Cytoprotective effects of L-carnitine on testicular biometry and stereology of albino rats treated with vincristine sulfate in the prepubertal phase
Autor(a) principal: | |
---|---|
Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/26121 |
Resumo: | This research evaluated the cytoprotective effects of L-carnitine on the testis of albino rats treated with vincristine sulfate in the prepubertal stage. Ninety animals were used, 30 of which were controls, 30 treated with vincristine sulfate, and 30 treated with L-carnitine and vincristine sulfate. Drug applications occurred at 15 days of life, and euthanasia at 40, 64, and 127 days of life, allowing the analysis of the gonads at different stages of development. Biometric measurements (body weight, absolute testicular weight, relative testicular weight, testicular volume, major and minor testicular axes) and stereological measurements (length and volume densities of the seminiferous tubules and interstitial tissue) were performed. The results showed that the preventive use of L-carnitine can reduce the testicular deleterious effects caused by vincristine sulfate, since variables such as absolute testicular weight, relative testicular weight, and testicular minor axis indicated the mitigation of damages resulting from the action of the antineoplastic, mainly in acute and subacute phases. |
id |
UNIFEI_01194700a9e616be9f20de5ccdc6df75 |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/26121 |
network_acronym_str |
UNIFEI |
network_name_str |
Research, Society and Development |
repository_id_str |
|
spelling |
Cytoprotective effects of L-carnitine on testicular biometry and stereology of albino rats treated with vincristine sulfate in the prepubertal phaseEfectos citoprotectores de la L-carnitina en la biometría y estereología testicular de ratas albinas tratadas con sulfato de vincristina en la fase prepuberal Efeitos citoprotetores de L-carnitine sobre a biometria e estereologia testicular de ratos albinos, tratados com sulfato de vincristine na fase pré-púbereL-carnitinaSulfato de vincristinaTestículo.L-carnitineSulfato de vincristinaTestículo.L-carnitinevincristine sulfatetestisTestis.This research evaluated the cytoprotective effects of L-carnitine on the testis of albino rats treated with vincristine sulfate in the prepubertal stage. Ninety animals were used, 30 of which were controls, 30 treated with vincristine sulfate, and 30 treated with L-carnitine and vincristine sulfate. Drug applications occurred at 15 days of life, and euthanasia at 40, 64, and 127 days of life, allowing the analysis of the gonads at different stages of development. Biometric measurements (body weight, absolute testicular weight, relative testicular weight, testicular volume, major and minor testicular axes) and stereological measurements (length and volume densities of the seminiferous tubules and interstitial tissue) were performed. The results showed that the preventive use of L-carnitine can reduce the testicular deleterious effects caused by vincristine sulfate, since variables such as absolute testicular weight, relative testicular weight, and testicular minor axis indicated the mitigation of damages resulting from the action of the antineoplastic, mainly in acute and subacute phases.Esta investigación evaluó los efectos citoprotectores de la L-carnitina en los testículos de ratas albinas tratadas con sulfato de vincristina en la fase prepuberal. Se utilizaron 90 animales, 30 de los cuales eran controles, 30 tratados con sulfato de vincristina y 30 animales tratados con L-carnitina y sulfato de vincristina. Las aplicaciones de fármacos ocurrieron a los 15 días de vida, y la eutanasia a los 40, 64 y 127 días de vida, lo que permitió el análisis de las gónadas en diferentes etapas de desarrollo. Se realizaron mediciones biométricas (peso corporal, peso testicular absoluto, peso testicular relativo, volumen testicular, ejes testiculares mayor y menor) y estereológicas (densidad de longitud, densidades de volumen de los túbulos seminíferos y tejido intersticial). Los resultados mostraron que el uso preventivo de L-carnitina puede reducir los efectos deletéreos testiculares causados por el sulfato de vincristina, ya que variables como peso testicular absoluto, peso testicular relativo y eje menor testicular indicaron la mitigación de los daños resultantes de la acción del antineoplásico, principalmente en las fases aguda y subaguda.Esta pesquisa avaliou os efeitos citoprotetores de L-carnitine sobre os testículos de ratos albinos tratados com sulfato de vincristine na fase pré-púbere. Foram utilizados 90 animais, sendo 30 animais controles, 30 tratados com sulfato de vincristine e 30 animais tratados com L-carnitine e sulfato de vincristine. As aplicações das drogas ocorreram aos 15 dias de vida, e a eutanásia aos 40, 64 e 127 dias de vida, possibilitando a análise da gônada em diferentes fases de desenvolvimento. Foram realizadas medidas biométricas (peso corpóreo, peso testicular absoluto, peso testicular relativo, volume testicular, eixos testiculares maior e menor) e medidas estereológicas (densidade de comprimento, densidades de volume dos túbulos seminíferos e do tecido intersticial). Os resultados demonstraram que o uso preventivo da L-carnitine pode reduzir os efeitos deletérios testiculares provocados pelo sulfato de vincristine, uma vez que variáveis como peso testicular absoluto, peso testicular relativo e eixo menor testicular apontaram mitigação dos danos decorrentes da ação do antineoplásico, principalmente em fase aguda e subaguda.Research, Society and Development2022-02-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2612110.33448/rsd-v11i3.26121Research, Society