Influence of Brazilian red propolis polymeric nanoparticles in haematology, renal, and hepatic evaluations in dogs
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2020 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Research, Society and Development |
| Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/10531 |
Resumo: | Recognized for various beneficial actions, propolis can be differentiated according to its origin. Red propolis, discovered in the northeast of Brazil, offers a strong antioxidant action. Nanoparticles are an innovative tool in the pharmaceutical field, as they help in efficient drug delivery. This study aimed to use red propolis nanoparticles in dogs and evaluate their action based on hematological and biochemical results. Eight healthy adult dogs (bodyweight, 6–27 kg) received 50 mg/animal of polymeric nanoparticles with 20% red propolis extract in a capsule, orally, once a day. Blood samples were collected weekly (five times), and hematologic, hepatic, and renal evaluations were performed. No significant changes were observed, except for alkaline phosphatase, which showed a significant reduction over time. This study in healthy adult dogs did not verify any hematologic, renal, or hepatic adverse effects of daily oral red propolis polymeric nanoparticles (capsules) administration. The results suggest a potential beneficial effect on the liver. |
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Influence of Brazilian red propolis polymeric nanoparticles in haematology, renal, and hepatic evaluations in dogsInfluencia de las nanopartículas poliméricas del propóleo rojo brasileño en las evaluaciones hematológicas, renales y hepáticas de perrosInfluência de nanopartículas poliméricas da própolis vermelha brasileira nas avaliações hematologia, renal e hepática de cãesCaninoEfectos adversosSangreRiñónHígado.CaninoEfeitos adversosSangueRimFígado. CanineAdverse effectsBloodKidneyLiver.Recognized for various beneficial actions, propolis can be differentiated according to its origin. Red propolis, discovered in the northeast of Brazil, offers a strong antioxidant action. Nanoparticles are an innovative tool in the pharmaceutical field, as they help in efficient drug delivery. This study aimed to use red propolis nanoparticles in dogs and evaluate their action based on hematological and biochemical results. Eight healthy adult dogs (bodyweight, 6–27 kg) received 50 mg/animal of polymeric nanoparticles with 20% red propolis extract in a capsule, orally, once a day. Blood samples were collected weekly (five times), and hematologic, hepatic, and renal evaluations were performed. No significant changes were observed, except for alkaline phosphatase, which showed a significant reduction over time. This study in healthy adult dogs did not verify any hematologic, renal, or hepatic adverse effects of daily oral red propolis polymeric nanoparticles (capsules) administration. The results suggest a potential beneficial effect on the liver.Reconocido por diversas acciones beneficiosas, el propóleo se puede diferenciar según su origen. El propóleo rojo, descubierto en el noreste de Brasil, ofrece una fuerte acción antioxidante. Las nanopartículas son una herramienta innovadora en el campo farmacéutico, ya que ayudan en la administración eficiente de medicamentos. Este estudio tuvo como objetivo utilizar nanopartículas de propóleo rojo en perros y evaluar su acción en base a resultados hematológicos y bioquímicos. Ocho perros adultos sanos (peso corporal, 6–27 kg) recibieron 50 mg / animal de nanopartículas poliméricas con extracto de propóleo rojo al 20% en una cápsula, por vía oral, una vez al día. Se recolectaron muestras de sangre semanalmente (cinco veces) y se realizaron evaluaciones hematológicas, hepáticas y renales. No se observaron cambios significativos, a excepción de la fosfatasa alcalina, que mostró una reducción significativa con el tiempo. Este estudio en perros adultos sanos no verificó ningún efecto adverso hematológico, renal o hepático de la administración oral diaria de nanopartículas poliméricas (cápsulas) de propóleo rojo. Los resultados sugieren un posible efecto beneficioso sobre el hígado.Reconhecida por diversas ações benéficas, a própolis pode ser diferenciada de acordo com sua origem. A própolis vermelha, descoberta no Nordeste do Brasil, oferece forte ação antioxidante. As nanopartículas são uma ferramenta inovadora na área farmacêutica, pois auxiliam na entrega eficiente de medicamentos. Este estudo teve como objetivo utilizar nanopartículas de própolis vermelha em cães e avaliar sua ação com base em resultados hematológicos e bioquímicos. Oito cães adultos saudáveis (peso corporal, 6–27 kg) receberam 50 mg / animal de nanopartículas poliméricas com extrato de própolis vermelha 20% em cápsula, por via oral, uma vez ao dia. Amostras de sangue foram coletadas semanalmente (cinco vezes) e avaliações hematológicas, hepáticas e renais foram realizadas. Não foram observadas alterações significativas, exceto para a fosfatase alcalina, que apresentou redução significativa ao longo do tempo. Este estudo em cães adultos saudáveis não verificou quaisquer efeitos adversos hematológicos, renais ou hepáticos da administração diária de nanopartículas poliméricas (cápsulas) de própolis vermelha oral. Os resultados sugerem um potencial efeito benéfico no fígado.Research, Society and Development2020-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/1053110.33448/rsd-v9i11.10531Research, Society and Development; Vol. 9 No. 11; e70391110531Research, Society and Development; Vol. 9 Núm. 11; e70391110531Research, Society and Development; v. 9 n. 11; e703911105312525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIenghttps://rsdjournal.org/index.php/rsd/article/view/10531/9258Copyright (c) 2020 Mariana Rivelo Rodrigues de Melo; Arnaldo Cesar Oliveira Gomes Lira Junior; Karina Pessoa Oliveira; Ticiano Gomes do Nascimento; Pierre Barnabé Escodro; Marcia Kikuyo Notomihttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMelo, Mariana Rivelo Rodrigues de Lira Junior, Arnaldo Cesar Oliveira Gomes Oliveira, Karina Pessoa Nascimento, Ticiano Gomes do Escodro, Pierre Barnabé Notomi, Marcia Kikuyo2020-12-10T23:37:57Zoai:ojs.pkp.sfu.ca:article/10531Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:32:34.999060Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
