Influência das Células da Glia na patogênese e progressão da Doença de Alzheimer
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Publication Date: | 2024 |
Other Authors: | , , , , , , , , , |
Format: | Article |
Language: | por |
Source: | Research, Society and Development |
Download full: | https://rsdjournal.org/index.php/rsd/article/view/45475 |
Summary: | Alzheimer's disease (AD) is a devastating neurodegenerative condition that affects millions of people worldwide, presenting progressive cognitive deficits, functional impairment, and behavioral changes. In recent years, the role of glial cells in the pathogenesis and progression of AD has been increasingly recognized. Astrocytes, microglia, and oligodendrocytes, essential cells of the central nervous system, play fundamental roles in regulating the neural environment and responding to pathological stimuli. However, their dysfunction is implicated in neuroinflammation, neuronal loss, and progression of AD symptoms. This literature review aims to critically evaluate the influence of glial cells on the pathogenesis and progression of AD, using a rigorous and systematic approach over the past 20 years, drawing from primary studies including clinical trials, meta-analyses, randomized clinical trials, and systematic reviews. Additionally, innovative therapeutic strategies targeting astrocytes and microglia, such as immunotherapies, have been presented and analyzed, showing potential in reducing beta-amyloid burden and improving cognitive outcomes in animal models of AD. However, significant challenges such as glial cell heterogeneity and the need for more specific biomarkers need to be overcome to translate these advances into clinical practice. In summary, this review highlights the critical role of glial cells in AD pathogenesis and identifies essential areas of future research for the development of more effective and personalized therapies for this neurodegenerative disease. |
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Influência das Células da Glia na patogênese e progressão da Doença de AlzheimerInfluence of Glial Cells in the pathogenesis and progression of Alzheimer's DiseaseInfluencia de las Células Gliales en la patogénesis y progresión de la Enfermedad de AlzheimerNeurogliaCélulas da GliaDoença de Alzheimer.NeuroglìaCélulas de la GlíaEnfermedad de Alzheimer. NeurogliaGlial cellsAlzheimer Disease.Alzheimer's disease (AD) is a devastating neurodegenerative condition that affects millions of people worldwide, presenting progressive cognitive deficits, functional impairment, and behavioral changes. In recent years, the role of glial cells in the pathogenesis and progression of AD has been increasingly recognized. Astrocytes, microglia, and oligodendrocytes, essential cells of the central nervous system, play fundamental roles in regulating the neural environment and responding to pathological stimuli. However, their dysfunction is implicated in neuroinflammation, neuronal loss, and progression of AD symptoms. This literature review aims to critically evaluate the influence of glial cells on the pathogenesis and progression of AD, using a rigorous and systematic approach over the past 20 years, drawing from primary studies including clinical trials, meta-analyses, randomized clinical trials, and systematic reviews. Additionally, innovative therapeutic strategies targeting astrocytes and microglia, such as immunotherapies, have been presented and analyzed, showing potential in reducing beta-amyloid burden and improving cognitive outcomes in animal models of AD. However, significant challenges such as glial cell heterogeneity and the need for more specific biomarkers need to be overcome to translate these advances into clinical practice. In summary, this review highlights the critical role of glial cells in AD pathogenesis and identifies essential areas of future research for the development of more effective and personalized therapies for this neurodegenerative disease.La enfermedad de Alzheimer (EA) es una afección neurodegenerativa devastadora que afecta a millones de personas en todo el mundo, presentando déficits cognitivos progresivos, deterioro funcional y alteraciones del comportamiento. En los últimos años, se ha reconocido cada vez más el papel de las células gliales en la patogénesis y progresión de la EA. Los astrocitos, microglías y oligodendrocitos, células esenciales del sistema nervioso central, desempeñan funciones fundamentales en la regulación del ambiente neural y en la respuesta a estímulos patológicos. Sin