Analysis of biomechanical properties of tibias after bone failure and ozone treatment in rats
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/7474 |
Resumo: | Introduction: Ozone is a potent antioxidant that acts as a precursor of various radicals, being indicated as a powerful therapy, assisting in the process of tissue healing. Objectives: The proposal of this study was to analyze material and structural properties via mechanical testing in tibias after application of ozone in bone defects produced surgically. Methods: Ten male 40-day old albino Wistar rats have been used, divided in two groups: control group and ozone group, this last one being treated with ozonized water in 25 µg/mL of concentration until the day of euthanasia. Trichotomy and longitudinal incision was conducted in the animals’ leg skin, exposing the tibia’s diaphysis of both antimers, and with help of a high rotation pen a flaw has been produced on the bone. After 60 days of surgery the animals were euthanized, and tibias were collected for biomechanical analysis. Results: The results of the biomechanical properties – structural and material – evidenced significant interactions through exposure to ozone, showing a diminished bone resistance in animals from the control group, observed by the decrease of the maximum force (N) needed to rupture the bone when compared to the value needed to break the bones of the animals from the ozone group, and the analysis of the morphometrical properties did not show any difference between both experimental groups. Conclusion: The use of ozone did not alter the morphological structures of the tibias, and the group which used ozone presented more resistance during mechanical testings, because the maximum force for the rupture of tibia was greater in this group. |
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Analysis of biomechanical properties of tibias after bone failure and ozone treatment in ratsAnálisis de las propiedades biomecánicas en las faltas huesas de tibasa después del tratamiento con ozonoAnálise de propriedades biomecânicas em falhas ósseas de tíbias após tratamento com ozônioTibiasBiomecânicaOzônioResistência.Tibias BiomecánicaOzonoResistencia.TibiasBiomechanicalOzoneResistance.Introduction: Ozone is a potent antioxidant that acts as a precursor of various radicals, being indicated as a powerful therapy, assisting in the process of tissue healing. Objectives: The proposal of this study was to analyze material and structural properties via mechanical testing in tibias after application of ozone in bone defects produced surgically. Methods: Ten male 40-day old albino Wistar rats have been used, divided in two groups: control group and ozone group, this last one being treated with ozonized water in 25 µg/mL of concentration until the day of euthanasia. Trichotomy and longitudinal incision was conducted in the animals’ leg skin, exposing the tibia’s diaphysis of both antimers, and with help of a high rotation pen a flaw has been produced on the bone. After 60 days of surgery the animals were euthanized, and tibias were collected for biomechanical analysis. Results: The results of the biomechanical properties – structural and material – evidenced significant interactions through exposure to ozone, showing a diminished bone resistance in animals from the control group, observed by the decrease of the maximum force (N) needed to rupture the bone when compared to the value needed to break the bones of the animals from the ozone group, and the analysis of the morphometrical properties did not show any difference between both experimental groups. Conclusion: The use of ozone did not alter the morphological structures of the tibias, and the group which used ozone presented more resistance during mechanical testings, because the maximum force for the rupture of tibia was greater in this group.Introducción: El ozono es un potente oxidante que actúa como precursor de varios radicales, siendo indicado con potente terapéutico con auxiliar en el proceso de reparación de tejidos. Objetivos: El propósito de este estudio fue analizar las propiedades materiales y estructurales mediante ensayos mecánicos en tibias después de la aplicación del ozono en la insuficiencia ósea producida quirúrgicamente. Metodología: Se utilizaron diez ratas wistar albinas macho con 40 días de