Total intravenous anesthesia with propofol and dexmedetomidine in bitches submitted to ovary-hysterectomy
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/28004 |
Resumo: | Total intravenous anesthesia is widely used in dogs, and the addition of adjuvants aims to complement analgesia and reduce the doses of propofol used. This study aimed to evaluate the association of dexmedetomidine and propofol in total intravenous anesthesia in dogs. Fifteen adults, healthy bitches weighing 13.8 ±4.7 kg were selected. After premedication with acepromazine and methadone. They were allocated to two groups: GDEX (n = 8) were administered dexmedetomidine (2 µg/kg bolus + 1 µg/kg/h IV) or control GC (n = 7) with saline, and then administered propofol to both groups. The animals were maintained on propofol, adjusted to the anesthetic plane, and supplemented with 100% oxygen. The following were evaluated: induction scale, electrocardiogram, heart and respiratory rates, systolic blood pressure with Doppler, end-tidal carbon dioxide pressure, and peripheral oxygen saturation. When necessary, fentanyl (2.5 µg/kg IV) was administered. In the end, propofol rate, fentanyl consumption, surgical time, extubation, anesthetic discharge, and bleeding score were recorded. There was a mean reduction of 46% in heart rate after administration of dexmedetomidine. At the same time after induction, the systolic blood pressure was 125 ±26 mmHg in the CG compared to 148 ±42 mmHg in the GDEX. There was also a reduction of 73% in the consumption of fentanyl and 29% in the rate of propofol. Also, the visual bleeding score was higher in the GDEX. In conclusion, the association of dexmedetomidine to the protocol decreased the rate of propofol and improved the intraoperative analgesia of bitches undergoing castration. |
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Total intravenous anesthesia with propofol and dexmedetomidine in bitches submitted to ovary-hysterectomyAnestesia intravenosa total con propofol y dexmedetomidina en perras sometidas a ovario-histerectomiaAnestesia total intravenosa com propofol e dexmedetomidina em cadelas submetidas à ovário-histerectomiaAgonistas alfa-2Anestesia IntravenosaCãesAdjuvantesBradicardia.Alpha-2 agonistIntravenous AnaesthesiaDogsAdjuvantsBradycardia.Agonistas alfa-2Anestesia IntravenosaPerrosAdyuvantesBradicardia.Total intravenous anesthesia is widely used in dogs, and the addition of adjuvants aims to complement analgesia and reduce the doses of propofol used. This study aimed to evaluate the association of dexmedetomidine and propofol in total intravenous anesthesia in dogs. Fifteen adults, healthy bitches weighing 13.8 ±4.7 kg were selected. After premedication with acepromazine and methadone. They were allocated to two groups: GDEX (n = 8) were administered dexmedetomidine (2 µg/kg bolus + 1 µg/kg/h IV) or control GC (n = 7) with saline, and then administered propofol to both groups. The animals were maintained on propofol, adjusted to the anesthetic plane, and supplemented with 100% oxygen. The following were evaluated: induction scale, electrocardiogram, heart and respiratory rates, systolic blood pressure with Doppler, end-tidal carbon dioxide pressure, and peripheral oxygen saturation. When necessary, fentanyl (2.5 µg/kg IV) was administered. In the end, propofol rate, fentanyl consumption, surgical time, extubation, anesthetic discharge, and bleeding score were recorded. There was a mean reduction of 46% in heart rate after administration of dexmedetomidine. At the same time after induction, the systolic blood pressure was 125 ±26 mmHg in the CG compared to 148 ±42 mmHg in the GDEX. There was also a reduction of 73% in the consumption of fentanyl and 29% in the rate of propofol. Also, the visual bleeding score was higher in the GDEX. In conclusion, the association of dexmedetomidine to the protocol decreased the rate of propofol and improved the intraoperative analgesia of bitches undergoing castration.La anestesia intravenosa es utilizada en perros y la adición de adyuvantes complementa la analgesia y reduce el propofol. El objetivo fue evaluar la asociación de dexmedetomidina y propofol en perros. Se seleccionaron quince adultas sanas con 8 ± 4,7 kg. Pre medicado