Antipyretic Effects of Citral and Possible Mechanisms of Action
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.1007/s10753-017-0615-4 http://hdl.handle.net/11449/164775 |
Resumo: | Citral is a mixture of the two monoterpenoid isomers (neral and geranial) widely used as a health-promoting food additive safe for human and animal (approved by the US Food and Drug Administration). In vitro studies have reported on the capability of citral to reduce inflammation. Here, we report antipyretic effects of citral in vivo using the most well-accepted model of sickness syndrome, i.e., systemic administration of) to rats. Citral given by gavage caused no change in control euthermic rats (treated with saline) but blunted most of the assessed parameters related to the sickness syndrome [fever (hallmark of infection), plasma cytokines (IL-1 beta, IL-6, and TNF-alpha) release, and prostaglandin E-2 (PGE(2)) synthesis (both peripherally and hypothalamic)]. Moreover, LPS caused a sharp increase in plasma corticosterone levels that was unaltered by citral. These data are consistent with the notion that citral has a corticosterone-independent potent antipyretic effect, acting on the peripheral febrigenic signaling (plasma levels of IL-1 beta, IL-6, TNF-alpha, and PGE(2)), eventually down-modulating hypothalamic PGE(2) production. |
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Antipyretic Effects of Citral and Possible Mechanisms of ActionendotoxinfeverLPSIL-1 betaIL-6TNF-alphacorticosteronesystemic inflammationsickness syndromeCitral is a mixture of the two monoterpenoid isomers (neral and geranial) widely used as a health-promoting food additive safe for human and animal (approved by the US Food and Drug Administration). In vitro studies have reported on the capability of citral to reduce inflammation. Here, we report antipyretic effects of citral in vivo using the most well-accepted model of sickness syndrome, i.e., systemic administration of) to rats. Citral given by gavage caused no change in control euthermic rats (treated with saline) but blunted most of the assessed parameters related to the sickness syndrome [fever (hallmark of infection), plasma cytokines (IL-1 beta, IL-6, and TNF-alpha) release, and prostaglandin E-2 (PGE(2)) synthesis (both peripherally and hypothalamic)]. Moreover, LPS caused a sharp increase in plasma corticosterone levels that was unaltered by citral. These data are consistent with the notion that citral has a corticosterone-independent potent antipyretic effect, acting on the peripheral febrigenic signaling (plasma levels of IL-1 beta, IL-6, TNF-alpha, and PGE(2)), eventually down-modulating hypothalamic PGE(2) production.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Univ Sao Paulo, Med Sch Ribeirao Preto, BR-14049900 Sao Paulo, BrazilUniv Estadual Paulista, Biosci Inst, Dept Physiol, Nat Prod Lab, BR-18618970 Sao Paulo, BrazilUniv Sao Paulo, Nursing Sch Ribeiro Preto, BR-14040902 Sao Paulo, BrazilUniv Sao Paulo, Dept Morphol Physiol & Basic Pathol, Dent Sch Ribeirao Preto, BR-14040904 Ribeirao Preto, SP, BrazilUniv Estadual Paulista, Biosci Inst, Dept Physiol, Nat Prod Lab, BR-18618970 Sao Paulo, BrazilFAPESP: 2016/17681-9SpringerUniversidade de São Paulo (USP)Universidade Estadual Paulista (Unesp)Emilio-Silva, Maycon T.Mota, Clarissa M. D.Hiruma-Lima, Clelia A. [UNESP]Antunes-Rodrigues, JoseCarnio, Evelin C.Branco, Luiz G. S.2018-11-26T17:56:03Z2018-11-26T17:56:03Z2017-10-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article1735-1741application/pdfhttp://dx.doi.org/10.1007/s10753-017-0615-4Inflammation. New York: Springer/plenum Publishers, v. 40, n. 5, p. 1735-1741, 2017.0360-3997http://hdl.handle.net/11449/16477510.1007/s10753-017-0615-4WOS:000409472600026WOS000409472600026.pdf38145049013868440000-0002-8645-3777Web of Sciencereponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengInflammation1,023info:eu-repo/semantics/openAccess2024-08-15T18:46:27Zoai:repositorio.unesp.br:11449/164775Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-15T18:46:27Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Antipyretic Effects of Citral and Possible Mechanisms of Action |
