Can propolis and their compounds be efficacy in the treatment of coronavirus disease 2019 (COVID-19)? A systematic review

Bibliographic Details
Main Author: Sobrinho, Rilcy Carla Silva
Publication Date: 2022
Other Authors: Meneses, Ivani Rosa de, Alves, Bruna Cristina, Oliveira, Christiane Fátima, Carvalho, Paulo, Taranto, Alex Gutterres, Mano-Sousa, Brayan Jonas, Duarte-Almeida, Joaquim Maurício
Format: Article
Language: eng
Source: Research, Society and Development
Download full: https://rsdjournal.org/index.php/rsd/article/view/30302
Summary: Despite the advancement of vaccination and the reduction in the number of deaths, there is still the emergence of new variants, such as the omicron of SARS-CoV-2 (COVID-19). In this sense, new natural antiviral therapies are highly explored. One of these products, propolis, have shown promising results against COVID-19, including the inhibition of the binding between the coronavirus and ACE2. This systematic review aimed to gather a summary of scientific evidence existing on the effective of the therapeutic use of propolis and their components in the treatment of COVID-19. The protocol for the present systematic review was registered on the PROSPERO (CRD42021267016). In this study, we analyzed 185 articles, selecting 13 of them. Some phenolic compounds and flavonoids, such as artepillin C, hesperetin, CAPE and rutin, were widely cited, as they have great potential for binding with the molecular targets of SARS-CoV-2. Some clinical studies that evaluated the effects of propolis against COVID-19 were included, and confirmed the effectiveness of propolis and its components. The results of this review demonstrate the effectiveness of using propolis and their components in the treatment of COVID-19 due to its antiviral activities. Additionally, the anti-inflammatory and immunomodulatory properties can help to patients with COVID-19.
id UNIFEI_661701072ec66454e4ac7ca512696454
oai_identifier_str oai:ojs.pkp.sfu.ca:article/30302
network_acronym_str UNIFEI
network_name_str Research, Society and Development
repository_id_str
spelling Can propolis and their compounds be efficacy in the treatment of coronavirus disease 2019 (COVID-19)? A systematic review¿Pueden los propóleos y sus compuestos ser efectivos en el tratamiento de la enfermedad por Coronavirus 2019 (COVID-19)? Una revisión sistemáticaA própolis e seus compostos podem ser eficazes no tratamento da doença do coronavírus 2019 (COVID-19)? Uma revisão sistemáticaSARS-CoV-2RutinaQuercetinaCAPERevisión sistemáticaEnseñanza en salud.SARS-CoV-2RutinaQuercetinaCAPERevisão SistemáticaEnsino em saúde.SARS-CoV-2RutinQuercetinCAPESystematic ReviewHealth teaching.Despite the advancement of vaccination and the reduction in the number of deaths, there is still the emergence of new variants, such as the omicron of SARS-CoV-2 (COVID-19). In this sense, new natural antiviral therapies are highly explored. One of these products, propolis, have shown promising results against COVID-19, including the inhibition of the binding between the coronavirus and ACE2. This systematic review aimed to gather a summary of scientific evidence existing on the effective of the therapeutic use of propolis and their components in the treatment of COVID-19. The protocol for the present systematic review was registered on the PROSPERO (CRD42021267016). In this study, we analyzed 185 articles, selecting 13 of them. Some phenolic compounds and flavonoids, such as artepillin C, hesperetin, CAPE and rutin, were widely cited, as they have great potential for binding with the molecular targets of SARS-CoV-2. Some clinical studies that evaluated the effects of propolis against COVID-19 were included, and confirmed the effectiveness of propolis and its components. The results of this review demonstrate the effectiveness of using propolis and their components in the treatment of COVID-19 due to its antiviral activities. Additionally, the anti-inflammatory and immunomodulatory properties can help to patients with COVID-19.A pesar del avance de la vacunación y la reducción en el número de muertes, todavía está surgiendo nuevas variantes, como el omicrón SARS-CoV-2 (COVID-19). En este sentido, las nuevas terapias antivirales naturales están muy exploradas. Uno de esos productos, el propóleo, ha mostrado