Canine gastric mucinous adenocarcinoma

Detalhes bibliográficos
Autor(a) principal: Alberti, Taina dos Santos
Data de Publicação: 2021
Outros Autores: Venancio, Fabiano da Rosa, Zamboni, Rosimeri, Scheid, Haide Valeska, Ladeira, Roberto Sopena, Sallis, Eliza Simone Viégas, Schild , Ana Lucia
Tipo de documento: Artigo
Idioma: por
Título da fonte: Research, Society and Development
Texto Completo: https://rsdjournal.org/index.php/rsd/article/view/19146
Resumo: This paper describes the macroscopic, histopathological and immunohistochemical (IHC) aspects of a case of mucinous adenocarcinoma in a Chow-chow canine, with a history of vomiting and weight loss. Ultrasonographic examination revealed diffuse thickening and loss of stratification of the stomach wall suggestive of gastric neoplasia. After death, the animal was sent to the Laboratório Regional de Diagnóstico of the Faculdade de Veterinária of the Universidade Federal de Pelotas (LRD/UFPel) to establish the definitive diagnosis. At necropsy, there was diffuse thickening of the stomach wall in the anthropyloric region and the caudal portion of the body of the organ. , with flattening of the folds and ulcerations in the mucosa, in addition to enlargement of the mesenteric lymph nodes. In the histopathological evaluation of the stomach, pleomorphic epithelial cells were observed, with paracentral nuclei and abundant cytoplasm containing mucin, characterizing signet ring cells. Neoplastic cells affected all layers of the gastric wall, being also observed inside lymphatic vessels, regional lymph nodes and liver. PAS staining showed the presence of mucin in the cytoplasm of neoplastic cells. In IHC there was immunostaining of tumor cells for cytokeratin. The diagnosis of gastric mucinous adenocarcinoma in this case was based on macroscopic findings, histopathological and confirmed by IHC.
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spelling Canine gastric mucinous adenocarcinomaAdenocarcinoma mucinoso gástrico caninoAdenocarcinoma mucinoso gástrico em caninoGastric carcinomaSignet ring cellsImmunohistochemistryGastrointestinal neoplasms.Carcinoma gástricoCélulas en anillo de selloInmunohistoquímicaNeoplasias gastrointestinales.Carcinoma gástricoCélulas em anel de sineteImuno-histoquímicaNeoplasias gastrointestinais.This paper describes the macroscopic, histopathological and immunohistochemical (IHC) aspects of a case of mucinous adenocarcinoma in a Chow-chow canine, with a history of vomiting and weight loss. Ultrasonographic examination revealed diffuse thickening and loss of stratification of the stomach wall suggestive of gastric neoplasia. After death, the animal was sent to the Laboratório Regional de Diagnóstico of the Faculdade de Veterinária of the Universidade Federal de Pelotas (LRD/UFPel) to establish the definitive diagnosis. At necropsy, there was diffuse thickening of the stomach wall in the anthropyloric region and the caudal portion of the body of the organ. , with flattening of the folds and ulcerations in the mucosa, in addition to enlargement of the mesenteric lymph nodes. In the histopathological evaluation of the stomach, pleomorphic epithelial cells were observed, with paracentral nuclei and abundant cytoplasm containing mucin, characterizing signet ring cells. Neoplastic cells affected all layers of the gastric wall, being also observed inside lymphatic vessels, regional lymph nodes and liver. PAS staining showed the presence of mucin in the cytoplasm of neoplastic cells. In IHC there was immunostaining of tumor cells for cytokeratin. The diagnosis of gastric mucinous adenocarcinoma in this case was based on macroscopic findings, histopathological and confirmed by IHC.Este artículo describe los aspectos macroscópicos, histopatológicos e inmunohistoquímicos (IHC) de un caso de adenocarcinoma mucinoso en un canino de Chow-chow, con antecedentes de vómitos y pérdida de peso. El examen ecográfico reveló engrosamiento difuso