Can daily consumption of a nephroprotective homeopathic product protect the kidneys from gentamicin toxicity?
Autor(a) principal: | |
---|---|
Data de Publicação: | 2021 |
Outros Autores: | , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/16592 |
Resumo: | The objective of this work was to determine whether preventive consumption of a homeopathic product via drinking water would protect mouse kidneys from a challenge with the nephrotoxic antibiotic gentamicin. We used 40 Swiss mice divided into four groups with ten animals each. The homeopathic product was supplied through water for 30 days in a preventive manner and gentamicin for 10 days to induce an experimental renal failure. The groups were as follows: Negative-CT (homeopathic and gentamicin was not provided), Positive-CT (did not receive homeopathic, but received gentamicin 40 mg/kg), T2 (received 0.002 ml of the product per animal/day, and received gentamicin 40 mg/kg), and T4 (0.004 ml of the product per animal/day and received gentamicin 40 mg/kg). On days 12 and 20, blood and tissue samples were collected from five animals in each group. No histopathological lesions were found in mouse kidneys. However, levels of thiobarbituric acid reactive substances, reactive oxygen species, and nitrite/nitrate ratios in the kidney of the Positive-CT group were higher compared to the other groups. As for glutathione S-transferase, on the 20th day, the groups that used the homeopathic product (T2 and T4) had higher activities than the positive TC. Therefore, the results suggest that prophylactic consumption of the hepatoprotective homeopathic product can decrease lipid peroxidation, nitrous stress, and oxidative stress at the renal level when consecutive doses of gentamicin induce insufficiency. |
id |
UNIFEI_ad620b55592a4e11a44fa7524050d5fd |
---|---|
oai_identifier_str |
oai:ojs.pkp.sfu.ca:article/16592 |
network_acronym_str |
UNIFEI |
network_name_str |
Research, Society and Development |
repository_id_str |
|
spelling |
Can daily consumption of a nephroprotective homeopathic product protect the kidneys from gentamicin toxicity?¿Puede el consumo diario de un producto homeopático nefroprotector proteger los riñones de la toxicidad de la gentamicina?O consumo diário de um produto homeopático nefrorprotetor pode proteger os rins da toxicidade da gentamicina?GentamicinaHomeopáticoInsuficiência renal.GentamicinaHomeopáticoInsuficiencia renal.GentamicinHomeopathicRenal failure.The objective of this work was to determine whether preventive consumption of a homeopathic product via drinking water would protect mouse kidneys from a challenge with the nephrotoxic antibiotic gentamicin. We used 40 Swiss mice divided into four groups with ten animals each. The homeopathic product was supplied through water for 30 days in a preventive manner and gentamicin for 10 days to induce an experimental renal failure. The groups were as follows: Negative-CT (homeopathic and gentamicin was not provided), Positive-CT (did not receive homeopathic, but received gentamicin 40 mg/kg), T2 (received 0.002 ml of the product per animal/day, and received gentamicin 40 mg/kg), and T4 (0.004 ml of the product per animal/day and received gentamicin 40 mg/kg). On days 12 and 20, blood and tissue samples were collected from five animals in each group. No histopathological lesions were found in mouse kidneys. However, levels of thiobarbituric acid reactive substances, reactive oxygen species, and nitrite/nitrate ratios in the kidney of the Positive-CT group were higher compared to the other groups. As for glutathione S-transferase, on the 20th day, the groups that used the homeopathic product (T2 and T4) had higher activities than the positive TC. Therefore, the results suggest that prophylactic consumption of the hepatoprotective homeopathic product can decrease lipid peroxidation, nitrous stress, and oxidative stress at the renal level when consecutive doses of gentamicin induce insufficiency.El objetivo de este trabajo fue determinar si el consumo preventivo de un producto homeopático a través del agua potable protegería los riñones de los ratones de un desafío con el antibiótico nefrotóxico gentamicina. Usamos 40 ratones suizos divididos en cuatro grupos con diez