resultados prometedores contra el COVID-19, incluida la inhibición del vínculo entre el coronavirus y la ACE2. Esta revisión sistemática tuvo como objetivo recopilar un resumen de la evidencia científica existente sobre la efectividad del uso terapéutico del propóleo y sus componentes en el tratamiento de la COVID-19. El protocolo de la presente revisión sistemática se registró en PROSPERO (CRD42021267016). En este estudio analizamos 185 artículos, seleccionando 13 de ellos. Algunos compuestos fenólicos y flavonoides, como la artepilina C, la hesperetina, la CAPE y la rutina, fueron ampliamente citados, ya que tienen un gran potencial para unirse a los objetivos moleculares del SARS-CoV-2. Se incluyeron algunos estudios clínicos que evaluaron los efectos del propóleo contra el COVID-19 y confirmaron la efectividad del propóleo y sus componentes. Los resultados de esta revisión demuestran la efectividad del uso de propóleos y sus componentes en el tratamiento de la COVID-19 debido a sus actividades antivirales. Además, las propiedades antiinflamatorias e inmunomoduladoras pueden ayudar a los pacientes con COVID-19.Apesar do avanço da vacinação e da redução do número de óbitos, ainda há o surgimento de novas variantes, como a ômicron do SARS-CoV-2 (COVID-19). Nesse sentido, novas terapias antivirais naturais são altamente exploradas. Um desses produtos, a própolis, tem mostrado resultados promissores contra o COVID-19, incluindo a inibição da ligação entre o coronavírus e a ECA2. Esta revisão sistemática teve como objetivo reunir um resumo das evidências científicas existentes sobre a eficácia do uso terapêutico da própolis e seus componentes no tratamento da COVID-19. O protocolo da presente revisão sistemática foi registrado no PROSPERO (CRD42021267016). Neste estudo, analisamos 185 artigos, selecionando 13 deles. Alguns compostos fenólicos e flavonoides, como artepillina C, hesperetina, CAPE e rutina, foram amplamente citados, pois possuem grande potencial de ligação com os alvos moleculares do SARS-CoV-2. Alguns estudos clínicos que avaliaram os efeitos da própolis contra a COVID-19 foram incluídos e confirmaram a eficácia da própolis e seus componentes. Os resultados desta revisão demonstram a eficácia do uso da própolis e seus componentes no tratamento da COVID-19 devido às suas atividades antivirais. Além disso, as propriedades anti-inflamatórias e imunomoduladoras podem ajudar pacientes com COVID-19.Research, Society and Development2022-06-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/3030210.33448/rsd-v11i8.30302Research, Society and Development; Vol. 11 No. 8; e3411830302Research, Society and Development; Vol. 11 Núm. 8; e3411830302Research, Society and Development; v. 11 n. 8; e34118303022525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/30302/26245Copyright (c) 2022 Rilcy Carla Silva Sobrinho; Ivani Rosa de Meneses; Bruna Cristina Alves; Christiane Fátima Oliveira; Paulo Carvalho; Alex Gutterres Taranto; Brayan Jonas Mano-Sousa; Joaquim Maurício Duarte-Almeidahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSobrinho, Rilcy Carla SilvaMeneses, Ivani Rosa deAlves, Bruna CristinaOliveira, Christiane FátimaCarvalho, PauloTaranto, Alex GutterresMano-Sousa, Brayan JonasDuarte-Almeida, Joaquim Maurício2022-07-01T13:34:06Zoai:ojs.pkp.sfu.ca:article/30302Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:47:06.480462Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false
dc.title.none.fl_str_mv Can propolis and their compounds be efficacy in the treatment of coronavirus disease 2019 (COVID-19)? A systematic review
¿Pueden los propóleos y sus compuestos ser efectivos en el tratamiento de la enfermedad por Coronavirus 2019 (COVID-19)? Una revisión sistemática
A própolis e seus compostos podem ser eficazes no tratamento da doença do coronavírus 2019 (COVID-19)? Uma revisão sistemática
title Can propolis and their compounds be efficacy in the treatment of coronavirus disease 2019 (COVID-19)? A systematic review
spellingShingle Can propolis and their compounds be efficacy in the treatment of coronavirus disease 2019 (COVID-19)? A systematic review
Sobrinho, Rilcy Carla Silva
SARS-CoV-2
Rutina
Quercetina
CAPE
Revisión sistemática
Enseñanza en salud.
SARS-CoV-2
Rutina
Quercetina
CAPE
Revisão Sistemática
Ensino em saúde.
