Evaluación de la citotoxicidad, genotoxicidad y toxicidad subcrónica de diésteres p-metoxicinámicos extraídos de Copernicia prunifera (Miller) H. E. Moore en modelo experimental
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/6251 |
Resumo: | P-methoxycinnamic diesters from carnauba wax powder (PCO - C) – cinnamic acid derivate – have been associated with new properties such as hypolipidemic, hypocholesterolemic and hypoglycaemic effects in mice. The present study aimed to investigate the safety profile of PCO - C by evaluating the subchronic oral toxicity, genotoxicity and mutagenicity using in vivo experimental models. Therefore, for the present research, characterized as experimental and of a quantitative nature, 80 Swiss mice, of both genders, were used for the analysis of mutagenicity, genotoxicity, analysis of the biochemical, hematological and toxicological profiles. PCO - C did not induce changes in the mass of animals besides not interfering in blood parameters. PCO - C showed no hemolysis of mouse erythrocytes. PCO - C caused no mutagenic or genotoxic effects in male and female mice treated with 500 mg/Kg/day during 90 days. In addition, PCO - C did not change some important serum parameters (alanine aminotransferase, aspartate aminotransferase, total cholesterol and creatinine), hematological profile, structural arrangement of the kidneys, heart, stomach and spleen. The results demonstrate that PCO - C is not genotoxic, and did not present toxicity when used orally for up to 90 days. Overall, the study has demonstrated the safety of PCO - C for potential uses in biomedical areas. |
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Evaluación de la citotoxicidad, genotoxicidad y toxicidad subcrónica de diésteres p-metoxicinámicos extraídos de Copernicia prunifera (Miller) H. E. Moore en modelo experimentalEvaluación de la citotoxicidad, genotoxicidad y toxicidad subcrónica de diésteres p-metoxicinámicos extraídos de Copernicia prunifera (Miller) H. E. Moore en modelo experimentalAvaliação da citotoxicidade, genotoxicidade e toxicidade subcrônica de diésteres p-metoxicinâmicos extraídos de Copernicia prunifera (Miller) H.E. Moore em modelo experimentalCarnauba waxP-methoxycinnamic diestersSubchronic oral toxicityMicronuclei.Cera de carnaubaDiésteres p-metoxicinámicosToxicidad oral subcrónicaMicronúcleos.Cera de carnaubaDiésteres p-metoxicinâmicosToxicidade oral subcrônicaMicronúcleos.P-methoxycinnamic diesters from carnauba wax powder (PCO - C) – cinnamic acid derivate – have been associated with new properties such as hypolipidemic, hypocholesterolemic and hypoglycaemic effects in mice. The present study aimed to investigate the safety profile of PCO - C by evaluating the subchronic oral toxicity, genotoxicity and mutagenicity using in vivo experimental models. Therefore, for the present research, characterized as experimental and of a quantitative nature, 80 Swiss mice, of both genders, were used for the analysis of mutagenicity, genotoxicity, analysis of the biochemical, hematological and toxicological profiles. PCO - C did not induce changes in the mass of animals besides not interfering in blood parameters. PCO - C showed no hemolysis of mouse erythrocytes. PCO - C caused no mutagenic or genotoxic effects in male and female mice treated with 500 mg/Kg/day during 90 days. In addition, PCO - C did not change some important serum parameters (alanine aminotransferase, aspartate aminotransferase, total cholesterol and creatinine), hematological profile, structural arrangement of the kidneys, heart, stomach and spleen. The results demonstrate that PCO - C is not genotoxic, and did not present toxicity when used orally for up to 90 days. Overall, the study has demonstrated the safety of PCO - C for potential uses in biomedical areas.Los diésteres P-metoxicinámicos del polvo de cera de carnauba (PCO-C), derivado del ácido cinámico, se han asociado con nuevas propiedades como los efectos hipolipidémicos, hipocolesterolémicos e hipoglucémicos en ratones. El presente estudio tuvo como objetivo investigar el perfil de seguridad de PCO - C mediante la evaluación de la toxicidad oral subcrónica, genotoxicidad y mutagenicidad utilizando modelos experimentales in vivo. Por lo tanto, para la presente investigación, caracterizada como experimental y de naturaleza cuantitativa, se utilizaron 80 ratones suizos, de ambos sexos, para el análisis de mutagenicidad, genotoxicidad, análisis de los perfiles bioquímicos, hematológicos y toxicológicos. PCO - C no indujo cambios en la masa de los animales además de no interferir en los parámetros sanguíneos. PCO - C no mostró hemólisis de eritrocitos de ratón. PCO - C no causó efectos mutagénicos o genotóxicos en ratones machos y hembras tratados con 500 mg / Kg / día durante 90 días. Además, PCO - C no cambió algunos parámetros importantes del suero (alanina aminotransferasa, aspartato aminotransferasa, colesterol total y creatinina), perfil hematológico, disposición estructural de los riñones, el corazón, el estómago y el bazo. Los resultados demuestran que PCO - C no es genotóxico y no presentó toxicidad cuando se usó por vía oral durante un máximo de 90 días. En general, el estudio ha demostrado la seguridad de PCO - C para usos potenciales en áreas biomédicas.Os diésteres p-metoxicinâmicos do pó de cera de carnaúba (PCO - C) - derivado do ácido cinâmico - foram associados a novas propriedades, como efeitos hipolipidêmicos, hipocolesterolêmicos e hipoglicêmicos em camundongos. O presente estudo teve como objetivo investigar o perfil de segurança da PCO - C, avaliando a toxicidade oral subcrônica, genotoxicidade e mutagenicidade usando modelos experimentais in vivo. Portanto, para a presente pesquisa, caracterizada como experimental e de natureza quantitativa, foram utilizados 80 camundongos Swiss, de ambos os gêneros, para a análise de mutagenicidade, genotoxicidade, análises dos perfis bioquímico, hematológico e toxicológico. O PCO - C não induziu alterações na massa de animais, além de não interferir nos parâmetros sanguíneos. PCO - C não mostrou hemólise de eritrócitos de camundongo. O PCO - C não causou efeitos mutagênicos ou genotóxicos em camundongos machos e fêmeas tratados com 500 mg / kg / dia durante 90 dias. Além disso, a PCO - C não alterou alguns parâmetros séricos importantes (alanina aminotransferase, aspartato aminotransferase, colesterol total e creatinina), perfil hematológico, disposição estrutural dos rins, coração, estômago e baço. Os resultados demonstram que o PCO - C não é genotóxico e não apresentou toxicidade quando usado por via oral por até 90 dias. No geral, o estudo demonstrou a segurança do PCO - C para possíveis usos em áreas biomédicas.Research, Society and Development2020-07-30info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/625110.33448/rsd-v9i8.6251Research, Society and Development; Vol. 9 No. 8; e603986251Research, Society and Development; Vol. 9 Núm. 8; e603986251Research, Society and Development; v. 9 n. 8; e6039862512525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/6251/5264Copyright (c) 2020 Bruno Bezerra da Silva, Jose Ytalo Gomes da Silva, Natália do Vale Canabrava, Marcelo Oliveira Holanda, Carla Laine Silva Lima, Eridan Orlando Pereira Tramontina Florean, Icaro Gusmão Pinto Vieira, Márcia Maria Mendes Marques, Maria Izabel Florindo Guedeshttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessCanabrava, Natália do ValeSilva, Jose Ytalo Gomes daSilva, Bruno Bezerra daHolanda, Marcelo OliveiraLima, Carla Laine SilvaFlorean, Eridan Orlando Pereira TramontinaVieira, Icaro Gusmão PintoMarques, Márcia Maria MendesGuedes, Maria Izabel Florindo2020-08-20T18:00:17Zoai:ojs.pkp.sfu.ca:article/6251Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:29:27.968025Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Evaluación de la citotoxicidad, genotoxicidad y toxicidad subcrónica de diésteres p-metoxicinámicos extraídos de Copernicia prunifera (Miller) H. E. Moore en modelo experimental Evaluación de la citotoxicidad, genotoxicidad y toxicidad subcrónica de diésteres p-metoxicinámicos extraídos de Copernicia prunifera (Miller) H. E. Moore en modelo experimental Avaliação da citotoxicidade, genotoxicidade e toxicidade subcrônica de diésteres p-metoxicinâmicos extraídos de Copernicia prunifera (Miller) H.E. Moore em modelo experimental |
| title |
Evaluación de la citotoxicidad, genotoxicidad y toxicidad subcrónica de diésteres p-metoxicinámicos extraídos de Copernicia prunifera (Miller) H. E. Moore en modelo experimental |
| spellingShingle |
Evaluación de la citotoxicidad, genotoxicidad y toxicidad subcrónica de diésteres p-metoxicinámicos extraídos de Copernicia prunifera (Miller) H. E. Moore en modelo experimental Canabrava, Natália do Vale Carnauba wax P-methoxycinnamic diesters Subchronic oral toxicity Micronuclei. Cera de carnauba Diésteres p-metoxicinámicos Toxicidad oral subcrónica Micronúcleos. Cera de carnauba Diésteres p-metoxicinâmicos Toxicidade oral subcrônica Micronúcleos. |
| title_short |
Evaluación de la citotoxicidad, genotoxicidad y toxicidad subcrónica de diésteres p-metoxicinámicos extraídos de Copernicia prunifera (Miller) H. E. Moore en modelo experimental |
| title_full |
