Antipyretic Effects of Citral and Possible Mechanisms of Action

Detalhes bibliográficos
Autor(a) principal: Emilio-Silva, Maycon T.
Data de Publicação: 2017
Outros Autores: Mota, Clarissa M. D., Hiruma-Lima, Clelia A. [UNESP], Antunes-Rodrigues, Jose, Carnio, Evelin C., Branco, Luiz G. S.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://dx.doi.org/10.1007/s10753-017-0615-4
http://hdl.handle.net/11449/164775
Resumo: Citral is a mixture of the two monoterpenoid isomers (neral and geranial) widely used as a health-promoting food additive safe for human and animal (approved by the US Food and Drug Administration). In vitro studies have reported on the capability of citral to reduce inflammation. Here, we report antipyretic effects of citral in vivo using the most well-accepted model of sickness syndrome, i.e., systemic administration of) to rats. Citral given by gavage caused no change in control euthermic rats (treated with saline) but blunted most of the assessed parameters related to the sickness syndrome [fever (hallmark of infection), plasma cytokines (IL-1 beta, IL-6, and TNF-alpha) release, and prostaglandin E-2 (PGE(2)) synthesis (both peripherally and hypothalamic)]. Moreover, LPS caused a sharp increase in plasma corticosterone levels that was unaltered by citral. These data are consistent with the notion that citral has a corticosterone-independent potent antipyretic effect, acting on the peripheral febrigenic signaling (plasma levels of IL-1 beta, IL-6, TNF-alpha, and PGE(2)), eventually down-modulating hypothalamic PGE(2) production.
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spelling Antipyretic Effects of Citral and Possible Mechanisms of ActionendotoxinfeverLPSIL-1 betaIL-6TNF-alphacorticosteronesystemic inflammationsickness syndromeCitral is a mixture of the two monoterpenoid isomers (neral and geranial) widely used as a health-promoting food additive safe for human and animal (approved by the US Food and Drug Administration). In vitro studies have reported on the capability of citral to reduce inflammation. Here, we report antipyretic effects of citral in vivo using the most well-accepted model of sickness syndrome, i.e., systemic administration of) to rats. Citral given by gavage caused no change in control euthermic rats (treated with saline) but blunted most of the assessed parameters related to the sickness syndrome [fever (hallmark of infection), plasma cytokines (IL-1 beta, IL-6, and TNF-alpha) release, and prostaglandin E-2 (PGE(2)) synthesis (both peripherally and hypothalamic)]. Moreover, LPS caused a sharp increase in plasma corticosterone levels that was unaltered by citral. These data are consistent with the notion that citral has a corticosterone-independent potent antipyretic effect, acting on the peripheral febrigenic signaling (plasma levels of IL-1 beta, IL-6, TNF-alpha, and PGE(2)), eventually down-modulating hypothalamic PGE(2) production.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Sao Paulo, Med Sch Ribeirao Preto, BR-14049900 Sao Paulo, BrazilUniv Estadual Paulista, Biosci Inst, Dept Physiol, Nat Prod Lab, BR-18618970 Sao Paulo, BrazilUniv Sao Paulo, Nursing Sch Ribeiro Preto, BR-14040902 Sao Paulo, BrazilUniv Sao Paulo, Dept Morphol Physiol & Basic Pathol, Dent Sch Ribeirao Preto, BR-14040904 Ribeirao Preto, SP, BrazilUniv Estadual Paulista, Biosci Inst, Dept Physiol, Nat Prod Lab, BR-18618970 Sao Paulo, BrazilFAPESP: 2016/17681-9SpringerUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Emilio-Silva, Maycon T.Mota, Clarissa M. D.Hiruma-Lima, Clelia A. [UNESP]Antunes-Rodrigues, JoseCarnio, Evelin C.Branco, Luiz G. S.2018-11-26T17:56:03Z2018-11-26T17:56:03Z2017-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1735-1741application/pdfhttp://dx.doi.org/10.1007/s10753-017-0615-4Inflammation. New York: Springer/plenum Publishers, v. 40, n. 5, p. 1735-1741, 2017.0360-3997http://hdl.handle.net/11449/16477510.1007/s10753-017-0615-4WOS:000409472600026WOS000409472600026.pdf38145049013868440000-0002-8645-3777Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInflammation1,023info:eu-repo/semantics/openAccess2024-08-15T18:46:27Zoai:repositorio.unesp.br:11449/164775Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T18:46:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Antipyretic Effects of Citral and Possible Mechanisms of Action
title Antipyretic Effects of Citral and Possible Mechanisms of Action
spellingShingle Antipyretic Effects of Citral and Possible Mechanisms of Action
Emilio-Silva, Maycon T.
