Behavior of Selenium and Selenium-Dependent Glutathione Peroxidase Activity in Cystic Fibrosis
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | por |
Título da fonte: | Research, Society and Development |
Texto Completo: | https://rsdjournal.org/index.php/rsd/article/view/2689 |
Resumo: | To investigate in the literature the behavior of different levels of selenium and the activity of glutathione peroxidase (GPx-Se) observed in patients with cystic fibrosis. This is an integrative literature review, carried out by searching for original articles, with no year limit, in English and Portuguese, indexed in the PubMed, Scopus and Web of Science databases. 56 articles were retrieved, of which 16.1% (n = 9) were included in this review, for reading the full text. It was observed that of the studies compiled, 33.3% (n=3) identified a reduction in the selenium concentrations, as well as in the GPx activity, although 11.1% (n=1) reported an increase only in the plasma concentrations of the mineral, and another 22.2% (n=2), added by GPx. On the other hand, 33.3% (n=3) of the studies did not find any significant differences regarding these parameters compared between the control group and the group with cystic fibrosis. It is concluded that the levels of selenium and the activity of the enzyme Glutathione Peroxidase Dependent on Selenium (GPx-Se) can present different behaviors in conditions of Cystic Fibrosis (CF), however, the fragile reasoning, which justify controversial and little results consistent, reinforces the need for further studies to deepen the theme. |
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Behavior of Selenium and Selenium-Dependent Glutathione Peroxidase Activity in Cystic FibrosisComportamiento de Selenio y Actividad de Glutatión Peroxidasa Dependiente de Selenio en Fibrosis QuísticaComportamento do Selênio e Atividade da Glutationa Peroxidase Dependente de Selênio na Fibrose CísticaGlutathione peroxidaseSeleniumCystic fibrosis.Glutatión peroxidasaSelenioFibrosis quística.Glutationa peroxidaseSelênioFibrose cística.To investigate in the literature the behavior of different levels of selenium and the activity of glutathione peroxidase (GPx-Se) observed in patients with cystic fibrosis. This is an integrative literature review, carried out by searching for original articles, with no year limit, in English and Portuguese, indexed in the PubMed, Scopus and Web of Science databases. 56 articles were retrieved, of which 16.1% (n = 9) were included in this review, for reading the full text. It was observed that of the studies compiled, 33.3% (n=3) identified a reduction in the selenium concentrations, as well as in the GPx activity, although 11.1% (n=1) reported an increase only in the plasma concentrations of the mineral, and another 22.2% (n=2), added by GPx. On the other hand, 33.3% (n=3) of the studies did not find any significant differences regarding these parameters compared between the control group and the group with cystic fibrosis. It is concluded that the levels of selenium and the activity of the enzyme Glutathione Peroxidase Dependent on Selenium (GPx-Se) can present different behaviors in conditions of Cystic Fibrosis (CF), however, the fragile reasoning, which justify controversial and little results consistent, reinforces the need for further studies to deepen the theme.Investigar en la literatura el comportamiento de los diferentes niveles de selenio y la actividad de la glutatión peroxidasa (GPx-Se) observada en pacientes con fibrosis quística. Esta es una revisión integradora de la literatura, realizada mediante la búsqueda de artículos originales, sin límite de años, en inglés y portugués, indexados en la base de datos PubMed, Scopus y Web of Science. Se recuperaron 56 artículos, de los cuales 16,1% (n = 9) se incluyeron en esta revisión, para leer el texto completo. Se observó que de los estudios compilados, el 33.3% (n = 