Encefalopatia hepática: uma revisão narrativa
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/40587 |
Resumo: | The liver is an indispensable organ for maintaining our body's homeostasis, being responsible for important functions such as the elimination of toxins. It has a considerable capacity for regeneration, however, when these aggressions do not cease, regeneration occurs incorrectly, resulting in scars and nodules. Given the epidemiological importance of HE, this article aims to discuss the pathophysiological mechanisms of the disease. This study is a narrative review with the purpose of discussing and describing HS and its pathophysiology, as well as demonstrating how this syndrome affects the personal lives of affected individuals. The following databases were used: SciElo (Scientific Electronic Library Online) and PubMed (US National Library of Medicine), with scientific data from January 2, 2023, with no language restriction and no restriction on the year of publication. Several studies show that the major neuroinhibitory system, GABA, is increased in HE. Furthermore, an important consideration for ammonia in the face of the syndrome must be exposed; the receptors that are located on the periphery of the mitochondria, due to the presence of ammonia, as well as ligandins, triggering the activation of neurosteroid production in astrocytes. In any case, all studies have stated that the later the diagnosis is made, the more severe the systemic consequences of the pathology will be. In addition, it is of fundamental importance that the medical centers responsible for offering hospital support to patients affected by HE are prepared. |
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Encefalopatia hepática: uma revisão narrativaHepatic encephalopathy: a narrative reviewEncefalopatía hepática: una revisión narrativaEncefalopatia hepáticaFisiopatologiaSemiologia. Encefalopatía hepáticaFisiopatologíaSemiología.Hepatic encephalopathyPathophysiologySemiology.The liver is an indispensable organ for maintaining our body's homeostasis, being responsible for important functions such as the elimination of toxins. It has a considerable capacity for regeneration, however, when these aggressions do not cease, regeneration occurs incorrectly, resulting in scars and nodules. Given the epidemiological importance of HE, this article aims to discuss the pathophysiological mechanisms of the disease. This study is a narrative review with the purpose of discussing and describing HS and its pathophysiology, as well as demonstrating how this syndrome affects the personal lives of affected individuals. The following databases were used: SciElo (Scientific Electronic Library Online) and PubMed (US National Library of Medicine), with scientific data from January 2, 2023, with no language restriction and no restriction on the year of publication. Several studies show that the major neuroinhibitory system, GABA, is increased in HE. Furthermore, an important consideration for ammonia in the face of the syndrome must be exposed; the receptors that are located on the periphery of the mitochondria, due to the presence of ammonia, as well as ligandins, triggering the activation of neurosteroid production in astrocytes. In any case, all studies have stated that the later the diagnosis is made, the more severe the systemic consequences of the pathology will be. In addition, it is of fundamental importance that the medical centers responsible for offering hospital support to patients affected by HE are prepared.El hígado es un órgano indispensable para mantener la homeostasis de nuestro organismo, siendo responsable de importantes funciones como la eliminación de toxinas. Tiene una considerable capacidad de regeneración, sin embargo, cuando estas agresiones no cesan, la regeneración se produce de forma incorrecta, dando lugar a cicatrices y nódulos. Dada la importancia epidemiológica de la EH, este artículo tiene como objetivo discutir los mecanismos fisiopatológicos de la enfermedad. Este estudio es una revisión narrativa con el objetivo de discutir y describir la HS y su fisiopatología, así como demostrar cómo este síndrome afecta la vida personal de los individuos