Genotoxic and cytotoxic activities of hexane extract in seeds from Platonia insignis Mart.
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/25504 |
Resumo: | Platonia insignis Mart. is a vegetable of the Clusiaceae Lindl., family that is popularly known as “bacuri” in Brazil. It is widely used in folk medicine to treat human diarrheas and inflammatory diseases. It has antiparasitic activity, antioxidant, anticarcinogenic action, in addition to vasorelaxant potential. The present study investigates the leishmanicidal, cytotoxic and genotoxic activities in different biological systems, as well as the chemical constituents of hexane extract from P. insignis seeds. The analysis of the non-volatile constituents was analyzed by GC/MS. A total of sixteen main constituents were detected in the saponifiable material (fatty acid methyl esters, ethyl ester, alcohols and hydrocarbons). In unsaponifiable fraction, nineteen constituents were detected, including a series of n-alkanes and prenylated xanthones gamma-mangostin as main component (70.23% of the total components). The results indicated that the seed hexane extract significantly inhibits the growth of promastigote forms of Leishmania amazonensis (IC50), displayed a significant toxicity against Artemia salina Leach and cytotoxicity and genotoxicity in V79 cell lines. |
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Genotoxic and cytotoxic activities of hexane extract in seeds from Platonia insignis Mart.Actividades genotóxicas y citotóxicas del extracto de hexano in semillas de Platonia insignis Mart.Atividades genotóxicas e citotóxicas do extrato hexânico de sementes de Platonia insignis Mart.BacuriLeishmanicidalCytotoxicityGenotoxicity.BacuriLeishmanicidaCitotoxicidadGenotoxicidad.BacuriLeishmanicidaCitotoxicidadeGenotoxicidade.Platonia insignis Mart. is a vegetable of the Clusiaceae Lindl., family that is popularly known as “bacuri” in Brazil. It is widely used in folk medicine to treat human diarrheas and inflammatory diseases. It has antiparasitic activity, antioxidant, anticarcinogenic action, in addition to vasorelaxant potential. The present study investigates the leishmanicidal, cytotoxic and genotoxic activities in different biological systems, as well as the chemical constituents of hexane extract from P. insignis seeds. The analysis of the non-volatile constituents was analyzed by GC/MS. A total of sixteen main constituents were detected in the saponifiable material (fatty acid methyl esters, ethyl ester, alcohols and hydrocarbons). In unsaponifiable fraction, nineteen constituents were detected, including a series of n-alkanes and prenylated xanthones gamma-mangostin as main component (70.23% of the total components). The results indicated that the seed hexane extract significantly inhibits the growth of promastigote forms of Leishmania amazonensis (IC50), displayed a significant toxicity against Artemia salina Leach and cytotoxicity and genotoxicity in V79 cell lines.Platonia insignis Mart. es un vegetal miembro de la familia Clusiaceae Lindl., que se conoce popularmente como "bacuri" en Brasil. Se usa ampliamente en la medicina popular para tratar las diarreas humanas y las enfermedades inflamatorias. Tiene actividad antiparasitaria, antioxidante, acción anticancerígena, además de potencial vasorrelajante. El presente estudio investiga las actividades leishmanicidas, citotóxicas y genotóxicas en diferentes sistemas biológicos, así como los componentes químicos del extracto de hexano de semillas de P. insignis. El análisis de los constituyentes no volátiles fue analizado por GC/MS. Se detectaron un total de dieciséis componentes principales en el material saponificable (ésteres metílicos de ácidos grasos, ésteres etílicos, alcoholes e hidrocarburos). En la fracción insaponificable se detectaron diecinueve constituyentes, entre ellos una serie de n-alcanos y xantonas preniladas gamma-mangostina como componente principal (70,23% del total de componentes). Los resultados indicaron que el extracto de semilla de hexano inhibe significativamente el crecimiento de formas promastigotas de Leishmania amazonensis (IC50), mostró una toxicidad significativa contra Artemia salina Leach y citotoxicidad y genotoxicidad en líneas celulares V79.Platonia insignis Mart. é um vegetal da família Clusiaceae Lindl., popularmente conhecida como “bacuri” no Brasil. É amplamente utilizado na medicina popular para tratar diarreias humanas e doenças inflamatórias. Possui atividade antiparasitária, ação antioxidante, anticarcinogênica, além de potencial vasorrelaxante. O presente estudo investiga as atividades leishmanicida, citotóxica e genotóxica em diferentes sistemas biológicos, bem como os constituintes químicos do extrato hexânico de sementes de P. insignis. A análise dos constituintes não voláteis foi analisada por CG/EM. Um total de dezesseis constituintes principais foram detectados no material saponificável (ésteres metílicos de ácidos graxos, éster etílico, álcoois e hidrocarbonetos). Na fração insaponificável, dezenove constituintes foram detectados, incluindo uma série de n-alcanos e xantonas preniladas gama-mangostina como componente principal (70,23% dos componentes totais). Os resultados indicaram que o extrato de hexano da semente inibe significativamente o crescimento das formas promastigotas de Leishmania amazonensis (CI50), apresentou toxicidade significativa contra