Drug interactions with antihypertensives
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/25488 |
Resumo: | Drug interaction (DI) occurs mainly due to self-medication, polypharmacy or prescription errors. Hypertensive individuals usually need more than one drug for treatment, increasing the probability of possible DI proportional to the amount of drugs used, which can lead to different consequences such as changes in the pharmacological effect, adverse reactions, cumulative toxicity, comorbidities or death. The antihypertensive therapeutic class, which is subdivided into several pharmacological classes with the same therapeutic use, is the class that most stands out in DI and antihypertensive drugs from different pharmacological classes can interact with each other and with other classes of medications in general . Thus, the aim of this study was to statistically analyze the main pharmacological classes and the main drugs related to DI with antihypertensive drugs through a systematic literature review selecting works published in the last twenty years. Drug interactions were evaluated according to severity, classified as mild, moderate and severe. The pharmacological classes causing DI with the most frequent antihypertensive drugs were hypoglycemic agents, non-steroidal anti-inflammatory drugs (NSAIDs), diuretics and a combination of two different types of antihypertensive drugs. The antihypertensive drugs that stood out in DI were captopril, enalapril, hydrochlorothiazide, propranolol, atenolol, amlodipine, amiodarone, losartan, spironolactone and furosemide. Therefore, health professionals need to pay attention to adverse reactions arising from these potential MI, notify and intervene when necessary to improve the efficiency of pharmacological treatment, avoiding damage to health. |
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Drug interactions with antihypertensivesInteracciones medicamentosas con antihipertensivosInterações medicamentosas com anti-hipertensivosInterações medicamentosasInterações farmacológicasFármacos anti-hipertensivosDrogas anti- hipertensivasMedicamentos anti-hipertensivos.Drug interactionsPharmacological interactionsAntihypertensive drugsInteracciones con las drogas Interacciones farmacológicasFármacos antihipertensivosDrogas antihipertensivasMedicamentos antihipertensivos.Drug interaction (DI) occurs mainly due to self-medication, polypharmacy or prescription errors. Hypertensive individuals usually need more than one drug for treatment, increasing the probability of possible DI proportional to the amount of drugs used, which can lead to different consequences such as changes in the pharmacological effect, adverse reactions, cumulative toxicity, comorbidities or death. The antihypertensive therapeutic class, which is subdivided into several pharmacological classes with the same therapeutic use, is the class that most stands out in DI and antihypertensive drugs from different pharmacological classes can interact with each other and with other classes of medications in general . Thus, the aim of this study was to statistically analyze the main pharmacological classes and the main drugs related to DI with antihypertensive drugs through a systematic literature review selecting works published in the last twenty years. Drug interactions were evaluated according to severity, classified as mild, moderate and severe. The pharmacological classes causing DI with the most frequent antihypertensive drugs were hypoglycemic agents, non-steroidal anti-inflammatory drugs (NSAIDs), diuretics and a combination of two different types of antihypertensive drugs. The antihypertensive drugs that stood out in DI were captopril, enalapril, hydrochlorothiazide, propranolol, atenolol, amlodipine, amiodarone, losartan, spironolactone and furosemide. Therefore, health professionals need to pay attention to adverse reactions arising from these potential MI, notify and intervene when necessary to improve the efficiency of pharmacological treatment, avoiding damage to health.La interacción farmacológica (IF) se produce principalmente debido a errores de automedicación, polifarmacia o prescripción. Los hipertensos suelen necesitar más de un fármaco para su tratamiento, aumentando la probabilidad de un posible IF proporcional a la cantidad de fármacos utilizados, lo que puede conllevar diferentes consecuencias como cambios en el efecto