afectados. Se utilizaron las siguientes bases de datos: SciElo (Scientific Electronic Library Online) y PubMed (US National Library of Medicine), con datos científicos desde el 2 de enero de 2023, sin restricción de idioma y sin restricción de año de publicación. Varios estudios muestran que el principal sistema neuroinhibidor, GABA, está aumentado en la EH. Además, se debe exponer una consideración importante para el amoníaco ante el síndrome; los receptores que se ubican en la periferia de la mitocondria, debido a la presencia de amoníaco, así como de ligandinas, desencadenan la activación de la producción de neuroesteroides en los astrocitos. En cualquier caso, todos los estudios han afirmado que cuanto más tardío sea el diagnóstico, más graves serán las consecuencias sistémicas de la patología. Además, es de fundamental importancia que los centros médicos encargados de brindar apoyo hospitalario a los pacientes afectados por EH estén preparados.O fígado é um órgão indispensável para a manutenção da homeostase do nosso corpo, sendo responsável por funções importantes como a eliminação de toxinas. Apresenta uma capacidade considerável de regeneração, porém, quando essas agressões não cessam, a regeneração ocorre de forma incorreta, surgindo cicatrizes e nódulos. Diante da importância epidemiológica do EH, este artigo visa discutir os mecanismos fisiopatológicos da doença. Este estudo trata-se de uma revisão narrativa com o propósito de discutir e descrever sobre a EH e sua fisiopatologia, como também, demonstrar como esta síndrome afeta a vida pessoal dos indivíduos acometidos. Foi utilizado o banco de dados: SciElo (Scientific Eletronic Library Online) e PubMed (US National Library of Medicine), com dados científicos de 2 de janeiro de 2023, sem restrição de idioma e sem restrição ao ano de publicação. Vários estudos mostram que o maior sistema neuroinibitório, GABA, está aumentado na EH. Ademais, uma importante consideração pela amônia diante da síndrome deve ser exposta; os receptores que ficam localizados na periferia da mitocôndria, pela presença da amônia, assim como de ligandinas, provocando a ativação da produção de neuroesteroides nos astrócitos. De qualquer maneira, todas as pesquisas afirmaram que quanto mais tardiamente é feito o diagnóstico, mais grave serão as consequências sistêmicas da patologia. Além disso, é de fundamental importância que os centros médicos responsáveis por oferecer o apoio hospitalar aos pacientes acometidos pela EH estejam preparados.Research, Society and Development2023-02-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/4058710.33448/rsd-v12i3.40587Research, Society and Development; Vol. 12 No. 3; e10712340587Research, Society and Development; Vol. 12 Núm. 3; e10712340587Research, Society and Development; v. 12 n. 3; e107123405872525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/40587/33090Copyright (c) 2023 Luiz Felipe Neves Frazão; Lucas Ribeiro Rodrigues; Adrian Victor Mendes Franco; Analyce Garcia Borges; Luis Eduardo Lopes Chaveiro Cardoso ; Joel Alves de Sousa Júnior ; Anne Pietra Cândida Silva ; Sthefany Christina de Souza França; Isabela Vieira dos Santos ; Eduarda Vieira Santos; Brenda Macedo Vilela; Rodrigo da Costa Rodrigues; Laura Marques Cruvinel ; Henrique Vargas Curyhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessFrazão, Luiz Felipe Neves Rodrigues, Lucas Ribeiro Franco, Adrian Victor Mendes Borges, Analyce Garcia Cardoso , Luis Eduardo Lopes Chaveiro Sousa Júnior , Joel Alves de Silva , Anne Pietra Cândida França, Sthefany Christina de Souza Santos , Isabela Vieira dos Santos, Eduarda Vieira Vilela, Brenda Macedo Rodrigues, Rodrigo da Costa Cruvinel , Laura Marques Cury, Henrique Vargas2023-03-23T08:33:38Zoai:ojs.pkp.sfu.ca:article/40587Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2023-03-23T08:33:38Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Encefalopatia hepática: uma revisão narrativa Hepatic encephalopathy: a narrative review Encefalopatía hepática: una revisión narrativa |
title |
Encefalopatia hepática: uma revisão narrativa |
spellingShingle |
Encefalopatia hepática: uma revisão narrativa Frazão, Luiz Felipe Neves Encefalopatia hepática Fisiopatologia Semiologia. Encefalopatía hepática Fisiopatología Semiología. Hepatic encephalopathy Pathophysiology Semiology. |
