Cinnamaldehyde and α-terpineol as an alternative for using as denture cleansers: antifungal activity and acrylic resin color stability
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2021 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/13512 |
Resumo: | Objective: here was investigated the potential of phytoconstituents as cinnamaldehyde and α-terpineol as denture cleansers, which was evaluated the antifungal activity, also their effect on the color change of the poly(methyl)methacrylate (PMMA). Methodology: Candida albicans biofilms were formed on PMMA specimens and exposed a 10 minutes daily treatment with cinnamaldehyde (10 mg/ mL), α-terpineol (10 mg/ mL), NaCl 0.9%, and NaClO 1%. Biofilms were collected, then analyzed the cell viability (CFU/ mL), cell metabolism (MTT), and roughness. Moreover, the color variation of the specimens during seven and 14 days was checked. Kruskal-Wallis, Mann Whitney, and ANOVA one-way were applied (α < 0.05). Results: cinnamaldehyde and α-terpineol decrease the number of viable cells compared to NaCl 0.9% by 76% and 83.2%, respectively (p< 0.05). Both substances reduce biofilm metabolism by around 70% (p< 0.05). Also, the phytoconstituents showed low biofilm roughness, similar to NaClO (p> 0.05), without changing the color of the acrylic resin (p> 0.05). Conclusion: cinnamaldehyde and α-terpineol, at a concentration of 10 mg/ mL, shows antifungal activity on C. albicans biofilms free from PMMA surface changes. From a clinical viewpoint, these substances have a strong potential to be incorporated into denture cleansers solutions. |
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Cinnamaldehyde and α-terpineol as an alternative for using as denture cleansers: antifungal activity and acrylic resin color stabilityCinamaldehído y α-terpineol como alternativa para su uso como limpiadores de prótesis: actividad antifúngica y estabilidad del color de la resina acrílicaCinamaldeído e α-terpineol como uma alternativa para uso como limpadores de prótese: atividade antifúngica e estabilidade de cor da resina acrílicaCandida albicansBiofilmDenture stomatitisDenture cleansersPhytotherapy.Candida albicansPlaca dentalEstomatitis subprotéticaLimpiadores de dentaduraFitoterapia.Candida albicansPlaca dentáriaEstomatite sob PróteseHigienizadores de dentaduraFitoterapia.Objective: here was investigated the potential of phytoconstituents as cinnamaldehyde and α-terpineol as denture cleansers, which was evaluated the antifungal activity, also their effect on the color change of the poly(methyl)methacrylate (PMMA). Methodology: Candida albicans biofilms were formed on PMMA specimens and exposed a 10 minutes daily treatment with cinnamaldehyde (10 mg/ mL), α-terpineol (10 mg/ mL), NaCl 0.9%, and NaClO 1%. Biofilms were collected, then analyzed the cell viability (CFU/ mL), cell metabolism (MTT), and roughness. Moreover, the color variation of the specimens during seven and 14 days was checked. Kruskal-Wallis, Mann Whitney, and ANOVA one-way were applied (α < 0.05). Results: cinnamaldehyde and α-terpineol decrease the number of viable cells compared to NaCl 0.9% by 76% and 83.2%, respectively (p< 0.05). Both substances reduce biofilm metabolism by around 70% (p< 0.05). Also, the phytoconstituents showed low biofilm roughness, similar to NaClO (p> 0.05), without changing the color of the acrylic resin (p> 0.05). Conclusion: cinnamaldehyde and α-terpineol, at a concentration of 10 mg/ mL, shows antifungal activity on C. albicans biofilms free from PMMA surface changes. From a clinical viewpoint, these substances have a strong potential to be incorporated into denture cleansers solutions.Objetivo: se investigó el potencial de los constituyentes fitoquímicos cinamaldehído y α-terpineol como potenciales limpiadores de prótesis dentales, en el que se evaluó la actividad antifúngica, así como el efecto de los tratamientos sobre el cambio de color del poli (metil) metacrilato (PMMA). Metodología: Se formaron biopelículas de Candida albicans en muestras de PMMA y se expusieron a un tratamiento diario durante 10 minutos con cinamaldehído (10 mg / ml) y α-terpineol (10 mg / ml), NaCl al 0,9% y NaClO al 1%. Se recolectaron biopelículas y se analizó la viabilidad celular (UFC / mL), el metabolismo celular (MTT) y la rugosidad del biofilm. Además, se verificó la variación de color de las muestras durante