Thromboembolic event index after total knee arthroplasty with the use of tranexamic acid: an integrative review

Detalhes bibliográficos
Autor(a) principal: Alves, Rafael Rosano Gotti
Data de Publicação: 2022
Outros Autores: Eustáquio, José Martins Juliano, Gomes, Sandro Marcílio Pereira, Morais, Maria Laura Oliveira, Morais, João Cesar Oliveira, Sacardo, Amanda Vieira, Parreira, Eduardo Rodrigues
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/37094
Resumo: Total knee arthroplasty (TKA) is a surgical procedure that consists of replacing the weight-bearing surfaces of the affected joint with a prosthesis, aiming at relieving pain and correcting deformities. Due to the inherent risk of venous thromboembolism, drugs are used for its prophylaxis. This integrative literature review aimed to analyze the complications involved in the use of tranexamic acid in patients undergoing total knee arthroplasty (TKA), specifically the thromboembolic events that occurred. Studies were selected from PubMed, SciELO, Medline and Thieme electronic databases. Eleven randomized clinical trials were included. The total number of patients included in the studies was 1.299 who underwent TKA. In total, seven thromboembolic events were recorded, thus occurring in 0.5% of the cases analyzed. Thus, the safety of the use of tranexamic acid is proven, so that 99.5% of the patients did not present thromboembolic events, with the index relative to positive cases being practically irrelevant. Thus, the concluion is that the drug is safe and effective to be used in this surgical procedure, in order to minimize bleeding, rarely resulting in thromboembolic events.
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spelling Thromboembolic event index after total knee arthroplasty with the use of tranexamic acid: an integrative review Tasa de eventos tromboembólicos después de la artroplastia total de rodilla con ácido tranexámico: una revisión integradoraÍndice de eventos tromboembólicos após artroplastia total do joelho com uso de ácido tranexâmico: uma revisão integrativaJoelhoArtroplastiaTromboembolismoÁcido tranexâmico.RodillaArtroplastiaTromboembolismoÁcido tranexámico.KneeArthroplastyThromboembolismTranexamic acid.Total knee arthroplasty (TKA) is a surgical procedure that consists of replacing the weight-bearing surfaces of the affected joint with a prosthesis, aiming at relieving pain and correcting deformities. Due to the inherent risk of venous thromboembolism, drugs are used for its prophylaxis. This integrative literature review aimed to analyze the complications involved in the use of tranexamic acid in patients undergoing total knee arthroplasty (TKA), specifically the thromboembolic events that occurred. Studies were selected from PubMed, SciELO, Medline and Thieme electronic databases. Eleven randomized clinical trials were included. The total number of patients included in the studies was 1.299 who underwent TKA. In total, seven thromboembolic events were recorded, thus occurring in 0.5% of the cases analyzed. Thus, the safety of the use of tranexamic acid is proven, so that 99.5% of the patients did not present thromboembolic events, with the index relative to positive cases being practically irrelevant. Thus, the concluion is that the drug is safe and effective to be used in this surgical procedure, in order to minimize bleeding, rarely resulting in thromboembolic events.La artroplastia total de rodilla (ATR) es un procedimiento quirúrgico que consiste en sustituir las superficies de carga de la articulación afectada por una prótesis, con el objetivo de aliviar el dolor y corregir las deformidades. Debido al riesgo inherente de tromboembolismo venoso, se utilizan fármacos para su profilaxis. Esta revisión integradora de la literatura tuvo como objetivo analizar las complicaciones involucradas en el uso de ácido tranexámico en pacientes sometidos a artroplastia total de rodilla (ATR), específicamente los eventos tromboembólicos ocurridos. Los estudios se seleccionaron de las bases de datos electrónicas PubMed, SciELO, Medline y Thieme. Se incluyeron once ensayos controlados aleatorios. El número total de pacientes incluidos en los estudios fue de 1.299 que se sometieron a ATR. En total se registraron siete eventos tromboembólicos, ocurriendo así en el 0,5% de los casos analizados. Así, queda demostrada la seguridad del uso del ácido tranexámico, de forma que el 99,5% de los pacientes no presentaron eventos tromboembólicos, siendo prácticamente irrelevante el índice relativo a los casos positivos. Por lo tanto, se concluye que el fármaco es seguro y eficaz para ser utilizado en este procedimiento quirúrgico, con el fin de minimizar el sangrado, resultando raramente en eventos tromboembólicos.A artroplastia total do joelho (ATJ) é um procedimento cirúrgico que consiste na substituição das superfícies de sustentação de peso da articulação afetada por uma prótese, com o objetivo de aliviar a dor e corrigir deformidades. Devido ao risco inerente de tromboembolismo venoso, drogas são utilizadas para sua profilaxia. Esta revisão integrativa da literatura teve como objetivo analisar as complicações envolvidas no uso do ácido tranexâmico em pacientes submetidos à artroplastia total do joelho (ATJ), especificamente os eventos tromboembólicos ocorridos. Os estudos foram selecionados nas bases de dados eletrônicas PubMed, SciELO, Medline e Thieme. Onze ensaios clínicos randomizados foram incluídos. O número total de pacientes incluídos nos estudos foi de 1.299 submetidos à ATJ. No total, foram registrados sete eventos tromboembólicos, ocorrendo assim em 0,5% dos casos analisados. Assim, fica comprovada