title_short |
Encefalopatia hepática: uma revisão narrativa |
title_full |
Encefalopatia hepática: uma revisão narrativa |
title_fullStr |
Encefalopatia hepática: uma revisão narrativa |
title_full_unstemmed |
Encefalopatia hepática: uma revisão narrativa |
title_sort |
Encefalopatia hepática: uma revisão narrativa |
author |
Frazão, Luiz Felipe Neves |
author_facet |
Frazão, Luiz Felipe Neves Rodrigues, Lucas Ribeiro Franco, Adrian Victor Mendes Borges, Analyce Garcia Cardoso , Luis Eduardo Lopes Chaveiro Sousa Júnior , Joel Alves de Silva , Anne Pietra Cândida França, Sthefany Christina de Souza Santos , Isabela Vieira dos Santos, Eduarda Vieira Vilela, Brenda Macedo Rodrigues, Rodrigo da Costa Cruvinel , Laura Marques Cury, Henrique Vargas |
author_role |
author |
author2 |
Rodrigues, Lucas Ribeiro Franco, Adrian Victor Mendes Borges, Analyce Garcia Cardoso , Luis Eduardo Lopes Chaveiro Sousa Júnior , Joel Alves de Silva , Anne Pietra Cândida França, Sthefany Christina de Souza Santos , Isabela Vieira dos Santos, Eduarda Vieira Vilela, Brenda Macedo Rodrigues, Rodrigo da Costa Cruvinel , Laura Marques Cury, Henrique Vargas |
author2_role |
author author author author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Frazão, Luiz Felipe Neves Rodrigues, Lucas Ribeiro Franco, Adrian Victor Mendes Borges, Analyce Garcia Cardoso , Luis Eduardo Lopes Chaveiro Sousa Júnior , Joel Alves de Silva , Anne Pietra Cândida França, Sthefany Christina de Souza Santos , Isabela Vieira dos Santos, Eduarda Vieira Vilela, Brenda Macedo Rodrigues, Rodrigo da Costa Cruvinel , Laura Marques Cury, Henrique Vargas |
dc.subject.por.fl_str_mv |
Encefalopatia hepática Fisiopatologia Semiologia. Encefalopatía hepática Fisiopatología Semiología. Hepatic encephalopathy Pathophysiology Semiology. |
topic |
Encefalopatia hepática Fisiopatologia Semiologia. Encefalopatía hepática Fisiopatología Semiología. Hepatic encephalopathy Pathophysiology Semiology. |
description |
The liver is an indispensable organ for maintaining our body's homeostasis, being responsible for important functions such as the elimination of toxins. It has a considerable capacity for regeneration, however, when these aggressions do not cease, regeneration occurs incorrectly, resulting in scars and nodules. Given the epidemiological importance of HE, this article aims to discuss the pathophysiological mechanisms of the disease. This study is a narrative review with the purpose of discussing and describing HS and its pathophysiology, as well as demonstrating how this syndrome affects the personal lives of affected individuals. The following databases were used: SciElo (Scientific Electronic Library Online) and PubMed (US National Library of Medicine), with scientific data from January 2, 2023, with no language restriction and no restriction on the year of publication. Several studies show that the major neuroinhibitory system, GABA, is increased in HE. Furthermore, an important consideration for ammonia in the face of the syndrome must be exposed; the receptors that are located on the periphery of the mitochondria, due to the presence of ammonia, as well as ligandins, triggering the activation of neurosteroid production in astrocytes. In any case, all studies have stated that the later the diagnosis is made, the more severe the systemic consequences of the pathology will be. In addition, it is of fundamental importance that the medical centers responsible for offering hospital support to patients affected by HE are prepared. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-02-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/40587 10.33448/rsd-v12i3.40587 |
url |
https://rsdjournal.org/index.php/rsd/article/view/40587 |
identifier_str_mv |
10.33448/rsd-v12i3.40587 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/40587/33090 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 12 No. 3; e10712340587 Research, Society and Development; Vol. 12 Núm. 3; e10712340587 Research, Society and Development; v. 12 n. 3; e10712340587 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052619773968384 |