vida, divididas en dos grupos: grupo de control y grupo de ozono, que fue tratado con agua ozonizada a una concentración de 25 g/ml hasta la fecha de la eutanasia. En la pierna de los animales, se realizó tricotomía e incisión longitudinal en la piel, exponiendo la diáfisis de la tibia de ambos antimémeros y con la ayuda de una pluma de alta rotación, produciendo una falla ósea. Después de 60 días de cirugía, los animales fueron eutanasiados, y las tibias fueron recolectadas para análisis biomecánicos. Resultados: las propiedades biomecánicas (estructurales y materiales) mostraron interacciones significativas a través de la exposición al ozono, evidenciando una disminución en la resistencia ósea de los animales del grupo de control, observadas por la disminución de la fuerza máxima (N) necesaria para romper el hueso en comparación con los valores necesarios para romper los huesos de los animales del grupo de ozono y los análisis de propiedades morfométricas no revelaron diferencias entre los grupos experimentales. Conclusión: El uso del ozono no alteró las propiedades morfológicas de las tibias y que el grupo que utilizó ozono exhibiera más resistencia en el ensayo mecánico, porque la fuerza máxima para la ruptura tibial fue mayor en este grupo.Introdução: O ozônio é um oxidante potente que age como precursor diversos radicais, sendo indicado com terapêutico potente com auxiliar no processo de reparação tecidual. Objetivos: A proposta do presente estudo foi analisar as propriedades materiais e estruturais por meio de ensaio mecânico em tíbias após aplicação de ozônio em falha óssea produzidas cirurgicamente. Metodologia: Foram utilizados 10 ratos albinos Wistar, machos, com 40 dias de vida, divididos em dois grupos: grupo controle e grupo ozônio, sendo este tratado com água ozonizada na concentração de 25 μg/ml até a data da eutanásia. Na perna dos animais foi realizada tricotomia e incisão longitudinal na pele, expondo a da diáfise da tíbia de ambos antimeros e com auxílio de uma caneta de alta-rotação, produzindo uma falha óssea. Após 60 dias da cirurgia os animais foram eutanesiados, as tibias foram coletadas para análise biomecânica. Resultados: as propriedades biomecânicas (estruturais e materiais) evidenciaram interações significativas mediante a exposição ao ozônio, evidenciando uma diminuição na resistência óssea dos animais do grupo controle, observado por meio da diminuição na força máxima (N) necessária para romper o osso quando comparado aos valores necessários para quebrar os ossos dos animais do grupo ozônio e as análises das propriedades morfométricas não revelaram diferenças entre os grupos experimentais. Conclusão: O uso do ozônio não alterou as propriedades morfológicas das tíbias e que o grupo que usou ozônio exibiu mais resistência no ensaio mecânico, pois a força máxima para ruptura da tíbia foi maior neste grupo.Research, Society and Development2020-08-29info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/747410.33448/rsd-v9i9.7474Research, Society and Development; Vol. 9 No. 9; e530997474Research, Society and Development; Vol. 9 Núm. 9; e530997474Research, Society and Development; v. 9 n. 9; e5309974742525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/7474/6718Copyright (c) 2020 Alexadre Aniceto Rodrigues; Thiago Donizeth da Silva; Evelise Aline Soares; José Antônio Dias Garcia; Flavia da Ré Guerra; Fábio Alexandre Vieira Junior; Jordan Ribeiro dos Santos Souza; Roberto Conde Santos; Alessandra Esteves; Wagner Rossi Costa Júnior; Maria Eduarda Brito Araújohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessRodrigues, Alexadre Aniceto Silva, Thiago Donizeth da Soares, Evelise AlineGarcia, José Antônio Dias Guerra, Flavia da Ré Vieira Junior, Fábio AlexandreSouza, Jordan Ribeiro dos Santos Santos, Roberto Conde Esteves, Alessandra Costa Júnior, Wagner Rossi Araújo, Maria Eduarda Brito 2020-09-18T01:42:11Zoai:ojs.pkp.sfu.ca:article/7474Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:30:11.349637Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Analysis of biomechanical properties of tibias after bone failure and ozone treatment in rats Análisis de las propiedades biomecánicas en las faltas huesas de tibasa después del tratamiento con ozono Análise de propriedades biomecânicas em falhas ósseas de tíbias após tratamento com ozônio |
title |
