Participation of endotoxin in root canal infections: A systematic review and meta-analysis
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNESP |
Texto Completo: | http://dx.doi.org/10.4103/ejd.ejd_84_17 http://hdl.handle.net/11449/231407 |
Resumo: | This systematic review and meta-analysis aimed to evaluate the relationship between endotoxin levels and presence of clinical signs/symptoms and radiographic features in patients with endodontic infection. Electronic searches were performed on Medline/ PubMed, Embase, Cochrane Library, Scielo, Science Direct, Web of Knowledge and Scopus databases for identification of relevant studies published up to December 2016. Grey literature was searched in Google Scholar. The selected literature was reviewed independently by two authors. Clinical studies evaluating the levels of endotoxin and the presence of clinical and radiographic features were included in this review. In order to determine the relationship between endotoxin levels and presence of clinical signs/symptoms and radiographic features meta-analyses were performed. Among the 385 articles identified in the initial search, 30 were included for full-text appraisal and only eight studies met the inclusion criteria for this systematic review. Meta-analysis revealed that individuals having teeth with tenderness to percussion (TTP) (P = 0.04; I2 57%) and previous episode of pain (PEP) (P = 0.001; I2 81%) had higher levels of endotoxin than their counterparts. Size of radiographic lesion > 2 mm (P = 0.02; I2 68%) and presence of root canal exudation (EX) (P = 0.0007; I2 0%) were associated with higher levels of endotoxin. This systematic review and meta-analyses provided a strong evidence that endotoxin are related with the presence of clinical signs/symptoms and radiographic features in patients with endodontic infection. |
id |
UNSP_08f0b1e050d31fda904006d49d549de0 |
---|---|
oai_identifier_str |
oai:repositorio.unesp.br:11449/231407 |
network_acronym_str |
UNSP |
network_name_str |
Repositório Institucional da UNESP |
repository_id_str |
2946 |
spelling |
Participation of endotoxin in root canal infections: A systematic review and meta-analysisEndodontic treatmentEndotoxinsMeta-analysisSystematic reviewThis systematic review and meta-analysis aimed to evaluate the relationship between endotoxin levels and presence of clinical signs/symptoms and radiographic features in patients with endodontic infection. Electronic searches were performed on Medline/ PubMed, Embase, Cochrane Library, Scielo, Science Direct, Web of Knowledge and Scopus databases for identification of relevant studies published up to December 2016. Grey literature was searched in Google Scholar. The selected literature was reviewed independently by two authors. Clinical studies evaluating the levels of endotoxin and the presence of clinical and radiographic features were included in this review. In order to determine the relationship between endotoxin levels and presence of clinical signs/symptoms and radiographic features meta-analyses were performed. Among the 385 articles identified in the initial search, 30 were included for full-text appraisal and only eight studies met the inclusion criteria for this systematic review. Meta-analysis revealed that individuals having teeth with tenderness to percussion (TTP) (P = 0.04; I2 57%) and previous episode of pain (PEP) (P = 0.001; I2 81%) had higher levels of endotoxin than their counterparts. Size of radiographic lesion > 2 mm (P = 0.02; I2 68%) and presence of root canal exudation (EX) (P = 0.0007; I2 0%) were associated with higher levels of endotoxin. This systematic review and meta-analyses provided a strong evidence that endotoxin are related with the presence of clinical signs/symptoms and radiographic features in patients with endodontic infection.Department of Restorative Dentistry São José dos Campos Dental School State University of São PauloSection of Periodontology Department of Dentistry and Oral Health Aarhus UniversityUniversidade de São Paulo (USP)Aarhus UniversityMartinho, Frederico Canatode Rabello, Diego Guilherme DiasFerreira, Luciana LouzadaNascimento, Gustavo Giacomelli2022-04-29T08:45:18Z2022-04-29T08:45:18Z2017-01-01info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article398-406http://dx.doi.org/10.4103/ejd.ejd_84_17European Journal of Dentistry, v. 11, n. 3, p. 398-406, 2017.1305-74641305-7456http://hdl.handle.net/11449/23140710.4103/ejd.ejd_84_172-s2.0-85027523819Scopusreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengEuropean Journal of Dentistryinfo:eu-repo/semantics/openAccess2022-04-29T08:45:18Zoai:repositorio.unesp.br:11449/231407Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462022-04-29T08:45:18Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false |
