Aging effects on the mongolian gerbil female prostate (Skene's paraurethral glands): Structural, ultrastructural, quantitative, and hormonal evaluations
Autor(a) principal: | |
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Data de Publicação: | 2008 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1002/ar.20637 http://hdl.handle.net/11449/21535 |
Resumo: | Different from the classic view, the prostate is not a gland exclusive to the male, also being an organ of the female genital system presenting morphofunctional similarity between human and rodent. Thus structural, ultrastructural, morphometric-stereological features of the female prostate (Skene's paraurethral gland) and steroid serological levels were evaluated during young, adult, and senile ages in the Mongolian gerbil. The morphofunctional precocity of the female gland in comparison with the male gland occurring in young gland is probably associated with the female circulating steroid levels. The hormonal imbalance in senesce coincides with its susceptibility to histopathological lesions, such as epithelial hypertrophy, metaplasia, and intraepithelial neoplasia. Differently than that of males, the aging degeneration of the female gland involves the accumulation of lipofuscin granules. However, the alterations in senile prostate did not damage its functionality. These analyses reinforce the use of this experimental model for the comprehension of glandular morphofunctional aspects with special attention to senescence. Thus, the appreciation of this organ becomes relevant to avoid future discomfort to women's health. |
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Aging effects on the mongolian gerbil female prostate (Skene's paraurethral glands): Structural, ultrastructural, quantitative, and hormonal evaluationsfemale prostateMongolian gerbilagingsteroids hormoneshistopathologyultrastructureDifferent from the classic view, the prostate is not a gland exclusive to the male, also being an organ of the female genital system presenting morphofunctional similarity between human and rodent. Thus structural, ultrastructural, morphometric-stereological features of the female prostate (Skene's paraurethral gland) and steroid serological levels were evaluated during young, adult, and senile ages in the Mongolian gerbil. The morphofunctional precocity of the female gland in comparison with the male gland occurring in young gland is probably associated with the female circulating steroid levels. The hormonal imbalance in senesce coincides with its susceptibility to histopathological lesions, such as epithelial hypertrophy, metaplasia, and intraepithelial neoplasia. Differently than that of males, the aging degeneration of the female gland involves the accumulation of lipofuscin granules. However, the alterations in senile prostate did not damage its functionality. These analyses reinforce the use of this experimental model for the comprehension of glandular morphofunctional aspects with special attention to senescence. Thus, the appreciation of this organ becomes relevant to avoid future discomfort to women's health.UNESP, IBILCE, Dept Biol, Lab Microscopy & Microanal, BR-15054000 Sao Jose do Rio Preto, SP, BrazilUniv Estadual Campinas, Inst Biol, Dept Cell Biol, Campinas, SP, BrazilUNIRP, Biol Sci & Vet Med Sch, Rio Preto Univ Ctr, Sao Jose do Rio Preto, SP, BrazilUNESP, IBILCE, Dept Biol, Lab Microscopy & Microanal, BR-15054000 Sao Jose do Rio Preto, SP, BrazilWiley-lissUniversidade Estadual Paulista (Unesp)Universidade Estadual de Campinas (UNICAMP)UNIRPCustodio, Ana Maria G.Santos, Fernanda C. A. [UNESP]Campos, Silvana G. P. [UNESP]Vilamaior, Patricia S. L. [UNESP]Goes, Rejane M. [UNESP]Taboga, Sebastiao R. [UNESP]2014-05-20T14:00:57Z2014-05-20T14:00:57Z2008-04-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article463-474http://dx.doi.org/10.1002/ar.20637Anatomical Record-advances In Integrative Anatomy and Evolutionary Biology. Hoboken: Wiley-liss, v. 291, n. 4, p. 463-474, 2008.1932-8486http://hdl.handle.net/11449/2153510.1002/ar.20637WOS:000254127400010706635812379043409471933473121570000-0002-0970-42880000-0001-9559-54970000-0002-3622-460XWeb of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengAnatomical Record-advances In Integrative Anatomy and Evolutionary Biology1.3730,766info:eu-repo/semantics/openAccess2024-04-11T19:33:57Zoai:repositorio.unesp.br:11449/21535Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-04-11T19:33:57Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Aging effects on the mongolian gerbil female prostate (Skene's paraurethral glands): Structural, ultrastructural, quantitative, and hormonal evaluations |