Analysis of biomechanical properties of tibias after bone failure and ozone treatment in rats |
spellingShingle |
Analysis of biomechanical properties of tibias after bone failure and ozone treatment in rats Rodrigues, Alexadre Aniceto Tibias Biomecânica Ozônio Resistência. Tibias Biomecánica Ozono Resistencia. Tibias Biomechanical Ozone Resistance. |
title_short |
Analysis of biomechanical properties of tibias after bone failure and ozone treatment in rats |
title_full |
Analysis of biomechanical properties of tibias after bone failure and ozone treatment in rats |
title_fullStr |
Analysis of biomechanical properties of tibias after bone failure and ozone treatment in rats |
title_full_unstemmed |
Analysis of biomechanical properties of tibias after bone failure and ozone treatment in rats |
title_sort |
Analysis of biomechanical properties of tibias after bone failure and ozone treatment in rats |
author |
Rodrigues, Alexadre Aniceto |
author_facet |
Rodrigues, Alexadre Aniceto Silva, Thiago Donizeth da Soares, Evelise Aline Garcia, José Antônio Dias Guerra, Flavia da Ré Vieira Junior, Fábio Alexandre Souza, Jordan Ribeiro dos Santos Santos, Roberto Conde Esteves, Alessandra Costa Júnior, Wagner Rossi Araújo, Maria Eduarda Brito |
author_role |
author |
author2 |
Silva, Thiago Donizeth da Soares, Evelise Aline Garcia, José Antônio Dias Guerra, Flavia da Ré Vieira Junior, Fábio Alexandre Souza, Jordan Ribeiro dos Santos Santos, Roberto Conde Esteves, Alessandra Costa Júnior, Wagner Rossi Araújo, Maria Eduarda Brito |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Rodrigues, Alexadre Aniceto Silva, Thiago Donizeth da Soares, Evelise Aline Garcia, José Antônio Dias Guerra, Flavia da Ré Vieira Junior, Fábio Alexandre Souza, Jordan Ribeiro dos Santos Santos, Roberto Conde Esteves, Alessandra Costa Júnior, Wagner Rossi Araújo, Maria Eduarda Brito |
dc.subject.por.fl_str_mv |
Tibias Biomecânica Ozônio Resistência. Tibias Biomecánica Ozono Resistencia. Tibias Biomechanical Ozone Resistance. |
topic |
Tibias Biomecânica Ozônio Resistência. Tibias Biomecánica Ozono Resistencia. Tibias Biomechanical Ozone Resistance. |
description |
Introduction: Ozone is a potent antioxidant that acts as a precursor of various radicals, being indicated as a powerful therapy, assisting in the process of tissue healing. Objectives: The proposal of this study was to analyze material and structural properties via mechanical testing in tibias after application of ozone in bone defects produced surgically. Methods: Ten male 40-day old albino Wistar rats have been used, divided in two groups: control group and ozone group, this last one being treated with ozonized water in 25 µg/mL of concentration until the day of euthanasia. Trichotomy and longitudinal incision was conducted in the animals’ leg skin, exposing the tibia’s diaphysis of both antimers, and with help of a high rotation pen a flaw has been produced on the bone. After 60 days of surgery the animals were euthanized, and tibias were collected for biomechanical analysis. Results: The results of the biomechanical properties – structural and material – evidenced significant interactions through exposure to ozone, showing a diminished bone resistance in animals from the control group, observed by the decrease of the maximum force (N) needed to rupture the bone when compared to the value needed to break the bones of the animals from the ozone group, and the analysis of the morphometrical properties did not show any difference between both experimental groups. Conclusion: The use of ozone did not alter the morphological structures of the tibias, and the group which used ozone presented more resistance during mechanical testings, because the maximum force for the rupture of tibia was greater in this group. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08-29 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/7474 10.33448/rsd-v9i9.7474 |
url |
https://rsdjournal.org/index.php/rsd/article/view/7474 |
identifier_str_mv |
10.33448/rsd-v9i9.7474 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/7474/6718 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 9 No. 9; e530997474 Research, Society and Development; Vol. 9 Núm. 9; e530997474 Research, Society and Development; v. 9 n. 9; e530997474 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052739277029376 |