a segurança do uso do ácido tranexâmico, de modo que 99,5% dos pacientes não apresentaram eventos tromboembólicos, sendo praticamente irrelevante o índice relativo aos casos positivos. Assim, conclui-se que o fármaco é seguro e eficaz para ser utilizado neste procedimento cirúrgico, a fim de minimizar o sangramento, raramente resultando em eventos tromboembólicos.Research, Society and Development2022-11-13info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3709410.33448/rsd-v11i15.37094Research, Society and Development; Vol. 11 No. 15; e160111537094Research, Society and Development; Vol. 11 Núm. 15; e160111537094Research, Society and Development; v. 11 n. 15; e1601115370942525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/37094/30876Copyright (c) 2022 Rafael Rosano Gotti Alves; José Martins Juliano Eustáquio; Sandro Marcílio Pereira Gomes; Maria Laura Oliveira Morais; João Cesar Oliveira Morais; Amanda Vieira Sacardo; Eduardo Rodrigues Parreirahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAlves, Rafael Rosano GottiEustáquio, José Martins JulianoGomes, Sandro Marcílio PereiraMorais, Maria Laura OliveiraMorais, João Cesar OliveiraSacardo, Amanda VieiraParreira, Eduardo Rodrigues2022-11-27T19:56:23Zoai:ojs.pkp.sfu.ca:article/37094Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:51:23.766011Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Thromboembolic event index after total knee arthroplasty with the use of tranexamic acid: an integrative review
Tasa de eventos tromboembólicos después de la artroplastia total de rodilla con ácido tranexámico: una revisión integradora
Índice de eventos tromboembólicos após artroplastia total do joelho com uso de ácido tranexâmico: uma revisão integrativa
title Thromboembolic event index after total knee arthroplasty with the use of tranexamic acid: an integrative review
spellingShingle Thromboembolic event index after total knee arthroplasty with the use of tranexamic acid: an integrative review
Alves, Rafael Rosano Gotti
Joelho
Artroplastia
Tromboembolismo
Ácido tranexâmico.
Rodilla
Artroplastia
Tromboembolismo
Ácido tranexámico.
Knee
Arthroplasty
Thromboembolism
Tranexamic acid.
title_short Thromboembolic event index after total knee arthroplasty with the use of tranexamic acid: an integrative review
title_full Thromboembolic event index after total knee arthroplasty with the use of tranexamic acid: an integrative review
title_fullStr Thromboembolic event index after total knee arthroplasty with the use of tranexamic acid: an integrative review
title_full_unstemmed Thromboembolic event index after total knee arthroplasty with the use of tranexamic acid: an integrative review
title_sort Thromboembolic event index after total knee arthroplasty with the use of tranexamic acid: an integrative review
author Alves, Rafael Rosano Gotti
author_facet Alves, Rafael Rosano Gotti
Eustáquio, José Martins Juliano
Gomes, Sandro Marcílio Pereira
Morais, Maria Laura Oliveira
Morais, João Cesar Oliveira
Sacardo, Amanda Vieira
Parreira, Eduardo Rodrigues
author_role author
author2 Eustáquio, José Martins Juliano
Gomes, Sandro Marcílio Pereira
Morais, Maria Laura Oliveira
Morais, João Cesar Oliveira
Sacardo, Amanda Vieira
Parreira, Eduardo Rodrigues
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Alves, Rafael Rosano Gotti
Eustáquio, José Martins Juliano
Gomes, Sandro Marcílio Pereira
Morais, Maria Laura Oliveira
Morais, João Cesar Oliveira
Sacardo, Amanda Vieira
Parreira, Eduardo Rodrigues
dc.subject.por.fl_str_mv Joelho
Artroplastia
Tromboembolismo
Ácido tranexâmico.
Rodilla
Artroplastia
Tromboembolismo
Ácido tranexámico.
Knee
Arthroplasty
Thromboembolism
Tranexamic acid.
topic Joelho
Artroplastia
Tromboembolismo
Ácido tranexâmico.
Rodilla
Artroplastia
Tromboembolismo
Ácido tranexámico.
Knee
Arthroplasty
Thromboembolism
Tranexamic acid.
description Total knee arthroplasty (TKA) is a surgical procedure that consists of replacing the weight-bearing surfaces of the affected joint with a prosthesis, aiming at relieving pain and correcting deformities. Due to the inherent risk of venous thromboembolism, drugs are used for its prophylaxis. This integrative literature review aimed to analyze the complications involved in the use of tranexamic acid in patients undergoing total knee arthroplasty (TKA), specifically the thromboembolic events that occurred. Studies were selected from PubMed, SciELO, Medline and Thieme electronic databases. Eleven randomized clinical trials were included. The total number of patients included in the studies was 1.299 who underwent TKA. In total, seven thromboembolic events were recorded, thus occurring in 0.5% of the cases analyzed. Thus, the safety of the use of tranexamic acid is proven, so that 99.5% of the patients did not present thromboembolic events, with the index relative to positive cases being practically irrelevant. Thus, the concluion is that the drug is safe and effective to be used in this surgical procedure, in order to minimize bleeding, rarely resulting in thromboembolic events.
publishDate 2022
dc.date.none.fl_str_mv 2022-11-13
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/37094
10.33448/rsd-v11i15.37094
url https://rsdjournal.org/index.php/rsd/article/view/37094
identifier_str_mv 10.33448/rsd-v11i15.37094
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/37094/30876
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 15; e160111537094
Research, Society and Development; Vol. 11 Núm. 15; e160111537094
Research, Society and Development; v. 11 n. 15; e160111537094
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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