Anticorpos anti-neutrófilos em pacientes com câncer de mama e sua correlação com parâmetros clinicopatológicos
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Tipo de documento: | Dissertação |
Idioma: | por |
Título da fonte: | Biblioteca Digital de Teses e Dissertações do UNIOESTE |
Texto Completo: | http://tede.unioeste.br/handle/tede/4225 |
Resumo: | Introduction: Anti-neutrophil cytoplasmic antibodies (ANCA) are able to activate neutrophils through binding to their antigens, such as myeloperoxidase (p-ANCA), inducing neutrophil degranulation and respiratory burst even in sterile situations. This corroborates for cellular and tissue damage, and may be involved in the development and progression of breast cancer. Objective: This study measured pANCA levels in serum and breast tissue of women (n= 150) diagnosed with benign breast lesions (n= 58) and mammary carcinoma (n= 92), correlating these levels with clinicopathological aspects. Methods: Peripheral blood and breast tissue samples were collected from women attended at Francisco Beltrão Cancer Hospital - CEONC, Paraná, Brazil, from May 2015 to December 2017. Blood samples were centrifuged to obtain serum, and the tissue fragments were homogenized and centrifuged for further analysis of the supernatants. The analyses were conducted in pools, grouped according to different clinicopathological characteristics. The pANCA dosage was performed by enzyme immunoassay (IBL International Myeloperoxidase-Ab ELISA Kit, RE75601). The results were evaluated by the statistical program GraphPad Prism 6.0, considering p≤0,05 as significant. Results: p-ANCA levels were found to be elevated in pools related to worse prognostic aspects such as high histological grade (serum p=0.0465, tissue p<0.0001) lymph nodal status (serum p<0.001, tissue p=0.034) and risk factors for breast cancer, as body mass index (tissue p<0.001), menopausal status (tissue p<0.001) and <45 years (serum p=0.0006, tissue p<0.0001) at diagnosis. Conclusion: Higher levels of p-ANCA demonstrate an association with clinicopathological parameters related to worst prognosis of breast cancer. It can be inferred that greater neutrophil activation might occurs in these conditions, and, consequently, greater degranulation and formation of NETs. |
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Panis, Carolinahttp://lattes.cnpq.br/6647155856678648Panis, Carolinahttp://lattes.cnpq.br/6647155856678648Amorim, João Paulo Arrudahttp://lattes.cnpq.br/4100033010756626Velásquez, Leonardo Garciahttp://lattes.cnpq.br/8391014209992634http://lattes.cnpq.br/7077767478457224Scandolara, Thalita Basso2019-04-25T13:35:06Z2019-02-25SCANDOLARA, Thalita Basso. Anticorpos anti-neutrófilos em pacientes com câncer de mama e sua correlação com parâmetros clinicopatológicos. 2019. 94 f. Dissertação (Mestrado em Ciências Aplicadas à Saúde) - Universidade Estadual do Oeste do Paraná, Francisco Beltrão, 2019.http://tede.unioeste.br/handle/tede/4225Introduction: Anti-neutrophil cytoplasmic antibodies (ANCA) are able to activate neutrophils through binding to their antigens, such as myeloperoxidase (p-ANCA), inducing neutrophil degranulation and respiratory burst even in sterile situations. This corroborates for cellular and tissue damage, and may be involved in the development and progression of breast cancer. Objective: This study measured pANCA levels in serum and breast tissue of women (n= 150) diagnosed with benign breast lesions (n= 58) and mammary carcinoma (n= 92), correlating these levels with clinicopathological aspects. Methods: Peripheral blood and breast tissue samples were collected from women attended at Francisco Beltrão Cancer Hospital - CEONC, Paraná, Brazil, from May 2015 to December 2017. Blood samples were centrifuged to obtain serum, and the tissue fragments were homogenized and centrifuged for further analysis of the supernatants. The analyses were conducted in pools, grouped according to different clinicopathological characteristics. The pANCA dosage was performed by enzyme immunoassay (IBL International Myeloperoxidase-Ab ELISA Kit, RE75601). The results were evaluated by the statistical program GraphPad Prism 6.0, considering p≤0,05 as significant. Results: p-ANCA levels were found to be elevated in pools related to worse prognostic aspects such as high histological grade (serum p=0.0465, tissue p<0.0001) lymph nodal status (serum p<0.001, tissue p=0.034) and risk factors for breast cancer, as body mass index (tissue p<0.001), menopausal status (tissue p<0.001) and <45 years (serum p=0.0006, tissue p<0.0001) at diagnosis. Conclusion: Higher levels of p-ANCA demonstrate an association with clinicopathological parameters related to worst prognosis of breast cancer. It can be inferred that greater neutrophil activation might occurs in these conditions, and, consequently, greater degranulation and formation of NETs.Introdução: Os anticorpos anti-citoplasma de neutrófilos (ANCA) são capazes de ativar neutrófilos através da ligação com seus antígenos, como a