3) identificó una reducción en las concentraciones de selenio, así como en la actividad GPx, aunque el 11.1% (n = 1) informó un aumento solo en las concentraciones plasmáticas de mineral, y otro 22.2% (n = 2), agregado por GPx. Por otro lado, el 33,3% (n = 3) de los estudios no encontraron diferencias significativas con respecto a estos parámetros en comparación entre el grupo control y el grupo con fibrosis quística. Se concluye que los niveles de selenio y la actividad de la enzima glutatión peroxidasa dependiente de selenio (GPx-Se) pueden presentar diferentes comportamientos en condiciones de fibrosis quística (FQ), sin embargo, el razonamiento frágil, que justifica resultados controvertidos y escasos consistente, refuerza la necesidad de más estudios para profundizar el tema.Investigar na literatura o comportamento de diferentes níveis de selênio e da atividade da Glutationa Peroxidase (GPx-Se) observado em pacientes com fibrose cística. Trata-se de revisão integrativa da literatura, realizada por meio de pesquisa de artigos originais, sem limite de ano, em inglês e português, indexados na base de dados PubMed, Scopus e Web of Science. Foram recuperados 56 artigos, dos quais 16,1% (n=9) foram incluídos nesta revisão, para leitura do texto integral. Observou-se que dos estudos compilados, 33,3% (n= 3) identificaram uma redução nas concentrações de selênio, como também da atividade da GPx, embora 11,1% (n=1) tenha relatado aumento apenas nas concentrações plasmáticas do mineral, e outros 22,2% (n=2), somada a atuação da GPx. Em contrapartida, 33,3% (n=3) dos estudos não encontraram diferenças significativas quanto a estes parâmetros comparados entre grupo controle e grupo com fibrose cística. Conclui-se que os níveis de selênio e a atividade da enzima Glutationa Peroxidase Dependente de Selênio (GPx-Se) podem apresentar diferentes comportamentos em condições de Fibrose Cística (FC), entretanto, a frágil fundamentação, que justificam resultados controversos e pouco consistentes, reforça a necessidade de mais estudos que aprofundem a temática.Research, Society and Development2020-03-20info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://rsdjournal.org/index.php/rsd/article/view/268910.33448/rsd-v9i4.2689Research, Society and Development; Vol. 9 No. 4; e86942689Research, Society and Development; Vol. 9 Núm. 4; e86942689Research, Society and Development; v. 9 n. 4; e869426892525-3409reponame:Research, Society and Developmentinstname:Universidade Federal de Itajubá (UNIFEI)instacron:UNIFEIporhttps://rsdjournal.org/index.php/rsd/article/view/2689/2738Copyright (c) 2020 Amanda Glenda Sousa Silva, Luana Santos Aráújo Dantas, Thaís Rodrigues Nogueira, Betânia de Jesus e Silva de Almendra Freitasinfo:eu-repo/semantics/openAccessSilva, Amanda Glenda SousaDantas, Luana Santos AráújoNogueira, Thaís RodriguesFreitas, Betânia de Jesus e Silva de Almendra2020-08-20T18:07:16Zoai:ojs.pkp.sfu.ca:article/2689Revistahttps://rsdjournal.org/index.php/rsd/indexPUBhttps://rsdjournal.org/index.php/rsd/oairsd.articles@gmail.com2525-34092525-3409opendoar:2024-01-17T09:27:11.096793Research, Society and Development - Universidade Federal de Itajubá (UNIFEI)false |
dc.title.none.fl_str_mv |
Behavior of Selenium and Selenium-Dependent Glutathione Peroxidase Activity in Cystic Fibrosis Comportamiento de Selenio y Actividad de Glutatión Peroxidasa Dependiente de Selenio en Fibrosis Quística Comportamento do Selênio e Atividade da Glutationa Peroxidase Dependente de Selênio na Fibrose Cística |
title |
Behavior of Selenium and Selenium-Dependent Glutathione Peroxidase Activity in Cystic Fibrosis |
spellingShingle |
Behavior of Selenium and Selenium-Dependent Glutathione Peroxidase Activity in Cystic Fibrosis Silva, Amanda Glenda Sousa Glutathione peroxidase Selenium Cystic fibrosis. Glutatión peroxidasa Selenio Fibrosis quística. Glutationa peroxidase Selênio Fibrose cística. |
title_short |
