HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2019 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNESP |
| Texto Completo: | http://dx.doi.org/10.1590/0037-8682-0427-2017 http://hdl.handle.net/11449/189420 |
Resumo: | Introduction: HPA polymorphism has been associated with HCV presence and fibrosis progression in chronic hepatitis C. However, it is unknown if there is an association between HPA-1 polymorphism and hepatocellular carcinoma (HCC). Therefore, this study aimed to evaluate HPA-1 polymorphism in the presence of HCC. Methods: PCR-SSP was used to perform HPA genotyping on 76 HCV-infected patients. Results: There was no association between patients with and without HCC. There was significant difference in HPA-1 genotypic frequency distribution between HCC and F1/F2 fibrosis degree. Conclusions: The HPA-1a/1b polymorphism appears to be more associated with liver damage progression than with HCC presence. |
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HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis CHepatitis C virusHepatocellular carcinomaHuman platelets antigensIntroduction: HPA polymorphism has been associated with HCV presence and fibrosis progression in chronic hepatitis C. However, it is unknown if there is an association between HPA-1 polymorphism and hepatocellular carcinoma (HCC). Therefore, this study aimed to evaluate HPA-1 polymorphism in the presence of HCC. Methods: PCR-SSP was used to perform HPA genotyping on 76 HCV-infected patients. Results: There was no association between patients with and without HCC. There was significant difference in HPA-1 genotypic frequency distribution between HCC and F1/F2 fibrosis degree. Conclusions: The HPA-1a/1b polymorphism appears to be more associated with liver damage progression than with HCC presence.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Laboratório de Biologia Molecular do Hemocentro Faculdade de Medicina de Botucatu Universidade Estadual PaulistaUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Agronômicas Departamento de Bioprocessos e BiotecnologiaUniversidade Estadual Paulista (UNESP) Faculdade de Medicina Departamento de Clínica MédicaLaboratório de Biologia Molecular do Hemocentro Faculdade de Medicina de Botucatu Universidade Estadual PaulistaUniversidade Estadual Paulista (UNESP) Faculdade de Ciências Agronômicas Departamento de Bioprocessos e BiotecnologiaUniversidade Estadual Paulista (UNESP) Faculdade de Medicina Departamento de Clínica MédicaFAPESP: 2014/20645-9Universidade Estadual Paulista (Unesp)Grotto, Rejane Maria Tommasini [UNESP]Santos, Francielle Martins [UNESP]Picelli, Natália [UNESP]Silva, Giovanni Faria [UNESP]Ferrasi, Adriana Camargo [UNESP]Sarnighausen, Valéria Cristina Rodrigues [UNESP]Pardini, Maria Inês de Moura Campos [UNESP]2019-10-06T16:40:08Z2019-10-06T16:40:08Z2019-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://dx.doi.org/10.1590/0037-8682-0427-2017Revista da Sociedade Brasileira de Medicina Tropical, v. 52.0037-8682http://hdl.handle.net/11449/18942010.1590/0037-8682-0427-2017S0037-868220190001006662-s2.0-85069269736S0037-86822019000100666.pdf461958833458208477884485643265850000-0002-4035-9486Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengRevista da Sociedade Brasileira de Medicina Tropicalinfo:eu-repo/semantics/openAccess2023-12-06T06:16:29Zoai:repositorio.unesp.br:11449/189420Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462023-12-06T06:16:29Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
| dc.title.none.fl_str_mv |
HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C |
| title |
HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C |
| spellingShingle |
HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C Grotto, Rejane Maria Tommasini [UNESP] Hepatitis C virus Hepatocellular carcinoma Human platelets antigens |
| title_short |
HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C |
| title_full |
HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C |
| title_fullStr |
HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C |
| title_full_unstemmed |
HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C |
| title_sort |
HPA-1a/1b could be considered a molecular predictor of poor prognosis in chronic hepatitis C |
| author |
Grotto, Rejane Maria Tommasini [UNESP] |
| author_facet |
Grotto, Rejane Maria Tommasini [UNESP] Santos, Francielle Martins [UNESP] Picelli, Natália [UNESP] Silva, Giovanni Faria [UNESP] Ferrasi, Adriana Camargo [UNESP] Sarnighausen, Valéria Cristina Rodrigues [UNESP] Pardini, Maria Inês de Moura Campos [UNESP] |
| author_role |
author |
| author2 |
Santos, Francielle Martins [UNESP] Picelli, Natália [UNESP] Silva, Giovanni Faria [UNESP] Ferrasi, Adriana Camargo [UNESP] Sarnighausen, Valéria Cristina Rodrigues [UNESP] Pardini, Maria Inês de Moura Campos [UNESP] |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Estadual Paulista (Unesp) |
| dc.contributor.author.fl_str_mv |
Grotto, Rejane Maria Tommasini [UNESP] Santos, Francielle Martins [UNESP] Picelli, Natália [UNESP] Silva, Giovanni Faria [UNESP] Ferrasi, Adriana Camargo [UNESP] Sarnighausen, Valéria Cristina Rodrigues [UNESP] Pardini, Maria Inês de Moura Campos [UNESP] |
| dc.subject.por.fl_str_mv |
Hepatitis C virus Hepatocellular carcinoma Human platelets antigens |
| topic |
Hepatitis C virus Hepatocellular carcinoma Human platelets antigens |
| description |
Introduction: HPA polymorphism has been associated with HCV presence and fibrosis progression in chronic hepatitis C. However, it is unknown if there is an association between HPA-1 polymorphism and hepatocellular carcinoma (HCC). Therefore, this study aimed to evaluate HPA-1 polymorphism in the presence of HCC. Methods: PCR-SSP was used to perform HPA genotyping on 76 HCV-infected patients. Results: There was no association between patients with and without HCC. There was significant difference in HPA-1 genotypic frequency distribution between HCC and F1/F2 fibrosis degree. Conclusions: The HPA-1a/1b polymorphism appears to be more associated with liver damage progression than with HCC presence. |
| publishDate |
2019 |
| dc.date.none.fl_str_mv |
2019-10-06T16:40:08Z 2019-10-06T16:40:08Z 2019-01-01 |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/0037-8682-0427-2017 Revista da Sociedade Brasileira de Medicina Tropical, v. 52. 0037-8682 http://hdl.handle.net/11449/189420 10.1590/0037-8682-0427-2017 S0037-86822019000100666 2-s2.0-85069269736 S0037-86822019000100666.pdf 4619588334582084 7788448564326585 0000-0002-4035-9486 |
| url |
http://dx.doi.org/10.1590/0037-8682-0427-2017 http://hdl.handle.net/11449/189420 |
| identifier_str_mv |
Revista da Sociedade Brasileira de Medicina Tropical, v. 52. 0037-8682 10.1590/0037-8682-0427-2017 S0037-86822019000100666 2-s2.0-85069269736 S0037-86822019000100666.pdf 4619588334582084 7788448564326585 0000-0002-4035-9486 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Revista da Sociedade Brasileira de Medicina Tropical |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
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Universidade Estadual Paulista (UNESP) |
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UNESP |
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UNESP |
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Repositório Institucional da UNESP |
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Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
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