| dc.title.none.fl_str_mv |
Influence of Brazilian red propolis polymeric nanoparticles in haematology, renal, and hepatic evaluations in dogs Influencia de las nanopartículas poliméricas del propóleo rojo brasileño en las evaluaciones hematológicas, renales y hepáticas de perros Influência de nanopartículas poliméricas da própolis vermelha brasileira nas avaliações hematologia, renal e hepática de cães |
| title |
Influence of Brazilian red propolis polymeric nanoparticles in haematology, renal, and hepatic evaluations in dogs |
| spellingShingle |
Influence of Brazilian red propolis polymeric nanoparticles in haematology, renal, and hepatic evaluations in dogs Melo, Mariana Rivelo Rodrigues de Canino Efectos adversos Sangre Riñón Hígado. Canino Efeitos adversos Sangue Rim Fígado. Canine Adverse effects Blood Kidney Liver. |
| title_short |
Influence of Brazilian red propolis polymeric nanoparticles in haematology, renal, and hepatic evaluations in dogs |
| title_full |
Influence of Brazilian red propolis polymeric nanoparticles in haematology, renal, and hepatic evaluations in dogs |
| title_fullStr |
Influence of Brazilian red propolis polymeric nanoparticles in haematology, renal, and hepatic evaluations in dogs |
| title_full_unstemmed |
Influence of Brazilian red propolis polymeric nanoparticles in haematology, renal, and hepatic evaluations in dogs |
| title_sort |
Influence of Brazilian red propolis polymeric nanoparticles in haematology, renal, and hepatic evaluations in dogs |
| author |
Melo, Mariana Rivelo Rodrigues de |
| author_facet |
Melo, Mariana Rivelo Rodrigues de Lira Junior, Arnaldo Cesar Oliveira Gomes Oliveira, Karina Pessoa Nascimento, Ticiano Gomes do Escodro, Pierre Barnabé Notomi, Marcia Kikuyo |
| author_role |
author |
| author2 |
Lira Junior, Arnaldo Cesar Oliveira Gomes Oliveira, Karina Pessoa Nascimento, Ticiano Gomes do Escodro, Pierre Barnabé Notomi, Marcia Kikuyo |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Melo, Mariana Rivelo Rodrigues de Lira Junior, Arnaldo Cesar Oliveira Gomes Oliveira, Karina Pessoa Nascimento, Ticiano Gomes do Escodro, Pierre Barnabé Notomi, Marcia Kikuyo |
| dc.subject.por.fl_str_mv |
Canino Efectos adversos Sangre Riñón Hígado. Canino Efeitos adversos Sangue Rim Fígado. Canine Adverse effects Blood Kidney Liver. |
| topic |
Canino Efectos adversos Sangre Riñón Hígado. Canino Efeitos adversos Sangue Rim Fígado. Canine Adverse effects Blood Kidney Liver. |
| description |
Recognized for various beneficial actions, propolis can be differentiated according to its origin. Red propolis, discovered in the northeast of Brazil, offers a strong antioxidant action. Nanoparticles are an innovative tool in the pharmaceutical field, as they help in efficient drug delivery. This study aimed to use red propolis nanoparticles in dogs and evaluate their action based on hematological and biochemical results. Eight healthy adult dogs (bodyweight, 6–27 kg) received 50 mg/animal of polymeric nanoparticles with 20% red propolis extract in a capsule, orally, once a day. Blood samples were collected weekly (five times), and hematologic, hepatic, and renal evaluations were performed. No significant changes were observed, except for alkaline phosphatase, which showed a significant reduction over time. This study in healthy adult dogs did not verify any hematologic, renal, or hepatic adverse effects of daily oral red propolis polymeric nanoparticles (capsules) administration. The results suggest a potential beneficial effect on the liver. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-12-01 |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/10531 10.33448/rsd-v9i11.10531 |
| url |
https://rsdjournal.org/index.php/rsd/article/view/10531 |
| identifier_str_mv |
10.33448/rsd-v9i11.10531 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/10531/9258 |
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https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
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https://creativecommons.org/licenses/by/4.0 |
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openAccess |
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application/pdf |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development; Vol. 9 No. 11; e70391110531 Research, Society and Development; Vol. 9 Núm. 11; e70391110531 Research, Society and Development; v. 9 n. 11; e70391110531 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
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Universidade Federal de Itajubá (UNIFEI) |
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UNIFEI |
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UNIFEI |
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Research, Society and Development |
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Research, Society and Development |
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Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
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rsd.articles@gmail.com |
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1797052743320338432 |