embargo, su disfunción está implicada en la neuroinflamación, la pérdida neuronal y la progresión de los síntomas de la EA. Esta revisión de literatura tiene como objetivo evaluar críticamente la influencia de las células gliales en la patogénesis y progresión de la EA, utilizando un enfoque riguroso y sistemático, de los últimos 20 años, a partir de algunos estudios primarios, incluidos ensayos clínicos, metaanálisis, ensayos clínicos aleatorizados y revisiones sistemáticas. Además, se presentaron y analizaron estrategias terapéuticas innovadoras, como inmunoterapias dirigidas a astrocitos y microglías, que han demostrado potencial en la reducción de la carga de beta-amiloide y la mejora de los resultados cognitivos en modelos animales de EA. Sin embargo, se deben superar desafíos significativos, como la heterogeneidad de las células gliales y la necesidad de biomarcadores más específicos, para traducir estos avances a la práctica clínica. En resumen, esta revisión destaca el papel crítico de las células gliales en la patogénesis de la EA e identifica áreas de investigación futura esenciales para el desarrollo de terapias más eficaces y personalizadas para esta enfermedad neurodegenerativa.A doença de Alzheimer (DA) é uma condição neurodegenerativa devastadora que afeta milhões de pessoas em todo o mundo, apresentando déficits cognitivos progressivos, comprometimento funcional e alterações comportamentais. Nos últimos anos, o papel das células gliais na patogênese e progressão da DA tem sido cada vez mais reconhecido. Astrócitos, microglias e oligodendrócitos, células essenciais do sistema nervoso central, desempenham funções fundamentais na regulação do ambiente neural e na resposta a estímulos patológicos. No entanto, sua disfunção está implicada na neuroinflamação, perda neuronal e progressão dos sintomas da DA. Esta revisão de literatura tem como objetivo avaliar criticamente a influência das células da glia na patogênese e progressão da DA, utilizando uma abordagem rigorosa e sistemática, dos últimos 20 anos, a partir de alguns estudos primários, incluindo ensaios clínicos, meta-análises, ensaios clínicos randomizados e revisões sistemáticas. Além disso, foi apresentado e analisado estratégias terapêuticas inovadoras, como imunoterapias direcionadas a astrócitos e microglias, que demonstraram potencial na redução da carga de beta-amiloide e melhoria dos resultados cognitivos em modelos animais de DA. No entanto, desafios significativos, como heterogeneidade das células gliais e necessidade de biomarcadores mais específicos, precisam ser superados para traduzir esses avanços para a prática clínica. Em suma, esta revisão destaca o papel crítico das células gliais na patogênese da DA e identifica áreas de pesquisa futura essenciais para o desenvolvimento de terapias mais eficazes e personalizadas para essa doença neurodegenerativa.Research, Society and Development2024-04-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4547510.33448/rsd-v13i4.45475Research, Society and Development; Vol. 13 No. 4; e1913445475Research, Society and Development; Vol. 13 Núm. 4; e1913445475Research, Society and Development; v. 13 n. 4; e19134454752525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/45475/36232Copyright (c) 2024 Luiz Henrique Cunha dos Santos; Manoel Rodrigues Pereira Neto; Pedro Augusto de Andrade Maranhão Melo; Mariana do Nascimento Oliveira; Rayssa Geovanna Silva Monteiro; Manoela Alves Bezerra Lins; Valentina Cavalcanti Siqueira Holanda; Antonio Pereira Caldas Neto; Adriana Costa Santos Bezerra; Evylla Carolina Castanha Bonfim; Gabriela Goedert Serranohttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessSantos, Luiz Henrique Cunha dos Pereira Neto, Manoel RodriguesMelo, Pedro Augusto de Andrade Maranhão Oliveira, Mariana do NascimentoMonteiro, Rayssa Geovanna Silva Lins, Manoela Alves Bezerra Holanda, Valentina Cavalcanti Siqueira Caldas Neto, Antonio PereiraBezerra, Adriana Costa Santos Bonfim, Evylla Carolina Castanha Serrano, Gabriela Goedert2024-04-04T18:36:37Zoai:ojs.pkp.sfu.ca:article/45475Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-04-04T18:36:37Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Influência das Células da Glia na patogênese e progressão da Doença de Alzheimer Influence of Glial Cells in the pathogenesis and progression of Alzheimer's Disease Influencia de las Células Gliales en la patogénesis y progresión de la Enfermedad de Alzheimer |
title |
Influência das Células da Glia na patogênese e progressão da Doença de Alzheimer |
