In silico evaluation of monoterpene ascaridol's antiprotozoal activity

Detalhes bibliográficos
Autor(a) principal: Fernandes, Viton Dyrk Guimarães
Data de Publicação: 2020
Outros Autores: Ribeiro, Ana Beatriz Bomfim Gomes, Holanda, Fabricio Rennan Silva de, Oliveira, Vinícius Filgueiras de, Anjos, Raline Mendonça dos, Alves, Maria Angélica Sátyro Gomes, Sousa, Aleson Pereira de, Oliveira Filho, Abrahão Alves de
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/6891
Resumo: This work aims to analyze in silico the antiprotozoal potential of Ascaridol. Using the free software PASS online® to evaluate the biological potential of the Ascaridol molecule, where this software provided the values of (Pa) probability of being active and (Pi) probability of being inactive of the compound in different pharmacological characteristics. Ascaridol showed a high probability of being active for the antiprotozoan (Pa= 0,790), Coccidial antiprotozoan (Pa= 0,476) and Leishimania antiprotozoan (Pa= 0,394). Such results corroborate with other studies proving that this compound present in several medicinal plants has great potential as an antiprotozoal agent, being a promising herbal agent.
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spelling In silico evaluation of monoterpene ascaridol's antiprotozoal activityEvaluación in silico de la actividad antiprotozoal del ascaridol de monoterpenoAvaliação in silico da atividade antiprotozoário do monoterpeno ascaridolAscaridolAntiprotozoarioFitoterapia.AscaridolAntiprotozoalHerbal medicine.AscaridolAntiprotozoárioFitoterapia.This work aims to analyze in silico the antiprotozoal potential of Ascaridol. Using the free software PASS online® to evaluate the biological potential of the Ascaridol molecule, where this software provided the values of (Pa) probability of being active and (Pi) probability of being inactive of the compound in different pharmacological characteristics. Ascaridol showed a high probability of being active for the antiprotozoan (Pa= 0,790), Coccidial antiprotozoan (Pa= 0,476) and Leishimania antiprotozoan (Pa= 0,394). Such results corroborate with other studies proving that this compound present in several medicinal plants has great potential as an antiprotozoal agent, being a promising herbal agent.Este trabajo tiene como objetivo analizar in silico el potencial antiprotozoario del ascaridol. Usando el software gratuito PASS online® para evaluar el potencial biológico de la molécula de Ascaridol, donde este software proporcionó los valores de (Pa) probabilidad de estar activo y (Pi) probabilidad de estar inactivo del compuesto en diferentes características farmacológicas. El ascaridol mostró una alta probabilidad de ser activo para el antiprotozoo (Pa= 0,790), el antiprotozoo coccidial (Pa= 0,476) y el antiprotozoo Leishimania (Pa= 0,394). Tales resultados corroboran con otros estudios que prueban que este compuesto presente en varias plantas medicinales tiene un gran potencial como agente antiprotozoario, siendo un agente herbal prometedor.Este trabalho tem como objetivo, analisar in silico o potencial antiprotozoário do Ascaridol. Utilizando o software gratuito PASS online® para avaliar o potencial biológico da molécula de Ascaridol, onde este software forneceu os valores de (Pa) probababilidade de ser ativo e (Pi) probabilidade de ser inativo do composto em diferentes características farmacológicas. O Ascaridol apresentou uma elevada probabilidade de ser ativo para as propriedades antiprotozoário (PA= 0,790), antiprotozoário Coccidial (PA= 0,476) e antiprotozoário Leishimania (PA= 0,394). Tais resultados corroboram com outros estudos comprovando que este composto presente em várias plantas medicinais possui um grande potencial como agente antiprotozoário, sendo um promissor agente fitoterápico.Research, Society and Development2020-08-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/689110.33448/rsd-v9i9.6891Research, Society and Development; Vol. 9 No. 9; e202996891Research, Society and Development; Vol. 9 Núm. 9; e202996891Research, Society and Development; v. 9 n. 9; e2029968912525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/6891/6336Copyright (c) 2020 Viton Dyrk Guimarães Fernandes, Ana Beatriz Bomfim Gomes Ribeiro, Fabricio Rennan Silva de Holanda, Vinícius Filgueiras de Oliveira, Raline Mendonça dos Anjos, Maria Angélica Sátyro Gomes Alves, Aleson Pereira de Sousa, Abrahão Alves de Oliveira Filhohttp://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFernandes, Viton Dyrk GuimarãesRibeiro, Ana Beatriz Bomfim GomesHolanda, Fabricio Rennan Silva de Oliveira, Vinícius Filgueiras de Anjos, Raline Mendonça dos Alves, Maria Angélica Sátyro GomesSousa, Aleson Pereira de Oliveira Filho, Abrahão Alves de 2020-09-18T01:42:11Zoai:ojs.pkp.sfu.ca:article/6891Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:29:50.592698Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv In silico evaluation of monoterpene ascaridol's antiprotozoal activity
Evaluación in silico de la actividad antiprotozoal del ascaridol de monoterpeno
Avaliação in silico da atividade antiprotozoário do monoterpeno ascaridol
title In silico evaluation of monoterpene ascaridol's antiprotozoal activity
spellingShingle In silico evaluation of monoterpene ascaridol's antiprotozoal activity
Fernandes, Viton Dyrk Guimarães
Ascaridol
Antiprotozoario
Fitoterapia.