con acepromacina y metadona asignada a los grupos GDEX (n = 8) administró dexmedetomidina (2 µg/kg bolo + 1 µg/kg/h IV) y GC control (n = 7) con solución salina, luego se administró propofol. Los animales se mantuvieron con propofol, ajustados al plano anestésico y suplementados con oxígeno. Se evaluaron: inducción, electrocardiograma, frecuencia cardiaca y respiratoria, presión arterial sistólica con Doppler, presión de dióxido de carbono al final de la espiración y saturación periférica de oxígeno. Cuando fue necesario, se administró fentanilo (2,5 µg/kg IV). Al final se registró lo consumo de prpoofol y fentanilo, tiempo quirúrgico, extubación, alta anestésica y puntaje de sangrado. Hubo una reducción media del 46% en la frecuencia cardíaca después de la administración de dexmedetomidina. Al mismo tiempo, después de la inducción, la presión arterial sistólica fue de 125 ±26 mmHg en el GC en comparación con 148 ±42 mmHg en el GDEX. También hubo una reducción del 73% en el consumo de fentanilo y 29% de propofol, la puntuación de sangrado visual fue mayor en el GDEX. Se concluye que la asociación de dexmedetomidina al protocolo disminuyó la tasa de propofol y mejoró la analgesia intraoperatoria de las perras.A anestesia intravenosa é amplamente emprega em cães e a adição de adjuvantes complementa a analgesia e reduz doses de propofol empregadas. O objetivo deste estudo foi avaliar a associação da dexmedetomidina ao propofol na anestesia intravenosa em cães. Foram selecionadas 15 cadelas, adultas, hígidas, pesando 13,8 ±4,7 kg. Após pré-medicação com acepromazina e metadona, foram distribuídas nos grupos GDEX (n = 8) em que foi administrada dexmedetomidina (2 µg/kg em bolus + 1 µg/kg/h IV) ou controle GC (n = 7), com salina no mesmo volume, para então administrar propofol em ambos grupos. Os animais foram mantidos com propofol ajustando-se a taxa ao plano anestésico e suplementados com oxigênio à 100%. Foram avaliados: escala de indução, eletrocardiograma, frequências cardíaca e respiratória, pressão arterial sistólica com doppler, pressão de gás carbônico expirado e saturação de oxigênio periférico. Quando necessário foi administrado fentanil (2,5 µg/kg IV). Ao final, foram contabilizados a taxa de propofol, consumo de fentanil, tempo cirúrgico, extubação, alta anestésica e escore de sangramento. Houve redução média de 46% de na frequência cardíaca após administração de dexmedetomidina. Ao mesmo tempo que após indução a pressão arterial sistólica foi de 125 ±26 mmHg no GC comparada 148 ±42 mmHg em GDEX. Houve também, redução de 73% no consumo de fentanil e 29% na taxa de propofol. Ainda, o escore visual de sangramento foi maior no GDEX. Conclui- se que a associação da dexmedetomidina ao protocolo diminuiu a taxa de propofol e melhorou a analgesia transoperatória de cadelas submetidas à castração.Research, Society and Development2022-04-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2800410.33448/rsd-v11i5.28004Research, Society and Development; Vol. 11 No. 5; e25411528004Research, Society and Development; Vol. 11 Núm. 5; e25411528004Research, Society and Development; v. 11 n. 5; e254115280042525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/28004/24532Copyright (c) 2022 Gustavo Antônio Boff; Bárbara Machado Naspolini; Ana Cristina Kalb; Bruna Pires; Camila Moura de Lima; Thomas Normanton Guim; Márcia Oliveira Nobre; Martielo Ivan Gehrckehttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessBoff, Gustavo AntônioNaspolini, Bárbara MachadoKalb, Ana CristinaPires, BrunaLima, Camila Moura deGuim, Thomas Normanton Nobre, Márcia OliveiraGehrcke, Martielo Ivan2022-04-17T18:18:56Zoai:ojs.pkp.sfu.ca:article/28004Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:45:33.671713Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Total intravenous anesthesia with propofol and dexmedetomidine in bitches submitted to ovary-hysterectomy Anestesia intravenosa total con propofol y dexmedetomidina en perras sometidas a ovario-histerectomia Anestesia total intravenosa com propofol e dexmedetomidina em cadelas submetidas à ovário-histerectomia |
title |
Total intravenous anesthesia with propofol and dexmedetomidine in bitches submitted to ovary-hysterectomy |
spellingShingle |