Artemia salina Leach e citotoxicidade e genotoxicidade em linhagens celulares V79.Research, Society and Development2022-01-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2550410.33448/rsd-v11i2.25504Research, Society and Development; Vol. 11 No. 2; e13911225504Research, Society and Development; Vol. 11 Núm. 2; e13911225504Research, Society and Development; v. 11 n. 2; e139112255042525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/25504/22391Copyright (c) 2022 Maria das Dores Alves de Oliveira; Patrícia e Silva Alves; Herbert Gonzaga Sousa; Danielle da Costa Silva; Mahendra Kumar Rai; Nerilson Marques Lima ; Teresinha de Jesus Aguiar dos Santos Andrade; Chistiane Mendes Feitosa; Joaquim Soares da Costa Júniorhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessOliveira, Maria das Dores Alves de Alves, Patrícia e Silva Sousa, Herbert Gonzaga Silva, Danielle da Costa Rai, Mahendra Kumar Lima , Nerilson Marques Andrade, Teresinha de Jesus Aguiar dos Santos Feitosa, Chistiane Mendes Costa Júnior, Joaquim Soares da 2022-02-07T01:42:50Zoai:ojs.pkp.sfu.ca:article/25504Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:43:46.198592Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Genotoxic and cytotoxic activities of hexane extract in seeds from Platonia insignis Mart. Actividades genotóxicas y citotóxicas del extracto de hexano in semillas de Platonia insignis Mart. Atividades genotóxicas e citotóxicas do extrato hexânico de sementes de Platonia insignis Mart. |
title |
Genotoxic and cytotoxic activities of hexane extract in seeds from Platonia insignis Mart. |
spellingShingle |
Genotoxic and cytotoxic activities of hexane extract in seeds from Platonia insignis Mart. Oliveira, Maria das Dores Alves de Bacuri Leishmanicidal Cytotoxicity Genotoxicity. Bacuri Leishmanicida Citotoxicidad Genotoxicidad. Bacuri Leishmanicida Citotoxicidade Genotoxicidade. |
title_short |
Genotoxic and cytotoxic activities of hexane extract in seeds from Platonia insignis Mart. |
title_full |
Genotoxic and cytotoxic activities of hexane extract in seeds from Platonia insignis Mart. |
title_fullStr |
Genotoxic and cytotoxic activities of hexane extract in seeds from Platonia insignis Mart. |
title_full_unstemmed |
Genotoxic and cytotoxic activities of hexane extract in seeds from Platonia insignis Mart. |
title_sort |
Genotoxic and cytotoxic activities of hexane extract in seeds from Platonia insignis Mart. |
author |
Oliveira, Maria das Dores Alves de |
author_facet |
Oliveira, Maria das Dores Alves de Alves, Patrícia e Silva Sousa, Herbert Gonzaga Silva, Danielle da Costa Rai, Mahendra Kumar Lima , Nerilson Marques Andrade, Teresinha de Jesus Aguiar dos Santos Feitosa, Chistiane Mendes Costa Júnior, Joaquim Soares da |
author_role |
author |
author2 |
Alves, Patrícia e Silva Sousa, Herbert Gonzaga Silva, Danielle da Costa Rai, Mahendra Kumar Lima , Nerilson Marques Andrade, Teresinha de Jesus Aguiar dos Santos Feitosa, Chistiane Mendes Costa Júnior, Joaquim Soares da |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Maria das Dores Alves de Alves, Patrícia e Silva Sousa, Herbert Gonzaga Silva, Danielle da Costa Rai, Mahendra Kumar Lima , Nerilson Marques Andrade, Teresinha de Jesus Aguiar dos Santos Feitosa, Chistiane Mendes Costa Júnior, Joaquim Soares da |
dc.subject.por.fl_str_mv |
Bacuri Leishmanicidal Cytotoxicity Genotoxicity. Bacuri Leishmanicida Citotoxicidad Genotoxicidad. Bacuri Leishmanicida Citotoxicidade Genotoxicidade. |
topic |
Bacuri Leishmanicidal Cytotoxicity Genotoxicity. Bacuri Leishmanicida Citotoxicidad Genotoxicidad. Bacuri Leishmanicida Citotoxicidade Genotoxicidade. |
description |
Platonia insignis Mart. is a vegetable of the Clusiaceae Lindl., family that is popularly known as “bacuri” in Brazil. It is widely used in folk medicine to treat human diarrheas and inflammatory diseases. It has antiparasitic activity, antioxidant, anticarcinogenic action, in addition to vasorelaxant potential. The present study investigates the leishmanicidal, cytotoxic and genotoxic activities in different biological systems, as well as the chemical constituents of hexane extract from P. insignis seeds. The analysis of the non-volatile constituents was analyzed by GC/MS. A total of sixteen main constituents were detected in the saponifiable material (fatty acid methyl esters, ethyl ester, alcohols and hydrocarbons). In unsaponifiable fraction, nineteen constituents were detected, including a series of n-alkanes and prenylated xanthones gamma-mangostin as main component (70.23% of the total components). The results indicated that the seed hexane extract significantly inhibits the growth of promastigote forms of Leishmania amazonensis (IC50), displayed a significant toxicity against Artemia salina Leach and cytotoxicity and genotoxicity in V79 cell lines. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-21 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/25504 10.33448/rsd-v11i2.25504 |
url |
https://rsdjournal.org/index.php/rsd/article/view/25504 |
identifier_str_mv |
10.33448/rsd-v11i2.25504 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/25504/22391 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 2; e13911225504 Research, Society and Development; Vol. 11 Núm. 2; e13911225504 Research, Society and Development; v. 11 n. 2; e13911225504 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052792437735424 |