dc.title.none.fl_str_mv |
Participation of endotoxin in root canal infections: A systematic review and meta-analysis |
title |
Participation of endotoxin in root canal infections: A systematic review and meta-analysis |
spellingShingle |
Participation of endotoxin in root canal infections: A systematic review and meta-analysis Martinho, Frederico Canato Endodontic treatment Endotoxins Meta-analysis Systematic review |
title_short |
Participation of endotoxin in root canal infections: A systematic review and meta-analysis |
title_full |
Participation of endotoxin in root canal infections: A systematic review and meta-analysis |
title_fullStr |
Participation of endotoxin in root canal infections: A systematic review and meta-analysis |
title_full_unstemmed |
Participation of endotoxin in root canal infections: A systematic review and meta-analysis |
title_sort |
Participation of endotoxin in root canal infections: A systematic review and meta-analysis |
author |
Martinho, Frederico Canato |
author_facet |
Martinho, Frederico Canato de Rabello, Diego Guilherme Dias Ferreira, Luciana Louzada Nascimento, Gustavo Giacomelli |
author_role |
author |
author2 |
de Rabello, Diego Guilherme Dias Ferreira, Luciana Louzada Nascimento, Gustavo Giacomelli |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade de São Paulo (USP) Aarhus University |
dc.contributor.author.fl_str_mv |
Martinho, Frederico Canato de Rabello, Diego Guilherme Dias Ferreira, Luciana Louzada Nascimento, Gustavo Giacomelli |
dc.subject.por.fl_str_mv |
Endodontic treatment Endotoxins Meta-analysis Systematic review |
topic |
Endodontic treatment Endotoxins Meta-analysis Systematic review |
description |
This systematic review and meta-analysis aimed to evaluate the relationship between endotoxin levels and presence of clinical signs/symptoms and radiographic features in patients with endodontic infection. Electronic searches were performed on Medline/ PubMed, Embase, Cochrane Library, Scielo, Science Direct, Web of Knowledge and Scopus databases for identification of relevant studies published up to December 2016. Grey literature was searched in Google Scholar. The selected literature was reviewed independently by two authors. Clinical studies evaluating the levels of endotoxin and the presence of clinical and radiographic features were included in this review. In order to determine the relationship between endotoxin levels and presence of clinical signs/symptoms and radiographic features meta-analyses were performed. Among the 385 articles identified in the initial search, 30 were included for full-text appraisal and only eight studies met the inclusion criteria for this systematic review. Meta-analysis revealed that individuals having teeth with tenderness to percussion (TTP) (P = 0.04; I2 57%) and previous episode of pain (PEP) (P = 0.001; I2 81%) had higher levels of endotoxin than their counterparts. Size of radiographic lesion > 2 mm (P = 0.02; I2 68%) and presence of root canal exudation (EX) (P = 0.0007; I2 0%) were associated with higher levels of endotoxin. This systematic review and meta-analyses provided a strong evidence that endotoxin are related with the presence of clinical signs/symptoms and radiographic features in patients with endodontic infection. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-01-01 2022-04-29T08:45:18Z 2022-04-29T08:45:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.4103/ejd.ejd_84_17 European Journal of Dentistry, v. 11, n. 3, p. 398-406, 2017. 1305-7464 1305-7456 http://hdl.handle.net/11449/231407 10.4103/ejd.ejd_84_17 2-s2.0-85027523819 |
url |
http://dx.doi.org/10.4103/ejd.ejd_84_17 http://hdl.handle.net/11449/231407 |
identifier_str_mv |
European Journal of Dentistry, v. 11, n. 3, p. 398-406, 2017. 1305-7464 1305-7456 10.4103/ejd.ejd_84_17 2-s2.0-85027523819 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
European Journal of Dentistry |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
398-406 |
dc.source.none.fl_str_mv |
Scopus reponame:Repositório Institucional da UNESP instname:Universidade Estadual Paulista (UNESP) instacron:UNESP |
instname_str |
Universidade Estadual Paulista (UNESP) |
instacron_str |
UNESP |
institution |
UNESP |
reponame_str |
Repositório Institucional da UNESP |
collection |
Repositório Institucional da UNESP |
repository.name.fl_str_mv |
Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP) |
repository.mail.fl_str_mv |
|
_version_ |
1797790285362626560 |