Comparison of cardiorespiratory effects and perioperative analgesia efficacy of dexmedetomidine or fentanyl continuous infusion during ovariohysterectomy in propofol-anesthetized dogs
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/43594 |
Resumo: | The present study aimed to compare the cardiorespiratory, perioperative analgesic and blood gas analysis of the constant rate infusion of dexmedetomidine or fentanyl in 16 female dogs undergoing to elective ovariohysterectomy. The dogs were premedicated with morphine (0.5 mg/kg) and dexmedetomidine (5 µg/kg) or acepromazine (0.05 mg/kg), both intramuscularly (IM), in GDEX or GFEN, respectively. After anesthesia induction with propofol intravenously (IV), animals of GFEN received bolus of fentanyl (2.5 µg/kg) IV followed by continuous rate infusion (CRI) (10 µg/kg/h) and the GDEX received bolus of saline solution 0.9% (corresponding volume of fentanyl) followed by CRI of dexmedetomidine (1 µg/kg/h) and anesthesia was maintained with propofol (0.22 mg/kg/min). In the end of surgery all animals were evaluated using the Glasgow composite measure pain scale (GCPS) and a visual analogue scale (VAS). Data was compared with a statistical p value > 0,05. The mean heart rate was statistically lower in GDEX when compared to GFEN (p = 0.0498): 54.25 ± 3.919 and 88.38 ± 8.766 beats per minute, respectively. Opposed, the average mean blood pressure was statistically higher in GDEX when compared to GFEN (p = 0.0021): 99.38 ± 8.551 and 80.75 ± 11.12 mmHg, respectively. The GDEX and GFEN, in the firsts 4 and 2 postoperative hours, respectively, presented values significantly higher than baseline in the GCPS, occurring analgesic rescues for both groups. It is concluded that both drugs in the proposed rates were safe and efficient for nociceptive control during intraoperative, however, failed to promote efficient postoperative analgesia. |
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Comparison of cardiorespiratory effects and perioperative analgesia efficacy of dexmedetomidine or fentanyl continuous infusion during ovariohysterectomy in propofol-anesthetized dogsComparación de los efectos cardiorrespiratorios y la eficacia analgésica perioperatoria de la infusión continua de dexmedetomidina o fentanilo durante la ovariohisterectomía en perras anestesiadas con propofolComparação dos efeitos cardiorrespiratórios e eficácia analgésica perioperatória da infusão contínua de dexmedetomidina ou fentanil durante a ovariohisterectomia de cadelas anestesiadas com propofolAnestesia intravenosa totalDexmedetomidinaFentaniloPerroPropofol.Anestesia total intravenosaCachorroDexmedetomidinaFentanilPropofol.DexmedetomidineFentanylDogsPropofolTotal intravenous anesthesia.The present study aimed to compare the cardiorespiratory, perioperative analgesic and blood gas analysis of the constant rate infusion of dexmedetomidine or fentanyl in 16 female dogs undergoing to elective ovariohysterectomy. The dogs were premedicated with morphine (0.5 mg/kg) and dexmedetomidine (5 µg/kg) or acepromazine (0.05 mg/kg), both intramuscularly (IM), in GDEX or GFEN, respectively. After anesthesia induction with propofol intravenously (IV), animals of GFEN received bolus of fentanyl (2.5 µg/kg) IV followed by continuous rate infusion (CRI) (10 µg/kg/h) and the GDEX received bolus of saline solution 0.9% (corresponding volume of fentanyl) followed by CRI of dexmedetomidine (1 µg/kg/h) and anesthesia was maintained with propofol (0.22 mg/kg/min). In the end of surgery all animals were evaluated using the Glasgow composite measure pain scale (GCPS) and a visual analogue scale (VAS). Data was compared with a statistical p value > 0,05. The mean heart rate was statistically lower in GDEX when compared to GFEN (p = 0.0498): 54.25 ± 3.919 and 88.38 ± 8.766 beats per minute, respectively. Opposed, the average mean blood pressure was statistically higher in GDEX when compared to GFEN (p = 0.0021): 99.38 ± 8.551 and 80.75 ± 11.12 mmHg, respectively. The GDEX and GFEN, in the firsts 4 and 2 postoperative hours, respectively, presented values significantly higher than baseline in the GCPS, occurring analgesic rescues for both groups. It is concluded that both drugs in the proposed rates were safe and efficient for nociceptive control during intraoperative, however, failed to promote efficient postoperative analgesia.El objetivo del estudio era comparar los efectos cardiorrespiratorios, analgésicos perioperatorios y hemogasométricos de 16 perras sometidas a ovariohisterectomía electiva bajo infusión continua de dexmedetomidina o fentanilo. Las perras fueron premedicadas