endotoxin
fever
LPS
IL-1 beta
IL-6
TNF-alpha
corticosterone
systemic inflammation
sickness syndrome
title_short Antipyretic Effects of Citral and Possible Mechanisms of Action
title_full Antipyretic Effects of Citral and Possible Mechanisms of Action
title_fullStr Antipyretic Effects of Citral and Possible Mechanisms of Action
title_full_unstemmed Antipyretic Effects of Citral and Possible Mechanisms of Action
title_sort Antipyretic Effects of Citral and Possible Mechanisms of Action
author Emilio-Silva, Maycon T.
author_facet Emilio-Silva, Maycon T.
Mota, Clarissa M. D.
Hiruma-Lima, Clelia A. [UNESP]
Antunes-Rodrigues, Jose
Carnio, Evelin C.
Branco, Luiz G. S.
author_role author
author2 Mota, Clarissa M. D.
Hiruma-Lima, Clelia A. [UNESP]
Antunes-Rodrigues, Jose
Carnio, Evelin C.
Branco, Luiz G. S.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade de São Paulo (USP)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Emilio-Silva, Maycon T.
Mota, Clarissa M. D.
Hiruma-Lima, Clelia A. [UNESP]
Antunes-Rodrigues, Jose
Carnio, Evelin C.
Branco, Luiz G. S.
dc.subject.por.fl_str_mv endotoxin
fever
LPS
IL-1 beta
IL-6
TNF-alpha
corticosterone
systemic inflammation
sickness syndrome
topic endotoxin
fever
LPS
IL-1 beta
IL-6
TNF-alpha
corticosterone
systemic inflammation
sickness syndrome
description Citral is a mixture of the two monoterpenoid isomers (neral and geranial) widely used as a health-promoting food additive safe for human and animal (approved by the US Food and Drug Administration). In vitro studies have reported on the capability of citral to reduce inflammation. Here, we report antipyretic effects of citral in vivo using the most well-accepted model of sickness syndrome, i.e., systemic administration of) to rats. Citral given by gavage caused no change in control euthermic rats (treated with saline) but blunted most of the assessed parameters related to the sickness syndrome [fever (hallmark of infection), plasma cytokines (IL-1 beta, IL-6, and TNF-alpha) release, and prostaglandin E-2 (PGE(2)) synthesis (both peripherally and hypothalamic)]. Moreover, LPS caused a sharp increase in plasma corticosterone levels that was unaltered by citral. These data are consistent with the notion that citral has a corticosterone-independent potent antipyretic effect, acting on the peripheral febrigenic signaling (plasma levels of IL-1 beta, IL-6, TNF-alpha, and PGE(2)), eventually down-modulating hypothalamic PGE(2) production.
publishDate 2017
dc.date.none.fl_str_mv 2017-10-01
2018-11-26T17:56:03Z
2018-11-26T17:56:03Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1007/s10753-017-0615-4
Inflammation. New York: Springer/plenum Publishers, v. 40, n. 5, p. 1735-1741, 2017.
0360-3997
http://hdl.handle.net/11449/164775
10.1007/s10753-017-0615-4
WOS:000409472600026
WOS000409472600026.pdf
3814504901386844
0000-0002-8645-3777
url http://dx.doi.org/10.1007/s10753-017-0615-4
http://hdl.handle.net/11449/164775
identifier_str_mv Inflammation. New York: Springer/plenum Publishers, v. 40, n. 5, p. 1735-1741, 2017.
0360-3997
10.1007/s10753-017-0615-4
WOS:000409472600026
WOS000409472600026.pdf
3814504901386844
0000-0002-8645-3777
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Inflammation
1,023
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1735-1741
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Web of Science
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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