siete y 14 días. Se utilizaron las pruebas de Kruskal-Wallis, Mann Whitney y ANOVA unidireccional (α <0,05). Resultados: el cinamaldehído y el α-terpineol disminuyeron el número de células viables, en comparación con NaCl al 0,9%, en un 76% y 83,2%, respectivamente (p <0,05). Ambas sustancias redujeron el metabolismo de la biopelícula en aproximadamente un 70% (p <0,05). Además, los fitoquímicos probados dieron como resultado un biofilm ligeramente rugoso, similar al NaClO (p> 0.05), sin cambiar el color de la resina acrílica de las muestras (p> 0.05). Conclusión: el cinamaldehído y el α-terpineol, a concentraciones de 10 mg / mL, mostraron actividad antifúngica en biofilms de C. albicans sin alterar el color de la resina acrílica. Desde un punto de vista clínico, estas sustancias tienen un gran potencial para incorporarse en soluciones para la limpieza de prótesis dentales.Objetivo: foi investigado o potencial dos fitoconstituintes cinamaldeído e α-terpineol como potenciais limpadores de prótese dentária, no qual foi avaliado a atividade antifúngica, bem como o efeito dos tratamentos na mudança de cor do poli(metil)metacrilato (PMMA). Metodologia: Biofilmes de Candida albicans foram formados sobre espécimes de PMMA e expostos a um tratamento diário por 10 minutos com cinamaldeído (10 mg/ mL) e α-terpineol (10 mg/ mL), NaCl 0,9%, e NaClO 1%. Os biofilmes foram coletados e realizadas as análises de viabilidade celular (UFC/ mL), metabolismo celular (MTT) e rugosidade do biofilme. Adicionalmente, foi checada a variação de cor dos espécimes durante sete e 14 dias. Os testes de Kruskal-Wallis, Mann Whitney, e ANOVA um fator foram utilizados (α < 0,05). Resultados: cinamaldeído e α-terpineol diminuíram o número de células viáveis, quando comparado ao NaCl 0,9%, em 76% e 83,2%, respectivamente (p< 0,05). Ambas substâncias reduziram o metabolismo do biofilme em aproximadamente 70% (p< 0,05). Além disso, os fitoconstituintes testados resultaram um biofilme pouco rugoso, similar a NaClO (p> 0,05), sem modificar a cor da resina acrílica dos espécimes (p> 0.05). Conclusão: cinamaldeído e α-terpineol, nas concentrações de 10 mg/ mL, apresentaram atividade antifúngica em biofilmes de C. albicans sem alterar a cor da resina acrílica. De um ponto de vista clínico, essas substâncias possuem um forte potencial para serem incorporadas em soluções para limpeza de próteses dentárias.Research, Society and Development2021-03-16info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1351210.33448/rsd-v10i3.13512Research, Society and Development; Vol. 10 No. 3; e28010313512Research, Society and Development; Vol. 10 Núm. 3; e28010313512Research, Society and Development; v. 10 n. 3; e280103135122525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/13512/11986Copyright (c) 2021 Loyse Martorano-Fernandes; Nadiny Cezar Rodrigues; Natanael Victor Furtunato Bezerra; Maria Heloisa de Souza Borges; Yuri Wanderley Cavalcanti; Leopoldina de Fátima Dantas de Almeidahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMartorano-Fernandes, LoyseRodrigues, Nadiny CezarBezerra, Natanael Victor Furtunato Borges, Maria Heloisa de Souza Cavalcanti, Yuri WanderleyAlmeida, Leopoldina de Fátima Dantas de2021-03-28T12:03:35Zoai:ojs.pkp.sfu.ca:article/13512Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:34:50.124202Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Cinnamaldehyde and α-terpineol as an alternative for using as denture cleansers: antifungal activity and acrylic resin color stability Cinamaldehído y α-terpineol como alternativa para su uso como limpiadores de prótesis: actividad antifúngica y estabilidad del color de la resina acrílica Cinamaldeído e α-terpineol como uma alternativa para uso como limpadores de prótese: atividade antifúngica e estabilidade de cor da resina acrílica |
| title |
Cinnamaldehyde and α-terpineol as an alternative for using as denture cleansers: antifungal activity and acrylic resin color stability |
| spellingShingle |
Cinnamaldehyde and α-terpineol as an alternative for using as denture cleansers: antifungal activity and acrylic resin color stability Martorano-Fernandes, Loyse Candida albicans Biofilm Denture stomatitis Denture cleansers Phytotherapy. Candida albicans Placa dental Estomatitis subprotética Limpiadores de dentadura Fitoterapia. Candida albicans Placa dentária Estomatite sob Prótese Higienizadores de dentadura Fitoterapia. |