Behavior of Selenium and Selenium-Dependent Glutathione Peroxidase Activity in Cystic Fibrosis |
title_full |
Behavior of Selenium and Selenium-Dependent Glutathione Peroxidase Activity in Cystic Fibrosis |
title_fullStr |
Behavior of Selenium and Selenium-Dependent Glutathione Peroxidase Activity in Cystic Fibrosis |
title_full_unstemmed |
Behavior of Selenium and Selenium-Dependent Glutathione Peroxidase Activity in Cystic Fibrosis |
title_sort |
Behavior of Selenium and Selenium-Dependent Glutathione Peroxidase Activity in Cystic Fibrosis |
author |
Silva, Amanda Glenda Sousa |
author_facet |
Silva, Amanda Glenda Sousa Dantas, Luana Santos Aráújo Nogueira, Thaís Rodrigues Freitas, Betânia de Jesus e Silva de Almendra |
author_role |
author |
author2 |
Dantas, Luana Santos Aráújo Nogueira, Thaís Rodrigues Freitas, Betânia de Jesus e Silva de Almendra |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Silva, Amanda Glenda Sousa Dantas, Luana Santos Aráújo Nogueira, Thaís Rodrigues Freitas, Betânia de Jesus e Silva de Almendra |
dc.subject.por.fl_str_mv |
Glutathione peroxidase Selenium Cystic fibrosis. Glutatión peroxidasa Selenio Fibrosis quística. Glutationa peroxidase Selênio Fibrose cística. |
topic |
Glutathione peroxidase Selenium Cystic fibrosis. Glutatión peroxidasa Selenio Fibrosis quística. Glutationa peroxidase Selênio Fibrose cística. |
description |
To investigate in the literature the behavior of different levels of selenium and the activity of glutathione peroxidase (GPx-Se) observed in patients with cystic fibrosis. This is an integrative literature review, carried out by searching for original articles, with no year limit, in English and Portuguese, indexed in the PubMed, Scopus and Web of Science databases. 56 articles were retrieved, of which 16.1% (n = 9) were included in this review, for reading the full text. It was observed that of the studies compiled, 33.3% (n=3) identified a reduction in the selenium concentrations, as well as in the GPx activity, although 11.1% (n=1) reported an increase only in the plasma concentrations of the mineral, and another 22.2% (n=2), added by GPx. On the other hand, 33.3% (n=3) of the studies did not find any significant differences regarding these parameters compared between the control group and the group with cystic fibrosis. It is concluded that the levels of selenium and the activity of the enzyme Glutathione Peroxidase Dependent on Selenium (GPx-Se) can present different behaviors in conditions of Cystic Fibrosis (CF), however, the fragile reasoning, which justify controversial and little results consistent, reinforces the need for further studies to deepen the theme. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-03-20 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/2689 10.33448/rsd-v9i4.2689 |
url |
https://rsdjournal.org/index.php/rsd/article/view/2689 |
identifier_str_mv |
10.33448/rsd-v9i4.2689 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.relation.none.fl_str_mv |
https://rsdjournal.org/index.php/rsd/article/view/2689/2738 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Research, Society and Development |
publisher.none.fl_str_mv |
Research, Society and Development |
dc.source.none.fl_str_mv |
Research, Society and Development; Vol. 9 No. 4; e86942689 Research, Society and Development; Vol. 9 Núm. 4; e86942689 Research, Society and Development; v. 9 n. 4; e86942689 2525-3409 reponame:Research, Society and Development instname:Universidade Federal de Itajubá (UNIFEI) instacron:UNIFEI |
instname_str |
Universidade Federal de Itajubá (UNIFEI) |
instacron_str |
UNIFEI |
institution |
UNIFEI |
reponame_str |
Research, Society and Development |
collection |
Research, Society and Development |
repository.name.fl_str_mv |
Research, Society and Development - Universidade Federal de Itajubá (UNIFEI) |
repository.mail.fl_str_mv |
rsd.articles@gmail.com |
_version_ |
1797052734349770752 |