Frequency of various types of neoplasia in a group of acromegalic patients

• Autor(a) principal: Bolfi, Fernanda [UNESP]
• Data de Publicação: 2013
• Outros Autores: Miot, Hélio Amante [UNESP], Resende, Mariangela [UNESP], Mazeto, Glaucia Maria Ferreira da Silva [UNESP], Romeiro, Fernando Gomes [UNESP], Yamashiro, Fábio Da Silva [UNESP], Nunes, Vânia dos Santos [UNESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNESP
• Texto Completo: http://dx.doi.org/10.1590/S0004-27302013000800005; http://hdl.handle.net/11449/109817
• topic: Acromegalia; câncer de tireoide; câncer de cólon; hiperparatireoidismo primário; Acromegaly; thyroid neoplasms; colonic neoplasms; primary hyperparathyroidism

OBJECTIVE: To determine the frequency of colon cancer, primary hyperparathyroidism, thyroid tumor, and skin cancer in all acromegalic patients in follow-up at the Clinics Hospital - Botucatu Medical School, from 2005 to 2011. SUBJECTS AND METHODS: These patients were evaluated retrospectively for colon cancer, primary hyperparathyroidism, dermatological, and thyroid tumors. RESULTS: Of 29 patients included at the beginning of the study, two were excluded. Among 19 patients submitted to colonoscopy, one presented colon adenocarcinoma (5%). Thyroid nodules were present in 63% of patients, and papilliferous carcinoma was confirmed in two patients (7,7%). Four patients were confirmed as having primary hyperparathyroidism (15%). The most common dermatologic lesions were thickened skin (100%), acrochordons (64%), epidermal cysts (50%), and pseudo-acanthosis nigricans (50%). Only one patient presented basal cell carcinoma. CONCLUSION: Although a small number of acromegalic patients was studied, our findings confirm the high frequency of thyroid neoplasias and primary hyperparathyroidism in this group of patients.