SARS-CoV-2
Rutin
Quercetin
CAPE
Systematic Review
Health teaching.
title_short Can propolis and their compounds be efficacy in the treatment of coronavirus disease 2019 (COVID-19)? A systematic review
title_full Can propolis and their compounds be efficacy in the treatment of coronavirus disease 2019 (COVID-19)? A systematic review
title_fullStr Can propolis and their compounds be efficacy in the treatment of coronavirus disease 2019 (COVID-19)? A systematic review
title_full_unstemmed Can propolis and their compounds be efficacy in the treatment of coronavirus disease 2019 (COVID-19)? A systematic review
title_sort Can propolis and their compounds be efficacy in the treatment of coronavirus disease 2019 (COVID-19)? A systematic review
author Sobrinho, Rilcy Carla Silva
author_facet Sobrinho, Rilcy Carla Silva
Meneses, Ivani Rosa de
Alves, Bruna Cristina
Oliveira, Christiane Fátima
Carvalho, Paulo
Taranto, Alex Gutterres
Mano-Sousa, Brayan Jonas
Duarte-Almeida, Joaquim Maurício
author_role author
author2 Meneses, Ivani Rosa de
Alves, Bruna Cristina
Oliveira, Christiane Fátima
Carvalho, Paulo
Taranto, Alex Gutterres
Mano-Sousa, Brayan Jonas
Duarte-Almeida, Joaquim Maurício
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Sobrinho, Rilcy Carla Silva
Meneses, Ivani Rosa de
Alves, Bruna Cristina
Oliveira, Christiane Fátima
Carvalho, Paulo
Taranto, Alex Gutterres
Mano-Sousa, Brayan Jonas
Duarte-Almeida, Joaquim Maurício
dc.subject.por.fl_str_mv SARS-CoV-2
Rutina
Quercetina
CAPE
Revisión sistemática
Enseñanza en salud.
SARS-CoV-2
Rutina
Quercetina
CAPE
Revisão Sistemática
Ensino em saúde.
SARS-CoV-2
Rutin
Quercetin
CAPE
Systematic Review
Health teaching.
topic SARS-CoV-2
Rutina
Quercetina
CAPE
Revisión sistemática
Enseñanza en salud.
SARS-CoV-2
Rutina
Quercetina
CAPE
Revisão Sistemática
Ensino em saúde.
SARS-CoV-2
Rutin
Quercetin
CAPE
Systematic Review
Health teaching.
description Despite the advancement of vaccination and the reduction in the number of deaths, there is still the emergence of new variants, such as the omicron of SARS-CoV-2 (COVID-19). In this sense, new natural antiviral therapies are highly explored. One of these products, propolis, have shown promising results against COVID-19, including the inhibition of the binding between the coronavirus and ACE2. This systematic review aimed to gather a summary of scientific evidence existing on the effective of the therapeutic use of propolis and their components in the treatment of COVID-19. The protocol for the present systematic review was registered on the PROSPERO (CRD42021267016). In this study, we analyzed 185 articles, selecting 13 of them. Some phenolic compounds and flavonoids, such as artepillin C, hesperetin, CAPE and rutin, were widely cited, as they have great potential for binding with the molecular targets of SARS-CoV-2. Some clinical studies that evaluated the effects of propolis against COVID-19 were included, and confirmed the effectiveness of propolis and its components. The results of this review demonstrate the effectiveness of using propolis and their components in the treatment of COVID-19 due to its antiviral activities. Additionally, the anti-inflammatory and immunomodulatory properties can help to patients with COVID-19.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-07
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/30302
10.33448/rsd-v11i8.30302
url https://rsdjournal.org/index.php/rsd/article/view/30302
identifier_str_mv 10.33448/rsd-v11i8.30302
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://rsdjournal.org/index.php/rsd/article/view/30302/26245
dc.rights.driver.fl_str_mv https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Research, Society and Development
publisher.none.fl_str_mv Research, Society and Development
dc.source.none.fl_str_mv Research, Society and Development; Vol. 11 No. 8; e3411830302
Research, Society and Development; Vol. 11 Núm. 8; e3411830302
Research, Society and Development; v. 11 n. 8; e3411830302
2525-3409
reponame:Research, Society and Development
instname:Universidade Federal de Itajubá (UNIFEI)
instacron:UNIFEI
instname_str Universidade Federal de Itajubá (UNIFEI)
instacron_str UNIFEI
institution UNIFEI
reponame_str Research, Society and Development
collection Research, Society and Development
repository.name.fl_str_mv Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)
repository.mail.fl_str_mv rsd.articles@gmail.com
_version_ 1797052714095476736

Similar Items