and Development; Vol. 11 No. 3; e2011326121Research, Society and Development; Vol. 11 Núm. 3; e2011326121Research, Society and Development; v. 11 n. 3; e20113261212525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/26121/22947Copyright (c) 2022 Edson Vinícius Leite Veloso; José Emanuel de Souza Sales; Wanesk Kerly Barbosa Lucena; Maria Eduarda Camargo Caldeira; Paula Páglia Braga Araújo; Ruthyanna Camila Medeiros da Silva; Raul Anderson de Souza Machado; Otávio Brilhante de Sousa; Danilo José Ayres de Menezeshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessVeloso, Edson Vinícius LeiteSales, José Emanuel de SouzaLucena, Wanesk Kerly BarbosaCaldeira, Maria Eduarda CamargoAraújo, Paula Páglia BragaSilva, Ruthyanna Camila Medeiros da Machado, Raul Anderson de SouzaSousa, Otávio Brilhante de Menezes, Danilo José Ayres de 2022-03-09T13:44:38Zoai:ojs.pkp.sfu.ca:article/26121Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:44:14.586434Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Cytoprotective effects of L-carnitine on testicular biometry and stereology of albino rats treated with vincristine sulfate in the prepubertal phase Efectos citoprotectores de la L-carnitina en la biometría y estereología testicular de ratas albinas tratadas con sulfato de vincristina en la fase prepuberal Efeitos citoprotetores de L-carnitine sobre a biometria e estereologia testicular de ratos albinos, tratados com sulfato de vincristine na fase pré-púbere |
title |
Cytoprotective effects of L-carnitine on testicular biometry and stereology of albino rats treated with vincristine sulfate in the prepubertal phase |
spellingShingle |
Cytoprotective effects of L-carnitine on testicular biometry and stereology of albino rats treated with vincristine sulfate in the prepubertal phase Veloso, Edson Vinícius Leite L-carnitina Sulfato de vincristina Testículo. L-carnitine Sulfato de vincristina Testículo. L-carnitine vincristine sulfate testis Testis. |
title_short |
Cytoprotective effects of L-carnitine on testicular biometry and stereology of albino rats treated with vincristine sulfate in the prepubertal phase |
title_full |
Cytoprotective effects of L-carnitine on testicular biometry and stereology of albino rats treated with vincristine sulfate in the prepubertal phase |
title_fullStr |
Cytoprotective effects of L-carnitine on testicular biometry and stereology of albino rats treated with vincristine sulfate in the prepubertal phase |
title_full_unstemmed |
Cytoprotective effects of L-carnitine on testicular biometry and stereology of albino rats treated with vincristine sulfate in the prepubertal phase |
title_sort |
Cytoprotective effects of L-carnitine on testicular biometry and stereology of albino rats treated with vincristine sulfate in the prepubertal phase |
author |
Veloso, Edson Vinícius Leite |
author_facet |
Veloso, Edson Vinícius Leite Sales, José Emanuel de Souza Lucena, Wanesk Kerly Barbosa Caldeira, Maria Eduarda Camargo Araújo, Paula Páglia Braga Silva, Ruthyanna Camila Medeiros da Machado, Raul Anderson de Souza Sousa, Otávio Brilhante de Menezes, Danilo José Ayres de |
author_role |
author |
author2 |
Sales, José Emanuel de Souza Lucena, Wanesk Kerly Barbosa Caldeira, Maria Eduarda Camargo Araújo, Paula Páglia Braga Silva, Ruthyanna Camila Medeiros da Machado, Raul Anderson de Souza Sousa, Otávio Brilhante de Menezes, Danilo José Ayres de |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Veloso, Edson Vinícius Leite Sales, José Emanuel de Souza Lucena, Wanesk Kerly Barbosa Caldeira, Maria Eduarda Camargo Araújo, Paula Páglia Braga Silva, Ruthyanna Camila Medeiros da Machado, Raul Anderson de Souza Sousa, Otávio Brilhante de Menezes, Danilo José Ayres de |
dc.subject.por.fl_str_mv |
L-carnitina Sulfato de vincristina Testículo. L-carnitine Sulfato de vincristina Testículo. L-carnitine vincristine sulfate testis Testis. |
topic |
L-carnitina Sulfato de vincristina Testículo. L-carnitine Sulfato de vincristina Testículo. L-carnitine vincristine sulfate testis Testis. |
description |
This research evaluated the cytoprotective effects of L-carnitine on the testis of albino rats treated with vincristine sulfate in the prepubertal stage. Ninety animals were used, 30 of which were controls, 30 treated with vincristine sulfate, and 30 treated with L-carnitine and vincristine sulfate. Drug applications occurred at 15 days of life, and euthanasia at 40, 64, and 127 days of life, allowing the analysis of the gonads at different stages of development. Biometric measurements (body weight, absolute testicular weight, relative testicular weight, testicular volume, major and minor testicular axes) and stereological measurements (length and volume densities of the seminiferous tubules and interstitial tissue) were performed. The results showed that the preventive use of L-carnitine can reduce the testicular deleterious effects caused by vincristine sulfate, since variables such as absolute testicular weight, relative testicular weight, and testicular minor axis indicated the mitigation of damages resulting from the action of the antineoplastic, mainly in acute and subacute phases. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/26121 10.33448/rsd-v11i3.26121 |
url |
https://rsdjournal.org/index.php/rsd/article/view/26121 |
identifier_str_mv |
10.33448/rsd-v11i3.26121 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/26121/22947 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 3; e2011326121 Research, Society and Development; Vol. 11 Núm. 3; e2011326121 Research, Society and Development; v. 11 n. 3; e2011326121 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052762665517056 |