title |
Aging effects on the mongolian gerbil female prostate (Skene's paraurethral glands): Structural, ultrastructural, quantitative, and hormonal evaluations |
spellingShingle |
Aging effects on the mongolian gerbil female prostate (Skene's paraurethral glands): Structural, ultrastructural, quantitative, and hormonal evaluations Custodio, Ana Maria G. female prostate Mongolian gerbil aging steroids hormones histopathology ultrastructure |
title_short |
Aging effects on the mongolian gerbil female prostate (Skene's paraurethral glands): Structural, ultrastructural, quantitative, and hormonal evaluations |
title_full |
Aging effects on the mongolian gerbil female prostate (Skene's paraurethral glands): Structural, ultrastructural, quantitative, and hormonal evaluations |
title_fullStr |
Aging effects on the mongolian gerbil female prostate (Skene's paraurethral glands): Structural, ultrastructural, quantitative, and hormonal evaluations |
title_full_unstemmed |
Aging effects on the mongolian gerbil female prostate (Skene's paraurethral glands): Structural, ultrastructural, quantitative, and hormonal evaluations |
title_sort |
Aging effects on the mongolian gerbil female prostate (Skene's paraurethral glands): Structural, ultrastructural, quantitative, and hormonal evaluations |
author |
Custodio, Ana Maria G. |
author_facet |
Custodio, Ana Maria G. Santos, Fernanda C. A. [UNESP] Campos, Silvana G. P. [UNESP] Vilamaior, Patricia S. L. [UNESP] Goes, Rejane M. [UNESP] Taboga, Sebastiao R. [UNESP] |
author_role |
author |
author2 |
Santos, Fernanda C. A. [UNESP] Campos, Silvana G. P. [UNESP] Vilamaior, Patricia S. L. [UNESP] Goes, Rejane M. [UNESP] Taboga, Sebastiao R. [UNESP] |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) Universidade Estadual de Campinas (UNICAMP) UNIRP |
dc.contributor.author.fl_str_mv |
Custodio, Ana Maria G. Santos, Fernanda C. A. [UNESP] Campos, Silvana G. P. [UNESP] Vilamaior, Patricia S. L. [UNESP] Goes, Rejane M. [UNESP] Taboga, Sebastiao R. [UNESP] |
dc.subject.por.fl_str_mv |
female prostate Mongolian gerbil aging steroids hormones histopathology ultrastructure |
topic |
female prostate Mongolian gerbil aging steroids hormones histopathology ultrastructure |
description |
Different from the classic view, the prostate is not a gland exclusive to the male, also being an organ of the female genital system presenting morphofunctional similarity between human and rodent. Thus structural, ultrastructural, morphometric-stereological features of the female prostate (Skene's paraurethral gland) and steroid serological levels were evaluated during young, adult, and senile ages in the Mongolian gerbil. The morphofunctional precocity of the female gland in comparison with the male gland occurring in young gland is probably associated with the female circulating steroid levels. The hormonal imbalance in senesce coincides with its susceptibility to histopathological lesions, such as epithelial hypertrophy, metaplasia, and intraepithelial neoplasia. Differently than that of males, the aging degeneration of the female gland involves the accumulation of lipofuscin granules. However, the alterations in senile prostate did not damage its functionality. These analyses reinforce the use of this experimental model for the comprehension of glandular morphofunctional aspects with special attention to senescence. Thus, the appreciation of this organ becomes relevant to avoid future discomfort to women's health. |
publishDate |
2008 |
dc.date.none.fl_str_mv |
2008-04-01 2014-05-20T14:00:57Z 2014-05-20T14:00:57Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1002/ar.20637 Anatomical Record-advances In Integrative Anatomy and Evolutionary Biology. Hoboken: Wiley-liss, v. 291, n. 4, p. 463-474, 2008. 1932-8486 http://hdl.handle.net/11449/21535 10.1002/ar.20637 WOS:000254127400010 7066358123790434 0947193347312157 0000-0002-0970-4288 0000-0001-9559-5497 0000-0002-3622-460X |
url |
http://dx.doi.org/10.1002/ar.20637 http://hdl.handle.net/11449/21535 |
identifier_str_mv |
Anatomical Record-advances In Integrative Anatomy and Evolutionary Biology. Hoboken: Wiley-liss, v. 291, n. 4, p. 463-474, 2008. 1932-8486 10.1002/ar.20637 WOS:000254127400010 7066358123790434 0947193347312157 0000-0002-0970-4288 0000-0001-9559-5497 0000-0002-3622-460X |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Anatomical Record-advances In Integrative Anatomy and Evolutionary Biology 1.373 0,766 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
463-474 |
dc.publisher.none.fl_str_mv |
Wiley-liss |
publisher.none.fl_str_mv |
Wiley-liss |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1799965472408469504 |