federal University of Paraná were included in the study. Socio-demographic data and blood counts were collected from patients’ medical records. The NLR was calculated and associated with OM and GVHD. Results: 45 patients were included in the study. Although NLR was higher in patients with OM and oral GVHD, no statistical difference was observed, and no relationship between OM and GVHD with NLR could be stated. Conclusion: Although both OM and GVHD are associated with an inflammatory response as well as the immune system, it was not associated with NLR. Further investigation considering other variables related to HSCT might find possible associations, as it could favor patient management and prevention.Universidade Estadual de Campinas2023-08-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/otherapplication/pdfhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/866899810.20396/bjos.v22i00.8668998Brazilian Journal of Oral Sciences; v. 22 (2023): Continuous Publication; e238998Brazilian Journal of Oral Sciences; Vol. 22 (2023): Continuous Publication; e2389981677-3225reponame:Brazilian journal of oral sciences (Online)instname:Universidade Estadual de Campinas (UNICAMP)instacron:UNICAMPenghttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8668998/32424Brazil; ContemporanyCopyright (c) 2022 Isabella Christina Costa Quadras, Fernanda Aparecida Stresser, Stephanie von Stein Cubas Warnavin, Vaneuza Araújo Moreira Funke, Rafael Zancan Mobile, Juliana Lucena Schusselhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessQuadras, Isabella Christina CostaStresser, Fernanda AparecidaWarnavin, Stephanie von Stein CubasFunke, Vaneuza Araújo MoreiraMobile, Rafael ZancanSchussel, Juliana Lucena2023-09-12T16:40:58Zoai:ojs.periodicos.sbu.unicamp.br:article/8668998Revistahttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/PUBhttps://periodicos.sbu.unicamp.br/ojs/index.php/bjos/oaibrjorals@fop.unicamp.br||brjorals@fop.unicamp.br1677-32251677-3217opendoar:2023-09-12T16:40:58Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP)false |
dc.title.none.fl_str_mv |
Can NLR be a biomarker for mucositis and gvhd in patients undergoing allogeneic HSCT? |
title |
Can NLR be a biomarker for mucositis and gvhd in patients undergoing allogeneic HSCT? |
spellingShingle |
Can NLR be a biomarker for mucositis and gvhd in patients undergoing allogeneic HSCT? Quadras, Isabella Christina Costa Neutrophils Lymphocytes Hematopoietic stem cell transplantation Mucositis Graft vs host disease |
title_short |
Can NLR be a biomarker for mucositis and gvhd in patients undergoing allogeneic HSCT? |
title_full |
Can NLR be a biomarker for mucositis and gvhd in patients undergoing allogeneic HSCT? |
title_fullStr |
Can NLR be a biomarker for mucositis and gvhd in patients undergoing allogeneic HSCT? |
title_full_unstemmed |
Can NLR be a biomarker for mucositis and gvhd in patients undergoing allogeneic HSCT? |
title_sort |
Can NLR be a biomarker for mucositis and gvhd in patients undergoing allogeneic HSCT? |
author |
Quadras, Isabella Christina Costa |
author_facet |
Quadras, Isabella Christina Costa Stresser, Fernanda Aparecida Warnavin, Stephanie von Stein Cubas Funke, Vaneuza Araújo Moreira Mobile, Rafael Zancan Schussel, Juliana Lucena |
author_role |
author |
author2 |
Stresser, Fernanda Aparecida Warnavin, Stephanie von Stein Cubas Funke, Vaneuza Araújo Moreira Mobile, Rafael Zancan Schussel, Juliana Lucena |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Quadras, Isabella Christina Costa Stresser, Fernanda Aparecida Warnavin, Stephanie von Stein Cubas Funke, Vaneuza Araújo Moreira Mobile, Rafael Zancan Schussel, Juliana Lucena |
dc.subject.por.fl_str_mv |
Neutrophils Lymphocytes Hematopoietic stem cell transplantation Mucositis Graft vs host disease |
topic |
Neutrophils Lymphocytes Hematopoietic stem cell transplantation Mucositis Graft vs host disease |
description |
Allogeneic hematopoietic stem cell transplantation (HSCT) is a treatment for many diseases; however, it can induce complications such as Oral Mucositis (OM) and Graft-versus- Host Disease (GVHD). The neutrophil-lymphocyte ratio (NLR) is a peripheral biomarker of systemic inflammation and an independent prognostic factor for several inflammatory diseases. Aim: This study aimed to evaluate the association of NLR with OM and GVHD in patients undergoing allogeneic HSCT. Methods: Patients who underwent allogeneic HSCT at the Bone Marrow Transplant Service of the Hospital de Clínicas Complex of the Federal University of Paraná were included in the study. Socio-demographic data and blood counts were collected from patients’ medical records. The NLR was calculated and associated with OM and GVHD. Results: 45 patients were included in the study. Although NLR was higher in patients with OM and oral GVHD, no statistical difference was observed, and no relationship between OM and GVHD with NLR could be stated. Conclusion: Although both OM and GVHD are associated with an inflammatory response as well as the immune system, it was not associated with NLR. Further investigation considering other variables related to HSCT might find possible associations, as it could favor patient management and prevention. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-08-25 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion info:eu-repo/semantics/other |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8668998 10.20396/bjos.v22i00.8668998 |
url |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8668998 |
identifier_str_mv |
10.20396/bjos.v22i00.8668998 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://periodicos.sbu.unicamp.br/ojs/index.php/bjos/article/view/8668998/32424 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.coverage.none.fl_str_mv |
Brazil; Contemporany |
dc.publisher.none.fl_str_mv |
Universidade Estadual de Campinas |
publisher.none.fl_str_mv |
Universidade Estadual de Campinas |
dc.source.none.fl_str_mv |
Brazilian Journal of Oral Sciences; v. 22 (2023): Continuous Publication; e238998 Brazilian Journal of Oral Sciences; Vol. 22 (2023): Continuous Publication; e238998 1677-3225 reponame:Brazilian journal of oral sciences (Online) instname:Universidade Estadual de Campinas (UNICAMP) instacron:UNICAMP |
instname_str |
Universidade Estadual de Campinas (UNICAMP) |
instacron_str |
UNICAMP |
institution |
UNICAMP |
reponame_str |
Brazilian journal of oral sciences (Online) |
collection |
Brazilian journal of oral sciences (Online) |
repository.name.fl_str_mv |
Brazilian journal of oral sciences (Online) - Universidade Estadual de Campinas (UNICAMP) |
repository.mail.fl_str_mv |
brjorals@fop.unicamp.br||brjorals@fop.unicamp.br |
_version_ |
1788167625269837824 |