farmacológico, reacciones adversas, toxicidad acumulada, comorbilidades o muerte. La clase terapéutica antihipertensiva, que se subdivide en varias clases farmacológicas con el mismo uso terapéutico, es la clase que más destaca en el IF y los fármacos antihipertensivos de diferentes clases farmacológicas pueden interactuar entre sí y con otras clases de medicamentos en general. Así, el objetivo de este estudio fue analizar estadísticamente las principales clases farmacológicas y los principales fármacos relacionados con el IF con fármacos antihipertensivos mediante una revisión sistemática de la literatura seleccionando trabajos publicados en los últimos veinte años. Las interacciones medicamentosas se evaluaron según la gravedad, clasificadas en leves, moderadas y graves. Las clases farmacológicas causantes de IF con los antihipertensivos más frecuentes fueron los hipoglucemiantes, los antiinflamatorios no esteroideos (AINE), los diuréticos y la combinación de dos tipos diferentes de antihipertensivos. Los antihipertensivos que destacaron en el IF fueron captopril, enalapril, hidroclorotiazida, propranolol, atenolol, amlodipino, amiodarona, losartán, espironolactona y furosemida. Por tanto, los profesionales sanitarios deben estar atentos a las reacciones adversas derivadas de estos potenciales IF, notificar e intervenir cuando sea necesario para mejorar la eficacia del tratamiento farmacológico, evitando daños a la salud.A interação medicamentosa (IM) ocorre principalmente devido automedicação, polifarmácia ou erros de prescrição. Indivíduos hipertensos geralmente necessitam mais de um medicamento no tratamento, aumentando a probabilidade de possíveis IM proporcionais a quantidade de medicamentos utilizados, podendo levar a diferentes consequências como alterações no efeito farmacológico, reações adversas, toxicidade acumulativa, comorbidades ou morte. A classe terapêutica anti-hipertensivos, que se subdivide em diversas classes farmacológicas com o mesmo uso terapêutico, é a classe que mais se destaca em IM e fármacos anti-hipertensivos de classes farmacológicas diferentes podem interagir entre si e com outras classes de medicamentos em geral. Assim, o objetivo deste trabalho foi analisar estatisticamente as principais classes farmacológicas e os principais fármacos relacionados a IM com anti-hipertensivos por meio de uma revisão sistemática de literatura selecionando trabalhos publicados nos últimos vinte anos. As interações medicamentosas foram avaliadas segundo a gravidade, classificadas em leves, moderadas e graves. As classes farmacológicas causadoras de IM com anti-hipertensivos mais frequentes foram os hipoglicemiantes, anti-inflamatórios não esteroides (AINES), diuréticos e combinação de dois tipos diferentes de anti-hipertensivos. Já os fármacos anti-hipertensivos que se destacaram em IM foram captopril, enalapril, hidroclorotiazida, propranolol, atenolol, anlodipino, amiodarona, losartana, espironolactona e furosemida. Portanto, os profissionais da área da saúde precisam se atentar para reações adversas oriundas dessas potenciais IM, notificar e intervir quando necessário para melhorar a eficiência do tratamento farmacológico evitando prejuízos à saúde.Research, Society and Development2022-01-17info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/2548810.33448/rsd-v11i2.25488Research, Society and Development; Vol. 11 No. 2; e4411225488Research, Society and Development; Vol. 11 Núm. 2; e4411225488Research, Society and Development; v. 11 n. 2; e44112254882525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/25488/22278Copyright (c) 2022 Katiucce Borges de Morais; Luciana Arantes Dantas; Celiana Maria Ferrarini Triches; Cínthia Alves Porfiro; Manoel Aguiar Neto Filho; Jacqueline Silva Guimarães dos Santoshttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMorais, Katiucce Borges deDantas, Luciana ArantesTriches, Celiana Maria FerrariniPorfiro, Cínthia AlvesNeto Filho, Manoel Aguiar Santos, Jacqueline Silva Guimarães dos2022-02-07T01:42:50Zoai:ojs.pkp.sfu.ca:article/25488Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:43:45.290086Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Drug interactions with antihypertensives Interacciones medicamentosas con antihipertensivos Interações medicamentosas com anti-hipertensivos |
title |
Drug interactions with antihypertensives |
spellingShingle |
