Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: An immunohistochemical study
Autor(a) principal: | |
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Data de Publicação: | 2021 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4322/acr.2020.219 http://hdl.handle.net/11449/207654 |
Resumo: | Spindle cell squamous cell carcinoma (SpSCC) is a rare biphasic malignant neoplasm, uncommonly affecting the oral cavity. The SpSCC diagnosis is difficult, especially when it exhibits inconspicuous morphology, inadequate tissue sampling, or association with an exuberant inflammatory reaction. Post-radiotherapy recurrent SpSCC occurring at the same site of conventional SCC is a rare phenomenon. A 59-year-old man was complained of “painful injury on the tongue” with 20 days of duration. He reported smoking and alcohol consumption. Medical history revealed conventional SCC on the tongue treated with surgery and radiotherapy 10 years ago. Intraoral examination showed a polypoid lesion with ulcerated areas, measuring 3 cm in diameter, on the tongue and floor of the mouth, at the same site of previous conventional SCC. The microscopical analysis showed small foci of carcinomatous component admixed with an exuberant inflammatory reaction. Immunohistochemistry highlighted the sarcomatoid component. Both malignant components were positive for EMA, CD138, p40 (deltaNp63), p63, and p53. Moreover, CK AE1/AE3 evidenced the carcinomatous component, whereas vimentin stained the sarcomatoid component. The Ki-67 was >10%. The current case emphasizes the importance of immunohistochemistry in the differential diagnosis of SpSCC from mimics and documents a rare complication of Ionizing Radiation. |
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Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: An immunohistochemical studyImmunohistochemistryRadiotherapySquamous cell carcinomaSquamous cell carcinoma of head and neckSpindle cell squamous cell carcinoma (SpSCC) is a rare biphasic malignant neoplasm, uncommonly affecting the oral cavity. The SpSCC diagnosis is difficult, especially when it exhibits inconspicuous morphology, inadequate tissue sampling, or association with an exuberant inflammatory reaction. Post-radiotherapy recurrent SpSCC occurring at the same site of conventional SCC is a rare phenomenon. A 59-year-old man was complained of “painful injury on the tongue” with 20 days of duration. He reported smoking and alcohol consumption. Medical history revealed conventional SCC on the tongue treated with surgery and radiotherapy 10 years ago. Intraoral examination showed a polypoid lesion with ulcerated areas, measuring 3 cm in diameter, on the tongue and floor of the mouth, at the same site of previous conventional SCC. The microscopical analysis showed small foci of carcinomatous component admixed with an exuberant inflammatory reaction. Immunohistochemistry highlighted the sarcomatoid component. Both malignant components were positive for EMA, CD138, p40 (deltaNp63), p63, and p53. Moreover, CK AE1/AE3 evidenced the carcinomatous component, whereas vimentin stained the sarcomatoid component. The Ki-67 was >10%. The current case emphasizes the importance of immunohistochemistry in the differential diagnosis of SpSCC from mimics and documents a rare complication of Ionizing Radiation.Universidade Estadual de São Paulo (UNESP) Faculdade de Odontologia de Araraquara Departamento de Diagnóstico e Cirurgia Medicina OralUniversidade de São Paulo (USP) Faculdade de Odontologia de Riberão Preto Departamento de Estomatologia Saúde Coletiva e Odontologia Legal Patologia OralUniversidade Estadual de São Paulo (UNESP) Faculdade de Odontologia de Araraquara Departamento de Diagnóstico e Cirurgia Medicina OralUniversidade Estadual Paulista (Unesp)Universidade de São Paulo (USP)Ferrisse, Túlio Morandin [UNESP]Rocha, Audrey Foster Lefort [UNESP]Lança, Maria Letícia De Almeida [UNESP]Silveira, Heitor Albergoni [UNESP]Almeida, Luciana Yamamoto [UNESP]Bufalino, Andreia [UNESP]León, Jorge Esquiche2021-06-25T10:58:43Z2021-06-25T10:58:43Z2021-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://dx.doi.org/10.4322/acr.2020.219Autopsy and Case Reports, v. 11.2236-1960http://hdl.handle.net/11449/20765410.4322/acr.2020.2192-s2.0-85104855505Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAutopsy and Case Reportsinfo:eu-repo/semantics/openAccess2021-10-23T17:45:55Zoai:repositorio.unesp.br:11449/207654Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462021-10-23T17:45:55Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: An immunohistochemical study |