Total intravenous anesthesia with propofol and dexmedetomidine in bitches submitted to ovary-hysterectomy Boff, Gustavo Antônio Agonistas alfa-2 Anestesia Intravenosa Cães Adjuvantes Bradicardia. Alpha-2 agonist Intravenous Anaesthesia Dogs Adjuvants Bradycardia. Agonistas alfa-2 Anestesia Intravenosa Perros Adyuvantes Bradicardia. |
title_short |
Total intravenous anesthesia with propofol and dexmedetomidine in bitches submitted to ovary-hysterectomy |
title_full |
Total intravenous anesthesia with propofol and dexmedetomidine in bitches submitted to ovary-hysterectomy |
title_fullStr |
Total intravenous anesthesia with propofol and dexmedetomidine in bitches submitted to ovary-hysterectomy |
title_full_unstemmed |
Total intravenous anesthesia with propofol and dexmedetomidine in bitches submitted to ovary-hysterectomy |
title_sort |
Total intravenous anesthesia with propofol and dexmedetomidine in bitches submitted to ovary-hysterectomy |
author |
Boff, Gustavo Antônio |
author_facet |
Boff, Gustavo Antônio Naspolini, Bárbara Machado Kalb, Ana Cristina Pires, Bruna Lima, Camila Moura de Guim, Thomas Normanton Nobre, Márcia Oliveira Gehrcke, Martielo Ivan |
author_role |
author |
author2 |
Naspolini, Bárbara Machado Kalb, Ana Cristina Pires, Bruna Lima, Camila Moura de Guim, Thomas Normanton Nobre, Márcia Oliveira Gehrcke, Martielo Ivan |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Boff, Gustavo Antônio Naspolini, Bárbara Machado Kalb, Ana Cristina Pires, Bruna Lima, Camila Moura de Guim, Thomas Normanton Nobre, Márcia Oliveira Gehrcke, Martielo Ivan |
dc.subject.por.fl_str_mv |
Agonistas alfa-2 Anestesia Intravenosa Cães Adjuvantes Bradicardia. Alpha-2 agonist Intravenous Anaesthesia Dogs Adjuvants Bradycardia. Agonistas alfa-2 Anestesia Intravenosa Perros Adyuvantes Bradicardia. |
topic |
Agonistas alfa-2 Anestesia Intravenosa Cães Adjuvantes Bradicardia. Alpha-2 agonist Intravenous Anaesthesia Dogs Adjuvants Bradycardia. Agonistas alfa-2 Anestesia Intravenosa Perros Adyuvantes Bradicardia. |
description |
Total intravenous anesthesia is widely used in dogs, and the addition of adjuvants aims to complement analgesia and reduce the doses of propofol used. This study aimed to evaluate the association of dexmedetomidine and propofol in total intravenous anesthesia in dogs. Fifteen adults, healthy bitches weighing 13.8 ±4.7 kg were selected. After premedication with acepromazine and methadone. They were allocated to two groups: GDEX (n = 8) were administered dexmedetomidine (2 µg/kg bolus + 1 µg/kg/h IV) or control GC (n = 7) with saline, and then administered propofol to both groups. The animals were maintained on propofol, adjusted to the anesthetic plane, and supplemented with 100% oxygen. The following were evaluated: induction scale, electrocardiogram, heart and respiratory rates, systolic blood pressure with Doppler, end-tidal carbon dioxide pressure, and peripheral oxygen saturation. When necessary, fentanyl (2.5 µg/kg IV) was administered. In the end, propofol rate, fentanyl consumption, surgical time, extubation, anesthetic discharge, and bleeding score were recorded. There was a mean reduction of 46% in heart rate after administration of dexmedetomidine. At the same time after induction, the systolic blood pressure was 125 ±26 mmHg in the CG compared to 148 ±42 mmHg in the GDEX. There was also a reduction of 73% in the consumption of fentanyl and 29% in the rate of propofol. Also, the visual bleeding score was higher in the GDEX. In conclusion, the association of dexmedetomidine to the protocol decreased the rate of propofol and improved the intraoperative analgesia of bitches undergoing castration. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-04-05 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/28004 10.33448/rsd-v11i5.28004 |
url |
https://rsdjournal.org/index.php/rsd/article/view/28004 |
identifier_str_mv |
10.33448/rsd-v11i5.28004 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/28004/24532 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 5; e25411528004 Research, Society and Development; Vol. 11 Núm. 5; e25411528004 Research, Society and Development; v. 11 n. 5; e25411528004 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052794023182336 |