Evaluación de la citotoxicidad, genotoxicidad y toxicidad subcrónica de diésteres p-metoxicinámicos extraídos de Copernicia prunifera (Miller) H. E. Moore en modelo experimental |
| title_fullStr |
Evaluación de la citotoxicidad, genotoxicidad y toxicidad subcrónica de diésteres p-metoxicinámicos extraídos de Copernicia prunifera (Miller) H. E. Moore en modelo experimental |
| title_full_unstemmed |
Evaluación de la citotoxicidad, genotoxicidad y toxicidad subcrónica de diésteres p-metoxicinámicos extraídos de Copernicia prunifera (Miller) H. E. Moore en modelo experimental |
| title_sort |
Evaluación de la citotoxicidad, genotoxicidad y toxicidad subcrónica de diésteres p-metoxicinámicos extraídos de Copernicia prunifera (Miller) H. E. Moore en modelo experimental |
| author |
Canabrava, Natália do Vale |
| author_facet |
Canabrava, Natália do Vale Silva, Jose Ytalo Gomes da Silva, Bruno Bezerra da Holanda, Marcelo Oliveira Lima, Carla Laine Silva Florean, Eridan Orlando Pereira Tramontina Vieira, Icaro Gusmão Pinto Marques, Márcia Maria Mendes Guedes, Maria Izabel Florindo |
| author_role |
author |
| author2 |
Silva, Jose Ytalo Gomes da Silva, Bruno Bezerra da Holanda, Marcelo Oliveira Lima, Carla Laine Silva Florean, Eridan Orlando Pereira Tramontina Vieira, Icaro Gusmão Pinto Marques, Márcia Maria Mendes Guedes, Maria Izabel Florindo |
| author2_role |
author author author author author author author author |
| dc.contributor.author.fl_str_mv |
Canabrava, Natália do Vale Silva, Jose Ytalo Gomes da Silva, Bruno Bezerra da Holanda, Marcelo Oliveira Lima, Carla Laine Silva Florean, Eridan Orlando Pereira Tramontina Vieira, Icaro Gusmão Pinto Marques, Márcia Maria Mendes Guedes, Maria Izabel Florindo |
| dc.subject.por.fl_str_mv |
Carnauba wax P-methoxycinnamic diesters Subchronic oral toxicity Micronuclei. Cera de carnauba Diésteres p-metoxicinámicos Toxicidad oral subcrónica Micronúcleos. Cera de carnauba Diésteres p-metoxicinâmicos Toxicidade oral subcrônica Micronúcleos. |
| topic |
Carnauba wax P-methoxycinnamic diesters Subchronic oral toxicity Micronuclei. Cera de carnauba Diésteres p-metoxicinámicos Toxicidad oral subcrónica Micronúcleos. Cera de carnauba Diésteres p-metoxicinâmicos Toxicidade oral subcrônica Micronúcleos. |
| description |
P-methoxycinnamic diesters from carnauba wax powder (PCO - C) – cinnamic acid derivate – have been associated with new properties such as hypolipidemic, hypocholesterolemic and hypoglycaemic effects in mice. The present study aimed to investigate the safety profile of PCO - C by evaluating the subchronic oral toxicity, genotoxicity and mutagenicity using in vivo experimental models. Therefore, for the present research, characterized as experimental and of a quantitative nature, 80 Swiss mice, of both genders, were used for the analysis of mutagenicity, genotoxicity, analysis of the biochemical, hematological and toxicological profiles. PCO - C did not induce changes in the mass of animals besides not interfering in blood parameters. PCO - C showed no hemolysis of mouse erythrocytes. PCO - C caused no mutagenic or genotoxic effects in male and female mice treated with 500 mg/Kg/day during 90 days. In addition, PCO - C did not change some important serum parameters (alanine aminotransferase, aspartate aminotransferase, total cholesterol and creatinine), hematological profile, structural arrangement of the kidneys, heart, stomach and spleen. The results demonstrate that PCO - C is not genotoxic, and did not present toxicity when used orally for up to 90 days. Overall, the study has demonstrated the safety of PCO - C for potential uses in biomedical areas. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-07-30 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://rsdjournal.org/index.php/rsd/article/view/6251 10.33448/rsd-v9i8.6251 |
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https://rsdjournal.org/index.php/rsd/article/view/6251 |
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10.33448/rsd-v9i8.6251 |
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eng |
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eng |
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https://rsdjournal.org/index.php/rsd/article/view/6251/5264 |
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http://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development; Vol. 9 No. 8; e603986251 Research, Society and Development; Vol. 9 Núm. 8; e603986251 Research, Society and Development; v. 9 n. 8; e603986251 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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