animales cada uno. El producto homeopático se suministró a través de agua durante 30 días de forma preventiva y gentamicina durante 10 días para inducir una insuficiencia renal experimental. Los grupos fueron los siguientes: CT negativo (no se proporcionó homeopático y gentamicina), CT positivo (no recibió homeopático, pero recibió gentamicina 40 mg/kg), T2 (recibió 0,002 ml del producto por animal/día, y recibió gentamicina 40 mg/kg) y T4 (0,004 ml del producto por animal / día y recibió gentamicina 40 mg/kg). Los días 12 y 20, se recogieron muestras de sangre y tejido de cinco animales de cada grupo. No se encontraron lesiones histopatológicas en riñones de ratón. Sin embargo, los niveles de sustancias reactivas con ácido tiobarbitúrico, especies reactivas de oxígeno y relaciones nitrito/nitrato en el riñón del grupo de CT positiva fueron más altos en comparación con los otros grupos. En cuanto a la glutatión S-transferasa, el día 20, los grupos que utilizaron el producto homeopático (T2 y T4) tuvieron actividades más altas que los TC positivos. Por lo tanto, los resultados sugieren que el consumo profiláctico del producto homeopático hepatoprotector puede disminuir la peroxidación lipídica, el estrés nitroso y el estrés oxidativo a nivel renal cuando dosis consecutivas de gentamicina inducen insuficiencia.O objetivo deste trabalho foi determinar se o consumo preventivo de um produto homeopático via água potável protegeria os rins de camundongos de um desafio com o antibiótico nefrotóxico gentamicina. Foram utilizados 40 camundongos Swiss divididos em quatro grupos com dez animais cada. O produto homeopático foi fornecido por meio de água por 30 dias de forma preventiva e gentamicina por 10 dias para induzir insuficiência renal experimental. Os grupos foram os seguintes: TC-negativa (não foi fornecida gentamicina e homeopática), TC-positiva (não recebeu homeopatia, mas recebeu gentamicina 40 mg/kg), T2 (recebeu 0,002 ml do produto por animal/dia, e receberam gentamicina 40 mg/kg) e T4 (0,004 ml do produto por animal/dia e receberam gentamicina 40 mg/kg). Nos dias 12 e 20, amostras de sangue e tecido foram coletadas de cinco animais em cada grupo. Nenhuma lesão histopatológica foi encontrada em rins de camundongos. No entanto, os níveis de substâncias reativas ao ácido tiobarbitúrico, espécies reativas de oxigênio e relações nitrito/nitrato no rim do grupo CT-positivo foram maiores em comparação com os outros grupos. Já para a glutationa S-transferase, no 20º dia, os grupos que usaram o produto homeopático (T2 e T4) apresentaram atividades superiores ao TC positivo. Portanto, os resultados sugerem que o consumo profilático do produto homeopático hepatoprotetor pode diminuir a peroxidação lipídica, o estresse nitroso e o estresse oxidativo no nível renal quando doses consecutivas de gentamicina induzem insuficiência.Research, Society and Development2021-07-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1659210.33448/rsd-v10i7.16592Research, Society and Development; Vol. 10 No. 7; e53310716592Research, Society and Development; Vol. 10 Núm. 7; e53310716592Research, Society and Development; v. 10 n. 7; e533107165922525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/16592/15166Copyright (c) 2021 Giovana Carolina Machado; Patricia Glombowsky; Gabriela Miotto Galli; Bianca Fagan Bissacotti; Priscila Marquezan Copetti; Leticia Druzian; Vera Maria Morsch; Ricardo Evandro Mendes; Aleksandro Schafer da Silvahttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMachado, Giovana CarolinaGlombowsky, PatriciaGalli, Gabriela Miotto Bissacotti, Bianca Fagan Copetti, Priscila Marquezan Druzian, LeticiaMorsch, Vera MariaMendes, Ricardo Evandro Silva, Aleksandro Schafer da2021-07-18T21:07:03Zoai:ojs.pkp.sfu.ca:article/16592Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:37:06.078452Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Can daily consumption of a nephroprotective homeopathic product protect the kidneys from gentamicin toxicity? ¿Puede el consumo diario de un producto homeopático nefroprotector proteger los riñones de la toxicidad de la gentamicina? O consumo diário de um produto homeopático nefrorprotetor pode proteger os rins da toxicidade da gentamicina? |
title |