mieloperoxidase (p-ANCA), induzindo a degranulação de neutrófilos e burst respiratório mesmo em situações estéreis. Isto corrobora para dano celular e tecidual, podendo estar envolvido no desenvolvimento e na progressão do câncer de mama. Objetivo: Neste trabalho realizou-se a dosagem dos níveis de p-ANCA no plasma e no tecido mamário de mulheres (n=150) diagnosticadas com lesões benignas da mama (n=58) e carcinoma mamário (n=92), correlacionando-os com aspectos clinicopatológicos. Metodologia: Amostras de sangue periférico e de tecido mamário foram coletadas de mulheres atendidas no Hospital do Câncer de Francisco Beltrão – CEONC, Paraná, Brasil, no período de maio de 2015 à Dezembro de 2017. As amostras de sangue foram centrifugadas para obtenção de plasma, e os fragmentos de tecido homogeneizados e centrifugados para posterior análise dos sobrenadantes. As análises foram conduzidas em pools, agrupadas de acordo com diferentes características clinicopatológicas. A dosagem de p-ANCA foi realizada através de imunoensaio enzimático (kit IBL International Myeloperoxidase-Ab ELISA, RE75601). Os resultados foram avaliados pelo programa estatístico GraphPad Prism 6.0, considerando-se p≤0,05 como significante. Resultados: Níveis de p-ANCA foram encontrados elevados em pools relacionados com aspectos de pior prognóstico como alto grau histológico (plasma p=0.0465, tecido p<0.0001) status linfonodal positivo (plasma p<0.001, tecido p=0.034) e fatores de risco para câncer, como índice de massa corporal (tecido p<0.001), status menopausal (tecido p<0.001) e <45 anos (plasmap=0.0006, tecido p<0.0001) ao diagnóstico. Conclusões: Maiores níveis de p-ANCA demonstram uma associação com parâmetros clinicopatológicos relacionados ao pior prognostico do câncer de mama, podendo inferir que ocorra maior ativação de neutrófilos e, consequentemente, maior degranulação e formação de NETs nestas condições patológicas.Submitted by Almir Squinsani (almir.squinsani@unioeste.br) on 2019-04-25T13:35:05Z No. of bitstreams: 2 Thalita_Basso_2019.pdf: 2021893 bytes, checksum: 041871280dbeff2856c6a3f3cf66974b (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5)Made available in DSpace on 2019-04-25T13:35:06Z (GMT). No. of bitstreams: 2 Thalita_Basso_2019.pdf: 2021893 bytes, checksum: 041871280dbeff2856c6a3f3cf66974b (MD5) license_rdf: 0 bytes, checksum: d41d8cd98f00b204e9800998ecf8427e (MD5) Previous issue date: 2019-02-25Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESapplication/pdfpor-5356284425524309716500Universidade Estadual do Oeste do ParanáFrancisco BeltrãoPrograma de Pós-Graduação em Ciências Aplicadas à SaúdeUNIOESTEBrasilCentro de Ciências da Saúdehttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessCâncer de mamaanticorpos anti-neutrófilosmieloperoxidaseAntineutrophil antibodiesMyeloperoxidaseBreast neoplasmsCIENCIAS DA SAUDEAnticorpos anti-neutrófilos em pacientes com câncer de mama e sua correlação com parâmetros clinicopatológicosAnti-neutrophil antibodies in patients with breast cancer and Its correlation with clinicopathological parametersinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesis629052525323063066460060060060029244165344086512387654494148233069292075167498588264571reponame:Biblioteca Digital de Teses e Dissertações do UNIOESTEinstname:Universidade Estadual do Oeste do Paraná (UNIOESTE)instacron:UNIOESTEORIGINALThalita_Basso_2019.pdfThalita_Basso_2019.pdfapplication/pdf2021893http://tede.unioeste.br:8080/tede/bitstream/tede/4225/5/Thalita_Basso_2019.pdf041871280dbeff2856c6a3f3cf66974bMD55CC-LICENSElicense_urllicense_urltext/plain; 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dc.title.por.fl_str_mv |
Anticorpos anti-neutrófilos em pacientes com câncer de mama e sua correlação com parâmetros clinicopatológicos |
dc.title.alternative.eng.fl_str_mv |
Anti-neutrophil antibodies in patients with breast cancer and Its correlation with clinicopathological parameters |
title |
Anticorpos anti-neutrófilos em pacientes com câncer de mama e sua correlação com parâmetros clinicopatológicos |
spellingShingle |
Anticorpos anti-neutrófilos em pacientes com câncer de mama e sua correlação com parâmetros clinicopatológicos Scandolara, Thalita Basso Câncer de mama anticorpos anti-neutrófilos mieloperoxidase Antineutrophil antibodies Myeloperoxidase Breast neoplasms CIENCIAS DA SAUDE |
title_short |
Anticorpos anti-neutrófilos em pacientes com câncer de mama e sua correlação com parâmetros clinicopatológicos |
title_full |
Anticorpos anti-neutrófilos em pacientes com câncer de mama e sua correlação com parâmetros clinicopatológicos |
title_fullStr |
Anticorpos anti-neutrófilos em pacientes com câncer de mama e sua correlação com parâmetros clinicopatológicos |
title_full_unstemmed |
Anticorpos anti-neutrófilos em pacientes com câncer de mama e sua correlação com parâmetros clinicopatológicos |
title_sort |
Anticorpos anti-neutrófilos em pacientes com câncer de mama e sua correlação com parâmetros clinicopatológicos |
author |
Scandolara, Thalita Basso |