con morfina (0,5 mg/kg) y dexmedemidina (5 µg/kg) o acepromacina (0,05 mg/kg), intramuscular (IM), en GDEX o GFEN, respectivamente. Tras la inducción anestésica con propofol intravenoso (IV), los animales de GFEN recibieron un bolo de fentanilo (2,5 µg/kg) IV seguido de infusión continua (IC) (10 µg/kg/h) y los de GDEX recibieron un bolo de solución salina al 0,9% (volumen correspondiente de fentanilo) seguido de dexmedetomidina IC (1 µg/kg/h) y la anestesia se mantuvo con propofol (0,22 mg/kg/min). Al final del procedimiento, todos los animales fueron evaluados mediante la Glasgow Composite Pain Scale (GCPS) y la Visual Analogue Scale (VAS). Los datos se compararon con un valor estadístico de p > 0,05. La frecuencia cardiaca media fue estadísticamente inferior en GDEX en comparación con GFEN (p = 0,0498): 54,25 ± 3,919 y 88,38 ± 8,766 latidos por minuto, respectivamente. Por el contrario, la presión arterial media final fue significativamente mayor en GDEX que en GFEN (p = 0,0021): 99,38 ± 8,551 y 80,75 ± 11,12 mmHg, respectivamente. GDEX y GFEN, en las primeras 4 y 2 horas del postoperatorio, respectivamente, presentaron puntuaciones estadísticamente superiores a las basales por GCPS, produciéndose rescate analgésico en ambos grupos. Concluimos que ambos fármacos en las dosis propuestas fueron seguros y eficaces en el control nociceptivo intraoperatorio; sin embargo, no consiguieron promover la analgesia postoperatoria.O estudo objetivou comparar os efeitos cardiorrespiratórios, analgésicos perioperativos e hemogasométricos de 16 cadelas submetidas a ovariohisterectomia eletiva sob infusão contínua de dexmedetomidina ou fentanil. Os cães foram pré-medicados com morfina (0,5 mg/kg) e dexmedemidina (5 µg/kg) ou acepromazina (0,05 mg/kg), ambos intramuscular (IM), no GDEX ou GFEN, respectivamente. Depois na indução anestésica com propofol intravenoso (IV), os animais do GFEN receberam bolus de fentanil (2,5 µg/kg) IV seguido de infusão contínua (IC) (10 µg/kg/h) e o GDEX recebeu bolus de solução salina 0,9% (volume correspondente de fentanil) seguido de IC de dexmedetomidina (1 µg/kg/h) e a anestesia foi mantida com propofol (0,22 mg/kg/min). Ao final do procedimento todos os animais foram avaliados usando a Escala composta de dor de Glasgow (GCPS) e a Escala analógica visual (VAS). Os dados foram comparados com um valor estatística de p > 0,05. A média da frequência cardíaca foi estatisticamente menor no GDEX quando comparado ao GFEN (p = 0,0498): 54,25 ± 3,919 e 88,38 ± 8,766 batimentos por minuto, respectivamente. Em oposição, a média final da pressão arterial média foi estatisticamente maior no GDEX quando comparado ao GFEN (p = 0,0021): 99,38 ± 8,551 e 80,75 ± 11,12 mmHg, respectivamente. O GDEX e GFEN, nas primeiras 4 e 2 horas de pós-operatório, respectivamente, apresentaram escores estatisticamente maiores que o basal pela GCPS, ocorrendo resgate analgésico em ambos os grupos. Conclui-se que ambos os fármacos nas taxas propostas foram seguros e eficientes no controle nociceptivo intraoperatório, no entanto, falharam em promover analgesia pós-operatória.Research, Society and Development2023-11-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4359410.33448/rsd-v12i13.43594Research, Society and Development; Vol. 12 No. 13; e17121343594Research, Society and Development; Vol. 12 Núm. 13; e17121343594Research, Society and Development; v. 12 n. 13; e171213435942525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/43594/35409Copyright (c) 2023 Gabriela Conterno; Felipe Comassetto; Murilo Gabriel Consolim; Ronise Tocheto; Nilson Oleskoviczhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessConterno, GabrielaComassetto, FelipeConsolim, Murilo Gabriel Tocheto, RoniseOleskovicz, Nilson2023-12-11T09:52:06Zoai:ojs.pkp.sfu.ca:article/43594Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-12-11T09:52:06Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Comparison of cardiorespiratory effects and perioperative analgesia efficacy of dexmedetomidine or fentanyl continuous infusion during ovariohysterectomy in propofol-anesthetized dogs Comparación de los efectos cardiorrespiratorios y la eficacia analgésica perioperatoria de la infusión continua de dexmedetomidina o fentanilo durante la ovariohisterectomía en perras anestesiadas con propofol Comparação dos efeitos cardiorrespiratórios e eficácia analgésica perioperatória da infusão contínua de dexmedetomidina ou fentanil durante a ovariohisterectomia de cadelas anestesiadas com propofol |
title |
Comparison of cardiorespiratory effects and perioperative analgesia efficacy of dexmedetomidine or fentanyl continuous infusion during ovariohysterectomy in propofol-anesthetized dogs |