y pérdida de estratificación de la pared del estómago sugestivo de neoplasia gástrica. Después de la muerte, el animal fue enviado al Laboratório Regional de Diagnóstico de la Faculdade de Veterinária de la Universidade Federal de Pelotas (LRD/UFPel) para establecer el diagnóstico definitivo. En la necropsia se observó engrosamiento difuso de la pared del estómago en la región antropilórica. y la porción caudal del cuerpo del órgano., con aplanamiento de los pliegues y ulceraciones en la mucosa, además de agrandamiento de los ganglios linfáticos mesentéricos. En la evaluación histopatológica del estómago se observaron células epiteliales pleomórficas, con núcleos paracentrales y abundante citoplasma conteniendo mucina, caracterizando las células en anillo de sello. Las células neoplásicas afectaron todas las capas de la pared gástrica, observándose también en el interior de los vasos linfáticos, los ganglios linfáticos regionales y el hígado. La tinción PAS mostró la presencia de mucina en el citoplasma de las células neoplásicas. En IHC hubo inmunotinción de células tumorales para citoqueratina. El diagnóstico de adenocarcinoma mucinoso gástrico en este caso se basó en hallazgos macroscópicos, histopatológicos y confirmados por IHC.Este trabalho descreve os aspectos macroscópicos, histopatológicos e imuno-histoquímicos (IHQ) de um caso de adenocarcinoma mucinoso em um canino da raça Chow-chow, com histórico de vômito e emagrecimento. No exame ultrassonográfico, foi observado espessamento difuso e perda da estratificação da parede do estômago sugestivo de neoplasia gástrica. Após o óbito o animal foi encaminhado ao Laboratório Regional de Diagnóstico da Faculdade de Veterinária da Universidade Federal de Pelotas (LRD/UFPel) para estabelecer o diagnóstico definitivo. Na necropsia havia espessamento difuso da parede do estômago na região antropilórica e porção caudal do corpo do órgão, com achatamento das pregas e ulcerações na mucosa, além de aumento dos linfonodos mesentéricos. Na avaliação histopatológica do estômago foram observadas células epiteliais pleomórficas, com núcleos paracentrais e abundante citoplasma contendo mucina, caracterizando células em anel de sinete. As células neoplásicas comprometiam todas as camadas da parede gástrica, sendo observadas, também, no interior de vasos linfáticos, linfonodos regionais e fígado. Na coloração de PAS foi evidenciada a presença de mucina no citoplasma das células neoplásicas. Na IHQ houve imunomarcação das células tumorais para citoqueratina. O diagnóstico de adenocarcinoma mucinoso gástrico, neste caso, foi baseado nos achados macroscópicos, histopatológicose confirmado pela IHQ.Research, Society and Development2021-08-25info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1914610.33448/rsd-v10i11.19146Research, Society and Development; Vol. 10 No. 11; e132101119146Research, Society and Development; Vol. 10 Núm. 11; e132101119146Research, Society and Development; v. 10 n. 11; e1321011191462525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/19146/17343Copyright (c) 2021 Taina dos Santos Alberti; Fabiano da Rosa Venancio; Rosimeri Zamboni; Haide Valeska Scheid; Roberto Sopena Ladeira; Eliza Simone Viégas Sallis; Ana Lucia Schild https://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAlberti, Taina dos Santos Venancio, Fabiano da RosaZamboni, RosimeriScheid, Haide Valeska Ladeira, Roberto Sopena Sallis, Eliza Simone ViégasSchild , Ana Lucia2021-10-23T19:01:11Zoai:ojs.pkp.sfu.ca:article/19146Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:39:06.947950Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Canine gastric mucinous adenocarcinoma
Adenocarcinoma mucinoso gástrico canino
Adenocarcinoma mucinoso gástrico em canino
title Canine gastric mucinous adenocarcinoma
spellingShingle Canine gastric mucinous adenocarcinoma
Alberti, Taina dos Santos
Gastric carcinoma
Signet ring cells
Immunohistochemistry
Gastrointestinal neoplasms.