| title_short |
Cinnamaldehyde and α-terpineol as an alternative for using as denture cleansers: antifungal activity and acrylic resin color stability |
| title_full |
Cinnamaldehyde and α-terpineol as an alternative for using as denture cleansers: antifungal activity and acrylic resin color stability |
| title_fullStr |
Cinnamaldehyde and α-terpineol as an alternative for using as denture cleansers: antifungal activity and acrylic resin color stability |
| title_full_unstemmed |
Cinnamaldehyde and α-terpineol as an alternative for using as denture cleansers: antifungal activity and acrylic resin color stability |
| title_sort |
Cinnamaldehyde and α-terpineol as an alternative for using as denture cleansers: antifungal activity and acrylic resin color stability |
| author |
Martorano-Fernandes, Loyse |
| author_facet |
Martorano-Fernandes, Loyse Rodrigues, Nadiny Cezar Bezerra, Natanael Victor Furtunato Borges, Maria Heloisa de Souza Cavalcanti, Yuri Wanderley Almeida, Leopoldina de Fátima Dantas de |
| author_role |
author |
| author2 |
Rodrigues, Nadiny Cezar Bezerra, Natanael Victor Furtunato Borges, Maria Heloisa de Souza Cavalcanti, Yuri Wanderley Almeida, Leopoldina de Fátima Dantas de |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Martorano-Fernandes, Loyse Rodrigues, Nadiny Cezar Bezerra, Natanael Victor Furtunato Borges, Maria Heloisa de Souza Cavalcanti, Yuri Wanderley Almeida, Leopoldina de Fátima Dantas de |
| dc.subject.por.fl_str_mv |
Candida albicans Biofilm Denture stomatitis Denture cleansers Phytotherapy. Candida albicans Placa dental Estomatitis subprotética Limpiadores de dentadura Fitoterapia. Candida albicans Placa dentária Estomatite sob Prótese Higienizadores de dentadura Fitoterapia. |
| topic |
Candida albicans Biofilm Denture stomatitis Denture cleansers Phytotherapy. Candida albicans Placa dental Estomatitis subprotética Limpiadores de dentadura Fitoterapia. Candida albicans Placa dentária Estomatite sob Prótese Higienizadores de dentadura Fitoterapia. |
| description |
Objective: here was investigated the potential of phytoconstituents as cinnamaldehyde and α-terpineol as denture cleansers, which was evaluated the antifungal activity, also their effect on the color change of the poly(methyl)methacrylate (PMMA). Methodology: Candida albicans biofilms were formed on PMMA specimens and exposed a 10 minutes daily treatment with cinnamaldehyde (10 mg/ mL), α-terpineol (10 mg/ mL), NaCl 0.9%, and NaClO 1%. Biofilms were collected, then analyzed the cell viability (CFU/ mL), cell metabolism (MTT), and roughness. Moreover, the color variation of the specimens during seven and 14 days was checked. Kruskal-Wallis, Mann Whitney, and ANOVA one-way were applied (α < 0.05). Results: cinnamaldehyde and α-terpineol decrease the number of viable cells compared to NaCl 0.9% by 76% and 83.2%, respectively (p< 0.05). Both substances reduce biofilm metabolism by around 70% (p< 0.05). Also, the phytoconstituents showed low biofilm roughness, similar to NaClO (p> 0.05), without changing the color of the acrylic resin (p> 0.05). Conclusion: cinnamaldehyde and α-terpineol, at a concentration of 10 mg/ mL, shows antifungal activity on C. albicans biofilms free from PMMA surface changes. From a clinical viewpoint, these substances have a strong potential to be incorporated into denture cleansers solutions. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-03-16 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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https://rsdjournal.org/index.php/rsd/article/view/13512 10.33448/rsd-v10i3.13512 |
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https://rsdjournal.org/index.php/rsd/article/view/13512 |
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10.33448/rsd-v10i3.13512 |
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eng |
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eng |
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https://rsdjournal.org/index.php/rsd/article/view/13512/11986 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development; Vol. 10 No. 3; e28010313512 Research, Society and Development; Vol. 10 Núm. 3; e28010313512 Research, Society and Development; v. 10 n. 3; e28010313512 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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