spellingShingle |
Comparison of cardiorespiratory effects and perioperative analgesia efficacy of dexmedetomidine or fentanyl continuous infusion during ovariohysterectomy in propofol-anesthetized dogs Conterno, Gabriela Anestesia intravenosa total Dexmedetomidina Fentanilo Perro Propofol. Anestesia total intravenosa Cachorro Dexmedetomidina Fentanil Propofol. Dexmedetomidine Fentanyl Dogs Propofol Total intravenous anesthesia. |
title_short |
Comparison of cardiorespiratory effects and perioperative analgesia efficacy of dexmedetomidine or fentanyl continuous infusion during ovariohysterectomy in propofol-anesthetized dogs |
title_full |
Comparison of cardiorespiratory effects and perioperative analgesia efficacy of dexmedetomidine or fentanyl continuous infusion during ovariohysterectomy in propofol-anesthetized dogs |
title_fullStr |
Comparison of cardiorespiratory effects and perioperative analgesia efficacy of dexmedetomidine or fentanyl continuous infusion during ovariohysterectomy in propofol-anesthetized dogs |
title_full_unstemmed |
Comparison of cardiorespiratory effects and perioperative analgesia efficacy of dexmedetomidine or fentanyl continuous infusion during ovariohysterectomy in propofol-anesthetized dogs |
title_sort |
Comparison of cardiorespiratory effects and perioperative analgesia efficacy of dexmedetomidine or fentanyl continuous infusion during ovariohysterectomy in propofol-anesthetized dogs |
author |
Conterno, Gabriela |
author_facet |
Conterno, Gabriela Comassetto, Felipe Consolim, Murilo Gabriel Tocheto, Ronise Oleskovicz, Nilson |
author_role |
author |
author2 |
Comassetto, Felipe Consolim, Murilo Gabriel Tocheto, Ronise Oleskovicz, Nilson |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Conterno, Gabriela Comassetto, Felipe Consolim, Murilo Gabriel Tocheto, Ronise Oleskovicz, Nilson |
dc.subject.por.fl_str_mv |
Anestesia intravenosa total Dexmedetomidina Fentanilo Perro Propofol. Anestesia total intravenosa Cachorro Dexmedetomidina Fentanil Propofol. Dexmedetomidine Fentanyl Dogs Propofol Total intravenous anesthesia. |
topic |
Anestesia intravenosa total Dexmedetomidina Fentanilo Perro Propofol. Anestesia total intravenosa Cachorro Dexmedetomidina Fentanil Propofol. Dexmedetomidine Fentanyl Dogs Propofol Total intravenous anesthesia. |
description |
The present study aimed to compare the cardiorespiratory, perioperative analgesic and blood gas analysis of the constant rate infusion of dexmedetomidine or fentanyl in 16 female dogs undergoing to elective ovariohysterectomy. The dogs were premedicated with morphine (0.5 mg/kg) and dexmedetomidine (5 µg/kg) or acepromazine (0.05 mg/kg), both intramuscularly (IM), in GDEX or GFEN, respectively. After anesthesia induction with propofol intravenously (IV), animals of GFEN received bolus of fentanyl (2.5 µg/kg) IV followed by continuous rate infusion (CRI) (10 µg/kg/h) and the GDEX received bolus of saline solution 0.9% (corresponding volume of fentanyl) followed by CRI of dexmedetomidine (1 µg/kg/h) and anesthesia was maintained with propofol (0.22 mg/kg/min). In the end of surgery all animals were evaluated using the Glasgow composite measure pain scale (GCPS) and a visual analogue scale (VAS). Data was compared with a statistical p value > 0,05. The mean heart rate was statistically lower in GDEX when compared to GFEN (p = 0.0498): 54.25 ± 3.919 and 88.38 ± 8.766 beats per minute, respectively. Opposed, the average mean blood pressure was statistically higher in GDEX when compared to GFEN (p = 0.0021): 99.38 ± 8.551 and 80.75 ± 11.12 mmHg, respectively. The GDEX and GFEN, in the firsts 4 and 2 postoperative hours, respectively, presented values significantly higher than baseline in the GCPS, occurring analgesic rescues for both groups. It is concluded that both drugs in the proposed rates were safe and efficient for nociceptive control during intraoperative, however, failed to promote efficient postoperative analgesia. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-11-25 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/43594 10.33448/rsd-v12i13.43594 |
url |
https://rsdjournal.org/index.php/rsd/article/view/43594 |
identifier_str_mv |
10.33448/rsd-v12i13.43594 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/43594/35409 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 12 No. 13; e17121343594 Research, Society and Development; Vol. 12 Núm. 13; e17121343594 Research, Society and Development; v. 12 n. 13; e17121343594 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052632330665984 |