Can daily consumption of a nephroprotective homeopathic product protect the kidneys from gentamicin toxicity? |
spellingShingle |
Can daily consumption of a nephroprotective homeopathic product protect the kidneys from gentamicin toxicity? Machado, Giovana Carolina Gentamicina Homeopático Insuficiência renal. Gentamicina Homeopático Insuficiencia renal. Gentamicin Homeopathic Renal failure. |
title_short |
Can daily consumption of a nephroprotective homeopathic product protect the kidneys from gentamicin toxicity? |
title_full |
Can daily consumption of a nephroprotective homeopathic product protect the kidneys from gentamicin toxicity? |
title_fullStr |
Can daily consumption of a nephroprotective homeopathic product protect the kidneys from gentamicin toxicity? |
title_full_unstemmed |
Can daily consumption of a nephroprotective homeopathic product protect the kidneys from gentamicin toxicity? |
title_sort |
Can daily consumption of a nephroprotective homeopathic product protect the kidneys from gentamicin toxicity? |
author |
Machado, Giovana Carolina |
author_facet |
Machado, Giovana Carolina Glombowsky, Patricia Galli, Gabriela Miotto Bissacotti, Bianca Fagan Copetti, Priscila Marquezan Druzian, Leticia Morsch, Vera Maria Mendes, Ricardo Evandro Silva, Aleksandro Schafer da |
author_role |
author |
author2 |
Glombowsky, Patricia Galli, Gabriela Miotto Bissacotti, Bianca Fagan Copetti, Priscila Marquezan Druzian, Leticia Morsch, Vera Maria Mendes, Ricardo Evandro Silva, Aleksandro Schafer da |
author2_role |
author author author author author author author author |
dc.contributor.author.fl_str_mv |
Machado, Giovana Carolina Glombowsky, Patricia Galli, Gabriela Miotto Bissacotti, Bianca Fagan Copetti, Priscila Marquezan Druzian, Leticia Morsch, Vera Maria Mendes, Ricardo Evandro Silva, Aleksandro Schafer da |
dc.subject.por.fl_str_mv |
Gentamicina Homeopático Insuficiência renal. Gentamicina Homeopático Insuficiencia renal. Gentamicin Homeopathic Renal failure. |
topic |
Gentamicina Homeopático Insuficiência renal. Gentamicina Homeopático Insuficiencia renal. Gentamicin Homeopathic Renal failure. |
description |
The objective of this work was to determine whether preventive consumption of a homeopathic product via drinking water would protect mouse kidneys from a challenge with the nephrotoxic antibiotic gentamicin. We used 40 Swiss mice divided into four groups with ten animals each. The homeopathic product was supplied through water for 30 days in a preventive manner and gentamicin for 10 days to induce an experimental renal failure. The groups were as follows: Negative-CT (homeopathic and gentamicin was not provided), Positive-CT (did not receive homeopathic, but received gentamicin 40 mg/kg), T2 (received 0.002 ml of the product per animal/day, and received gentamicin 40 mg/kg), and T4 (0.004 ml of the product per animal/day and received gentamicin 40 mg/kg). On days 12 and 20, blood and tissue samples were collected from five animals in each group. No histopathological lesions were found in mouse kidneys. However, levels of thiobarbituric acid reactive substances, reactive oxygen species, and nitrite/nitrate ratios in the kidney of the Positive-CT group were higher compared to the other groups. As for glutathione S-transferase, on the 20th day, the groups that used the homeopathic product (T2 and T4) had higher activities than the positive TC. Therefore, the results suggest that prophylactic consumption of the hepatoprotective homeopathic product can decrease lipid peroxidation, nitrous stress, and oxidative stress at the renal level when consecutive doses of gentamicin induce insufficiency. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07-04 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/16592 10.33448/rsd-v10i7.16592 |
url |
https://rsdjournal.org/index.php/rsd/article/view/16592 |
identifier_str_mv |
10.33448/rsd-v10i7.16592 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/16592/15166 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 10 No. 7; e53310716592 Research, Society and Development; Vol. 10 Núm. 7; e53310716592 Research, Society and Development; v. 10 n. 7; e53310716592 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052807365263360 |