Carcinoma gástrico
Células en anillo de sello
Inmunohistoquímica
Neoplasias gastrointestinales.
Carcinoma gástrico
Células em anel de sinete
Imuno-histoquímica
Neoplasias gastrointestinais.
title_short Canine gastric mucinous adenocarcinoma
title_full Canine gastric mucinous adenocarcinoma
title_fullStr Canine gastric mucinous adenocarcinoma
title_full_unstemmed Canine gastric mucinous adenocarcinoma
title_sort Canine gastric mucinous adenocarcinoma
author Alberti, Taina dos Santos
author_facet Alberti, Taina dos Santos
Venancio, Fabiano da Rosa
Zamboni, Rosimeri
Scheid, Haide Valeska
Ladeira, Roberto Sopena
Sallis, Eliza Simone Viégas
Schild , Ana Lucia
author_role author
author2 Venancio, Fabiano da Rosa
Zamboni, Rosimeri
Scheid, Haide Valeska
Ladeira, Roberto Sopena
Sallis, Eliza Simone Viégas
Schild , Ana Lucia
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Alberti, Taina dos Santos
Venancio, Fabiano da Rosa
Zamboni, Rosimeri
Scheid, Haide Valeska
Ladeira, Roberto Sopena
Sallis, Eliza Simone Viégas
Schild , Ana Lucia
dc.subject.por.fl_str_mv Gastric carcinoma
Signet ring cells
Immunohistochemistry
Gastrointestinal neoplasms.
Carcinoma gástrico
Células en anillo de sello
Inmunohistoquímica
Neoplasias gastrointestinales.
Carcinoma gástrico
Células em anel de sinete
Imuno-histoquímica
Neoplasias gastrointestinais.
topic Gastric carcinoma
Signet ring cells
Immunohistochemistry
Gastrointestinal neoplasms.
Carcinoma gástrico
Células en anillo de sello
Inmunohistoquímica
Neoplasias gastrointestinales.
Carcinoma gástrico
Células em anel de sinete
Imuno-histoquímica
Neoplasias gastrointestinais.
description This paper describes the macroscopic, histopathological and immunohistochemical (IHC) aspects of a case of mucinous adenocarcinoma in a Chow-chow canine, with a history of vomiting and weight loss. Ultrasonographic examination revealed diffuse thickening and loss of stratification of the stomach wall suggestive of gastric neoplasia. After death, the animal was sent to the Laboratório Regional de Diagnóstico of the Faculdade de Veterinária of the Universidade Federal de Pelotas (LRD/UFPel) to establish the definitive diagnosis. At necropsy, there was diffuse thickening of the stomach wall in the anthropyloric region and the caudal portion of the body of the organ. , with flattening of the folds and ulcerations in the mucosa, in addition to enlargement of the mesenteric lymph nodes. In the histopathological evaluation of the stomach, pleomorphic epithelial cells were observed, with paracentral nuclei and abundant cytoplasm containing mucin, characterizing signet ring cells. Neoplastic cells affected all layers of the gastric wall, being also observed inside lymphatic vessels, regional lymph nodes and liver. PAS staining showed the presence of mucin in the cytoplasm of neoplastic cells. In IHC there was immunostaining of tumor cells for cytokeratin. The diagnosis of gastric mucinous adenocarcinoma in this case was based on macroscopic findings, histopathological and confirmed by IHC.
publishDate 2021
dc.date.none.fl_str_mv 2021-08-25
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/19146
10.33448/rsd-v10i11.19146
url https://rsdjournal.org/index.php/rsd/article/view/19146
identifier_str_mv 10.33448/rsd-v10i11.19146
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/19146/17343
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 10 No. 11; e132101119146
Research, Society and Development; Vol. 10 Núm. 11; e132101119146
Research, Society and Development; v. 10 n. 11; e132101119146
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
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