spellingShingle |
Influência das Células da Glia na patogênese e progressão da Doença de Alzheimer Santos, Luiz Henrique Cunha dos Neuroglia Células da Glia Doença de Alzheimer. Neuroglìa Células de la Glía Enfermedad de Alzheimer. Neuroglia Glial cells Alzheimer Disease. |
title_short |
Influência das Células da Glia na patogênese e progressão da Doença de Alzheimer |
title_full |
Influência das Células da Glia na patogênese e progressão da Doença de Alzheimer |
title_fullStr |
Influência das Células da Glia na patogênese e progressão da Doença de Alzheimer |
title_full_unstemmed |
Influência das Células da Glia na patogênese e progressão da Doença de Alzheimer |
title_sort |
Influência das Células da Glia na patogênese e progressão da Doença de Alzheimer |
author |
Santos, Luiz Henrique Cunha dos |
author_facet |
Santos, Luiz Henrique Cunha dos Pereira Neto, Manoel Rodrigues Melo, Pedro Augusto de Andrade Maranhão Oliveira, Mariana do Nascimento Monteiro, Rayssa Geovanna Silva Lins, Manoela Alves Bezerra Holanda, Valentina Cavalcanti Siqueira Caldas Neto, Antonio Pereira Bezerra, Adriana Costa Santos Bonfim, Evylla Carolina Castanha Serrano, Gabriela Goedert |
author_role |
author |
author2 |
Pereira Neto, Manoel Rodrigues Melo, Pedro Augusto de Andrade Maranhão Oliveira, Mariana do Nascimento Monteiro, Rayssa Geovanna Silva Lins, Manoela Alves Bezerra Holanda, Valentina Cavalcanti Siqueira Caldas Neto, Antonio Pereira Bezerra, Adriana Costa Santos Bonfim, Evylla Carolina Castanha Serrano, Gabriela Goedert |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Santos, Luiz Henrique Cunha dos Pereira Neto, Manoel Rodrigues Melo, Pedro Augusto de Andrade Maranhão Oliveira, Mariana do Nascimento Monteiro, Rayssa Geovanna Silva Lins, Manoela Alves Bezerra Holanda, Valentina Cavalcanti Siqueira Caldas Neto, Antonio Pereira Bezerra, Adriana Costa Santos Bonfim, Evylla Carolina Castanha Serrano, Gabriela Goedert |
dc.subject.por.fl_str_mv |
Neuroglia Células da Glia Doença de Alzheimer. Neuroglìa Células de la Glía Enfermedad de Alzheimer. Neuroglia Glial cells Alzheimer Disease. |
topic |
Neuroglia Células da Glia Doença de Alzheimer. Neuroglìa Células de la Glía Enfermedad de Alzheimer. Neuroglia Glial cells Alzheimer Disease. |
description |
Alzheimer's disease (AD) is a devastating neurodegenerative condition that affects millions of people worldwide, presenting progressive cognitive deficits, functional impairment, and behavioral changes. In recent years, the role of glial cells in the pathogenesis and progression of AD has been increasingly recognized. Astrocytes, microglia, and oligodendrocytes, essential cells of the central nervous system, play fundamental roles in regulating the neural environment and responding to pathological stimuli. However, their dysfunction is implicated in neuroinflammation, neuronal loss, and progression of AD symptoms. This literature review aims to critically evaluate the influence of glial cells on the pathogenesis and progression of AD, using a rigorous and systematic approach over the past 20 years, drawing from primary studies including clinical trials, meta-analyses, randomized clinical trials, and systematic reviews. Additionally, innovative therapeutic strategies targeting astrocytes and microglia, such as immunotherapies, have been presented and analyzed, showing potential in reducing beta-amyloid burden and improving cognitive outcomes in animal models of AD. However, significant challenges such as glial cell heterogeneity and the need for more specific biomarkers need to be overcome to translate these advances into clinical practice. In summary, this review highlights the critical role of glial cells in AD pathogenesis and identifies essential areas of future research for the development of more effective and personalized therapies for this neurodegenerative disease. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-04-09 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/45475 10.33448/rsd-v13i4.45475 |
url |
https://rsdjournal.org/index.php/rsd/article/view/45475 |
identifier_str_mv |
10.33448/rsd-v13i4.45475 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/45475/36232 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 13 No. 4; e1913445475 Research, Society and Development; Vol. 13 Núm. 4; e1913445475 Research, Society and Development; v. 13 n. 4; e1913445475 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
institution |
UNIFEI |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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