Drug interactions with antihypertensives Morais, Katiucce Borges de Interações medicamentosas Interações farmacológicas Fármacos anti-hipertensivos Drogas anti- hipertensivas Medicamentos anti-hipertensivos. Drug interactions Pharmacological interactions Antihypertensive drugs Interacciones con las drogas Interacciones farmacológicas Fármacos antihipertensivos Drogas antihipertensivas Medicamentos antihipertensivos. |
title_short |
Drug interactions with antihypertensives |
title_full |
Drug interactions with antihypertensives |
title_fullStr |
Drug interactions with antihypertensives |
title_full_unstemmed |
Drug interactions with antihypertensives |
title_sort |
Drug interactions with antihypertensives |
author |
Morais, Katiucce Borges de |
author_facet |
Morais, Katiucce Borges de Dantas, Luciana Arantes Triches, Celiana Maria Ferrarini Porfiro, Cínthia Alves Neto Filho, Manoel Aguiar Santos, Jacqueline Silva Guimarães dos |
author_role |
author |
author2 |
Dantas, Luciana Arantes Triches, Celiana Maria Ferrarini Porfiro, Cínthia Alves Neto Filho, Manoel Aguiar Santos, Jacqueline Silva Guimarães dos |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Morais, Katiucce Borges de Dantas, Luciana Arantes Triches, Celiana Maria Ferrarini Porfiro, Cínthia Alves Neto Filho, Manoel Aguiar Santos, Jacqueline Silva Guimarães dos |
dc.subject.por.fl_str_mv |
Interações medicamentosas Interações farmacológicas Fármacos anti-hipertensivos Drogas anti- hipertensivas Medicamentos anti-hipertensivos. Drug interactions Pharmacological interactions Antihypertensive drugs Interacciones con las drogas Interacciones farmacológicas Fármacos antihipertensivos Drogas antihipertensivas Medicamentos antihipertensivos. |
topic |
Interações medicamentosas Interações farmacológicas Fármacos anti-hipertensivos Drogas anti- hipertensivas Medicamentos anti-hipertensivos. Drug interactions Pharmacological interactions Antihypertensive drugs Interacciones con las drogas Interacciones farmacológicas Fármacos antihipertensivos Drogas antihipertensivas Medicamentos antihipertensivos. |
description |
Drug interaction (DI) occurs mainly due to self-medication, polypharmacy or prescription errors. Hypertensive individuals usually need more than one drug for treatment, increasing the probability of possible DI proportional to the amount of drugs used, which can lead to different consequences such as changes in the pharmacological effect, adverse reactions, cumulative toxicity, comorbidities or death. The antihypertensive therapeutic class, which is subdivided into several pharmacological classes with the same therapeutic use, is the class that most stands out in DI and antihypertensive drugs from different pharmacological classes can interact with each other and with other classes of medications in general . Thus, the aim of this study was to statistically analyze the main pharmacological classes and the main drugs related to DI with antihypertensive drugs through a systematic literature review selecting works published in the last twenty years. Drug interactions were evaluated according to severity, classified as mild, moderate and severe. The pharmacological classes causing DI with the most frequent antihypertensive drugs were hypoglycemic agents, non-steroidal anti-inflammatory drugs (NSAIDs), diuretics and a combination of two different types of antihypertensive drugs. The antihypertensive drugs that stood out in DI were captopril, enalapril, hydrochlorothiazide, propranolol, atenolol, amlodipine, amiodarone, losartan, spironolactone and furosemide. Therefore, health professionals need to pay attention to adverse reactions arising from these potential MI, notify and intervene when necessary to improve the efficiency of pharmacological treatment, avoiding damage to health. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-01-17 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/25488 10.33448/rsd-v11i2.25488 |
url |
https://rsdjournal.org/index.php/rsd/article/view/25488 |
identifier_str_mv |
10.33448/rsd-v11i2.25488 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/25488/22278 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 11 No. 2; e4411225488 Research, Society and Development; Vol. 11 Núm. 2; e4411225488 Research, Society and Development; v. 11 n. 2; e4411225488 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
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1797052702560092160 |