author_facet |
Scandolara, Thalita Basso |
author_role |
author |
dc.contributor.advisor1.fl_str_mv |
Panis, Carolina |
dc.contributor.advisor1Lattes.fl_str_mv |
http://lattes.cnpq.br/6647155856678648 |
dc.contributor.referee1.fl_str_mv |
Panis, Carolina |
dc.contributor.referee1Lattes.fl_str_mv |
http://lattes.cnpq.br/6647155856678648 |
dc.contributor.referee2.fl_str_mv |
Amorim, João Paulo Arruda |
dc.contributor.referee2Lattes.fl_str_mv |
http://lattes.cnpq.br/4100033010756626 |
dc.contributor.referee3.fl_str_mv |
Velásquez, Leonardo Garcia |
dc.contributor.referee3Lattes.fl_str_mv |
http://lattes.cnpq.br/8391014209992634 |
dc.contributor.authorLattes.fl_str_mv |
http://lattes.cnpq.br/7077767478457224 |
dc.contributor.author.fl_str_mv |
Scandolara, Thalita Basso |
contributor_str_mv |
Panis, Carolina Panis, Carolina Amorim, João Paulo Arruda Velásquez, Leonardo Garcia |
dc.subject.por.fl_str_mv |
Câncer de mama anticorpos anti-neutrófilos mieloperoxidase |
topic |
Câncer de mama anticorpos anti-neutrófilos mieloperoxidase Antineutrophil antibodies Myeloperoxidase Breast neoplasms CIENCIAS DA SAUDE |
dc.subject.eng.fl_str_mv |
Antineutrophil antibodies Myeloperoxidase Breast neoplasms |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE |
description |
Introduction: Anti-neutrophil cytoplasmic antibodies (ANCA) are able to activate neutrophils through binding to their antigens, such as myeloperoxidase (p-ANCA), inducing neutrophil degranulation and respiratory burst even in sterile situations. This corroborates for cellular and tissue damage, and may be involved in the development and progression of breast cancer. Objective: This study measured pANCA levels in serum and breast tissue of women (n= 150) diagnosed with benign breast lesions (n= 58) and mammary carcinoma (n= 92), correlating these levels with clinicopathological aspects. Methods: Peripheral blood and breast tissue samples were collected from women attended at Francisco Beltrão Cancer Hospital - CEONC, Paraná, Brazil, from May 2015 to December 2017. Blood samples were centrifuged to obtain serum, and the tissue fragments were homogenized and centrifuged for further analysis of the supernatants. The analyses were conducted in pools, grouped according to different clinicopathological characteristics. The pANCA dosage was performed by enzyme immunoassay (IBL International Myeloperoxidase-Ab ELISA Kit, RE75601). The results were evaluated by the statistical program GraphPad Prism 6.0, considering p≤0,05 as significant. Results: p-ANCA levels were found to be elevated in pools related to worse prognostic aspects such as high histological grade (serum p=0.0465, tissue p<0.0001) lymph nodal status (serum p<0.001, tissue p=0.034) and risk factors for breast cancer, as body mass index (tissue p<0.001), menopausal status (tissue p<0.001) and <45 years (serum p=0.0006, tissue p<0.0001) at diagnosis. Conclusion: Higher levels of p-ANCA demonstrate an association with clinicopathological parameters related to worst prognosis of breast cancer. It can be inferred that greater neutrophil activation might occurs in these conditions, and, consequently, greater degranulation and formation of NETs. |
publishDate |
2019 |
dc.date.accessioned.fl_str_mv |
2019-04-25T13:35:06Z |
dc.date.issued.fl_str_mv |
2019-02-25 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/masterThesis |
format |
masterThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
SCANDOLARA, Thalita Basso. Anticorpos anti-neutrófilos em pacientes com câncer de mama e sua correlação com parâmetros clinicopatológicos. 2019. 94 f. Dissertação (Mestrado em Ciências Aplicadas à Saúde) - Universidade Estadual do Oeste do Paraná, Francisco Beltrão, 2019. |
dc.identifier.uri.fl_str_mv |
http://tede.unioeste.br/handle/tede/4225 |
identifier_str_mv |
SCANDOLARA, Thalita Basso. Anticorpos anti-neutrófilos em pacientes com câncer de mama e sua correlação com parâmetros clinicopatológicos. 2019. 94 f. Dissertação (Mestrado em Ciências Aplicadas à Saúde) - Universidade Estadual do Oeste do Paraná, Francisco Beltrão, 2019. |
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http://tede.unioeste.br/handle/tede/4225 |
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por |
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por |
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600 600 600 600 |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by-nc-nd/4.0/ |
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Universidade Estadual do Oeste do Paraná Francisco Beltrão |
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Programa de Pós-Graduação em Ciências Aplicadas à Saúde |
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UNIOESTE |
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Brasil |
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Centro de Ciências da Saúde |
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Universidade Estadual do Oeste do Paraná Francisco Beltrão |
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