title |
Antipyretic Effects of Citral and Possible Mechanisms of Action |
spellingShingle |
Antipyretic Effects of Citral and Possible Mechanisms of Action Emilio-Silva, Maycon T. endotoxin fever LPS IL-1 beta IL-6 TNF-alpha corticosterone systemic inflammation sickness syndrome |
title_short |
Antipyretic Effects of Citral and Possible Mechanisms of Action |
title_full |
Antipyretic Effects of Citral and Possible Mechanisms of Action |
title_fullStr |
Antipyretic Effects of Citral and Possible Mechanisms of Action |
title_full_unstemmed |
Antipyretic Effects of Citral and Possible Mechanisms of Action |
title_sort |
Antipyretic Effects of Citral and Possible Mechanisms of Action |
author |
Emilio-Silva, Maycon T. |
author_facet |
Emilio-Silva, Maycon T. Mota, Clarissa M. D. Hiruma-Lima, Clelia A. [UNESP] Antunes-Rodrigues, Jose Carnio, Evelin C. Branco, Luiz G. S. |
author_role |
author |
author2 |
Mota, Clarissa M. D. Hiruma-Lima, Clelia A. [UNESP] Antunes-Rodrigues, Jose Carnio, Evelin C. Branco, Luiz G. S. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Estadual Paulista (Unesp) |
dc.contributor.author.fl_str_mv |
Emilio-Silva, Maycon T. Mota, Clarissa M. D. Hiruma-Lima, Clelia A. [UNESP] Antunes-Rodrigues, Jose Carnio, Evelin C. Branco, Luiz G. S. |
dc.subject.por.fl_str_mv |
endotoxin fever LPS IL-1 beta IL-6 TNF-alpha corticosterone systemic inflammation sickness syndrome |
topic |
endotoxin fever LPS IL-1 beta IL-6 TNF-alpha corticosterone systemic inflammation sickness syndrome |
description |
Citral is a mixture of the two monoterpenoid isomers (neral and geranial) widely used as a health-promoting food additive safe for human and animal (approved by the US Food and Drug Administration). In vitro studies have reported on the capability of citral to reduce inflammation. Here, we report antipyretic effects of citral in vivo using the most well-accepted model of sickness syndrome, i.e., systemic administration of) to rats. Citral given by gavage caused no change in control euthermic rats (treated with saline) but blunted most of the assessed parameters related to the sickness syndrome [fever (hallmark of infection), plasma cytokines (IL-1 beta, IL-6, and TNF-alpha) release, and prostaglandin E-2 (PGE(2)) synthesis (both peripherally and hypothalamic)]. Moreover, LPS caused a sharp increase in plasma corticosterone levels that was unaltered by citral. These data are consistent with the notion that citral has a corticosterone-independent potent antipyretic effect, acting on the peripheral febrigenic signaling (plasma levels of IL-1 beta, IL-6, TNF-alpha, and PGE(2)), eventually down-modulating hypothalamic PGE(2) production. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10-01 2018-11-26T17:56:03Z 2018-11-26T17:56:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1007/s10753-017-0615-4 Inflammation. New York: Springer/plenum Publishers, v. 40, n. 5, p. 1735-1741, 2017. 0360-3997 http://hdl.handle.net/11449/164775 10.1007/s10753-017-0615-4 WOS:000409472600026 WOS000409472600026.pdf 3814504901386844 0000-0002-8645-3777 |
url |
http://dx.doi.org/10.1007/s10753-017-0615-4 http://hdl.handle.net/11449/164775 |
identifier_str_mv |
Inflammation. New York: Springer/plenum Publishers, v. 40, n. 5, p. 1735-1741, 2017. 0360-3997 10.1007/s10753-017-0615-4 WOS:000409472600026 WOS000409472600026.pdf 3814504901386844 0000-0002-8645-3777 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Inflammation 1,023 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1735-1741 application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
Web of Science reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1808128126097555456 |