title |
Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: An immunohistochemical study |
spellingShingle |
Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: An immunohistochemical study Ferrisse, Túlio Morandin [UNESP] Immunohistochemistry Radiotherapy Squamous cell carcinoma Squamous cell carcinoma of head and neck |
title_short |
Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: An immunohistochemical study |
title_full |
Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: An immunohistochemical study |
title_fullStr |
Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: An immunohistochemical study |
title_full_unstemmed |
Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: An immunohistochemical study |
title_sort |
Post-radiotherapy recurrence of conventional oral squamous cell carcinoma showing sarcomatoid components: An immunohistochemical study |
author |
Ferrisse, Túlio Morandin [UNESP] |
author_facet |
Ferrisse, Túlio Morandin [UNESP] Rocha, Audrey Foster Lefort [UNESP] Lança, Maria Letícia De Almeida [UNESP] Silveira, Heitor Albergoni [UNESP] Almeida, Luciana Yamamoto [UNESP] Bufalino, Andreia [UNESP] León, Jorge Esquiche |
author_role |
author |
author2 |
Rocha, Audrey Foster Lefort [UNESP] Lança, Maria Letícia De Almeida [UNESP] Silveira, Heitor Albergoni [UNESP] Almeida, Luciana Yamamoto [UNESP] Bufalino, Andreia [UNESP] León, Jorge Esquiche |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade de São Paulo (USP) |
dc.contributor.author.fl_str_mv |
Ferrisse, Túlio Morandin [UNESP] Rocha, Audrey Foster Lefort [UNESP] Lança, Maria Letícia De Almeida [UNESP] Silveira, Heitor Albergoni [UNESP] Almeida, Luciana Yamamoto [UNESP] Bufalino, Andreia [UNESP] León, Jorge Esquiche |
dc.subject.por.fl_str_mv |
Immunohistochemistry Radiotherapy Squamous cell carcinoma Squamous cell carcinoma of head and neck |
topic |
Immunohistochemistry Radiotherapy Squamous cell carcinoma Squamous cell carcinoma of head and neck |
description |
Spindle cell squamous cell carcinoma (SpSCC) is a rare biphasic malignant neoplasm, uncommonly affecting the oral cavity. The SpSCC diagnosis is difficult, especially when it exhibits inconspicuous morphology, inadequate tissue sampling, or association with an exuberant inflammatory reaction. Post-radiotherapy recurrent SpSCC occurring at the same site of conventional SCC is a rare phenomenon. A 59-year-old man was complained of “painful injury on the tongue” with 20 days of duration. He reported smoking and alcohol consumption. Medical history revealed conventional SCC on the tongue treated with surgery and radiotherapy 10 years ago. Intraoral examination showed a polypoid lesion with ulcerated areas, measuring 3 cm in diameter, on the tongue and floor of the mouth, at the same site of previous conventional SCC. The microscopical analysis showed small foci of carcinomatous component admixed with an exuberant inflammatory reaction. Immunohistochemistry highlighted the sarcomatoid component. Both malignant components were positive for EMA, CD138, p40 (deltaNp63), p63, and p53. Moreover, CK AE1/AE3 evidenced the carcinomatous component, whereas vimentin stained the sarcomatoid component. The Ki-67 was >10%. The current case emphasizes the importance of immunohistochemistry in the differential diagnosis of SpSCC from mimics and documents a rare complication of Ionizing Radiation. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-06-25T10:58:43Z 2021-06-25T10:58:43Z 2021-01-01 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4322/acr.2020.219 Autopsy and Case Reports, v. 11. 2236-1960 http://hdl.handle.net/11449/207654 10.4322/acr.2020.219 2-s2.0-85104855505 |
url |
http://dx.doi.org/10.4322/acr.2020.219 http://hdl.handle.net/11449/207654 |
identifier_str_mv |
Autopsy and Case Reports, v. 11. 2236-1960 10.4322/acr.2020.219 2-s2.0-85104855505 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Autopsy and Case Reports |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799964838650183680 |