Ascaridol
Antiprotozoal
Herbal medicine.
Ascaridol
Antiprotozoário
Fitoterapia.
title_short In silico evaluation of monoterpene ascaridol's antiprotozoal activity
title_full In silico evaluation of monoterpene ascaridol's antiprotozoal activity
title_fullStr In silico evaluation of monoterpene ascaridol's antiprotozoal activity
title_full_unstemmed In silico evaluation of monoterpene ascaridol's antiprotozoal activity
title_sort In silico evaluation of monoterpene ascaridol's antiprotozoal activity
author Fernandes, Viton Dyrk Guimarães
author_facet Fernandes, Viton Dyrk Guimarães
Ribeiro, Ana Beatriz Bomfim Gomes
Holanda, Fabricio Rennan Silva de
Oliveira, Vinícius Filgueiras de
Anjos, Raline Mendonça dos
Alves, Maria Angélica Sátyro Gomes
Sousa, Aleson Pereira de
Oliveira Filho, Abrahão Alves de
author_role author
author2 Ribeiro, Ana Beatriz Bomfim Gomes
Holanda, Fabricio Rennan Silva de
Oliveira, Vinícius Filgueiras de
Anjos, Raline Mendonça dos
Alves, Maria Angélica Sátyro Gomes
Sousa, Aleson Pereira de
Oliveira Filho, Abrahão Alves de
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Fernandes, Viton Dyrk Guimarães
Ribeiro, Ana Beatriz Bomfim Gomes
Holanda, Fabricio Rennan Silva de
Oliveira, Vinícius Filgueiras de
Anjos, Raline Mendonça dos
Alves, Maria Angélica Sátyro Gomes
Sousa, Aleson Pereira de
Oliveira Filho, Abrahão Alves de
dc.subject.por.fl_str_mv Ascaridol
Antiprotozoario
Fitoterapia.
Ascaridol
Antiprotozoal
Herbal medicine.
Ascaridol
Antiprotozoário
Fitoterapia.
topic Ascaridol
Antiprotozoario
Fitoterapia.
Ascaridol
Antiprotozoal
Herbal medicine.
Ascaridol
Antiprotozoário
Fitoterapia.
description This work aims to analyze in silico the antiprotozoal potential of Ascaridol. Using the free software PASS online® to evaluate the biological potential of the Ascaridol molecule, where this software provided the values of (Pa) probability of being active and (Pi) probability of being inactive of the compound in different pharmacological characteristics. Ascaridol showed a high probability of being active for the antiprotozoan (Pa= 0,790), Coccidial antiprotozoan (Pa= 0,476) and Leishimania antiprotozoan (Pa= 0,394). Such results corroborate with other studies proving that this compound present in several medicinal plants has great potential as an antiprotozoal agent, being a promising herbal agent.
publishDate 2020
dc.date.none.fl_str_mv 2020-08-16
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/6891
10.33448/rsd-v9i9.6891
url https://rsdjournal.org/index.php/rsd/article/view/6891
identifier_str_mv 10.33448/rsd-v9i9.6891
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/6891/6336
dc.rights.driver.fl_str_mv http://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 9 No. 9; e202996891
Research, Society and Development; Vol. 9 Núm. 9; e202996891
Research, Society and Development; v. 9 n. 9; e202996891
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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